Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: March 27, 2023
Thousands
of
microorganisms
compose
the
human
gut
microbiota,
fighting
pathogens
in
infectious
diseases
and
inhibiting
or
inducing
inflammation
different
immunological
contexts.
The
microbiome
is
a
dynamic
complex
ecosystem
that
helps
proliferation,
growth,
differentiation
epithelial
immune
cells
to
maintain
intestinal
homeostasis.
Disorders
cause
alteration
this
microbiota
lead
an
imbalance
host's
regulation.
Growing
evidence
supports
microbial
community
associated
with
development
progression
inflammatory
diseases.
Therefore,
understanding
interaction
between
modulation
system
fundamental
mechanisms
involved
pathologies,
as
well
for
search
new
treatments.
Here
we
review
main
bacteria
capable
impacting
response
pathologies
discuss
by
which
can
alter
disease
outcomes.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 7, 2025
Diabetes
mellitus
represents
a
significant
global
health
problem.
The
number
of
people
suffering
from
this
metabolic
disease
is
constantly
rising
and
although
the
incidence
heterogeneous
depending
on
region,
country,
economic
situation,
lifestyle,
diet
level
medical
care,
it
increasing
worldwide,
especially
among
youths
children,
mainly
due
to
lifestyle
environmental
changes.
pathogenesis
two
most
common
subtypes
diabetes
mellitus,
type
1
(T1DM)
2
(T2DM),
substantially
different,
so
each
form
characterized
by
different
causation,
etiology,
pathophysiology,
presentation,
treatment.
Research
in
recent
decades
increasingly
indicates
potential
role
gut
microbiome
initiation,
development,
progression
disease.
Intestinal
microbes
their
fermentation
products
have
an
important
impact
host
metabolism,
immune
system,
nutrient
digestion
absorption,
barrier
integrity
protection
against
pathogens.
This
review
summarizes
current
evidence
changes
microbial
populations
both
types
mellitus.
Attention
focused
abundance
specific
bacterial
groups
at
taxonomic
levels
humans,
shift
also
assessed
relation
geographic
location,
age,
antidiabetic
drug.
causal
relationship
between
bacteria
still
unclear,
future
studies
applying
new
methodological
approaches
broader
range
microorganisms
inhabiting
digestive
tract
are
urgently
needed.
would
not
only
provide
better
understanding
disease,
but
use
beneficial
species
probiotics
for
treatment
diabetes.
Cellular Molecular and Biomedical Reports,
Journal Year:
2023,
Volume and Issue:
3(1), P. 35 - 40
Published: March 1, 2023
Various
microorganisms
are
located
on
the
human
skin,
mucous
membrane
and
inside
body.
Many
of
these
beneficial
few
even
essential,
however,
some
pathogens
known
to
cause
infection
have
ability
attack
damage
host
tissue.
Treatment
infectious
bacterial
disease
by
antibiotics
is
one
major
conventional
strategies.
Gram-positive
Gram-negative
bacteria
developed
resistance
various
mechanisms,
including
overexpression
efflux
pumps,
preventing
drug
penetration
into
cells,
genetic
mutations,
increased
production
competitive
inhibitors
antibiotics,
or
enzymes
that
inactivate
hydrolyze
antibiotics.
Consequently,
finding
a
new
approach
overcome
hindrances
vital
for
treatment
severe
infections.
Nanomaterials
can
be
effective
therapeutic
compounds,
with
unique
properties
compared
bulk
materials.
Metal
metal
oxide
nanoparticles,
particularly
silver
demonstrated
strong
antibacterial
activity
against
most
(if
not
all)
multidrug-resistant
bacteria.
Several
mechanisms
been
proposed
their
interaction
nucleic
acids
completely
understood,
so
this
review
discusses
recent
advances
in
area.
PLoS ONE,
Journal Year:
2023,
Volume and Issue:
18(2), P. e0281373 - e0281373
Published: Feb. 17, 2023
Advances
in
wound
treatment
depend
on
the
availability
of
animal
models
that
reflect
key
aspects
human
healing
physiology.
To
this
date,
accepted
mouse
do
not
defects
process
for
chronic
wounds
are
associated
with
type
two
diabetic
skin
ulcers.
The
long
term,
systemic
physiologic
stress
occurs
middle
aged
or
older
Type
2
diabetes
patients
is
difficult
to
simulate
preclinical
model.
We
have
strived
incorporate
essential
elements
a
manageable
model:
term
metabolic
from
obesity
include
effects
age
and
thereafter
onset
diabetes.
At
six-weeks
age,
male
C57BL/6
mice
were
separated
into
groups
fed
chow
High-Fat
Diet
0.5,
3,
6
months.
Treatment
included
stressed
induction
by
streptozotocin
at
5
months,
further
evaluation
8
months
old.
show
model
results
severe
phenotype
insulin
resistance
glucose
intolerance
and,
more
importantly,
changes.
transcriptional
signature
gene
expression
overlapped
observed
elderly
who
develop
foot
believe
unique
old
contrasts
current
induced
