Naringenin: A potential flavonoid phytochemical for cancer therapy

Life Sciences, Journal Year: 2022, Volume and Issue: 305, P. 120752 - 120752

Published: June 29, 2022

Language: Английский

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Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 15765 - 15765

Published: Dec. 12, 2022

Cancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target molecular pathways driving cancer. However, there has no discernible increase in overall survival rate cancer patients. Therefore, innovative chemo-preventive techniques and agents are required supplement standard treatments boost their efficacy. Fruits vegetables should be tapped into as a source compounds that can serve therapy. Phytochemicals play an important role sources new medication treatment. Some synthetic natural chemicals effective for chemoprevention, i.e., use exogenous medicine inhibit or impede tumor development. They help regulate linked development spread enhance antioxidant status, inactivating carcinogens, suppressing proliferation, inducing cell cycle arrest death, regulating immune system. While focusing on four main categories plant-based agents, epipodophyllotoxin, camptothecin derivatives, taxane diterpenoids, vinca alkaloids mode action, we review effects phytochemicals, like quercetin, curcumin, piperine, epigallocatechin gallate (EGCG), gingerol. We examine different signaling associated with how inflammation key mechanism growth.

Language: Английский

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Remodeling tumor microenvironment with natural products to overcome drug resistance

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 10, 2022

With cancer incidence rates continuing to increase and occurrence of resistance in drug treatment, there is a pressing demand find safer more effective anticancer strategy for patients. Natural products, have the advantage low toxicity multiple action targets, are always used treatment prevention early stage supplement late stage. Tumor microenvironment necessary cells survive progression, immune activation vital means tumor eliminate cells. A number studies found that various natural products could target regulate such as T cells, macrophages, mast well inflammatory cytokines microenvironment. tuning via mechanisms activate response immeasurable potential immunotherapy. In this review, it highlights research findings related regulating responses against cancer, especially reveals possibility utilizing remodel overcome resistance.

Language: Английский

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Review: Mechanisms and perspective treatment of radioresistance in non-small cell lung cancer

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 14, 2023

Radiotherapy is the major treatment of non-small cell lung cancer (NSCLC). The radioresistance and toxicity are main obstacles that leading to therapeutic failure poor prognosis. Oncogenic mutation, stem cells (CSCs), tumor hypoxia, DNA damage repair, epithelial-mesenchymal transition (EMT), microenvironment (TME) may dominate occurrence at different stages radiotherapy. Chemotherapy drugs, targeted immune checkpoint inhibitors combined with radiotherapy treat NSCLC improve efficacy. This article reviews potential mechanism in NSCLC, discusses current drug research overcome advantages Traditional Chinese medicine (TCM) improving efficacy reducing

Language: Английский

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β-Elemene induced ferroptosis via TFEB-mediated GPX4 degradation in EGFR wide-type non-small cell lung cancer

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 62, P. 257 - 272

Published: Sept. 7, 2023

β-Elemene (β-ELE), derived from Curcuma wenyujin, has anticancer effect on non-small cell lung cancer (NSCLC). However, the potential target and detail mechanism were still not clear. TFEB is master regulator of lysosome biogenesis. Ferroptosis, a promising strategy for therapy could be triggered via suppression glutathione peroxidase 4 (GPX4). Weather TFEB-mediated degradation contributes to GPX4 decline how β-ELE modulates this process are To observe action TFEB, role in induced ferroptosis. Surface plasmon resonance (SPR) molecular docking applied binding affinity TFEB. Activation observed by immunofluorescence, western blot, flow cytometry qPCR. Ferroptosis was lipid ROS, labile iron pool (LIP) assay blot. A549TFEB KO cells established CRISPR/Cas9. The regulation ferroptosis treated A549WT cells, which further studied orthotopic NOD/SCID mouse model. can bind notably activate transcriptional increase downstream gene GLA, MCOLN1, SLC26A11 involved activity EGFR wild-type NSCLC cells. increased ubiquitination lysosomal localization, with GPX4. Furthermore, ferroptosis, promoted overexpression or compromised knockout. Genetic knockout inactivation GPX4, demonstrated mice This study firstly that NSCLC, gives clue mediated would novel induction therapy.

