Biomarkers in Neuropsychiatry, Journal Year: 2022, Volume and Issue: 7, P. 100055 - 100055
Published: Aug. 17, 2022
Language: Английский
Cells, Journal Year: 2024, Volume and Issue: 13(16), P. 1398 - 1398
Published: Aug. 22, 2024
Atopic dermatitis (AD) is a prevalent and chronic inflammatory skin condition characterized by multifaceted pathophysiology that gives rise to diverse clinical manifestations. The management of AD remains challenging due the suboptimal efficacy existing treatment options. Nonetheless, recent progress in elucidating underlying mechanisms disease has facilitated identification new potential therapeutic targets promising drug candidates. In this review, we summarize newest data, considering multiple connections between IL-22 AD. presence circulating been found correlate with severity identified as critical factor driving response associated condition. Elevated levels patients are correlated increased proliferation keratinocytes, alterations microbiota, impaired epidermal barrier function. Collectively, these factors contribute manifestation characteristic symptoms observed
Language: Английский
Citations
6
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112936 - 112936
Published: Aug. 19, 2024
Language: Английский
Citations
5
World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(12), P. 1804 - 1814
Published: Nov. 27, 2024
BACKGROUND The pathogenesis of cognitive impairment in schizophrenia (SCZ) remains unclear. Accumulating studies showed that inflammatory-immune dysregulation and altered brain derived neurotrophic factor (BDNF) levels play a crucial role the psychopathology SCZ. However, their association with dysfunction first-episode SCZ patients has not been thoroughly investigated. AIM To explore interaction effects between function inflammatory cytokines BDNF METHODS current study is cross-sectional case-control investigation recruited 84 (SCZ group) 80 healthy controls (HCs at Huzhou Third Municipal Hospital August 2021 September 2023. ELISA was employed to measure serum interleukin (IL)-1β, IL-4, IL-6, IL-10, BDNF. Chinese brief test (C-BCT) positive negative syndrome scales were measured severity psychiatric symptoms. RESULTS Compared HC group, group exhibited elevated IL-1β IL-6 levels, decreased reduced C-BCT scores (all P < 0.001). In SCZ, negatively correlated (r = -0.324, 0.05). Information processing speed -0.315, 0.05) positively 0.290, 0.05); attention, working memory, comprehensive ability, executive Multiple regression analysis influenced dimensions (β -0.218 -0.327, all attention ability by -0.199 -0.261, ; 0.209, . CONCLUSION Our findings suggested interrelationships immune deficiency might underlie pathological mechanisms impairments patients.
Language: Английский
Citations
4
Immunity, Journal Year: 2024, Volume and Issue: 58(1), P. 218 - 231.e12
Published: Dec. 6, 2024
Language: Английский
Citations
4
Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13
Published: Sept. 13, 2022
It is worth noting that neuroinflammation well recognized as a symptom of neurodegenerative diseases (NDs). The regulation becomes an attractive focus for innovative ND treatment technologies. There evidence IL-22 associated with the development and progression wide assortment NDs. For example, can activate glial cells, causing them to generate pro-inflammatory cytokines encourage lymphocyte infiltration in brain. mRNA highly expressed Alzheimer’s disease (AD) patients, high expression has also been detected brains patients other We examine role NDs this review, we believe therapeutic potential these diseases.
Language: Английский
Citations
18
PLoS ONE, Journal Year: 2022, Volume and Issue: 17(10), P. e0275839 - e0275839
Published: Oct. 18, 2022
Background Schizophrenia and especially deficit schizophrenia (DSCZ) are characterized by increased activity of neuroimmunotoxic pathways a generalized cognitive decline (G-CoDe). There is no data on whether the interleukin (IL)-6/IL-23/T helper 17 (IL-6/IL-23/Th17)-axis more associated with DSCZ than non-deficit (NDSCZ) changes in this axis G-CoDe phenome (a factor extracted from all symptom domains) schizophrenia. Methods This study included 45 NDSCZ patients 40 controls delineated IL-6/IL-23/Th17 axis, trace elements (copper, zinc) ions (magnesium, calcium) DSCZ, phenome. Results Increased plasma IL-23 IL-6 levels were Th17 upregulation, assessed as latent vector (LV) IL-17, IL-21, IL-22, TNF-α. The IL-6/IL-23/Th17-axis score, an LV IL-23, IL-6, LV, was significantly higher controls. We discovered that 70.7% variance explained (positively) IL-10 (both inversely); 54.6% scores (inversely) magnesium, copper, calcium, zinc (all positively). Conclusion pathogenic contributes to neurocognitive schizophrenia, due its key role peripheral inflammation neuroinflammation consequent immunotoxic effects neuronal circuits. These clinical impairments prominent subjects lowered IL-10, zinc.
