Cell Reports,
Journal Year:
2025,
Volume and Issue:
44(2), P. 115284 - 115284
Published: Feb. 1, 2025
ATP-citrate
lyase
(ACLY)
generates
cytosolic
acetyl-coenzyme
A
(acetyl-CoA)
for
lipid
synthesis
and
is
a
promising
therapeutic
target
in
diseases
with
altered
metabolism.
Here,
we
developed
inducible
whole-body
Acly-knockout
mice
to
determine
the
requirement
ACLY
normal
tissue
functions,
uncovering
its
crucial
role
skin
homeostasis.
ACLY-deficient
upregulates
acetyl-CoA
synthetase
ACSS2;
deletion
of
both
Acly
Acss2
from
exacerbates
abnormalities,
differential
effects
on
two
major
lipid-producing
compartments.
While
epidermis
depleted
barrier
lipids,
sebaceous
glands
increase
production
sebum,
supplied
at
least
part
by
circulating
fatty
acids
coinciding
adipose
lipolysis
fat
depletion.
Dietary
supplementation
further
boosts
sebum
partially
rescues
lipoatrophy
aberrant
phenotypes.
The
data
establish
critical
maintaining
integrity
highlight
as
key
organ
systemic
regulation.
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 1215 - 1229
Published: May 1, 2023
Abstract:
Of
the
human
organs,
skin
is
most
visible
one
that
displays
manifestations
of
ageing.
It
has
a
very
intricate
microanatomical
structure
and
performs
several
key
physiological
functions.
The
pathophysiology
cutaneous
ageing
characterized
by
deterioration
structural
stability
functional
integrity,
implying
continuous
reduction
in
maximal
function
reserve
capacity,
as
result
accumulating
damage
due
to
both
intrinsic
extrinsic
factors.
Elimination
unfavorable
expressions
associated
with
facial
patient
demand
aesthetic
dermatology.
Even
though
progress
been
made
nonsurgical
therapies
like
fillers
lasers,
non-invasive
interventions
using
care
products
designed
for
rejuvenation
at
an
early
stage
are
popular
accessible
solution
among
people.
In
this
review,
we
have
scrutinized
ageing-associated
changes
molecular,
cellular
tissue
levels.
To
optimize
process
towards
healthy
skin,
propose
integrated,
multilayer-targeted
intervention,
which
involves
topical
application
anti-ageing
formulations
from
outside
oral
supplementation
inside.
Additionally,
promising
naturally
derived
ingredients
reviewed
anti-aging
perspective.
Most
them
possess
various
bioactivities
may
contribute
development
mentioned
remedy.
Keywords:
barrier,
ageing,
causative
factors,
remedy,
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 24, 2023
Osteoporosis
(OP)
and
Dermatoporosis
(DP)
are
expressions
of
the
aging
process
at
skin
bone
levels,
respectively.
Both
conditions
associated
with
increased
morbidity
for
elderly
people,
this
requires
necessary
interventions.
They
share
many
common
risk
factors;
among
these,
vitamin
D
(VD)
deficiency
appears
to
have
a
role.
VD
is
involved
in
either
disease
mechanisms,
which
immunomodulation.
has
been
linked
OP
because
it
inhibits
body's
capacity
absorb
calcium
maintain
optimal
health.
Available
evidence
suggests
that
proper
vitaminosis
also
be
vital
preventing
age-related
issues.
DP
often
seen
individuals,
particularly
those
long-term
sun
exposure
history
chronic
damage.
can
DP,
since
its
involvement
collagen
production,
epidermal
barrier
function,
inflammation
regulation,
wound
healing,
protection.
Aim
review
summarize
most
updated
existing
on
role
development
fragility
syndromes
such
as
possible
benefits
supplementation
simple
harmful
weapon
against
aging.