Language: Английский

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Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114955 - 114955

Published: June 1, 2023

Bioactive natural products (BNPs) are the marrow of medicinal plants, which secondary metabolites organisms and have been most famous drug discovery database. for their enormous number great safety in medical applications. However, BNPs troubled by poor druggability compared with synthesis drugs challenged as medicine (only a few applied clinical settings). In order to find reasonable solution improving BNPs, this review summarizes bioactive nature based on pharmacological research tries explain reasons BNPs. And then focused boosting loaded delivery systems, further concludes advantages systems improvement from perspective nature, discusses why need predicts next direction.

Language: Английский

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Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3980 - 3980

Published: Aug. 5, 2023

Lung cancer is a heterogeneous group of malignancies with high incidence worldwide. It the most frequently occurring in men and second common women. Due to its frequent diagnosis variable response treatment, lung was reported as top cause cancer-related deaths worldwide 2020. Many aberrant signaling cascades are implicated pathogenesis cancer, including those involved apoptosis (B cell lymphoma protein, Bcl-2-associated X first signal ligand), growth inhibition (tumor suppressor protein or gene serine/threonine kinase 11), promotion (epidermal factor receptor/proto-oncogenes/phosphatidylinositol-3 kinase). Accordingly, these pathways their molecules have become promising targets for chemopreventive chemotherapeutic agents. Recent research provides compelling evidence use plant-based compounds, known collectively phytochemicals, anticancer This review discusses major contributing pathophysiology well currently available treatments prospective drug candidates. The potential naturally bioactive compounds context also discussed, critical analysis mechanistic actions presented by preclinical clinical studies.

Language: Английский

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Targeting Inflammation in Non-Small Cell Lung Cancer through Drug Repurposing

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(3), P. 451 - 451

Published: March 16, 2023

Lung cancer is the most common cause of cancer-related deaths. cancers can be classified as small-cell (SCLC) or non-small cell (NSCLC). About 84% all lung are NSCLC and about 16% SCLC. For past few years, there have been a lot new advances in management terms screening, diagnosis treatment. Unfortunately, NSCLCs resistant to current treatments eventually progress advanced stages. In this perspective, we discuss some drugs that repurposed specifically target inflammatory pathway utilizing its well-defined tumor microenvironment. Continuous conditions responsible induce DNA damage enhance division rate tissues. There existing anti-inflammatory which were found suitable for repurposing carcinoma (NSCLC) treatment drug modification delivery via inhalation. Repurposing their through airway promising strategy treat NSCLC. review, candidates inflammation-mediated will comprehensively discussed together with administration inhalation from physico-chemical nanocarrier perspectives.

Language: Английский

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Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116304 - 116304

Published: Feb. 23, 2024

Glycyrrhetinic acid (GA) shows great efficiency against non-small cell lung cancer (NSCLC), but the detailed mechanism is unclear, which has limited its clinical application. Herein, we investigated potential targets of GA NSCLC by activity-based protein profiling (ABPP) technology and combination histopathology proteomics validation. In vitro in vivo results indicated significantly inhibited via promotion peroxiredoxin-6 (Prdx6) caspase-3 (Casp3)-mediated mitochondrial apoptosis. This original finding will provide theoretical data support to improve treatment with application GA.

Language: Английский

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Antitumor Effects of Ononin by Modulation of Apoptosis in Non-Small-Cell Lung Cancer through Inhibiting PI3K/Akt/mTOR Pathway

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 17

Published: Dec. 27, 2022

Lung cancer is a leading global cause of cancer-related death in both males and females. Non-small-cell lung (NSCLC) the most commonly diagnosed type that can be difficult to control with conventional chemotherapeutic surgical approaches resulting poor prognosis. Paclitaxel (PTX) used drug for NSCLC, which tissue injury healthy cells affect quality life patients cancer. In order treat alternative medications minimal or no side effects are highly needed. Ononin an isoflavone glycoside extracted from Astragali Radix (AR) has various pharmacological activities. Therefore, this study investigated whether ononin inhibits NSCLC progression promotes apoptosis synergistically PTX vitro vivo. Antitumorigenic properties were determined by MTT assay, colony formation migratory capacity, apoptotic marker expression A549 HCC827 cells. The combination increased markers ROS generation inhibited cell proliferation through PI3K/Akt/mTOR signaling pathways. Furthermore, prevented translocation NF-κB cytosol nucleus. Also, we xenograft mice model confirm vivo antitumorigenic efficacies reduction CD34 Ki67 expressions. Based on histological analysis, cotreatment reduced PTX-induced liver kidney damage. Overall, our findings suggested therapeutic index PTX-based chemotherapy could improved reducing toxicity increasing antitumor capabilities when combined ononin.

Language: Английский

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