Covert cerebrospinal fluid dynamics dysfunction: evolution from conventional to innovative therapies DOI Creative Commons
Yi Xu, Hua Yin, Lingge Li

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 12, 2025

Cerebrospinal fluid (CSF) dynamics disorders are intricately linked to diverse neurological pathologies, though they usually mild and covert. Contemporary insights into glymphatic system function, particularly the CSF transport, drainage, its role in clearing metabolic waste toxic substances both normal pathological states, pivotal of aquaporin-4 (AQP4) CSF-interstitial (ISF) exchange, have established novel theoretical frameworks subclinical dysfunction, promoted development non-surgical therapeutic approaches for them simultaneously. This review comprehensively analyzes advancement interventions disorders, emphasizing transition from methodologies innovative approaches. Current treatment strategies primarily encompass three directions: pharmacological therapy, physical biological regulation therapy. In terms interventions, developments traditional diuretics small-molecule drugs show promising potential. techniques such as lower body negative pressure, transcranial magnetic stimulation, vagus nerve stimulation provided new options clinical practice. Meanwhile, exemplified by recombinant VEGF-C administration, has paradigms. These demonstrated potential improving enhancing elimination. Future research should focus on developing individualized protocols, elucidating mechanisms, assessing longitudinal outcomes. will facilitate more precise exploration optimized multimodal combinations handling so-called convert dysfunction.

Language: Английский

Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice DOI Creative Commons
Miao Wang, Congcong Yan, Xi Li

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 16, 2024

Abstract Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD). In this study, based on the superficial spatial distribution of mLVs, near-infrared light employed modulate drainage, significantly improving cognition both aged and AD (5xFAD APP/PS1) mice, alleviating AD-associated pathology by reducing Aβ deposition, neuroinflammation neuronal damage. Furthermore, transmission electron microscopy imaging RNA sequencing data indicate amelioration mitochondrial metabolism cellular junction meningeal endothelial cells (mLECs) modulation. These studies collectively suggest that treatment can improve cognitive function strengthening scavenging ability mLVs through restoring mLEC function. conclusion, drainage potentiation promotes pathological remission enhancement aging mouse models, offers strategy neurodegenerative diseases.

Language: Английский

Citations

28
The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ahsas Goyal

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 394, P. 111002 - 111002

Published: April 9, 2024

Lung inflammatory disorders are a major global health burden, impacting millions of people and raising rates morbidity death across many demographic groups. An industrial chemical common environmental contaminant, formaldehyde (FA) presents serious concerns to the respiratory system, including onset aggravation lung disorders. Epidemiological studies have shown significant associations between FA exposure levels incidence severity several diseases. causes inflammation in tract via immunological activation, oxidative stress, airway remodelling, aggravating pre-existing pulmonary compromising function. Additionally, functions as sensitizer, causing allergic responses hypersensitivity pneumonitis sensitive people. Understanding complicated processes behind formaldehyde-induced is critical for directing targeted strategies aimed at minimizing exposures alleviating burden formaldehyde-related illnesses on health. This abstract explores intricate relationship diseases, asthma, bronchitis, inflammation, injury fibrosis.

Language: Английский

Citations

26
Therapeutic non-invasive brain treatments in Alzheimer’s disease: recent advances and challenges DOI Creative Commons

Chongyun Wu,

Luoman Yang,

Shu Feng

et al.

Inflammation and Regeneration, Journal Year: 2022, Volume and Issue: 42(1)

Published: Oct. 3, 2022

Abstract Alzheimer’s disease (AD) is one of the major neurodegenerative diseases and most common form dementia. Characterized by loss learning, memory, problem-solving, language, other thinking abilities, AD exerts a detrimental effect on both patients’ families’ quality life. Although there have been significant advances in understanding mechanism underlying pathogenesis progression AD, no cure for AD. The failure numerous molecular targeted pharmacologic clinical trials leads to an emerging research shift toward non-invasive therapies, especially multiple treatments. In this paper, we reviewed widely studied including photobiomodulation (PBM), transcranial magnetic stimulation (TMS), direct current (tDCS), exercise therapy. Firstly, pathological changes challenges studies. We then introduced these therapies discussed factors that may affect effects therapies. Additionally, review possible mechanisms effects. Finally, summarized treatments future studies applications. concluded it would be critical understand exact find optimal treatment parameters improve translational value Moreover, combined use also promising direction sheds light or prevention

Language: Английский

Citations

48
Photophysical Mechanisms of Photobiomodulation Therapy as Precision Medicine DOI Creative Commons
Ann Liebert, William Capon, Junxiong Pang

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 237 - 237

Published: Jan. 17, 2023

Despite a significant focus on the photochemical and photoelectrical mechanisms underlying photobiomodulation (PBM), its complex functions are yet to be fully elucidated. To date, there has been limited attention photophysical aspects of PBM. One effect relates non-visual phototransduction pathway, which involves mechanotransduction modulation cytoskeletal structures, biophotonic signaling, micro-oscillatory cellular interactions. Herein, we propose number PBM that do not depend cytochrome c oxidase. These include interactions with biophotons mechanotransductive processes. hypotheses contingent light ion channels cytoskeleton, production biophotons, properties biological molecules. Specifically, processes review supported by resonant recognition model (RRM). This previous research demonstrated protein micro-oscillations act as signature their function can activated wavelengths light. We extend this work exploring local oscillatory proteins because they may affect global body circuits could explain observed neuro-cortical electroencephalogram (EEG) oscillations. In particular, since dysrhythmic gamma oscillations associated neurodegenerative diseases pain syndromes, including migraine aura fibromyalgia, suggest transcranial should target where patients affected impaired neural aberrant brain wave patterns. also highlights examples disorders potentially treatable precise mimicking activity in other tissues, such liver, with, for example, Crigler-Najjar syndrome conditions involving dysregulation cytoskeleton. novel therapeutic modality thus behave “precision medicine” treatment various neurological morbidities. The perspectives presented herein offer new understanding effects PBM, is important when considering relevance therapy (PBMt) clinical applications, optimization health outcomes performance.

