Antioxidant activity of the main phenolics found in red fruits: An in vitro and in silico study

Food Chemistry, Journal Year: 2024, Volume and Issue: 452, P. 139459 - 139459

Published: April 24, 2024

Language: Английский

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Bioaccessibility and Antioxidant Capacity of Grape Seed and Grape Skin Phenolic Compounds After Simulated In Vitro Gastrointestinal Digestion

Plant Foods for Human Nutrition, Journal Year: 2024, Volume and Issue: 79(2), P. 432 - 439

Published: March 19, 2024

Abstract Grapes present recognized beneficial effects on human health due to their polyphenolic composition. The grape overproduction together with the wine sales down and world socioeconomic situation makes valorization a promising strategy give an added-value this natural product. objective of work was study influence in vitro gastrointestinal digestion antioxidant capacity profile skin seed extracts different varieties (Tempranillo, Graciano, Maturana tinta Hondarrabi zuri). After digestion, total phenolic content (TPC) decreased significantly for all varieties. highest decrease Tempranillo going from 108 ± 9 50 3 mg / g dry matter (dm). This variety also showed 90% capacity. However, there increase TPC. variation Tempranillo. It varied 10.1 0.8 55.1 0.9 dm. Among red extract lowest undigested anthocyanin but bioaccessibility index (BI) 77%. For flavanols, flavonols procyanidins BI at intestinal phase between 11% (+)-epicatechin gallate 130% procyanidin A2. results suggest that are reliable source bioaccessible polyphenols, be used development supplements specific functionalities depending variety.

Language: Английский

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Anti-fatigue effect of Lateolabrax japonicus peptides in mice and the underlying action mechanism via in vitro and in vivo assays

Food Bioscience, Journal Year: 2024, Volume and Issue: 58, P. 103763 - 103763

Published: Feb. 16, 2024

Language: Английский

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Effects of dietary supplements on athletic performance in elite soccer players: a systematic review

Journal of the International Society of Sports Nutrition, Journal Year: 2023, Volume and Issue: 20(1)

Published: July 18, 2023

Dietary supplements are widely used among athletes, and soccer players no exception. Nevertheless, evidence supporting the use of dietary aiming to enhance performance in is somewhat contradictory, scarce, or even nonexistent. Thus, present study aimed systematically review synthesize effects on athletic (e.g. distance covered, sprinting, jump performance) elite players. Studies enrolling highly trained, elite, world-class using were searched MEDLINE/PubMed, Web Science, Scopus, EBSCO databases June 2022. In total, 1043 studies identified, 18 met eligibility criteria. The evaluated impacts several supplements, including caffeine, creatine, protein, beverages with carbohydrates electrolytes, tart cherry juice, nitrate-rich beetroot sodium bicarbonate minerals, yohimbine, a proprietary nutraceutical blend. Caffeine supplementation doses between 3 6 mg/kg body mass may improve height sprint ability, particularly female players, but individual response caffeine must be considered. Creatine sprint, agility, performance. Protein can matches, especially if protein ingested from food not up recommendations. Beverages containing electrolytes as part strategies achieve carbohydrate intake during training match-days alone do benefit Tart juice might useful for maintaining after matches that produce higher force loss exercise-induced muscle damage, although polyphenols diet attenuate supplementation. Nitrate-rich concentrate decrease days following matches. Further investigation necessary, protocols included other substances. Finally, available data does support yohimbine Resurgex Plus® Still, more well-designed research needed advice regarding enhancement.

Language: Английский

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The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise: A Review

Foods, Journal Year: 2023, Volume and Issue: 12(5), P. 916 - 916

Published: Feb. 21, 2023

Food bioactive compounds (FBC) comprise a vast class of substances, including polyphenols, with different chemical structures, and they exert physiological effects on individuals who consume them, such as antioxidant anti-inflammatory action. The primary food sources the are fruits, vegetables, wines, teas, seasonings, spices, there still no daily recommendations for their intake. Depending intensity volume, physical exercise can stimulate oxidative stress muscle inflammation to generate recovery. However, little is known about role that polyphenols may have in process injury, inflammation, regeneration. This review aimed relate supplementation mentation some post-exercise inflammatory markers. consulted papers suggest 74 900 mg cocoa, 250 1000 green tea extract around 4 weeks, 90 up 5 days curcumin attenuate cell damage markers during after exercise. regarding anthocyanins, quercetins, resveratrol, results conflicting. Based these findings, new reflection was made possible impact associating several FBCs simultaneously. Finally, benefits discussed here do not consider existing divergences literature. Some contradictions inherent few studies carried out so far. Methodological limitations, time, doses used, forms supplementation, protocols, collection times, create barriers knowledge consolidation must be overcome.

Language: Английский

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The Role of Dietary Phenolic Compounds in the Prevention and Treatment of Rheumatoid Arthritis: Current Reports

Published: April 8, 2024

Rheumatoid arthritis (RA) is a complex illness with both hereditary and environmental compo-nents. Globally, in 2019, 18 million people had RA. RA characterised by persistent inflammation of the synovial membrane that lines joints, cartilage loss, bone erosion. Phenolic molecules are most prevalent secondary metabolites plants, diverse spectrum biological ac-tions benefit functional meals nutraceuticals. These compounds have received lot at-tention recently because they antioxidant, anti-inflammatory, immunomodulatory, anti-rheumatoid activity modulating tumour necrosis factor, mitogen-activated protein kinase, nu-clear factor kappa-light-chain-enhancer activated B cells, c-Jun N-terminal kinases, as well other preventative properties. This article discusses dietary polyphenols, their pharmacological properties, innovative delivery technologies for treatment RA, focus on possible activities. Nonetheless, commercialization polyphenols may be achievable only after confirming safety profile completing successful clinical trials.