Cosmetics,
Journal Year:
2022,
Volume and Issue:
9(1), P. 14 - 14
Published: Jan. 19, 2022
The
investigation
into
promising
botanical
materials
for
natural
cosmetics
is
expanding
due
to
environmental
and
health
awareness.
Here,
we
aimed
evaluate
the
phytochemical
substances
potential
skin-related
pharmacological
activities
of
four
Mucuna
seeds,
namely
M.
gigantea
(Willd.)
DC.
(MGG),
interrupta
Gagnep.
(MIT),
monosperma
Wight
(MMM),
pruriens
(L.)
(MPR),
belonging
Fabaceae
family.
In
methodology,
seeds
were
authenticated
using
morphological
molecular
approaches.
L-DOPA,
phenolics,
flavonoid
content,
incorporated
with
HPLC
GC–MS
fingerprinting
analyses,
determined.
Then,
antimicrobial,
antioxidant,
antiaging
results
revealed
that
MPR
showed
highest
L-DOPA
content
(75.94
mg/100
mg
extract),
whereas
MGG
exhibited
phenolic
(56.73
±
0.62
gallic/g
extract
1030.11
3.97
quercetin/g
extract,
respectively).
Only
MMM
could
inhibit
all
S.
aureus,
epidermidis,
C.
albicans,
but
no
sample
acnes.
Furthermore,
samples
demonstrated
antioxidant
activity.
Interestingly,
strong
collagenase,
elastase,
hyaluronidase
inhibitory
activities.
We
conclude
ethanolic
extracts
are
probably
advantageous
in
development
skincare
cosmeceutical
products.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 8053 - 8053
Published: April 29, 2023
Nanocarriers,
and
especially
nanostructured
lipid
carriers
(NLC),
represent
one
of
the
most
effective
systems
for
topical
drug
administration.
NLCs
are
biodegradable,
biocompatible
provide
a
prolonged
release.
The
glutamate
release
inhibitor
Riluzole
(RLZ)
is
currently
used
amyotrophic
lateral
sclerosis
(ALS),
with
anti-proliferative
effects
potentially
beneficial
diseases
excessive
cell
turnover.
However,
RLZ
possesses
low
water
solubility
high
light-sensibility.
We
present
here
optimized
loaded
(RLZ-NLCs)
as
potential
treatment.
RLZ-NLCs
were
prepared
by
hot-pressure
homogenization
method
using
active
essential
oils
liquid
lipids,
design
experiments
approach.
developed
obtaining
optimal
properties
dermal
application
(mean
size
below
200
nm,
negative
surface
charge
entrapment
efficacy).
In
vitro
study
demonstrates
that
allow
successful
delivery
in
sustained
manner.
Moreover,
not
angiogenic
able
to
inhibit
keratinocyte
proliferation.
Hence,
system
loading
combination
natural
constitutes
promising
strategy
against
hyperproliferative
conditions.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1070 - 1070
Published: Feb. 21, 2023
Food
allergy
represents
a
growing
public
health
and
socio-economic
problem
with
an
increasing
prevalence
over
the
last
two
decades.
Despite
its
substantial
impact
on
quality
of
life,
current
treatment
options
for
food
are
limited
to
strict
allergen
avoidance
emergency
management,
creating
urgent
need
effective
preventive
strategies.
Advances
in
understanding
pathogenesis
allow
develop
more
precise
approaches
targeting
specific
pathophysiological
pathways.
Recently,
skin
has
become
important
target
prevention
strategies,
as
it
been
hypothesized
that
exposure
through
impaired
barrier
might
induce
immune
response
resulting
subsequent
development
allergy.
This
review
aims
discuss
evidence
supporting
this
complex
interplay
between
dysfunction
by
highlighting
crucial
role
epicutaneous
sensitization
causality
pathway
leading
progression
clinical
We
also
summarize
recently
studied
prophylactic
therapeutic
interventions
repair
emerging
strategy
controversies
future
challenges.
