Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: 77, P. 104 - 116
Published: Jan. 13, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: March 24, 2023
Abstract Allergic diseases such as allergic rhinitis (AR), asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic caused by an impaired immune system. Accompanied high recurrence rates, the steadily rising incidence rates of these attracting increasing attention. The pathogenesis is complex involves many factors, including maternal-fetal environment, living genetics, epigenetics, body’s status. exhibits a marked heterogeneity, with phenotype endotype defining visible features associated molecular mechanisms, respectively. With rapid development immunology, biology, biotechnology, new biological drugs have been designed for treatment diseases, anti-immunoglobulin E (IgE), anti-interleukin (IL)-5, anti-thymic stromal lymphopoietin (TSLP)/IL-4, to control symptoms. For doctors scientists, it becoming more important understand influencing pathogenesis, progress diseases. This review aimed assess epidemiology, therapeutic interventions AR, AAS, AD, FA. We hope help scientists systematically.
Language: Английский
Citations
143
Microorganisms, Journal Year: 2022, Volume and Issue: 10(7), P. 1303 - 1303
Published: June 27, 2022
The objective of this narrative review was to check the influence human microbiota in pathogenesis acne and how treatment with probiotics as adjuvant or alternative therapy affects evolution vulgaris. Acne is a chronic inflammatory skin disease involving pilosebaceous units. complex multifactorial genetic, metabolic, hormonal factors which both gut are implicated. Numerous studies have shown bidirectionality between intestinal homeostasis, communication mainly established by modifying immune system. Increased data on mechanisms action regarding relevance Cutibacterium acnes, well importance gut-skin axis, becoming known. Diverse varied vitro potential beneficial effects context. Clinical trials topical oral scarce, although they positive results, especially through modulation microbiota, generating an anti-inflammatory response restoring integrity, metabolic pathways insulin-like growth factor I (IGF-1). Given aggressiveness some standard treatments, should continue be investigated therapy.
Language: Английский
Citations
79
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Jan. 17, 2023
Spinal cord injury (SCI) brings a heavy burden to individuals and society, there is no effective treatment at present. Exosomes (EX) are cell secreted vesicles containing molecules such as nucleic acids proteins, which hold promise for the of SCI. Netrin-1 an axon guidance factor that regulates neuronal growth. We investigated effects engineered EX enriched in netrin-1 chemically synthetic modified message RNA (modRNA) treating SCI attempt find novel therapeutic approach SCI.Netrin-1 modRNA was transfected into bone marrow mesenchymal stem cells obtain with (EX-netrin1). built inflammatory model vitro lipopolysaccharide (LPS) study effect EX-netrin1 on For experiments vitro, ELISA, CCK-8 assay, immunofluorescence staining, lactate dehydrogenase release test, real-time quantitative polymerase chain reaction, western blot were conducted. At same time, we constructed rat MRI, hematoxylin-eosin Nissl staining used assess extent rats.In showed had viability oligodendrocytes PC12 cells. could attenuate LPS-induced inflammation pyroptosis accelerate axonal/dentritic growth cells/oligodendrocytes. In addition, activate PI3K/AKT/mTOR signalling pathway upon binding its receptor unc5b. When Unc5b PI3K inhibited, weakened, be reversed by or mTOR activator. Our vivo indicated promote recovery rats SCI.We found regulated inflammation, via Unc5b/PI3K/AKT/mTOR pathway, provides new strategy
Language: Английский
Citations
42
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 8, 2024
Rosacea is an inflammatory skin disease involving diverse symptoms with a variable clinical progress which can severely impact the patient’s quality of life as well their mental health. The pathophysiological model rosacea involves unbalanced immune system predisposed to excessive inflammation, in addition vascular and nervous alterations, being certain cutaneous microorganisms’ triggers onset. gut-skin axis explains bidirectional interaction between gut microbiota some diseases such atopic dermatitis, psoriasis, or rosacea. introduction consolidation next-generation sequencing recent years has provided unprecedented information about microbiome. However, characterization patients been little explored, contrast other dermatitis psoriasis. Furthermore, evolution not always adequate it common for them present sustained symptomatology frequent flare-ups. In this context, probiotic supplementation could improve these happens pathologies. Through review we aim establish compile basics directions current knowledge understand mechanisms by microbiome influences pathogenesis rosacea, how modulation benefit patients.
Language: Английский
Citations
18
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13
Published: Jan. 18, 2023
Psoriasis is a chronic autoimmune inflammatory skin disorder characterized by epidermal hyperplasia and aberrant immune response. In addition to cytokine production, psoriasis associated with activation of the Akt/mTOR pathway. mTOR/S6K1 regulates T-lymphocyte migration, keratinocytes proliferation upregulated in psoriatic lesions. Several drugs that target Th1/Th17 cytokines or their receptors have been approved for treating humans variable results necessitating improved therapies. Fisetin, natural dietary polyphenol anti-oxidant anti-proliferative properties, covalently binds mTOR/S6K1. The effects fisetin on its underlying mechanisms not clearly defined. Here, we evaluated immunomodulatory Th1/Th17-cytokine-activated adult human (HEKa) anti-CD3/CD28-stimulated CD4 + T cells compared these activities those rapamycin (an mTOR inhibitor). Transcriptomic analysis HEKa revealed 12,713 differentially expressed genes (DEGs) fisetin-treated group 7,374 DEGs rapamycin-treated group, both individually treated group. Gene ontology enriched functional groups related PI3K/Akt/mTOR signaling pathways, psoriasis, development. Using silico molecular modeling, observed high binding affinity IL-17A. vitro , significantly inhibited activity, increased expression autophagy markers LC3A/B Atg5 suppressed secretion IL-17A activated lymphocytes co-cultured HEKa. Topical administration an imiquimod (IMQ)-induced mouse model exhibited better effect than reducing psoriasis-like inflammation phosphorylation promoting keratinocyte differentiation mice Fisetin also T-lymphocytes F4/80 macrophage infiltration into skin. We conclude potently inhibits pathway promotes alleviate IMQ-induced disease mice. Altogether, our findings suggest as potential treatment possibly other diseases.
