Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action

Chinese Medicine, Journal Year: 2023, Volume and Issue: 18(1)

Published: Feb. 13, 2023

Colorectal cancer (CRC) is a disease with complex pathogenesis, it prone to metastasis, and its development involves abnormalities in multiple signaling pathways. Surgery, chemotherapy, radiotherapy, target therapy, immunotherapy remain the main treatments for CRC, but improvement overall survival rate quality of life urgently needed. Traditional Chinese medicine (TCM) has long history preventing treating CRC. It could affect CRC cell proliferation, apoptosis, cycle, migration, invasion, autophagy, epithelial-mesenchymal transition, angiogenesis, chemoresistance by regulating pathways, such as PI3K/Akt, NF-κB, MAPK, Wnt/β-catenin, epidermal growth factor receptors, p53, TGF-β, mTOR, Hedgehog, immunomodulatory In this paper, pathways potential targets TCM active ingredients treatment were systematically summarized, providing theoretical basis new ideas further exploring pathogenesis developing anti-CRC drugs.

Language: Английский

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PIWI-interacting RNA-YBX1 inhibits proliferation and metastasis by the MAPK signaling pathway via YBX1 in triple-negative breast cancer

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 5, 2024

Abstract Breast cancer is the second leading cause of death in women worldwide, with triple-negative breast (TNBC) having worst prognosis. Although there are numerous studies on TNBC, no effective treatment for it, and it still a major problem today. Studies PIWI-interacting RNAs (piRNAs) increasing investigating mechanism piRNAs proliferation metastasis TNBC may lead to new potential targets. Here, we identified novel piRNA, piR-YBX1, which was downregulated compared matched normal tissue. Overexpression piR-YBX1 significantly inhibited proliferation, migration, invasion ability cells both vivo vitro. Mechanistically, could bind directly mRNA Y-box binding protein 1 ( YBX1 ) overexpression levels, while function be partly rescued by YBX1. In addition, RAF1 key molecule MAPK signaling pathway, p-MEK p-ERK1/2, can reverted conclusion, our findings discovered that piR-YBX1/YBX1/MAPK axis suppresses therefore has an therapeutic agent cancer.

Language: Английский

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Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 511 - 511

Published: March 29, 2025

Oxidative stress (OS) is an established hallmark of cancer and neurodegenerative disorders (NDDs), which contributes to genomic instability neuronal loss. This review explores the contrasting role OS in stem cells (CSCs) NDDs. Elevated levels reactive oxygen species (ROS) contribute promote tumor initiation progression CSCs, while NDDs such as Alzheimer’s Parkinson’s disease, accelerates death impairs cellular repair mechanisms. Both scenarios involve disruption delicate balance between pro-oxidant antioxidant systems, leads chronic oxidative stress. Notably, CSCs neurons display alterations redox-sensitive signaling pathways, including Nrf2 NF-κB, influence cell survival, proliferation, differentiation. Mitochondrial dynamics further illustrate these differences: enhanced function supports adaptability whereas impairments heighten vulnerability. Understanding common mechanisms OS-induced redox imbalance may provide insights for developing interventions, addressing aging hallmarks, potentially mitigating or preventing both

Language: Английский

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Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence

Military Medical Research, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 11, 2025

Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.

Language: Английский

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Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 957, P. 175991 - 175991

Published: Aug. 23, 2023

Language: Английский

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The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 214, P. 219 - 235

Published: Feb. 15, 2024

Language: Английский

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Exploring the Key Signaling Pathways and ncRNAs in Colorectal Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4548 - 4548

Published: April 21, 2024

Colorectal cancer (CRC) is the third most prevalent to be diagnosed, and it has a substantial mortality rate. Despite numerous studies being conducted on CRC, remains significant health concern. The disease-free survival rates notably decrease as CRC progresses, emphasizing urgency for effective diagnostic therapeutic approaches. development caused by environmental factors, which mostly lead disruption of signaling pathways. Among these pathways, Wingless/Integrated (Wnt) pathway, Phosphatidylinositol 3-kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) Mitogen-Activated Protein Kinase (MAPK) Transforming Growth Factor-β (TGF-β) p53 pathway are considered important. These pathways also regulated non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs). They have emerged crucial regulators gene expression in changing their levels. altered patterns ncRNAs been implicated progression development, suggesting potential targets. This review provides an overview five key regulation involved pathogenesis that studied identify promising avenues diagnosis treatment strategies.

Language: Английский

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Prospects of compounds of herbal plants as anticancer agents: a comprehensive review from molecular pathways

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 22, 2024

Cancer refers to the proliferation and multiplication of aberrant cells inside human body, characterized by their capacity proliferate infiltrate various anatomical regions. Numerous biochemical pathways signaling molecules have an impact on cancer auto biogenesis process. The regulation crucial cellular processes necessary for cell survival proliferation, which are triggered phytochemicals, is significantly influenced pathways. These or components regulated phytochemicals. Medicinal plants a significant reservoir diverse anticancer medications employed in chemotherapy. effects phytochemicals mediated several methods, including induction apoptosis, cessation cycle, inhibition kinases, prevention carcinogenic substances. This paper analyzes phytochemistry seven prominent plant constituents, namely, alkaloids, tannins, flavonoids, phenols, steroids, terpenoids, saponins, focusing involvement MAPK/ERK pathway, TNF signaling, death receptors, p53, p38, actin dynamics. Hence, this review has examined range encompassing structural characteristics potential mechanisms. It underscored significance plant-derived bioactive compounds cancer, utilizing molecular In addition, endeavor also seeks incentivize scientists carry out clinical trials derived from plants.

Language: Английский

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Pyrimidine scaffold dual‐target kinase inhibitors for cancer diseases: A review on design strategies, synthetic approaches, and structure–activity relationship (2018‒2023)

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(1)

Published: Jan. 1, 2025

Abstract Cancer, the second leading cause of death globally, causes a significant threat to life. Despite advancements in treatment cancer, persistent challenges include severe side effects and emergence acquired drug resistance. Additionally, many traditional chemotherapy drugs show restricted efficacy high toxicity, primarily attributed their lack selectivity. Thus, development targeting protein kinases has emerged as noteworthy priority for addressing human cancers. Medicinal chemists have shown considerable interest dual candidates strategy create medicines that are safer, more efficient, cost‐effective. Furthermore, Food Drug Administration (FDA) approved several dual‐target anticancer treatment, emphasizing lower risks interactions improved pharmacokinetics safety profiles. This review focuses on synthetic efforts, design strategies, structure–activity relationship pyrimidine scaffold‐based kinase inhibitors developed with potential within recent 6 years (2018‒2023). Collectively, these strategies expected offer fresh perspectives future directions pyrimidine‐based design, potentially advancing cancer therapeutics.

Language: Английский

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PD-1/PD-L1 and DNA Damage Response in Cancer

Cells, Journal Year: 2023, Volume and Issue: 12(4), P. 530 - 530

Published: Feb. 7, 2023

The application of immunotherapy for cancer treatment is rapidly becoming more widespread. Immunotherapeutic agents are frequently combined with various types treatments to obtain a durable antitumor clinical response in patients who have developed resistance monotherapy. Chemotherapeutic drugs that induce DNA damage and trigger (DDR) an increase the expression programmed death ligand-1 (PD-L1) can be employed by cells avoid immune surveillance. PD-L1 exposed on turn targeted re-establish immune-reactive tumor microenvironment, which ultimately increases tumor’s susceptibility therapies. Here we review recent advances how DDR regulates point out effect etoposide, irinotecan, platinum compounds anti-tumor response.

Language: Английский

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