The Mediterranean Diet: An Update of the Clinical Trials

Nutrients, Journal Year: 2022, Volume and Issue: 14(14), P. 2956 - 2956

Published: July 19, 2022

The Mediterranean Diet (MedDiet) is a term used to identify dietary pattern originating from the unique multi-millennial interplay between natural food resources and eating practices of people living in basin. Scientific evidence has described healthy properties MedDiet its beneficial role several pathological conditions. Nevertheless, current socio-economic trends have moved away this lifestyle. Thus, clinical biological supporting benefits needed overcome these limitations. Clinical nutrition research examines effects interventions on or health-related outcomes determined study population. produced by studies useful for guidance public health messaging. We provided an update trials registered database clinicaltrials.gov evaluating specific diseases. Our findings revealed increased number last decade found that most disease-related focused cardiovascular diseases, metabolic cancer. majority MedDiet’s could be primarily related anti-inflammatory anti-oxidant as well effectiveness controlling waist circumference obesity. Moreover, strict long-lasting adherence components (e.g., olive oil polyphenols) seem emerge insights interventional improvements. These present further into how it strengthen overall health.

Language: Английский

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Phytobioactive compounds as therapeutic agents for human diseases: A review

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(6), P. 2500 - 2529

Published: April 17, 2023

Phytobioactive compounds are plant secondary metabolites and bioactive abundantly present in medicinal plants have remarkable therapeutic potential. Oxidative stress antibiotic resistance major causes of present-day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, inflammation. The data for this review were collected from Google Scholar, PubMed, Directory Open Access Journals (DOAJ), Science Direct by using keywords: "Medicinal plants, compounds, Polyphenols, Alkaloids, Carotenoids etc." Several studies reported the pharmacological potential phytobioactives. alkaloids, terpenes, polysaccharides isolated showed antioxidant, anticancer, cytotoxic, anti-inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, antidiabetic activities. This literature was planned to provide comprehensive insight into biopharmacological phytobioactive compounds. techniques used extraction isolation bioassays required their biological activities antimicrobial, cytotoxic activities, been discussed. Characterization structural elucidation HPLC, TLC, FTIR, GC-MS/MS, NMR also concludes that may be alternative synthetic agents treatment various diseases.

Language: Английский

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Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114993 - 114993

Published: June 9, 2023

Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality worldwide seriously threatens human health life. Cardiomyocyte death considered the pathological basis of various CVDs, including myocardial infarction, heart failure, aortic dissection. Multiple mechanisms, such as ferroptosis, necrosis, apoptosis, contribute cardiomyocyte death. Among them, ferroptosis an iron-dependent form programmed cell that plays vital role in physiological processes, from development aging immunity CVD. The dysregulation has been shown be closely associated with CVD progression, yet its underlying mechanisms are still not fully understood. In recent years, growing amount evidence suggests non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular involved regulation thus affecting progression. Some ncRNAs also exhibit potential value biomarker and/or therapeutic target for patients this review, we systematically summarize findings on their We focus clinical applications diagnostic prognostic biomarkers well targets treatment. DATA AVAILABILITY: No new data were created or analyzed study. Data sharing applicable article.

Language: Английский

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Non-coding RNAs regulating mitochondrial function in cardiovascular diseases

Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 101(5), P. 501 - 526

Published: April 4, 2023

Language: Английский

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Exploring the Safety, Efficacy, and Bioactivity of Herbal Medicines: Bridging Traditional Wisdom and Modern Science in Healthcare

Future Integrative Medicine, Journal Year: 2024, Volume and Issue: 3(1), P. 35 - 49

Published: March 25, 2024

This review explores the convergence of traditional wisdom and modern science in realm herbal medicines, focusing on safety, efficacy, bioactivity these natural remedies contemporary healthcare. The rich history deeply embedded cultural traditions, is witnessing a resurgence as quest for holistic personalized healthcare gains momentum. Herbal medicine, time-honored practice passed down through generations, experiencing renewed interest amid growing acknowledgment its potential benefits. delves into safety profiles remedies, subjecting them to rigorous scientific scrutiny. Additionally, it investigates efficacy interventions, aiming bridge gap between historical anecdotes empirical research. complex compounds, often containing numerous active ingredients, focal point, unraveling mechanisms which substances interact with human body. In world where synthesis holds promise advancing healthcare, this contributes ongoing dialogue. By critically examining aims illuminate evolving landscape medicine. goal integrate best both worlds enhance global well-being, acknowledging medicine valuable complement practices.

