IMPACTO DA ASSOCIAÇÃO ENTRE VITAMINA D E DENSIDADE MAMÁRIA NA REDUÇÃO DO RISCO DE CÂNCER DE MAMA DOI Creative Commons
Maria Stefania Nóbrega Batista, Lara Moreira Mendes Carneiro

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, Journal Year: 2022, Volume and Issue: 3(11), P. e3112155 - e3112155

Published: Nov. 7, 2022

Considerando o aumento do número de casos câncer, em especial câncer mama, fica evidente a necessidade identificar fatores risco modificáveis da doença. Estudos relataram uma associação inversa entre status vitamina D e mama através redução densidade mamográfica, um conhecido fator câncer. O objetivo deste trabalho é definir se há mamográfica esta pode reduzir mama. Foi realizada revisão integrativa literatura, com os descritores Ciências Saúde “Vitamin D” AND “Mammographic Density” nas seguintes bibliotecas virtuais: MEDLINE, PUBMED, LILACS SCIELO. Os estudos que avaliaram relação têm achados heterogêneos; uns mostram pacientes níveis séricos normais D, outros, não. Contudo, dosagem insuficiente não deve ser desconsiderada, especialmente devido seu efeito comprovadamente importante na formação óssea homeostase cálcio.

Nuclear Receptors: Mechanistic Insights into Endocrine Resistance in Prostate and Breast Cancers DOI Creative Commons
Macrina B. Silva-Cázares,

Stephanie I. Núñez-Olvera,

Ricardo Hernández-Barrientos

et al.

Receptors, Journal Year: 2024, Volume and Issue: 3(4), P. 444 - 456

Published: Oct. 14, 2024

This review focuses on the pivotal roles of nuclear receptors (NRs) in driving endocrine resistance prostate and breast cancers. In cancer (PCa), androgen receptor (AR) amplification, mutations, altered coactivator interactions sustain tumor growth under deprivation therapy (ADT), leading to castration-resistant (CRPC). Orphan NRs like RORβ, TLX, COUP-TFII further contribute CRPC by regulating stemness therapeutic mechanisms. cancer, NRs, including estrogen alpha (ERα), (AR), glucocorticoid (GR), liver homolog-1 (LRH-1), modulate signaling pathways alternative survival mechanisms PI3K/AKT/mTOR NFκB, promoting therapies such as tamoxifen. Understanding these NR-mediated is critical for developing targeted overcome improve patient outcomes hormone-dependent

Language: Английский

Citations

1
Vitamin D and microRNAs: Role in the pathogenesis and prognosis of breast cancer (Review) DOI Creative Commons
Luca Falzone, Giuseppe Gattuso, Saverio Candido

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 3(1)

Published: Sept. 19, 2023

A growing body of evidence has demonstrated how the development breast cancer (BC) is associated with several environmental risk factors able to induce both genetic and epigenetic modifications, leading neoplastic transformation. In this context, it been shown dietary influence BC cell progression by modulating biomarkers, which microRNAs (miRNAs/miRs) are one most extensively studied. Of note, have implicated in protection; a number studies focused on protective role vitamin D (VitD) BC, as well its potential therapeutic application patients undergoing treatments. Despite numerous available literature, conflicting data reported about modifications induced VitD expression levels miRNAs involved BC. Therefore, present review reports latest findings describing existing interplay between discusses epigenetics pathogenesis prognosis tumor. Specifically, dual association described, presenting demonstrating receptor (VDR) modulation miRNAs, some directly bind mRNA coding for VDR, thus regulating activation pathway.

Language: Английский

Citations

3
Calcitriol suppresses gastric cancer progression and cisplatin resistance by inhibiting glycolysis and M2 macrophage polarization through inhibition of mTOR activation DOI

Li Jie,

Wang Hengyue,

Han Ting

et al.

