The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1713 - 1713

Published: March 6, 2022

Obesity and diabetes are the most demanding health problems today, their prevalence, as well comorbidities, is on rise all over world. As time goes on, both becoming big issues that have a impact people’s lives. Diabetes metabolic endocrine illness set apart by hyperglycemia glucose narrow-mindedness because of insulin opposition. Heftiness typical, complex, developing overall wellbeing worry has for quite some been connected to significant medical in individuals, things considered. Because wide variety low adverse effects, herbal products an important hotspot drug development. Synthetic compounds not structurally diverse lack drug-likeness properties. Thus, it basic keep exploring possible wellsprings novel drugs. We conducted this review literature searching Scopus, Science Direct, Elsevier, PubMed, Web databases. From 1990 until October 2021, research reports, articles, original articles English presented. It provides top bottom data examination plant-inferred might be utilized against heftiness or potentially hostile treatments. Our expanded comprehension systems activity phytogenic compounds, extra examination, could prompt advancement remedial methodologies diseases. In clinical trials, huge number these food kinds restorative plants, bioactive shown beneficial treatment obesity.

Language: Английский

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Prospective multifunctional roles and pharmacological potential of dietary flavonoid narirutin

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 112932 - 112932

Published: April 9, 2022

Plant-based phytochemicals are now being used to treat plenty of physiological diseases. Herbal drugs have gained popularity in recent years because their strength, purity, and cheap cost-effectiveness. Citrus fruits contain significant amounts flavanones, which falls the category polyphenols. Flavanones occupy a major fraction total polyphenols present plasma when orange juice is taken highly or moderate states. Narirutin disaccharide derivative available citrus fruits, primarily dihydroxy flavanone. From pharmacological viewpoint, narirutin bioactive phytochemical with therapeutic efficacy. Many experimental researches were published on use narirutin. Anticancer activity, neuroprotection, stress relief, hepatoprotection, anti-allergic antidiabetic anti-adipogenic anti-obesity action, immunomodulation couple primary properties. also has antioxidant, anti-inflammatory activities. The ultimate goal this review provide current scenario research narirutin; make better understanding for potential narirutin, as well its biosynthesis strategies side effects. Extensive literature searches studies undertaken determine properties

Language: Английский

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Nanomedicine-Based Delivery Strategies for Breast Cancer Treatment and Management

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2856 - 2856

Published: March 5, 2022

Breast cancer is one of the most common types among women globally. It caused by mutations in estrogen/progesterone receptors and conventional treatment methods are commonly utilized. About 70-80 percent individuals with early-stage non-metastatic disease may be cured. Conventional far less than optimal ratio, as demonstrated through high mortality rate this cancer. However, like surgery, radiotherapy, chemotherapy not effective expected lead to concerns about low bioavailability, cellular uptake, emerging resistance, adverse toxicities. A nanomedicine-based approach a promising alternative for breast treatment. The present era witnessing rapid advancements nanomedicine platform investigating novel therapeutic applications modern intelligent healthcare management strategies. This paper focuses on interventions that becoming more widely accepted improving effectiveness reducing undesired side effects patients. By evaluating state-of-the-art tools taking challenges involved into consideration, various aspects proposed nano-enabled approaches have been discussed review.

Language: Английский

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Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

Molecules, Journal Year: 2022, Volume and Issue: 27(7), P. 2165 - 2165

Published: March 27, 2022

Breast cancer (BrCa) is the most common malignancy in women and second significant cause of death from cancer. BrCa one challenging malignancies to treat, it accounts for a large percentage cancer-related deaths. The number cases requiring more effective therapy has increased dramatically. Scientists are looking productive agents, such as organic combinations, prevention treatment because chemotherapeutic agents linked metastasis, resistance drugs, side effects. Natural compounds produced by living organisms promote apoptosis inhibit slowing spread As result, these may delay BrCa, enhancing survival rates reducing deaths caused BrCa. Several natural production while lowering cell proliferation triggering death. compounds, addition therapeutic approaches, efficient potential treating This review highlights demonstrated various studies have anticancer properties cells. Future research into biological anti-BrCa pave way new era treatment, with drugs playing key role improving patient rates.

Language: Английский

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Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5236 - 5236

Published: Aug. 16, 2022

Throughout the United States, cancer remains second leading cause of death. Traditional treatments induce significant medical toxic effects and unpleasant adverse reactions, making them inappropriate for long-term use. Consequently, anticancer-drug resistance relapse are frequent in certain situations. Thus, there is an urgent necessity to find effective antitumor medications that specific have few consequences. Curcumin a polyphenol derivative found turmeric plant (Curcuma longa L.), provides chemopreventive, antitumor, chemo-, radio-sensitizing properties. In this paper, we summarize new nano-based formulations polyphenolic curcumin because growing interest its application against cancers tumors. According recent studies, use nanoparticles can overcome hydrophobic nature curcumin, as well improving stability cellular bioavailability vitro vivo. Several strategies nanocurcumin production been developed, each with own set advantages unique features. Because majority curcumin-based nanoformulation evidence still conceptual stage, numerous issues impeding provision possible therapeutic option. To support science, further work necessary develop viable anti-cancer adjuvant. review, cover various nanoformulations implications uses cancer, current state clinical studies patents. We address knowledge gaps future research orientations required feasible treatment candidate.

