Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Oct. 24, 2022
The
highest
density
of
microbes
resides
in
human
gastrointestinal
tract,
known
as
“Gut
microbiome”.
Of
note,
the
members
genus
Lactobacillus
that
belong
to
phyla
Firmicutes
are
most
important
probiotic
bacteria
gut
microbiome.
These
gut-residing
species
not
only
communicate
with
each
other
but
also
epithelial
lining
balance
barrier
integrity,
mucosal
defence
and
ameliorate
host
immune
responses.
body
suffers
from
several
inflammatory
diseases
affecting
gut,
lungs,
heart,
bone
or
neural
tissues.
Mounting
evidence
supports
significant
role
spp.
their
components
(such
metabolites,
peptidoglycans,
and/or
surface
proteins)
modulatingimmune
responses,
primarily
through
exchange
immunological
signals
between
tract
distant
organs.
This
bidirectional
crosstalk
which
is
mediated
by
promotes
anti-inflammatory
response,
thereby
supporting
improvement
symptoms
pertaining
asthma,
chronic
obstructive
pulmonary
disease
(COPD),
neuroinflammatory
multiple
sclerosis,
alzheimer’s
disease,
parkinson’s
disease),
cardiovascular
diseases,
bowel
(IBD)
infections
patients.
metabolic
disorders,
obesity
diabetes
characterized
a
low-grade
inflammation.
Genus
alleviates
disorders
regulating
oxidative
stress
response
pathways.
Osteoporosis
associated
inflammation
resorption.
metabolites
act
powerful
cell
controllers
exhibit
regulatory
resorption
formation,
health.
Thus,
this
review
demonstrated
mechanisms
summarized
benefit
alleviating
different
organs
animal
clinical
trials.
present
narrative
explores
detail
complex
interactions
gut-dwelling
promote
host’s
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(20), P. 4466 - 4466
Published: Oct. 21, 2023
The
gut
microbiome
is
a
diverse
bacterial
community
in
the
human
gastrointestinal
tract
that
plays
important
roles
variety
of
biological
processes.
Short-chain
fatty
acids
(SCFA)
are
produced
through
fermentation
dietary
fiber.
Certain
microbes
responsible
for
producing
SCFAs
such
as
acetate,
propionate
and
butyrate.
An
imbalance
diversity
can
lead
to
metabolic
disorders
inflammation-related
diseases.
Changes
SCFA
levels
associated
microbiota
were
observed
IBD,
suggesting
an
association
between
disease.
affect
reactive
oxygen
species
(ROS)
with
IBD.
Gut
closely
related
it
study
them
further.
Molecular Biomedicine,
Journal Year:
2022,
Volume and Issue:
3(1)
Published: Oct. 11, 2022
Abstract
The
gut
microbiota
is
critical
to
human
health,
such
as
digesting
nutrients,
forming
the
intestinal
epithelial
barrier,
regulating
immune
function,
producing
vitamins
and
hormones,
metabolites
interact
with
host.
Meanwhile,
increasing
evidence
indicates
that
has
a
strong
correlation
occurrence,
progression
treatment
of
cardiovascular
diseases
(CVDs).
In
patients
CVDs
corresponding
risk
factors,
composition
ratio
have
significant
differences
compared
their
healthy
counterparts.
Therefore,
dysbiosis,
microbiota-generated
metabolites,
related
signaling
pathway
may
serve
explanations
for
some
mechanisms
about
occurrence
development
CVDs.
Several
studies
also
demonstrated
many
traditional
latest
therapeutic
treatments
are
associated
its
generated
pathways.
Given
information,
we
summarized
advances
in
current
research
regarding
effect
on
main
CVDs,
highlighted
roles
several
introduced
promising
microbiota.
this
review
mainly
focuses
exploring
role
potential
which
eventually
provide
better
solutions
well
prevention
Journal of sport and health science/Journal of Sport and Health Science,
Journal Year:
2022,
Volume and Issue:
12(1), P. 36 - 44
Published: Sept. 9, 2022
The
gut
microbiota
refers
to
the
collection
of
trillions
intestinal
microorganisms
that
modulate
central
aspects
health
and
disease
through
influential
effects
on
host
physiology.
Recently,
a
connection
has
been
made
between
exercise.
Initial
investigations
demonstrated
beneficial
exercise
microbiota,
with
cross-sectional
studies
revealing
positive
correlations
exercise-associated
states,
healthy
interventions
showed
post-intervention
increases
in
abundance
bacterial
taxa.
More
recent
have
focused
exploring
reverse
relationship:
influence
performance.
Murine
revealed
certain
taxa
may
enhance
endurance
performance
by
augmenting
various
lactate
metabolism.