Environmental Toxicology, Journal Year: 2023, Volume and Issue: 39(2), P. 830 - 839

Published: Oct. 4, 2023

Abstract The tumor microenvironment (TME) plays a critical role in progression, with macrophages and cells interacting within the TME, influencing cancer development. Despite known anticancer properties of calcitriol, its TME remains uncertain. This study aimed to explore effects calcitriol on impact gastric cell proliferation cisplatin resistance. In vitro models were established using conditioned medium from (CCM) (MCM) treated or without calcitriol. results revealed that treatment suppressed expression glycolysis‐related genes proteins (GLUT1, HKII, LDHA) MCM‐induced cells, leading increased apoptosis reduced viability, along decreased Cyclin D1 gene expression. Moreover, inhibited mTOR activation cells. Additionally, hindered CCM‐induced M2 macrophage polarization by reducing CD206 increasing TNFα THP1‐derived macrophages, attenuating These findings suggest may impede progression targeting glycolysis through regulation TME.

Language: Английский

Citations

3
RNA Regulatory Networks 2.0 DOI Open Access
Francisco J. Enguita, Ana Lúcia Leitão, John S. Mattick

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 9001 - 9001

Published: May 19, 2023

The central role of RNA molecules in cell biology has been an expanding subject study since the proposal “RNA world” hypothesis 60 years ago [...]

Language: Английский

Citations

2
The emerging roles of LINC00511 in breast cancer development and therapy DOI Creative Commons
Lifeng Zhao, S. Biswas, Yepeng Li

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 14, 2024

Breast cancer (BC) is associated with malignant tumors in women worldwide persistently high incidence and mortality rates. The traditional therapies including surgery, chemotherapy, radiotherapy targeted therapy have certain therapeutic effects on BC patients, but acquired drug resistance can lead to tumor recurrence metastasis. This remains a clinical challenge that difficult solve during treatment. Therefore, continued research needed identify effective targets treatment methods, ultimately implement personalized strategies. Several studies implicated the long non-coding RNA LINC00511 closely linked occurrence, development of BC. Here we will review structure mechanisms action lnc various cancers, then explore its expression related regulatory In addition, discuss biological functions potential applications

Language: Английский

Citations

0
Vitamin D supplementation improves the prognosis of patients with colorectal cancer liver metastases DOI Open Access
Miran Rada,

Lucyna Krzywoń,

Audrey Kapelanski-Lamoureux

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 5, 2022

Abstract Colorectal cancer liver metastasis (CRCLM) is one of the deadliest cancers. CRCLM tumours have two distinct histopathological growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement (RHGP). The DHGP are angiogenic, while their RHGP counterparts vessel co-opting. patients with a better response to anti-angiogenic agents chemotherapy, as well prognosis. To determine influence vitamin D supplementation in CRCLM, we analyzed HGPs 5-year OS (n=106). Interestingly, found an inverse correlation between presence patients. Additionally, that administered was significantly higher. cells lesions characterized by direct contact hepatocytes, this phenomenon enhances motility facilitates infiltration through parenchyma co-opt pre-existing vessels. Significantly, our vitro data demonstrated downregulation markers co-cultured hepatocytes upon exposure D. Altogether, study highlights role provides rationale investigate contribution prognosis

Language: Английский

Citations

2
IMPACTO DA ASSOCIAÇÃO ENTRE VITAMINA D E DENSIDADE MAMÁRIA NA REDUÇÃO DO RISCO DE CÂNCER DE MAMA DOI Creative Commons
Maria Stefania Nóbrega Batista, Lara Moreira Mendes Carneiro

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, Journal Year: 2022, Volume and Issue: 3(11), P. e3112155 - e3112155

Published: Nov. 7, 2022

Considerando o aumento do número de casos câncer, em especial câncer mama, fica evidente a necessidade identificar fatores risco modificáveis da doença. Estudos relataram uma associação inversa entre status vitamina D e mama através redução densidade mamográfica, um conhecido fator câncer. O objetivo deste trabalho é definir se há mamográfica esta pode reduzir mama. Foi realizada revisão integrativa literatura, com os descritores Ciências Saúde “Vitamin D” AND “Mammographic Density” nas seguintes bibliotecas virtuais: MEDLINE, PUBMED, LILACS SCIELO. Os estudos que avaliaram relação têm achados heterogêneos; uns mostram pacientes níveis séricos normais D, outros, não. Contudo, dosagem insuficiente não deve ser desconsiderada, especialmente devido seu efeito comprovadamente importante na formação óssea homeostase cálcio.

Citations

0