Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 190 - 190
Published: Feb. 4, 2025
There
are
different
types
of
cancer
treatments,
including
surgery,
radiotherapy,
and
chemotherapy.
However,
the
complexity
has
resulted
in
treatment
challenges
to
medicinal
scientists
a
socio-economic
burden
public
health
system
globally.
The
pharmacological
limitations
associated
with
current
conventional
anticancer
drugs
include
lack
specificity,
poor
bioavailability,
toxicity,
drug
resistance,
delivery
mechanisms,
which
make
challenging.
Thus,
number
cases
is
escalating
rapidly,
especially
breast
prostate
women
men,
respectively.
application
nanoformulations
gaining
momentum
for
treating
types.
they
also
exhibit
that
must
be
addressed
effective
treatment.
Nanoliposomes
widely
explored
interesting
therapeutic
outcomes.
They
have
been
functionalized
PEG
further
improve
their
Hence,
this
review
provides
an
update
on
PEGylated
nanoliposomes
loaded
cancer,
focusing
pre-clinical
studies
published
last
decade
(2015
2024)
reflect
recent
advancements
made
design
PEGylation
nanoliposomes.
Highlights
clinically
commercially
available
presented
review.
Next Nanotechnology,
Journal Year:
2023,
Volume and Issue:
2, P. 100013 - 100013
Published: June 1, 2023
Polymers
show
a
vast
possibility
of
chemical
modification
novel
properties
and
nanomedicine
generation
in
biomedical
fields.
Polymeric
nanoparticle
(PNPs)
is
commonly
used
as
drug
carrier,
they
have
good
biodegradability,
biocompatibility,
high
drug-loading
capacity.
PNPs
are
the
broadly
nanocarrier
including
polymeric
micelles,
liposomes,
dendrimers,
sponges,
colloidal
carriers.
These
NPs
also
low
toxicity,
increased
therapeutic
effectiveness,
improved
penetration,
controlled
release
enhanced
physical
stability.
widely
delivery
system
subsequently
able
to
load
natural
synthetic
agents
including,
protein,
peptides,
growth
factors,
DNAs,
mRNA,
drugs.
can
be
applied
via
several
routes
administration
nasal,
oral,
intravenous,
topical
ocular.
potentially
target
specific
cells/tissues,
promising
way
increase
local
concentration,
decrease
toxicity
side
effects,
prevent
nonspecific
interaction.
The
present
review
focuses
on
biodegradable
polymers,
classifications,
types,
method
preparation
PNPs,
applications
targeted
their
limitations.
This
presents
for
respiratory,
cancers,
liver
cirrhosis,
ocular,
diabetic
wounds,
Alzheimer's
disease.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 868 - 868
Published: March 7, 2023
The
new
era
of
nanomedicine
offers
significant
opportunities
for
cancer
diagnostics
and
treatment.
Magnetic
nanoplatforms
could
be
highly
effective
tools
diagnosis
treatment
in
the
future.
Due
to
their
tunable
morphologies
superior
properties,
multifunctional
magnetic
nanomaterials
hybrid
nanostructures
can
designed
as
specific
carriers
drugs,
imaging
agents,
theranostics.
Multifunctional
are
promising
theranostic
agents
due
ability
diagnose
combine
therapies.
This
review
provides
a
comprehensive
overview
development
advanced
combining
optical
providing
photoresponsive
platforms
medical
applications.
Moreover,
this
discusses
various
innovative
developments
using
nanostructures,
including
drug
delivery,
treatment,
tumor-specific
ligands
that
deliver
chemotherapeutics
or
hormonal
resonance
imaging,
tissue
engineering.
Additionally,
artificial
intelligence
(AI)
used
optimize
material
properties
based
on
predicted
interactions
with
cell
membranes,
vasculature,
biological
fluid,
immune
system
enhance
effectiveness
therapeutic
agents.
Furthermore,
an
AI
approaches
assess
practical
utility
Finally,
presents
current
knowledge
perspectives
systems
models.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 541 - 569
Published: Jan. 1, 2024
Natural
products
have
proven
to
significant
curative
effects
and
are
increasingly
considered
as
potential
candidates
for
clinical
prevention,
diagnosis,
treatment.
Compared
with
synthetic
drugs,
natural
not
only
diverse
structures
but
also
exhibit
a
range
of
biological
activities
against
different
disease
states
molecular
targets,
making
them
attractive
development
in
the
field
medicine.
Despite
advancements
use
purposes,
there
remain
obstacles
that
hinder
their
full
potential.
These
challenges
include
issues
such
limited
solubility
stability
when
administered
orally,
well
short
durations
effectiveness.
To
address
these
concerns,
nano-drug
delivery
systems
emerged
promising
solution
overcome
barriers
faced
application
products.
offer
notable
advantages,
large
specific
surface
area,
enhanced
targeting
capabilities,
ability
achieve
sustained
controlled
release.
Extensive
vitro
vivo
studies
provided
further
evidence
supporting
efficacy
safety
nanoparticle-based
delivering
preclinical
models.
This
review
describes
limitations
product
applications
current
status
combined
nanotechnology.
The
latest
advances
from
three
aspects:
connecting
warheads,
self-assembly,
co-delivery.
Finally,
translation
nano-drugs
discussed.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 889 - 889
Published: March 9, 2023
Anticancer
drugs
in
monotherapy
are
ineffective
to
treat
various
kinds
of
cancer
due
the
heterogeneous
nature
cancer.
Moreover,
available
anticancer
possessed
hurdles,
such
as
drug
resistance,
insensitivity
cells
drugs,
adverse
effects
and
patient
inconveniences.