Language: Английский
Citations
17
Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1677 - 1677
Published: May 15, 2025
Background/Objectives: Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive dementia and brain accumulation of Aβ-peptide-containing plaques, gliosis, neuroimmune changes, neurofibrillary tangles. Mushroom polysaccharides have been previously reported to anti-neuroinflammation activity through the gut–brain axis. This study aimed evaluate whether dietary intervention with Phallus atrovolvatus, recently identified edible mushroom in Thailand, could benefit on gut health alleviate AD-related changes. Methods: Male female 6–8-month-old littermate wild-type control (C57BL/6J) AppNL−G−F mice were randomly assigned either diet or supplemented aqueous extract (MAE) for 8 weeks quantify changes body weight, intestine, immune cells, short chain fatty acids, cytokines, amyloid-β (Aβ) levels, memory. Results: MAE had no adverse effects leakiness increased pyruvate levels serum. Splenocyte profiling revealed significant increase frequency IgM+, IA_IE+, CD14+ cells MAE-administered AppNL−G−Ffemale compared their vehicle controls. AppNL−G−Fmale that received showed cytotoxic CD8 T within cervical lymph nodes counterparts. Aβ deposition gliosis significantly reduced hippocampi MAE-supplemented groups. However, feeding did not alter spatial recognition memory sex genotype Conclusions: Our findings demonstrated administration P. atrovolvatus neuroprotective potential against impact
Language: Английский
Citations
0
Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)
Published: Aug. 17, 2024
Parkinson's disease (PD) is the second most common neurodegenerative disease, and its hallmark pathological features are loss of dopaminergic (DA) neurons in midbrain substantia nigra pars compacta (SNpc) accumulation alpha-synuclein (α-syn). It has been shown that integrity blood-brain barrier (BBB) damaged PD patients, a large number infiltrating T cells inflammatory cytokines have detected cerebrospinal fluid (CSF) brain parenchyma patients animal models, including significant change proportion different CD4
Language: Английский
Citations
3
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 20, 2024
Colitis is an inflammatory bowel disease (IBD) characterized by immune cell dysregulation and alterations in the gut microbiome. In our previous report, we showed a natural product cruciferous vegetables ligand of aryl hydrocarbon receptor (AhR), indole-3-carbinol (I3C), was able to reduce colitis-induced severity microbial dysbiosis interleukin-22 (IL-22) dependent manner.
Language: Английский
Citations
3
International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(22), P. 15281 - 15281
Published: Nov. 18, 2022
Schizophrenia patients show increased disabilities and lower quality of life (DisQoL). Nevertheless, there are no data on whether the activation interleukin (IL)-6, IL-23, T helper (Th)-17 axis, magnesium calcium levels impact DisQoL scores. This study recruited 90 with schizophrenia (including 40 deficit schizophrenia) healthy controls assessed World Health Association QoL instrument-Abbreviated version Sheehan Disability scale, Brief Assessment Cognition in (BACS), IL-6, IL-17, IL-21, IL-22, tumor necrosis factor (TNF)-α, calcium. Regression analyses showed that a large part first extracted from physical, psychological, social environmental HR-QoL interference school/work, life, home responsibilities was predicted by generalized cognitive deterioration (G-CoDe) index (a latent vector BACs scores), various symptom domains (“symptomatome”), whereas biomarkers had effects. Partial Least Squares analysis IL6IL23Th17 axis magnesium/calcium highly significant total (indirect + direct) effects HR-QoL/disabilities, which were mediated G-CoDe symptomatome negative positive symptoms). The explained 63.1% variance behavioral-cognitive-psycho-social (BCPS) worsening single trait G-CoDe, symptomatome, disability data. In summary, BCPS is partly caused neuroimmunotoxic subjects lowered antioxidant defenses (magnesium calcium), thereby probably damaging neuronal circuits may underpin schizophrenia.
Language: Английский
Citations
13