Interactions between environmental sensitivity and gut microbiota are associated with biomarkers of stress-related psychiatric symptoms DOI Creative Commons
Shuhei Iimura, Satoshi Takasugi,

Miyabi Yasuda

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 339, P. 136 - 144

Published: July 10, 2023

Humans vary in their sensitivity to stressful and supportive environments experiences. Such individual differences environmental are associated with mechanisms of stress-related psychiatric symptoms. In recent years, researchers have focused on bidirectional interactions the brain-gut-microbiota axis as a neurophysiological pathway contributing symptoms, evidence is rapidly accumulating.Data sensitivity, gut microbiota, permeability (lipopolysaccharide-binding protein; LBP) inflammation (C-reactive CRP) were collected from 90 adults (50 % female; Mage = 42.1; SDage 10.0). Environmental was measured using self-report questionnaire. Study participants' feces analyzed, observed operational taxonomic units for richness, Shannon's index evenness, phylogenetic diversity biodiversity evaluated indicators microbiota. addition, serum analyzed CRP LBP. We investigated whether interaction between microbiota biomarkers permeability.The (excluding index) explained levels these biomarkers. Individuals high displayed higher LBP, when richness low. However, even highly susceptible individuals had lower high.Our study indicates that can be risk factor permeability, low, suggesting interaction.

Language: Английский

Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: a narrative review DOI Creative Commons
Alison Warren, Yvonne Nyavor,

A Beguelin

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 2, 2024

More than 20% of American adults live with a mental disorder, many whom are treatment resistant or continue to experience symptoms. Other approaches needed improve health care, including prevention. The role the microbiome has emerged as central tenet in and physical their interconnectedness (well-being). Under normal conditions, healthy promotes homeostasis within host by maintaining intestinal brain barrier integrity, thereby facilitating well-being. Owing multidirectional crosstalk between neuro-endocrine-immune systems, dysbiosis is main driver immune-mediated systemic neural inflammation that can promote disease progression detrimental well-being broadly particular. In predisposed individuals, immune dysregulation shift autoimmunity, especially presence psychological triggers. chronic stress response involves system, which intimately involved gut microbiome, particularly process education. This interconnection forms microbiota-gut-immune-brain axis disorders. this brief review, we aim highlight relationships stress, health, along ways dysregulated system an autoimmune concomitant neuropsychological consequences context axis. Finally, review evidenced-based prevention strategies potential therapeutic targets.

Language: Английский

Citations

17
Therapeutic role of gut microbiota in lung injury-related cognitive impairment DOI Creative Commons
Yanxia Cheng,

Guangtao Hu,

Lin Deng

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Feb. 13, 2025

Lung injury can lead to specific neurocognitive dysfunction, and the “triple-hit” phenomenon may be key theoretical mechanism for progressive impairment of lung injury-related cognitive impairment. The brain communicate biologically through immune regulation pathway, hypoxic neural circuit, mitochondrial microbial influence, which is called “lung-brain axis.” gut microbiota a highly complex community microorganisms that reside in with via “gut-lung dysregulation migration pathogenic bacteria lung, directly or indirectly regulate response their metabolites, cause aggravate injury. interact “gut-brain influence function behavior pathway mechanisms, hypothalamic–pituitary–adrenal (HPA) axis regulation. Based on axis” axis,” combined mechanisms caused by injury, we proposed hypothesis. It states pathophysiological changes trigger series events such as disorder, inflammatory responses, changes, activate “lung-gut thus forming leads development deterioration This hypothesis provides more comprehensive framework studying understanding dysfunction context review proposes existence an interactive tandem network information exchange among gut, brain, referred “gut-lung-brain further explores potential multiple interactions We found there are many numerous factors interaction within impact functions related mediated hypothesis, direct translocation microbes modulation, vagal nerve activity, HPA regulation, others. As research deepens, based it discovered therapy significantly change pathogenesis process also relieve therapeutically modulate behavior. perspective new idea follow-up treatment microbiota.

Language: Английский

Citations

2
Risk factors and consequences of mental health problems in nurses: A scoping review of cohort studies DOI Creative Commons
Jiaxin Yang, Yamin Chen, Yusheng Tian

et al.

International Journal of Mental Health Nursing, Journal Year: 2024, Volume and Issue: 33(5), P. 1197 - 1211

Published: April 15, 2024

Abstract Mental health problems in nurses are prevalent and impairing. To date, no literature has comprehensively synthesised cohort evidence on mental among nurses. This scoping review aimed to synthesise the existing risk factors consequences of A systematic search was conducted PubMed, EMBASE, Epistemonikos database, Web Science, CINAHL, PsycINFO from inception March 2023. We identified 171 studies 16 countries, mostly (95.3%) high‐income economies. indicated that worldwide encountered significant challenges, including depression, cognitive impairment, anxiety, trauma/post‐traumatic stress disorder, burnout, sleep other negative problems. These were closely related various modifiable such as nurses' behaviours lifestyles, social support, workplace bullying violence, shift work, job demands, resources. Moreover, have effects their physical health, behaviour lifestyle, occupation organisation, intrapersonal factors. findings provided an enhanced understanding complexities nurses, shed light policy enactment alleviate impact Addressing should be a top priority.