Further,
short-chain
fatty
acids-which
metabolism
at
organ
sites,
including
within
skeletal
muscle-have
shown
capacity
mice.
This
review
highlights
what
is
currently
known
about
exercise,
particular
focus
ergogenic
potential
how
it
be
leveraged
Microorganisms,
Journal Year:
2022,
Volume and Issue:
11(1), P. 104 - 104
Published: Dec. 31, 2022
The
food
market
is
one
of
the
most
innovative
segments
world
economy.
Recently,
among
consumers
there
a
forming
trend
healthier
lifestyle
and
interest
in
functional
foods.
Products
with
positive
health
properties
are
good
source
nutrients
for
consumers'
nutritional
needs
reduce
risk
metabolic
diseases
such
as
diabetes,
atherosclerosis,
or
obesity.
They
also
seem
to
boost
immune
system.
One
types
"probiotic
products",
which
contain
viable
microorganisms
beneficial
properties.
However,
due
some
technical
difficulties
their
development
marketing,
new
alternative
has
started
be
sought.
Many
scientific
studies
point
possibility
effects
on
human
health,
so-called
"postbiotics",
characteristic
metabolites
microbiome.
Both
immunobiotics
post-immunobiotics
components
that
affect
response
two
ways:
inhibition
(suppressing
allergies
inflammation)
an
enhancement
(providing
host
defenses
against
infection).
This
work's
aim
was
conduct
literature
review
possibilities
using
probiotics
postbiotics
affecting
response,
emphasis
recently
published
works.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(14), P. 2244 - 2244
Published: July 12, 2024
Aging
is
the
most
prominent
risk
factor
for
neurodegeneration
occurrence.
The
common
neurodegenerative
diseases
(NDs),
Alzheimer’s
(AD)
and
Parkinson’s
(PD)
diseases,
are
characterized
by
incidence
of
proteinopathy,
abnormal
activation
glial
cells,
oxidative
stress,
neuroinflammation,
impaired
autophagy
cellular
senescence
excessive
patient’s
age.
Moreover,
mitochondrial
disfunction,
epigenetic
alterations
neurogenesis
inhibition,
together
with
increased
blood–brain
barrier
permeability
gut
dysbiosis,
have
been
linked
to
ND
pathogenesis.
Since
NDs
still
lack
curative
treatment,
recent
research
has
sought
therapeutic
options
in
restoring
microbiota
supplementing
probiotic
bacteria-derived
metabolites
beneficial
action
host—so
called
postbiotics.
current
review
focuses
on
literature
explaining
mechanisms
involved
pathogenesis
addressing
impact
that
postbiotics
as
a
whole
mixture
particular
metabolites,
such
short-chain
fatty
acids
(SCFAs),
lactate,
polyamines,
polyphenols,
tryptophan
exopolysaccharides
bacterial
extracellular
vesicles,
ageing-associated
processes
underlying
also
discusses
issue
implementing
into
prophylaxis
therapy,
depicting
them
compounds
senescence-triggered
dysfunctions
worth
translating
from
bench
pharmaceutical
market
response
“silver
consumers”
demands.
Journal of Food Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
Abstract
Sleep
disturbances
are
increasingly
prevalent,
significantly
impacting
physical
and
mental
health.
Recent
research
reveals
a
bidirectional
relationship
between
gut
microbiota
sleep,
mediated
through
the
microbiota–gut–brain
axis.
This
review
examines
role
of
in
sleep
physiology
explores
how
biotics,
including
probiotics,
prebiotics,
synbiotics,
postbiotics,
fermented
foods,
can
enhance
quality.
Drawing
from
animal
human
studies,
we
discuss
neurobiological
mechanisms
by
which
biotics
may
influence
modulation
neurotransmitters,
immune
responses,
hormonal
regulation.
Key
microbial
metabolites,
such
as
short‐chain
fatty
acids,
highlighted
for
their
supporting
sleep‐related
neurochemical
processes.
Additionally,
this
presents
dietary
strategies
food
processing
technologies,
like
fermentation,
innovative
approaches
enhancement.
Although
promising,
available
has
limitations,
small
sample
sizes,
variability
biotic
strains
dosages,
reliance
on
subjective
assessments.
underscores
need
standardized
protocols,
objective
assessments
polysomnography,
personalized
interventions.
Emerging
findings
highlight
therapeutic
potential
improvement,
though
further
large‐scale
trials
essential
to
refine
strain
selection,
dosage,
formulation.
interdisciplinary
exploration
seeks
advance
food‐based
interventions
holistic
managing
disorders
improving
quality
life.
