Nanotechnology revolutionises breast cancer treatment: harnessing lipid-based nanocarriers to combat cancer cells DOI

Farheen Fatima Qizilbash,

Ali Sartaj, Zufika Qamar

et al.

Journal of drug targeting, Journal Year: 2023, Volume and Issue: 31(8), P. 794 - 816

Published: Aug. 1, 2023

One of the most common cancers that occur in females is breast cancer. Despite significant leaps and bounds have been made treatment cancer, disease remains one leading causes death among women a major public health challenge. The therapeutic efficacy chemotherapeutics hindered by chemoresistance toxicity. Nano-based lipid drug delivery systems offer controlled release, nanometric size site-specific targeting. Breast cancer includes surgery, chemotherapy radiotherapy. this, no single method for condition currently effective due to stem cell metastasis chemo-resistance. Therefore, employment nanocarrier necessary order target cells. This article addresses options, including modern procedures such as chemotherapy, etc. some innovative options highlighting role lipidic nanocarriers loaded with chemotherapeutic drugs nanoemulsion, solid-lipid nanoparticles, nanostructured carriers liposomes, their investigations demonstrated they can limit growth, reduce risk recurrence, well minimise post-chemotherapy metastasis. also explores FDA-approved lipid-based nanocarriers, commercially available formulations, ligand-based formulations are being considered further research.

Language: Английский

Advancements in Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Breast Cancer Therapy DOI

Harneet Marwah,

Hitesh Kumar Dewangan

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(37), P. 2922 - 2936

Published: Aug. 16, 2024

Solid Lipid Nanocarriers (SLNs) offer a promising avenue for breast cancer treatment, disease that accounts 12.5% of global cases. Despite strides in combined therapies (surgery, chemotherapy, radiation, and endocrine therapy), challenges like systemic toxicity, drug resistance, adverse effects persist. The manuscript offers several novel contributions to the field treatment through use SLNs, these are innovative delivery systems, multifunctionality, biocompatibility, potential overcome integration with emerging therapies, focus on personalized medicine, ongoing future research directions reduced side effects. SLNs present strategy due their unique physicochemical properties. They can encapsulate both hydrophilic hydrophobic drugs, ensuring controlled release targeted delivery, thus enhancing solubility bioavailability reducing multifunctional nature improves while biocompatibility supports therapy. Challenges pharmacists include maintaining stability, effective loading, timed delivery. Combining gene immunotherapy holds promise more treatments. represent significant advancement, providing precise fewer effects, overcoming resistance. Ongoing will refine therapy, targeting cells minimal integrating other treatments comprehensive approaches. Advances nanotechnology medicine tailor specific subtypes, effectiveness. Clinical trials new developments crucial realizing SLNs' full care. In conclusion, transformative approach addressing issues aims optimize potentially revolutionizing care hope patients.

Language: Английский

Citations

9
A comprehensive review of anti-cancer mechanisms of polyphenol honokiol and nano carrier-based approaches to enhance its therapeutic potential DOI
Raghu Solanki, Laxminarayan Rawat, Saba Tabasum

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

1
Special Issue: Nanotherapeutics in Women's Health Emerging Nanotechnologies for Triple‐Negative Breast Cancer Treatment DOI Creative Commons
Sofia Torres Quintas, Ana Manuela Canha Borges, Maria José Oliveira

et al.

Small, Journal Year: 2023, Volume and Issue: unknown

Published: March 28, 2023

Breast cancer appears as the major cause of cancer-related deaths in women, with more than 2 260 000 cases reported worldwide 2020, resulting 684 996 deaths. Triple-negative breast (TNBC), characterized by absence estrogen, progesterone, and human epidermal growth factor type receptors, represents ≈20% all cancers. TNBC has a highly aggressive clinical course is prevalent younger women. The standard therapy for advanced chemotherapy, but responses are often short-lived, high rate relapse. lack therapeutic targets limited options confer to individuals suffering from poorest prognosis among patients, remaining challenge. In recent years, advances nanomedicine provided innovative options, nanoformulations play an important role overcoming shortcomings left conventional therapies: payload degradation its low solubility, stability, circulating half-life, difficulties regarding biodistribution due physiological biological barriers. this integrative review, field treatment, including novel nanoparticle-, exosome-, hybrid-based formulations summarized their drawbacks challenges discussed future applications.

Language: Английский

Citations

22
Nanomedicine Technologies for Diagnosis and Treatment of Breast Cancer DOI

Katerina Kitsios,

Shahriar Sharifi, Morteza Mahmoudi

et al.

ACS Pharmacology & Translational Science, Journal Year: 2023, Volume and Issue: 6(5), P. 671 - 682

Published: April 21, 2023

Breast cancer is one of the most common cancers in women worldwide, yet conventional treatments have several shortcomings, including low specificity, systemic toxicity, and drug resistance. Nanomedicine technologies provide a promising alternative while also overcoming limitations posed by therapies. This mini-Review highlights important signaling pathways related to occurrence development breast current therapies, followed an analysis various nanomedicine developed for diagnosis treatment cancers.