Language: Английский

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The state of the science on the health benefits of blueberries: a perspective

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 11, 2024

Mounting evidence indicates that blueberry consumption is associated with a variety of health benefits. It has been suggested regular blueberries can support and/or protect against cardiovascular disease and function, pre-diabetes type 2 diabetes, brain cognitive function in individuals conditions age-related decline. Further, mechanistic investigations highlight the role anthocyanins mediating these benefits, part through interactions gut microbiota. Also, nutritional interventions have demonstrated ability to improve recovery following exercise-induced muscle damage, attributable anti-inflammatory effects. Despite advancements research, research gaps persist which affects generalizability findings from clinical trials. To evaluate current state knowledge gaps, roundtable scientific experts convened Washington, DC (December 6–7, 2022). Discussions centered around five domains: health, exercise recovery. This article synthesizes outcomes discussion among researchers domains, offering insights into benefits delineating future directions.

Language: Английский

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Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(7), P. 1487 - 1487

Published: July 18, 2022

Efforts in discovering new and effective neurotherapeutics are made daily, although most fail to reach clinical trials. The main reason is their poor bioavailability, related aqueous solubility, limited permeability through biological membranes, the hepatic first-pass metabolism. Nevertheless, crossing blood–brain barrier major drawback associated with brain drug delivery. To overcome it, intranasal administration has become more attractive, some cases even surpassing oral route. unique anatomical features of nasal cavity allow partial direct delivery brain, circumventing barrier. Systemic absorption also avoids metabolism, increasing systemic bioavailability highly metabolized entities. present physicochemical characteristics that require them be formulated lipidic nanosystems as self-emulsifying systems (SEDDS). These isotropic mixtures oils, surfactants, co-surfactants that, after dilution, generate micro or nanoemulsions loading high concentrations lipophilic drugs. SEDDS should precipitation sites, increase permeation absorptive enhance stability labile drugs against enzymatic activity. Thus, combining advantages those route for delivery, an drugs’ targeting could expected. This review deeply characterizes a nanosystem, gathering important information regarding mechanisms loaded SEDDS. In end, vivo results discussed, globally revealing efficacy comparison common solutions suspensions.

Language: Английский

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Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 24, 2023

This study determined if 18 days of supplementation with blueberries (BL) compared to placebo (PL) could mitigate muscle soreness and damage improve inflammation resolution in untrained adults (n = 49, ages 18-50 years) after engaging a 90-min bout "weekend warrior" eccentric exercise. The BL freeze dried supplement provided 1 cup fresh per day equivalent 805 mg/day total phenolics 280 anthocyanins. Urine levels eight gut-derived increased 14- 18-days 83% higher concentrations vs. PL (p < 0.001). exercise caused significant during 4d recovery decrease performance no differences between BL. Plasma oxylipins were identified 76) grouped by fatty acid substrates enzyme systems. Linoleic (LA) generated from cytochrome P450 (CYP) (9,10-, 12,13-dihydroxy-9Z-octadecenoic acids) (diHOMEs) lower (treatment effect, p 0.051). A compositive variable 9 plasma hydroxydocosahexaenoic acids (HDoHEs) docosahexaenoic (DHA, 22:6) lipoxygenase (LOX) was significantly 0.008). composite 14-HDoHE, 17-HDoHE, the eicosapentaenoic (EPA)-derived oxylipin 18-hydroxyeicosapentaenoic (18-HEPE) (specialized pro-resolving lipid mediators, SPM, intermediates) vs 0.014). Pearson correlations showed positive relationships post-exercise DHA-LOX HDoHEs SPM intermediates urine blueberry (r 0.324, 0.023, r 0.349, 0.015, respectively). These data indicate that 18d intake cup/day linked reduction pro-inflammatory diHOMES sustained elevations DHA- EPA-derived anti-inflammatory response unaccustomed adults.

Language: Английский

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Acute Effects of Dark Chocolate on Physical Performance in Young Elite Soccer Players: A Pilot Study

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 965 - 965

Published: Jan. 20, 2025

Background: Dark chocolate is rich in polyphenols and has been linked to cardiovascular metabolic benefits. Its potential effects on recovery, fatigue reduction, subjective wellness elite athletes, however, remain underexplored. This pilot study examined the acute of dark consumption scores, perception effort, GPS-based performance measures soccer players during a 4-week intervention period. Methods: Twenty-two were assessed two conditions—when consuming 25g/day 85% (DC), or with no dietary (CG). Subjective daily through validated self-report questionnaires. External loads monitored training matches. Results: Athletes DC group reported significant reductions muscle soreness scores an increase match physical (distance at very high deceleration), as compared CG group. Conclusions: Daily may reduce damage enhance athletes. These findings suggest that could be practical strategy support recovery overall well-being high-performance contexts.

Language: Английский

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