Effect of dietary restriction on health span in Caenorhabditis elegans: A systematic review

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 182, P. 112294 - 112294

Published: Sept. 26, 2023

Dietary restriction (DR) interventions have demonstrated their efficacy in extending lifespan; however, the association between lifespan extension and health span remains unclear. This article aims to analyze relationship DR-induced Caenorhabditis elegans (C. elegans), a widely used animal model studies. By examining various parameters such as lipofuscin accumulation (an aging marker) locomotor feeding capacities (indicators of muscle degradation rate), we compiled papers that investigate report on these effects.The majority reviewed consistently demonstrate DR improves both C. elegans. Worms subjected exhibit slower compared those fed ad libitum, indicating reduction age-related cellular damage. Additionally, DR-treated worms display higher locomotion capacity, suggesting rate degradation. However, it is worth noting there are some discrepancies among regarding capacity. These contradictions can be attributed different methods employed initiate DR. While many approaches slow degeneration enhance pumping rates through adaptation limited food sources, other methods, using eat-2 mutant or mimic effects eat-2, reduce capacity consequently restrict intake. In conclusion, findings suggest strong correlation longevity elegans, evidenced by improvements parameters. not only extend but also mitigate markers preserve Although conflicting results observed overall evidence supports notion promotes healthier this model.

Language: Английский

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The importance of high total body water/fat free mass ratio and serial changes in body composition for predicting hospital mortality in patients with severe pneumonia: a prospective cohort study

BMC Pulmonary Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 27, 2024

Language: Английский

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Food Insecurity and COVID-19 Infection: Findings From the 2020−2021 National Health Interview Survey

AJPM Focus, Journal Year: 2023, Volume and Issue: 2(2), P. 100069 - 100069

Published: Jan. 18, 2023

The purpose of this study was to examine the sociodemographic and health-related factors associated with food insecurity association between COVID-19 infection using a nationally representative sample in U.S.Cross-sectional data 61,050 adults (aged ≥18 years) from 2020 2021 National Health Interview Survey were analyzed. Food measured by 10-item U.S. Department Agriculture Security Module. Weighted multivariable logistic regression models used estimate associations insecurity.A total 6.8% participants lived food-insecure households, 18.9% tested positive for infection. Young 18-34 or middle 35-64 age, female sex, minor race/ethnicity (Hispanic/non-Hispanic Black/non-Hispanic Asian/others), education level less than high school, unmarried status, unemployment, poverty (below federal level), having no health insurance, larger number children household, poorer self-reported presence chronic conditions significantly (AOR ranged 1.20 3.15, all p<0.0001). independently (AOR=1.25, 95% CI=1.11, 1.40), controlling factors. greatest magnitude observed non-Hispanic Black (AOR=1.47, CI=1.15, 1.88), (AOR=1.44, CI=1.20, 1.71), those below (AOR=1.39, CI=1.12, 1.73) across subgroups.Food disproportionately affected vulnerable subgroups such as young adults, individuals, minority groups, lower socioeconomic Policies addressing may help reduce likelihood infection, especially subgroups.

Language: Английский

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Association between Alcohol Consumption and Body Composition in Russian Adults and Patients Treated for Alcohol-Related Disorders: The Know Your Heart Cross-Sectional Study

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(4), P. 2905 - 2905

Published: Feb. 7, 2023

There is conflicting evidence about the association between alcohol consumption and body composition (BC). We aimed to investigate this in Russian adults. The study population included 2357 residents of Arkhangelsk aged 35-69 years, 272 in-patients treated for problems (narcological patients) who participated Know Your Heart (KYH) cross-sectional 2015-2017. participants were divided into five subgroups based on their use characteristics: non-drinkers, non-problem drinkers, hazardous harmful narcological patients. Considering men, drinkers had a larger waist circumference (WC), waist-to-hip ratio (WHR), percentage fat mass (%FM) compared drinkers. In drinking these differences opposite: lower index (BMI), hip (HC), %FM. Men among patients lowest mean BMI, WC, HC, WHR, %FM other men. As women, non-drinkers Women BMI HC but an increased WHR women. conclusion, levels inverted J-shaped with adiposity-related BC parameters: they elevated reduced even alcohol-related diagnoses.

Language: Английский

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Molecular Linkage between Immune System Disorders and Atherosclerosis

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(11), P. 8780 - 8815

Published: Nov. 1, 2023

A strong relationship exists between immune dysfunction and cardiovascular disease. Immune dysregulation can promote the development of diseases as well exacerbate their course. The disorders may occur due to presence primary defects (currently known inborn errors immunity) more common secondary deficiencies. Secondary deficiencies be caused by certain chronic conditions (such diabetes, kidney disease, obesity, autoimmune diseases, or cancer), nutritional (including both lack nutrients bioactive non-nutrient compounds), medical treatments addictive substances. This article unravels molecular linkage aforementioned system atherosclerosis.