Language: Английский
Citations
28
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 4, 2024
Psoriasis is a chronic autoimmune inflammatory disease characterized by erroneous metabolism of keratinocytes. The development psoriasis closely related to abnormal activation and disorders the immune system. Dysregulated skin protective mechanisms can activate pathways within epithelial microenvironment (EIME), leading autoimmune-related diseases. In this review, we initially emphasized pathogenesis psoriasis, paying particular attention interactions between cells production cytokines in psoriasis. Subsequently, delved into significance EIME emergence A thorough understanding these processes crucial targeted therapies for Finally, discussed potential novel aimed at modulating This comprehensive examination sheds light on intricate underlying provides insights therapeutic avenues immune-mediated
Language: Английский
Citations
15
Clinics and Practice, Journal Year: 2024, Volume and Issue: 14(1), P. 214 - 241
Published: Jan. 26, 2024
Cutaneous melanoma is a public health problem. Efforts to reduce its incidence have failed, as it continues increase. In recent years, many risk factors been identified. Numerous diagnostic systems exist that greatly assist in early clinical diagnosis. The histopathological aspect illustrates the grim nature of these cancers. Currently, pathogenic pathways and tumor microclimate are key development therapeutic methods. Revolutionary therapies like targeted therapy immune checkpoint inhibitors starting replace traditional Targeted aims at specific molecule chain block it, stopping cell growth dissemination. main function boost cellular immunity order combat cancer cells. Unfortunately, different rates effectiveness side effects, cannot be applied all patients. These shortcomings basis increased mortality rates. This study covers stages evolutionary sequence melanoma. With data front us, we see need for new research efforts directed will bring greater benefits terms patient survival prognosis, with fewer adverse effects.
Language: Английский
Citations
8
AAPS PharmSciTech, Journal Year: 2022, Volume and Issue: 23(6)
Published: July 7, 2022
Language: Английский
Citations
34
Inflammopharmacology, Journal Year: 2023, Volume and Issue: 31(3), P. 1341 - 1359
Published: April 3, 2023
Abstract Diosmin is a flavonoid with promising anti-inflammatory and antioxidant properties. However, it has difficult physicochemical characteristics since its solubility demands pH level of 12, which an impact on the drug’s bioavailability. The aim this work development characterization diosmin nanocrystals using anti-solvent precipitation technique to be used for topical treatment psoriasis. Results revealed that stabilized hydroxypropyl methylcellulose (HPMC E15) in ratio (diosmin:polymer; 1:1) reached desired particle size (276.9 ± 16.49 nm); provided colloidal properties possessed high drug release profile. Additionally, in-vivo assessment was carried out evaluate compare activities nanocrystal gel three different doses powder alleviating imiquimod-induced psoriasis rats investigating their possible mechanisms. Herein, 125 mg 5% imiquimod cream (IMQ) applied topically 5 consecutive days shaved backs induce especially highest dose offered best effect. This confirmed by causing most statistically significant reduction area severity index (PASI) score serum inflammatory cytokines levels. Furthermore, capable maintaining balance between T helper (Th17) regulatory (Treg) cells. Moreover, tackled TLR7/8/NF-κB, miRNA-31, AKT/mTOR/P70S6K elevated TNFAIP3/A20 (a negative regulator NF-κB) expression psoriatic skin tissues. highlights role tackling rats, thus could novel therapy Graphical abstract
Language: Английский
Citations
17
Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 59 - 77
Published: Jan. 1, 2024
Background: The traditional Matricaria chamomilla L. has been used to treat dermatitis for thousands of years. Due emerging trends in alternative medicine, patients prefer natural remedies relieve their symptoms. Therefore, finding safe and effective plant medicines topical applications on the skin is an important treatment strategy dermatologists. German chamomile ( L.) from Compositae family a famous medicinal plant, often known as "star species."However, function essential oil inflammation not thoroughly examined earlier research. Methods: GC-MS analyzed components MCEO, this study explored anti-inflammation effects MCEO psoriasis with network pharmacological pathway prediction. Following this, we clinical samples confirm secretory characteristic relative inflammatory markers. therapeutic effect was detected by examination human keratinocytes HaCaT. At same time, prepared imiquimod-induced psoriatic-like mice investigate potential inhibition functions psoriatic injury inflammation. Results: significantly reduced interleukin-22/tumor necrosis factor α/lipopolysaccharide-stimulated elevation HaCaT cell inflammation, which correlated downregulating PI3K/Akt/mTOR p38MAPK pathways activation mediated cells treated IL-22/TNF-α/LPS. Skin evaluated based PASI score, HE staining, cytokine levels. results showed that could contribute disease treatment. Conclusion: inhibited induced IL-22/TNF-α/LPS, mechanisms associated inhibiting excessive crosstalk between pathways. ameliorated IMQ-induced levels cytokines but IL-17A. Thus, anti-inflammatory drugs different targets combined were psoriasis. Keywords: , oil, psoriasis, HaCaT, IMQ, mouse
Language: Английский
Citations
6