The Multifaceted Role of Curcumin in Advanced Nanocurcumin Form in the Treatment and Management of Chronic Disorders

Molecules, Journal Year: 2021, Volume and Issue: 26(23), P. 7109 - 7109

Published: Nov. 24, 2021

Curcumin is the primary polyphenol in turmeric's curcuminoid class. It has a wide range of therapeutic applications, such as anti-inflammatory, antioxidant, antidiabetic, hepatoprotective, antibacterial, and anticancer effects against various cancers, but poor solubility low bioavailability. Objective: To improve curcumin's bioavailability, plasma concentration, cellular permeability processes. The nanocurcumin approach over curcumin been proven appropriate for encapsulating or loading (nanocurcumin) to increase its potential. Conclusion: Though incorporating into form may be viable method overcoming intrinsic limitations, there are reasonable concerns regarding toxicological safety once it enters biological pathways. This review article mainly highlights benefits curcumin.

Language: Английский

---

Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: Sept. 1, 2023

Tumors have evolved in various mechanisms to evade the immune system, hindering antitumor response and facilitating tumor progression. Immunotherapy has become a potential treatment strategy specific different cancer types by utilizing multifarious molecular enhance against tumors. Among these mechanisms, ubiquitin-proteasome system (UPS) is significant non-lysosomal pathway protein degradation, regulated deubiquitinating enzymes (DUBs) that counterbalance ubiquitin signaling. Ubiquitin-specific proteases (USPs), largest DUB family with strongest variety, play critical roles modulating cell function, regulating response, participating antigen processing presentation during According recent studies, expressions of some USP members cells are involved escape microenvironment. This review explores targeting USPs as new approach for immunotherapy, highlighting basic preclinical studies investigating applications inhibitors. By providing insights into structure function immunity, this aims at assisting developing therapeutic approaches enhancing immunotherapy efficacy.

Language: Английский

---

Therapeutic Insights on Ferroptosis in Parkinson's disease

European Journal of Pharmacology, Journal Year: 2022, Volume and Issue: 930, P. 175133 - 175133

Published: July 2, 2022

Language: Английский

---

Multiple health benefits of curcumin and its therapeutic potential

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(29), P. 43732 - 43744

Published: April 20, 2022

Language: Английский

---

Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: July 15, 2022

Increasing evidence has demonstrated that circular RNAs (circRNAs) are implicated in cancer progression. However, the aberrant expression and biological functions of circRNAs clear cell renal carcinoma (cRCC) remain largely elusive.Differentially expressed cRCC were filtered via bioinformatics analysis. Aberrant circPOLR2A was validated tissues lines qRT-PCR. Sanger sequencing used to identify backsplicing site circPOLR2A. In vitro vivo functional experiments performed evaluate role malignancy. RNA pull-down, mass spectrometry, RIP, FISH immunofluorescence assays validate circPOLR2A-interacting proteins. Ubiquitination modification interaction between proteins detected Co-IP western blotting. The m6A by meRIP assay.Bioinformatics analysis revealed highly metastatic tissues. CircPOLR2A associated with tumor size TNM stage patients. accelerated proliferation, migration, invasion angiogenesis, while inhibiting apoptosis. Further mechanistic research suggested could interact UBE3C PEBP1 proteins, act as a specific ubiquitin E3 ligase for protein. UBE3C/circPOLR2A/PEBP1 protein-RNA ternary complex enhanced UBE3C-mediated ubiquitination degradation protein which inactivate ERK signaling pathway. Rescue downstream target Furthermore, confirmed, reader YTHDF2 regulate expression.Our study modulated protein, further activated pathway during progression metastasis. reader, YTHDF2, regulated cRCC. Hence, be potential diagnosis treatment

Language: Английский

---

Immune Evasion and Drug Resistance Mediated by USP22 in Cancer: Novel Targets and Mechanisms

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 20, 2022

Regulation of ubiquitination is involved in various processes cancer occurrence and development, including cell cycle arrest, proliferation, apoptosis, invasion, metastasis, immunity. Ubiquitination plays an important role not only at the transcriptional post-translational levels but also protein level. When a pathological state, abnormally activated biological will induce progression immune evasion. The main function deubiquitinases (DUBs) to remove ubiquitin chains from substrates, changing activity substrates. It has great potential improve prognosis by targeting DUB regulate proteome. Ubiquitin-specific peptidase 22 (USP22) belongs ubiquitin-specific protease (USP) family DUBs been reported be related physiological processes. USP22 expressed malignant tumors such as prostate cancer, lung liver colorectal which suggests that may play tumors. stabilize programmed death ligand 1 (PD-L1) deubiquitination while regulating T-cell infiltration into Regulatory T cells (Tregs) are unique class immunosuppressive CD4 + primarily suppress system expressing master transcription factor forkhead box 3 (FOXP3). was found positive regulator stable FOXP3 expression. Treg-specific ablation leads reduced tumor volume multiple models. This resistance immunotherapy. In this article, we review summarize functions signal transduction pathways during tumorigenesis, evasion, drug resistance. Furthermore, propose new possibility combining with chemotherapeutic, targeted, drugs treatment cancer.

Language: Английский

---

Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer Therapy

Cells, Journal Year: 2023, Volume and Issue: 13(1), P. 29 - 29

Published: Dec. 22, 2023

Ubiquitination is a reversible post-translational modification based on the chemical addition of ubiquitin to proteins with regulatory effects various signaling pathways. can alter molecular functions tagged substrates respect protein turnover, biological activity, subcellular localization or protein–protein interaction. As result, wide variety cellular processes are under ubiquitination-mediated control, contributing maintenance homeostasis. It follows that dysregulation ubiquitination reactions plays relevant role in pathogenic states human diseases such as neurodegenerative diseases, immune-related pathologies and cancer. In recent decades, enzymes ubiquitin–proteasome system (UPS), including E3 ligases deubiquitinases (DUBs), have attracted attention novel druggable targets for development new anticancer therapeutic approaches. This perspective article summarizes peculiarities shared by involved reaction which, when deregulated, lead tumorigenesis. Accordingly, an overview main pharmacological interventions targeting UPS clinical use still trials provided, also highlighting limitations efficacy these Therefore, attempts circumvent drug resistance side well UPS-related emerging technologies therapeutics discussed.

Language: Английский

---

Targeting ferroptosis in ischemia/reperfusion renal injury

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2022, Volume and Issue: 395(11), P. 1331 - 1341

Published: Aug. 3, 2022

Language: Английский

---

Mechanistic Insight on Autophagy Modulated Molecular Pathways in Cerebral Ischemic Injury: From Preclinical to Clinical Perspective

Neurochemical Research, Journal Year: 2022, Volume and Issue: 47(4), P. 825 - 843

Published: Jan. 7, 2022

Language: Английский

---

In silico, in vitro screening of antioxidant and anticancer potentials of bioactive secondary metabolites from an endophytic fungus (Curvularia sp.) from Phyllanthus niruri L

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(32), P. 48908 - 48925

Published: Feb. 24, 2022

Language: Английский

---