Language: Английский

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Halalopathy: Stimulation of the Immune System Through Enrichment of Potential Energy

International Journal of Regenerative Medicine, Journal Year: 2022, Volume and Issue: unknown, P. 1 - 5

Published: July 25, 2022

The human mind is highly exposed to different sources of information. According halalopathy, supportive information enriches potential, while distracting increases entropy. Potential energy and entropy are inversely proportional. enrichment potential creates favourable circumstances for prevention recovery, the accumulation accelerates aging development diseases. availability plays a crucial role in how immune system can exist behave. Fight mode i.e., high where errors defects detected corrected simultaneously. Fright which dispersed accelerated, causing respond randomly attack indiscriminately. flight mode, suppressed, leads slowing down response, thereby bypassing many mutations. main objective halalopathy develop methods strategies enrich keep fight active thus stimulate better recovery.

Language: Английский

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Disease Progression, Clinical Features, and Risk Factors for Pneumonia in Unvaccinated Children and Adolescents with Measles: A Re-Emerging Disease in Romania

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(20), P. 13165 - 13165

Published: Oct. 13, 2022

Measles causes in vaccinated children, with some exceptions, a mild disease, while the unvaccinated can suffer complications that result serious consequences and even death. Although introduction of measles vaccine has reduced number cases viral spread, current downward vaccination trend resulted resurgence disease. Currently, Romania coverage below 95% safety threshold. Thus, an outbreak started 2016 still ongoing Romania, many being identified Western region pediatric population. Our objective was to conduct thorough examination clinical characteristics, evolution, risk factors children this region. To reach our objectives we used retrospective cohort analysis. The authors reviewed laboratory data from patients hospitalized at “Victor Babes” Hospital for Infectious Diseases Pulmonology Timisoara. We found total 136 qualifying among admitted facility. two comparison groups consisted 104 under 10 years 32 between 18 years. An important characteristic both study high prevalence Roma ethnicity, which, although represents minority over 40% study. infection source 40.4% inside family, 71.9% infections group adolescents were isolated (p-value = 0.047). multivariate factor analysis as independent development pneumonia older age (OR 1.62), poor nutritional status 1.25), ethnicity 2.44), presence anemia 1.58), procalcitonin 3.09). It is essential handle these patient measles, especially conjunction unknown status. achieve rate greater than 95 percent Romanian awareness must be promoted, moreover More comprehensive preventative methods developed promptly eradicating via vigorous campaign.

Language: Английский

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Increased nutrition risk is associated with a prolonged negative conversion of viral RNA in children and adolescents with COVID‐19

Nutrition in Clinical Practice, Journal Year: 2023, Volume and Issue: 38(5), P. 1073 - 1081

Published: April 11, 2023

Abstract Background This study aimed to determine the factors affecting time negative conversion of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in children and adolescents, with particular reference nutrition risk assessment on admission. Methods retrospective observational was conducted a sentinel hospital for novel Quanzhou, China. The population comprised adolescents COVID‐19 admitted isolation wards between March 25 April 12, 2022. Based Screening Tool Assessment Malnutrition Paediatrics (STAMP), screening performed within 24 h Univariate multivariate analyses were used identify independent viral RNA conversion. Results A total 185 patients confirmed included this study. median (from first day positive nucleic acid test consecutive results) 15 days (IQR 12–18 days), ranging from 4 days. High (hazard ratio [HR]: 0.543, 95% CI: 0.334–0.881) fever (HR: 0.663; 0.483–0.910) influencing SARS‐CoV‐2 RNA. Conclusion independently associated delayed clearance infection, so these should be considered during treatment plans infected adolescents.

Language: Английский

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Journal of Medicinal and Chemical Sciences, Journal Year: 2023, Volume and Issue: 6(12)

Published: Sept. 10, 2023

The COVID-19 pandemic has been going on since the end of 2019 until now and many positive residents have confirmed to be suffering from symptoms COVID-19. However, there is still little literature discussing nutrition based community characteristics after pandemic. Therefore, this article aims analyze This study was an observational descriptive analytic design cross-sectional study. samples were participants service who teachers parents kindergarten school. data analyzed using T-test linear regression analysis. results indicated that significant differences between pretest score posttest with a p-value <0.001. In addition, all factors including age, educational level, score, weight, height altogether significantly contribute nutritional status. Several measures need taken mitigate impact those providing services healthy lifestyle improve community’s health.

Language: Английский

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Malnutrition and the Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Multi-Institutional Population-Based Propensity Score-Matched Analysis

Life, Journal Year: 2024, Volume and Issue: 14(6), P. 746 - 746

Published: June 12, 2024

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global health crisis, exacerbating issues like malnutrition due increased metabolic demands and reduced intake during illness. Malnutrition, significant risk factor, is linked worse outcomes in patients with COVID-19, such as mortality extended hospital stays. This retrospective cohort study investigated the relationship between clinical within 90–180 days using data obtained from TriNetX database. Patients aged >18 years diagnosed COVID-19 1 January 2022, 31 March 2024 were enrolled study. The propensity score-matching (PSM) method was used match (malnutrition group) those without (control group). primary composite outcome cumulative hazard ratio (HR) for post-COVID-19 condition, all-cause hospitalization, 90 180 after diagnosis. secondary individual components of outcomes. Two cohorts, each consisting 15,004 balanced baseline characteristics, identified PSM. During 90–180-day follow-up period, group exhibited higher incidence mortality, or condition (HR = 2.315, 95% confidence interval: 2.170–2.471, p < 0.0001). Compared malnutrition, may be associated adverse

Language: Английский

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