iPSC-derived astrocytes to model phenotype-specific differential neuroinflammatory and metabolic responses in X-linked adrenoleukodystrophy DOI Open Access
Parveen Parasar,

Navtej Kaur,

Laila Poisson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 10, 2022

SUMMARY X-linked adrenoleukodystrophy (X-ALD) is an inherited progressive metabolic disorder caused by pathogenic variants in the ABCD1 gene, which leads to accumulation of very long chain fatty acids body fluids and tissues including brain spinal cord. In absence a clear genotype-phenotype correlation molecular mechanisms severe cerebral (cALD) milder adrenomyeloneuropathy (AMN) phenotypes remain unknown. Given our previous evidence role astrocytes neuroinflammatory response X-ALD we investigated profiles derived from induced pluripotent stem cells (iPSC). The iPSCs were turn generated skin fibroblasts healthy controls patients with AMN or cALD. cALD exhibited lack acids, hallmark disease. Further, harbor significantly higher phosphorylation STAT3, increased Toll-like receptor expression chemokine cytokine expression. this first report miRNA sequencing astrocytes, observed that miR-9 was associated increasing disease severity phenotype. CRISPR-Cas9 knock-in ABCD1ABCD1 gene differentially affected key molecular, microRNA targets astrocytes. Extensive characterization iPSC-derived astrocyte model demonstrates critical aspects inflammatory mutation can be further utilized for exploring contribution differential

Language: Английский

Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis DOI Creative Commons
Shuo Zhang, Yue Gao,

Yini Zhao

et al.

Molecular Neurodegeneration, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 21, 2025

Abstract Alzheimer’s disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain barrier disruption allows immune cells to infiltrate central nervous system (CNS), worsening neuroinflammation and progression. We examine recent findings on interactions between CNS-resident microglia, forming self-perpetuating inflammatory cycle leading neuronal dysfunction. Moreover, this emphasizes developments dysregulation factors from both periphery CNS, their impact With ongoing development new therapeutic strategies, underscores importance modulating CNS therapy.

Language: Английский

Citations

2
Interleukin-22 Contributes to Blood–Brain Barrier Disruption via STAT3/VEGFA Activation in Escherichia coli Meningitis DOI Creative Commons
Ruicheng Yang, Jiaqi Chen,

Xinyi Qu

et al.

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(3), P. 988 - 999

Published: Feb. 6, 2024

Escherichia coli continues to be the predominant Gram-negative pathogen causing neonatal meningitis worldwide. Inflammatory mediators have been implicated in pathogenesis of and are key therapeutic targets. The role interleukin-22 (IL-22) various diseases is diverse, with both protective pathogenic effects. However, little understood about mechanisms underlying damaging effects IL-22 on blood–brain barrier (BBB) E. meningitis. We observed that meningitic infection induced expression serum brain mice. tight junction proteins (TJPs) components ZO-1, Occludin, Claudin-5 were degraded mouse human microvascular endothelial cells (hBMEC) following administration. Moreover, coli-caused increase BBB permeability wild-type mice was restored by knocking out IL-22. Mechanistically, activated STAT3-VEGFA signaling cascade meningitis, thus eliciting degradation TJPs induce disruption. Our data indicated an essential host accomplice during disruption could targeted for therapy bacterial

Language: Английский

Citations

15
Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease DOI Open Access

Abigail G. White,

Elias Elias,

Andrea Orozco

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5085 - 5085

Published: May 7, 2024

The brain is the central organ of adaptation to stress because it perceives and determines threats that induce behavioral, physiological, molecular responses. In humans, chronic manifests as an enduring consistent feeling pressure being overwhelmed for extended duration. This can result in a persistent proinflammatory response peripheral nervous system (CNS), resulting cellular, behavioral effects. Compounding stressors may increase risk chronic-stress-induced inflammation, which yield serious health consequences, including mental disorders. review summarizes current knowledge surrounding neuroinflammatory rodent models stress—a relationship continually defined. Many studies investigating effects on neuroinflammation have identified significant changes inflammatory modulators, nuclear factor-κB (NF-κB) toll-like receptors (TLRs), cytokines, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6. suggests these are key factors response, contribute establishment anxiety depression-like symptoms. neurological modulating through gene knockdown (KD) knockout (KO), conventional alternative medicine approaches, discussed.