Language: Английский

Citations

14
Microbiota-brain axis: Exploring the role of gut microbiota in psychiatric disorders - A comprehensive review DOI
Jawahar Singh,

Vanlallawmzuali,

Amit Kant Singh

et al.

Asian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 97, P. 104068 - 104068

Published: May 7, 2024

Language: Английский

Citations

10
Gut Microbiota-Based Interventions for Parkinson’s Disease: Neuroprotective Mechanisms and Current Perspective DOI
Deepak Kumar, Mahendra Bishnoi, Kanthi Kiran Kondepudi

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Language: Английский

Citations

1
Anxiety disorders and the gut microbiota: a bibliometric and visual analysis DOI Creative Commons

Linli Guo,

Qin Ding, Qing Li

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Introduction Anxiety disorder is a common mental illness, yet its specific mechanisms remain unclear. Recent research has revealed connection between gut microbiota and anxiety disorders. This study aims to assess the current global landscape, highlight topics of interest, explore future directions in field disorders microbiota. Methods We extracted review articles related from Web Science, covering period 2004 2023. used VOSviewer 1.6.18.0, Scimago Graphica, CiteSpace 6.2. R2 visualize contributions countries, institutions, journals, authors, citations, keywords this field. Result A total 1198 were included bibliometric analysis. Over past two decades, both publications citations have shown steady increase. China, United States, Canada top three countries terms publication output. John Cryan University College Cork had highest number citation impact area research. The journal Nutrients publications, while Brain Behavior Immunity most citations. Key themes recent years anxiety, microbiota, depression, stress, gut-brain axis, probiotics, all which are likely be important directions. Conclusion analysis key areas emerging trends, including risk factors, stressors, inflammatory responses, probiotics. These insights can guide researchers towards more comprehensive understanding advancements field, help shape facilitate identification new therapeutic targets for disorder, ultimately improving clinical outcomes.

Language: Английский

Citations

1
The brain-gut microbiota network (BGMN) is correlated with symptom severity and neurocognition in patients with schizophrenia DOI Creative Commons

Runlin Peng,

Wei Wang,

Liqin Liang

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121052 - 121052

Published: Jan. 1, 2025

Language: Английский

Citations

1
Irritable Bowel Syndrome: A Hallmark of Psychological Distress in Women? DOI Creative Commons
Giuseppe Marano, Gianandrea Traversi, Roberto Pola

et al.

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 277 - 277

Published: Feb. 11, 2025

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain, bloating, and altered habits. Women are disproportionately affected IBS due to complex interplay between genetic, environmental, psychosocial factors, along with crucial role of the gut–brain axis in modulating both function pain perception. Evidence suggests strong association psychological distress symptoms. report higher levels compared men, sex biological variable that shapes several aspects mechanisms, epidemiology, clinical manifestations IBS. This paper explores bidirectional relationship factors focus on women. Stress, anxiety, depression, childhood trauma contribute symptomatology, societal unique women may exacerbate this condition. Strategies for integrated care approaches gender-specific treatment strategies improve patient outcomes quality life needed.

Language: Английский

Citations

1
Relationship between human oral microbiome dysbiosis and neuropsychiatric diseases: An updated overview DOI

Kai Tao,

Yanling Yuan,

Qinglian Xie

et al.

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 471, P. 115111 - 115111

Published: June 12, 2024

Language: Английский

Citations

7
Gut–Brain Axis: Focus on Sex Differences in Neuroinflammation DOI Open Access
Mario Caldarelli, Pierluigi Rio, Andrea Marrone

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5377 - 5377

Published: May 15, 2024

In recent years, there has been a growing interest in the concept of “gut–brain axis”. addition to well-studied diseases associated with an imbalance gut microbiota, such as cancer, chronic inflammation, and cardiovascular diseases, research is now exploring potential role microbial dysbiosis onset development brain-related diseases. When function intestinal barrier altered by dysbiosis, aberrant immune system response interacts nervous system, leading state “neuroinflammation”. The microbiota–brain axis mediated inflammatory immunological mechanisms, neurotransmitters, neuroendocrine pathways. This narrative review aims illustrate molecular basis neuroinflammation elaborate on gut–brain virtue analyzing various metabolites produced microbiome how they might impact system. Additionally, current will highlight sex influences these mechanisms. fact, hormones brain–gut microbiota at different levels, central enteric one, enteroendocrine cells. A deeper understanding human health disease crucial guide diagnoses, treatments, preventive interventions.

Language: Английский

Citations

4