Language: Английский

Citations

39
Glymphatic function plays a protective role in ageing-related cognitive decline DOI Creative Commons
Junjun Wang, Ying Zhou,

Kemeng Zhang

et al.

Age and Ageing, Journal Year: 2023, Volume and Issue: 52(7)

Published: June 15, 2023

The glymphatic pathway, characterised as a cerebral drainage system, influences cognitive function in neurodegenerative diseases; however, evidence is limited normal ageing population. aim of this study was to investigate the effect on ageing-related decline.

Language: Английский

Citations

27
Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases DOI Open Access

Oxana Semyachkina-Glushkovskaya,

Ivan V. Fedosov, Thomas Penzel

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3221 - 3221

Published: Feb. 6, 2023

Emerging evidence suggests that an important function of the sleeping brain is removal wastes and toxins from central nervous system (CNS) due to activation waste (BWRS). The meningeal lymphatic vessels (MLVs) are part BWRS. A decrease in MLV associated with Alzheimer’s Parkinson’s diseases, intracranial hemorrhages, tumors trauma. Since BWRS activated during sleep, a new idea now being actively discussed scientific community: night stimulation might be innovative promising strategy for neurorehabilitation medicine. This review highlights trends photobiomodulation BWRS/MLVs deep sleep as breakthrough technology effective unnecessary compounds order increase neuroprotection CNS well prevent or delay various diseases.

Language: Английский

Citations

23
The glymphatic system and Amyotrophic lateral sclerosis DOI
Andrew Eisen, Maiken Nedergaard,

E. G. Gray

et al.

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 234, P. 102571 - 102571

Published: Jan. 22, 2024

Language: Английский

Citations

9
Non-pharmacological treatment of Alzheimer’s disease: an update DOI Creative Commons
Shaofen Wang, Haochen Xu, Guangdong Liu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Feb. 13, 2025

Alzheimer’s disease (AD) is a neurodegenerative disorder that significantly impairs memory, cognitive function, and the ability to perform daily tasks. The pathological features of AD include β-amyloid plaques, neurofibrillary tangles, neuronal loss. Current treatments target changes but often fail noticeably slow progression can cause severe complications, limiting their effectiveness. In addition therapies targeting core pathology AD, more comprehensive approach may be needed for its treatment. recent years, non-pharmacological such as physical therapy, exercise cell nanoparticles have shown great potential in mitigating alleviating clinical symptoms. This article reviews advances treatment approaches highlighting contributions management facilitating exploration novel therapeutic strategies.

Language: Английский

Citations

1
The effect of photobiomodulation on the brain during wakefulness and sleep DOI Creative Commons

Cécile Moro,

Audrey Valverde, Marjorie Dole

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: July 28, 2022

Over the last seventy years or so, many previous studies have shown that photobiomodulation, use of red to near infrared light on body tissues, can improve central and peripheral neuronal function survival in both health disease. These improvements are thought arise principally from an impact photobiomodulation mitochondrial non-mitochondrial mechanisms a range different cell types, including neurones. This has downstream effects stimulatory protective genes. An often-neglected feature nearly all these is they been induced during state wakefulness. Recent when applied sleep, also be benefit, but way, by improving flow cerebrospinal fluid clearance toxic waste-products brain. In this review, we consider potential differential dependent arousal. We speculate cells systems depending whether it wakefulness may follow circadian rhythm. further arousal-dependent mediated through biophoton – ultra-weak emission network communication repair across

Language: Английский

Citations

35
Research Evidence of the Role of the Glymphatic System and Its Potential Pharmacological Modulation in Neurodegenerative Diseases DOI Open Access
Joji Philip Verghese,

Alana Terry,

Edoardo Rosario de Natale

et al.

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(23), P. 6964 - 6964

Published: Nov. 25, 2022

The glymphatic system is a unique pathway that utilises end-feet Aquaporin 4 (AQP4) channels within perivascular astrocytes, which believed to cause cerebrospinal fluid (CSF) inflow into space (PVS), providing nutrients and waste disposal of the brain parenchyma. It theorised bulk flow CSF PVS removes products, soluble proteins, products metabolic activity, such as amyloid-β (Aβ). In experimental model, selectively active during slow-wave sleep, its activity affected by both sleep dysfunction deprivation. Dysfunction has been proposed potential key driver neurodegeneration. This hypothesis indirectly supported close relationship between neurodegenerative diseases alterations, frequently occurring years before clinical diagnosis. Therefore, detailed characterisation function in human physiology disease would shed light on early stage pathophysiology. study also critical identifying means for pharmacological modulation, may have modification. review will critically outline primary evidence from literature about neurodegeneration discuss rationale current knowledge modulation animal model applications trials.

Language: Английский

Citations

32