Language: Английский

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Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 114 - 114

Published: Jan. 15, 2025

Curcumin, a bioactive compound derived from the rhizome of Curcuma longa L., has garnered significant attention for its potent anticancer properties. Despite promising therapeutic potential, poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers viable solution to these challenges by enabling development curcumin-based nanoparticles (CNPs) that enhance bioavailability efficacy. This review provides comprehensive overview recent advancements in design synthesis CNPs cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, inorganic nanoparticles, highlighting their role improving pharmacokinetic pharmacodynamic profiles. The mechanisms which exert effects, such as inducing apoptosis, inhibiting cell proliferation, modulating signaling pathways, are explored details. Furthermore, we examine preclinical studies have demonstrated efficacy treating different types tumors, breast, colorectal, pancreatic cancers. Finally, addresses current future perspectives translation CNPs, emphasizing need further research optimize targeted delivery outcomes. By synthesizing latest research, this underscores potential avenue advancing

Language: Английский

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Nutritional Value, Medicinal Importance, and Health-Promoting Effects of Dietary Mushroom (Pleurotus ostreatus)

Journal of Food Quality, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 9

Published: Aug. 27, 2022

Pleurotus ostreatus is the second cultivated and most popular edible mushroom after Agaricus bisporus worldwide. As dietary supplements, nutraceuticals like that go beyond usual health benefits of mushrooms are becoming more popular. The objective this study to put together a summary nutrition information link it possible health-improving effects eating oyster mushrooms. This review based on secondary data from 102 published articles about P. ostreatus. All papers were examined following predetermined criteria for inclusion exclusion, contained 83 publications. high nutritional content beneficial make high-quality food. It makes up lack protein by switching between diet wheat, rice, maize. Nowadays, famous precious functional food ingredients due fact they may be cholesterol-free low in calories, carbohydrates, fat, sodium. Side side, offer crucial nutrients including riboflavin, selenium, potassium, niacin, proteins, fiber.

Language: Английский

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Bioactive-Based Cosmeceuticals: An Update on Emerging Trends

Molecules, Journal Year: 2022, Volume and Issue: 27(3), P. 828 - 828

Published: Jan. 27, 2022

Cosmetic-containing herbals are a cosmetic that has or is claimed to have medicinal properties, with bioactive ingredients purported medical benefits. There no legal requirements prove these products live up their claims. The name combination of “cosmetics” and “pharmaceuticals”. “Nutricosmetics” related dietary supplements food beverage additives marketed as having benefits affect appearance. topical cosmetic–pharmaceutical hybrids intended enhance the health beauty skin. improve appearance by delivering essential nutrients Several herbal products, such cosmetic-containing herbals, available. present review highlights use natural in many curative effects well healing on skin hair growth minimal side effects. A brief description given plants, used parts, active ingredients, therapeutic properties associated them. Mainly, utilization phytoconstituents care hair, dryness skin, acne, eczema, inflammation aging, growth, dandruff, along for colorant, explained detail review.

Language: Английский

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Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 22

Published: April 11, 2022

Alzheimer’s disease (AD) is a common neurodegenerative brain disorder that causes cellular response alterations, such as impaired cholinergic mechanism, amyloid-beta (Aβ) AD aggregation, neuroinflammation, and several other pathways. still the most prevalent form of dementia affects many individuals across globe. The exact cause obscure. There are yet no effective medications for halting, preventing, or curing AD’s progress. Plenty natural products isolated from sources analyzed in preclinical clinical settings neuroprotective effects preventing treating AD. In addition, their derivatives have been promising Natural bioactive compounds play an active modulatory role pathological molecular mechanisms development. This review focuses on plant demonstrated activities maybe to treat prevent this article summarizes literature pertaining agents treatment Rapid metabolism, nonspecific targeting, low solubility, lack BBB permeability, limited bioavailability shortcomings molecules We can use nanotechnology nanocarriers based different types approaches.

Language: Английский

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Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis

Evidence-based Complementary and Alternative Medicine, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 10

Published: March 28, 2022

The present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract Lannea coromandelica in animal models. This is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role sleeping time, hole board, cross, open field, studies. Mice were treated doses 100, 150, 200 mg/kg body weight apparatus coordination; 100 field tests; 400 activity test. Extraction specifies a significantly decreased time duration sodium-induced experimental locomotor exploratory behaviors mice open-field hole-cross tests compared to effects control. Furthermore, increased with dose-dependent onset action. hole-board test also demonstrated reduced number head dips. findings showed that L. potential effects. In addition, alloxan-induced diabetic mice, at revealed significant could be used manage blood glucose levels more research.

Language: Английский

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