Further
studies
needed
before
these
promising
strategies
can
be
routinely
implemented
advice
general
population.
Experimental Dermatology,
Journal Year:
2024,
Volume and Issue:
33(1)
Published: Jan. 1, 2024
Abstract
Cutaneous
tissues
is
among
the
main
target
of
outdoor
stressors
such
as
ozone
(O
3
),
particulate
matter
(PM),
and
ultraviolet
radiation
(UV)
all
involved
in
inducing
extrinsic
skin
aging.
Only
a
few
reports
have
studied
multipollutant
interaction
its
effect
on
damage.
In
present
work,
we
intended
to
evaluate
ability
pollutants
O
PM
further
aggravate
cutaneous
UV
addition,
preventive
properties
cosmeceutical
formulation
mixture
(AOX
mix)
containing
15%
vitamin
C
(L‐ascorbic
acid),
1%
E
(α‐tocopherol)
0.5%
ferulic
acid
was
also
investigated.
Skin
explants
obtained
from
three
different
subjects
were
exposed
200
mJ
light,
0.25
ppm
for
2
h,
30
min
diesel
engine
exhaust
(DEE),
alone
or
combination
4
days
(time
point
D1
D4).
The
results
showed
clear
additive
DEE
with
terms
keratin
10,
Desmocollin
Claudin
loss.
exposure
significantly
induced
inflammatory
response
measured
NLRP1/ASC
co‐localization
suggesting
activation
inflammasome
machinery.
Finally,
loss
Aquaporin3
affected
by
combined
stressors.
Furthermore,
daily
topical
pre‐treatment
AOX
Mix
prevented
changes
multipollutants.
conclusion,
this
study
first
investigate
effects
most
harmful
human
confirms
that
an
antioxidant
application
may
prevent
pollution‐induced
Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(6), P. 191 - 191
Published: Nov. 5, 2024
Skin
diseases
are
a
common
health
problem
affecting
millions
of
people
worldwide.
Effective
treatment
often
depends
on
the
precise
delivery
drugs
to
affected
areas.
One
promising
approach
is
currently
transdermal
drug
system
(TDDS),
whose
significant
challenge
poor
penetration
many
compounds
into
skin
due
stratum
corneum
(SC),
which
acts
as
formidable
barrier.
To
overcome
this
limitation,
nanocarriers
have
emerged
highly
effective
alternative.
This
review
discusses
use
liposomes
and
ethosomes
for
delivery.
Liposomes
micro-
or
nanostructures
consisting
lipid
bilayer
surrounding
an
aqueous
core.
They
facilitate
may
be
advantageous
site-specific
targeting.
Some
methods
treating
involve
incorporating
such
acyclovir,
dithranol,
tretinoin
bioactive
fluconazole,
melanin,
glycolic
acid,
kojic
CoQ10
nanocarriers.
The
inability
pass
through
narrowed
intercellular
channels
led
invention
lipid-based
vesicular
systems
ethosomes.
structurally
similar
conventional
liposomes,
they
prepared
from
phospholipids,
but
contain
high
ethanol
concentration.
Ethosomes
noninvasive
carriers
that
allow
reach
deep
layers
skin.
Examples
commonly
used
substances
combined
with
in
cosmetics
include
methotrexate,
ascorbic
vitamin
A
E,
colchicine.
development
area
rutin-loaded
Encapsulating
rutin
significantly
improves
its
stability
enhances
penetration,
allowing
more
efficient
deeper
layers.
In
cosmetics,
rutin–ethosome
formulations
protect
oxidative
stress,
reduce
redness,
improve
capillary
strength,
making
it
valuable
formulation
anti-aging
anti-inflammatory
products.
results
first
clinical
trial
acyclovir–ethosome
confirm
require
further
investigation.
work
provides
update
recent
advances
pharmaceutical
cosmetic
applications,
mentioning
essential
points
commercially
available
formulations,
trials,
patents
past.