Language: Английский

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The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3821 - 3821

Published: Aug. 31, 2023

Lycopene is a compound of colored origin that shows strong antioxidant activity. The positive effect lycopene the result its pleiotropic effect. ability to neutralize free radicals via one foundations pro-health effect, including inhibit development many civilization diseases. Therefore, this study focuses on importance in inhibiting diseases such as cardiovascular diseases, within nervous system, diabetes, liver and ulcerative colitis. According research mentioned, supplementation has significant promise for treatment illnesses marked by chronic inflammation oxidative stress. However, majority supporting data lycopene′s health benefits comes from experimental research, whereas evidence clinical studies both scarcer less certain any benefits. Research humans still required establish effectiveness.

Language: Английский

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Lycopene: A Potent Antioxidant with Multiple Health Benefits

Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when used as dietary supplement. In vitro vivo , lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions diseases including inflammation, obesity, diabetes mellitus. shown alleviate affect the bone, eye, kidney, liver, lungs, heart, nervous system. This review presents state of art regarding lycopene’s benefits its potential applications system delivery. Furthermore, protective effects against toxins, safety use, possible toxicity are explored.

Language: Английский

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Bioactivity and Bioavailability of Carotenoids Applied in Human Health: Technological Advances and Innovation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7603 - 7603

Published: July 11, 2024

This article presents a groundbreaking perspective on carotenoids, focusing their innovative applications and transformative potential in human health medicine. Research jointly delves deeper into the bioactivity bioavailability of revealing therapeutic uses technological advances that have to revolutionize medical treatments. We explore pioneering which carotenoids are used treat chronic diseases such as cancer, cardiovascular disease, age-related macular degeneration, offering novel protective mechanisms benefits. Our study also shows cutting-edge innovations carotenoid extraction bioavailability, including development supramolecular carriers advanced nanotechnology, dramatically improve absorption efficacy these compounds. These not only ensure consistent quality but tailor therapies each patient's needs, paving way for personalized By integrating latest scientific discoveries techniques, this research provides prospective clinical establishing new benchmark future studies field. findings underscore importance optimizing extraction, administration, bioactivity, methods develop more effective, targeted, treatments, thus visionary insight modern practices.

Language: Английский

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Nutritional Benefits of Lycopene and Beta‐Carotene: A Comprehensive Overview

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(11), P. 8715 - 8741

Published: Oct. 16, 2024

Certain carotene components, such as lycopene and beta-carotene, are found in tomatoes, carrots, sweet potatoes, etc. good for human health. It gives plants their distinctive red color. A class of lipid-soluble natural pigments known carotenoids is the precursor vitamin vital antioxidant defense against peroxides cells tissues. This review provides an overview current state knowledge research on sources, structures, physiochemical properties, absorption metabolism, functional advantages, prevention many diseases associated with beta-carotene. These antioxidants have been linked to a lower risk cardiovascular disease cancer, they also help draw pollinators flowers. Carrots potatoes rich sources which strengthens immune system improves eye The vivid color reproductive organs, including flowers fruits, caused by carotenoid, secondary metabolite that produced plastids. other health advantages attributed lycopene. When ingested through food or supplements, beta-carotene manage prevent number diseases, metabolic, inflammatory, cardiovascular, hepatic, ophthalmic, skeletal, infertility disorders. main point toxicity uncommon, these generally accepted be safe at different doses. Including nutrients your diet can improve general provide illness prevention.

Language: Английский

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Lycopene as a Therapeutic Agent against Aflatoxin B1-Related Toxicity: Mechanistic Insights and Future Directions

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 452 - 452

Published: April 11, 2024

Aflatoxin (AFT) contamination poses a significant global public health and safety concern, prompting widespread apprehension. Of the various AFTs, aflatoxin B1 (AFB1) stands out for its pronounced toxicity association with spectrum of chronic ailments, including cardiovascular disease, neurodegenerative disorders, cancer. Lycopene, lipid-soluble natural carotenoid, has emerged as potential mitigator deleterious effects induced by AFB1 exposure, spanning cardiac injury, hepatotoxicity, nephrotoxicity, intestinal damage, reproductive impairment. This protective mechanism operates reducing oxidative stress, inflammation, lipid peroxidation, activating mitochondrial apoptotic pathway, facilitating activation biogenesis, endogenous antioxidant system, nuclear factor erythroid 2-related 2 (Nrf2)/kelch-like ECH-associated protein 1 (KEAP1) peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) pathways, well regulating activities cytochrome P450 (CYP450) enzymes. review provides an overview lycopene against exposure-induced underlying molecular mechanisms. Furthermore, it explores profile clinical applications lycopene. The present underscores lycopene’s promising detoxification agent intent to stimulate further research practical utilization in this domain.

Language: Английский

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