Language: Английский

Citations

17
Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells DOI Creative Commons
Amina Akhlaq, Muhammad Ashraf, Muhammad Ovais Omer

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(35), P. 31826 - 31838

Published: Aug. 25, 2023

Breast and cervical cancers are the most common heterogeneous malignancies in women. Chemotherapy with conventional drug delivery systems having several limitations along development of multidrug resistance compelled us to seek out targeted therapeutics. Nanoparticles suitable substitutes circumvent for treatment cancer. The current study was aimed investigate anticancer effect carvacrol-loaded chitosan nanoparticles topoisomerase inhibitors. average size found be 80 nm 24.7 mV ζ-potential, maximum absorbance observed at 275 nm. Among all combinations, carvacrol doxorubicin combination group exerted greater dose-dependent growth inhibition both MCF-7 HeLa cells as compared single doxorubicin. Combination index values showed a strong synergistic they were between 0.2 0.4, 0.31 0.34 cells. on reduced dose 16.32-fold 4.09-fold 6.23 μg/mL IC50, while cells, this 13.18-fold 3.83-fold 9.33 IC50. As reduction than 1, indicated favorable reduction. It concluded that inhibitors may represent an innovative promising strategy improve efficacy, resistance, chemotherapeutics

Language: Английский

Citations

17
Functionalized SWCNTs@Ag–TiO2 nanocomposites induce ROS-mediated apoptosis and autophagy in liver cancer cells DOI Creative Commons
Majid S. Jabir, Mustafa K. A. Mohammed, Salim Albukhaty

et al.

Nanotechnology Reviews, Journal Year: 2023, Volume and Issue: 12(1)

Published: Jan. 1, 2023

Abstract Hybrid nanomaterials with unique physiochemical properties have received a lot of attention, making them attractive for application in different fields like cancer treatment. This study was designed to investigate the combined effects single-walled carbon nanotubes (SWCNTs) hybridized silver titanium dioxide composite (SWCNTs@Ag–TiO 2 ). Transmission electron microscopy and field emission scanning images demonstrated accumulation SWCNTs Ag–TiO due an increased main grain size functionalization 40 nm. The D G bands @Ag–TiO shifted 1,366 1,534 cm −1 , respectively. SWCNTs@Ag-TiO were assessed their cytotoxicity autophagy induction liver cells (Hep-G2) using lactate dehydrogenase assay, MTT flow cytometry methods. results showed that SWCNTs@Ag–TiO exhibited strong anti-cancer activity vitro against Hep-G2 by inducing apoptosis via controlling AKT JNK mitogen-activated protein kinase pathways. show coated silver/titanium ) reduce cells’ viability proliferation. It shown excessive amount reactive oxygen species crucial mediator both cell death caused . Based on these findings, it appears potential be developed as nanotherapeutics treatment cells.

Language: Английский

Citations

17
Bacterial nanotechnology as a paradigm in targeted cancer therapeutic delivery and immunotherapy DOI Creative Commons
Ahmad Gholami, Milad Mohkam, Saeede Soleimanian

et al.

Microsystems & Nanoengineering, Journal Year: 2024, Volume and Issue: 10(1)

Published: Aug. 20, 2024

Cancer, a multifaceted and diverse ailment, presents formidable obstacles to traditional treatment modalities. Nanotechnology novel prospects for surmounting these challenges through its capacity facilitate meticulous regulated administration of therapeutic agents malignant cells while concurrently modulating the immune system combat neoplasms. Bacteria their derivatives have emerged as highly versatile multifunctional platforms cancer nanotherapy within realm nanomaterials. This comprehensive review delves into groundbreaking implementations bacterial nanotechnology therapy. encompasses four primary facets: utilization bacteria living conveyors medicinal substances, employment components that stimulate system, deployment vectors tools delivering genetic material, development bacteria-derived nano-drugs intelligent nano-medications. Furthermore, we elucidate merits modalities operation pertaining nano-systems, along with synergize other cutting-edge nanotechnologies, such CRISPR-Cas systems. Additionally, offer insightful viewpoints regarding forthcoming trajectories this expanding domain. It is our deduction embodies propitious innovative paradigm in therapy, which has potential provide numerous advantages synergistic effects enhancing outcomes quality life individuals afflicted cancer.

Language: Английский

Citations

7
Fabrication, Characterization and Evaluation of Gallic Acid-Encapsulated Curdlan Gum Nanoparticles with Potential Application for Breast Cancer Treatment DOI

Ezhilarasi Pandi,

Bazeera Ferdhous Proskhan,

Selvaraj Kunjiappan

et al.

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: 32(7), P. 3071 - 3088

Published: Jan. 5, 2024

Language: Английский

Citations

6
The impact of mucormycosis (black fungus) on SARS-CoV-2-infected patients: at a glance DOI Open Access
Md. Rezaul Islam, Md. Mominur Rahman,

Md. Tanjimul Ahasan

et al.

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(46), P. 69341 - 69366

Published: Aug. 19, 2022

Language: Английский

Citations

23
Ultrasound-Responsive Nanocarriers for Breast Cancer Chemotherapy DOI Creative Commons
Gelan Ayana, Jaemyung Ryu, Se‐woon Choe

et al.

Micromachines, Journal Year: 2022, Volume and Issue: 13(9), P. 1508 - 1508

Published: Sept. 11, 2022

Breast cancer is the most common type of and it treated with surgical intervention, radiotherapy, chemotherapy, or a combination these regimens. Despite chemotherapy's ample use, has limitations such as bioavailability, adverse side effects, high-dose requirements, low therapeutic indices, multiple drug resistance development, non-specific targeting. Drug delivery vehicles carriers, which nanocarriers are prominent, have been introduced to overcome chemotherapy limitations. Nanocarriers preferentially used in breast because their role protecting agents from degradation, enabling efficient concentration target cells tissues, overcoming resistance, relatively small size. However, affected by physiological barriers, bioavailability transported drugs, other factors. To resolve issues, use external stimuli introduced, ultrasound, infrared light, thermal stimulation, microwaves, X-rays. Recently, ultrasound-responsive become popular they cost-effective, non-invasive, specific, tissue-penetrating, deliver high concentrations target. In this paper, we review recent developments ultrasound-guided for discuss relevant challenges, provide insights into future directions.

Language: Английский

Citations

23