Language: Английский

Citations

12
Armeniacae semen amarum: a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokinetics DOI Creative Commons
Shun Tang, Minmin Wang, Yu‐Hui Peng

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 23, 2024

Armeniacae semen amarum —seeds of Prunus armeniaca L. (Rosaceae) (ASA), also known as Kuxingren in Chinese, is a traditional Chinese herbal drug commonly used for lung disease and intestinal disorders. It has long been to treat coughs asthma, well lubricate the colon reduce constipation. ASA refers dried ripe seed diverse species Rosaceae contains variety phytochemical components, including glycosides, organic acids, amino flavonoids, terpenes, phytosterols, phenylpropanoids, other components. Extensive data shows that exhibits various pharmacological activities, such anticancer activity, anti-oxidation, antimicrobial anti-inflammation, protection cardiovascular, neural, respiratory digestive systems, antidiabetic effects, liver kidney, activities. In clinical practice, can be single or combination with medicines, forming ASA-containing formulas, afflictions. However, it important consider potential adverse reactions pharmacokinetic properties during its use. Overall, bioactive diversified actions potent efficacies, promising merits in-depth study on functional mechanisms facilitate application.

Language: Английский

Citations

8
Butyrate promotes post-stroke outcomes in aged mice via interleukin-22 DOI
Zhili Chen, Ling Xin, Yang Liu

et al.

Experimental Neurology, Journal Year: 2023, Volume and Issue: 363, P. 114351 - 114351

Published: Feb. 17, 2023

Language: Английский

Citations

12
Progress and prospects of Parkinson’s disease with depression research: A global bibliometric analysis based on CiteSpace DOI Creative Commons
Jianling Li,

Jianhang You,

Zhigang Li

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(7), P. e41537 - e41537

Published: Feb. 14, 2025

Background: Parkinson’s disease (PD) is a common neurodegenerative disorder marked by motor impairments such as stiffness, involuntary shaking, and slowed movement. In addition, PD patients frequently experience nonmotor symptoms, especially depression. This study uses mixed-methods scientometric analysis to review global research trends advancements in vital for clinicians, researchers, policymakers, identifying knowledge gaps directing future efforts. Methods: We conducted comprehensive literature on depression using the Web of Science database from 2004 2023, facilitated CiteSpace 6.1.R6. Our examined collaborations among authors, institutions, countries, keywords, incorporating insights RCTs qualitative studies. calculated effect sizes confidence intervals with precision. Ethical approval was not required used publicly available data without personal information. Results: included 3048 papers 915 reviews, involving 17,927 authors 12,466 institutions. The United States University Toronto led publications. Studies revealed significant narrow intervals, particularly prevalence impact patients. High-frequency keywords “Parkinson’s disease,” “depression,” “quality life,” “non-motor symptom,” “dementia.” Visual mapping identified critical nodes directions. Conclusion: Over past 2 decades, PD-depression link has accelerated. highlights prevailing areas, providing evidence-based recommendations therapeutic strategies. offers valuable clinicians emphasizing priorities improve patient outcomes.