Hence,
plant-based
phytochemicals
could
be
a
better
substitute
for
conventional
chemotherapy
treatment
properties:
lesser
effects,
action
via
multiple
pathways,
economical,
etc.
Various
preclinical
studies
have
demonstrated
that
combination
with
is
more
efficacious
than
individually
because
plant-derived
compounds
lower
efficacy
drugs.
suffer
from
poor
aqueous
solubility
reduced
bioavailability,
which
must
resolved
Therefore,
nanotechnology-based
novel
carriers
employed
codelivery
These
include
nanoemulsion,
nanosuspension,
nanostructured
lipid
carriers,
solid
nanoparticles,
polymeric
micelles,
dendrimers,
metallic
carbon
nanotubes
provide
benefits
improved
solubility,
higher
efficacy,
dose,
dosing
frequency,
bioavailability
compliance.
This
review
summarizes
cancer,
therapy
deliver
Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Feb. 18, 2025
Abstract
Researchers
have
found
that
mutations
in
the
BRCA
gene
associated
with
breast
cancer
a
40–50%
chance
of
being
high
risk
for
hereditary
(BC).
Therefore,
detecting
BRCA1
is
crucial
genetic
analysis,
early
detection,
and
clinical
treatment
BC.
Traditional
detection
methods
include
high-performance
liquid
chromatography
(HPLC),
single-strand
conformation
polymorphism
assays
(SSCP),
PCR,
real-time
DNA
sequencing.
However,
these
are
limited
by
cost,
analysis
time,
complexity.
it
necessary
to
develop
an
ultrasensitive,
fast,
low-cost,
simple
method
detection.
In
recent
years,
various
BC
biosensing
strategies
been
investigated,
including
optical,
electrical,
electrochemical,
mechanical
biosensing.
particular,
sensitivity
short
times
electrochemical
biosensors
make
them
suitable
recognizing
biomarkers.
Additionally,
can
be
increased
incorporating
nanomaterials.
this
regard,
main
focus
present
study
introduction
common
diagnosing
BRCA-1/2
genes.
addition
introducing
as
efficient
tool,
also
discusses
latest
most
significant
developed
gene.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(8), P. 1566 - 1566
Published: July 28, 2022
Nanomedicines
have
gained
popularity
due
to
their
potential
therapeutic
applications,
especially
cancer
treatment.
Targeted
nanoparticles
can
deliver
drugs
directly
cells
and
enable
prolonged
drug
release,
reducing
off-target
toxicity
increasing
efficacy.
However,
translating
nanomedicines
from
preclinical
clinical
settings
has
been
difficult.
Rapid
advancements
in
nanotechnology
promise
enhance
therapies.
Nanomedicine
offers
advanced
targeting
multifunctionality.
Nanoparticles
(NPs)
several
uses
nowadays.
They
studied
as
transporters,
tumor
gene
delivery
agents,
imaging
contrast
agents.
Nanomaterials
based
on
organic,
inorganic,
lipid,
or
glycan
substances
synthetic
polymers
used
This
review
focuses
polymeric
nanoparticle
strategies
for
anticancer
nanomedicines.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 22, 2023
Breast
cancer
(BC)
is
the
most
frequently
diagnosed
malignant
tumor
among
women
in
world.
BC
heterogeneous
with
different
subtypes
including
luminal
A-like,
B-like
(HER2-/HER2+),
HER2
enriched,
and
triple-negative
BC.
The
therapeutic
strategies
surgery,
chemotherapy,
radiotherapy,
targeted
therapy,
endocrine
therapy
are
well
developed
commonly
used
treatment
of
However,
some
adverse
effects
these
conventional
treatments
limited
their
wide
application
clinical.
Therefore,
it
necessary
to
develop
more
safe
efficient
individualized
Nanomedicine,
as
promising
strategy
for
controlled
drug
delivery,
widely
multiple
aspects
therapy.
Importantly,
accumulative
evidences
show
that
nanomedicine
has
achieved
good
outcomes
a
huge
amount
patients
benefited
from
related
treatments.
In
this
review,
we
summarized
discussed
major
problems
occurred
during
administration
potential
roles
promoting
efficacy
by
overcoming
obstacles
current
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(20), P. 14017 - 14040
Published: Jan. 1, 2024
Nanotechnology
revolutionizes
breast
cancer
treatment
by
improving
drug
delivery,
overcoming
barriers,
and
reducing
side
effects.
This
review
highlights
its
potential
superiority
over
conventional
methods,
transforming
management.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(3), P. e25477 - e25477
Published: Feb. 1, 2024
The
health
of
the
reproductive
system
is
intricately
linked
to
female
fertility
and
quality
life.
There
has
been
a
growing
prevalence
disorders
among
women,
particularly
in
younger
age
groups,
resulting
significant
adverse
effects
on
their
health.
Consequently,
there
an
urgent
need
for
effective
treatment
modalities.
Nanotechnology,
as
advanced
discipline,
provides
innovative
avenues
managing
treating
diseases
by
enabling
precise
manipulation
regulation
biological
molecules
cells.
By
utilizing
nanodelivery
systems,
drugs
can
be
administered
with
pinpoint
accuracy,
leading
reduced
side
improved
therapeutic
efficacy.
Moreover,
nanomaterial
imaging
techniques
enhance
diagnostic
precision
sensitivity,
aiding
assessment
disease
severity
progression.
Furthermore,
implementation
nanobiosensors
facilitates
early
detection
prevention
ailments.
This
comprehensive
review
aims
summarize
recent
applications
nanotechnology
diseases.
latest
advancements
drug
delivery,
diagnosis,
approaches
will
discussed,
emphasis
potential
improve
outcomes
overall