Language: Английский

Citations

0
Unraveling the role of the IL-20 cytokine family in neurodegenerative diseases: Mechanisms and therapeutic insights DOI
Pouya Goleij, Afshin Amini, Mohammad Amin Khazeei Tabari

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114399 - 114399

Published: March 10, 2025

Language: Английский

Citations

0
Dietary Supplementation of Edible Mushroom Phallus atrovolvatus Aqueous Extract Attenuates Brain Changes in the AppNL−G−F Mouse Model of Alzheimer’s Disease DOI Open Access

Raweephorn Kaewsaen,

Wasaporn Chanput,

Lalida Rojanathammanee

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1677 - 1677

Published: May 15, 2025

Background/Objectives: Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive dementia and brain accumulation of Aβ-peptide-containing plaques, gliosis, neuroimmune changes, neurofibrillary tangles. Mushroom polysaccharides have been previously reported to anti-neuroinflammation activity through the gut–brain axis. This study aimed evaluate whether dietary intervention with Phallus atrovolvatus, recently identified edible mushroom in Thailand, could benefit on gut health alleviate AD-related changes. Methods: Male female 6–8-month-old littermate wild-type control (C57BL/6J) AppNL−G−F mice were randomly assigned either diet or supplemented aqueous extract (MAE) for 8 weeks quantify changes body weight, intestine, immune cells, short chain fatty acids, cytokines, amyloid-β (Aβ) levels, memory. Results: MAE had no adverse effects leakiness increased pyruvate levels serum. Splenocyte profiling revealed significant increase frequency IgM+, IA_IE+, CD14+ cells MAE-administered AppNL−G−Ffemale compared their vehicle controls. AppNL−G−Fmale that received showed cytotoxic CD8 T within cervical lymph nodes counterparts. Aβ deposition gliosis significantly reduced hippocampi MAE-supplemented groups. However, feeding did not alter spatial recognition memory sex genotype Conclusions: Our findings demonstrated administration P. atrovolvatus neuroprotective potential against impact

Language: Английский

Citations

0
A Review on the Protective Effects of Probiotics against Alzheimer’s Disease DOI Creative Commons
Vibhuti Mishra, Dhananjay Yadav,

Kavita Singh Solanki

et al.

Biology, Journal Year: 2023, Volume and Issue: 13(1), P. 8 - 8

Published: Dec. 22, 2023

This review summarizes the protective effects of probiotics against Alzheimer’s disease (AD), one most common neurodegenerative disorders affecting older adults. is characterized by deposition tau and amyloid β peptide (Aβ) in different parts brain. Symptoms observed patients with AD include struggles writing, speech, memory, knowledge. The gut microbiota reportedly plays an important role brain functioning due to its bidirectional communication via gut–brain axis. emotional cognitive centers are linked functions peripheral intestinal system this Dysbiosis has been disorders, indicating significance homeostasis for proper function. Probiotics play protecting symptoms as they restore a great extent. characteristics, status axis, AD. Review research articles related treatment were searched PubMed database. Recent studies conducted using animal models given preference. clinical trials separately. Several on human clearly explain benefits improving cognition memory experimental subjects. Based these studies, novel therapeutic approaches can be designed

Language: Английский

Citations

9
Evaluation of serum interleukin-17 A and interleukin-22 levels in pediatric patients with autism spectrum disorder: a pilot study DOI Creative Commons
Dina E. Sallam,

Youstina Sabry Shaker,

Gehan Ahmed Mostafa

et al.

BMC Pediatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 5, 2024

Abstract Background Many neurodevelopmental abnormalities are connected to autism spectrum disorder (ASD), which can result in inflammation and elevated cytokine levels due immune system dysregulation. Interleukin (IL)-17 A IL-22 have been linked the regulation of host defense against pathogens at barrier surface, regeneration injured tissue, integration neurological, endocrine, systems. Several studies investigated possible connection between IL-17 ASD as well severity behavioral symptoms, but few them included IL-22. Objectives To measure serum interleukin children with investigate their association disease severity. Methods This pilot study was performed on 24 matched controls. Childhood Autism Rating Scale (CARS) assessed severity, were by enzyme-linked immunosorbent assay (ELISA). Results In patients, showed a significant increase compared controls ( p -values < 0.001). We according categories CARS could not find any differences > 0.05). Only had positive correlation scores. Conclusions Raised associated ASD; only IL-22, A, is correlated finding proposes future effective target for treatment. fully comprehend significance these cytokines effects diagnosis treatment, more research wider scale required.

Language: Английский

Citations

3