Wound Repair and Regeneration,
Journal Year:
2024,
Volume and Issue:
33(1)
Published: Nov. 28, 2024
Diabetes
mellitus
remains
a
global
challenge
to
public
health
as
it
results
in
non-healing
chronic
ulcers
of
the
lower
limb.
These
wounds
are
challenging
heal,
and
despite
different
treatments
available
improve
healing,
there
is
still
high
rate
failure
relapse,
often
necessitating
amputation.
Chronic
diabetic
do
not
follow
an
orderly
progression
through
wound
healing
process
associated
with
persistent
inflammatory
state
characterised
by
accumulation
pro-inflammatory
macrophages,
cytokines
proteases.
Photobiomodulation
has
been
successfully
utilised
involves
illuminating
at
specific
wavelengths
using
predominantly
light-emitting
diodes
or
lasers.
induces
diminishing
inflammation
oxidative
stress,
among
others.
Research
into
application
photobiomodulation
for
current
ongoing
drawn
attention
many
researchers
healthcare
sector.
This
review
focuses
on
pathway
influence
this
wavelengths.
Molecular Therapy — Nucleic Acids,
Journal Year:
2023,
Volume and Issue:
31, P. 541 - 552
Published: Feb. 14, 2023
Apis
mellifera
royal
jelly
(RJ)
is
a
well-known
remedy
in
traditional
medicine
around
the
world
and
its
versatile
effects
range
from
antibacterial
to
anti-inflammatory
properties
pro-regenerative
properties.
As
glandular
product,
RJ
has
been
shown
contain
substantial
number
of
extracellular
vesicles
(EVs),
and,
this
study,
we
aimed
investigate
extent
involvement
RJEVs
wound
healing-associated
effects.
Molecular
analysis
verified
presence
exosomal
markers
such
as
CD63
syntenin,
cargo
molecules
MRJP1,
defensin-1,
jellein-3.
Furthermore,
were
demonstrated
modulate
mesenchymal
stem
cell
(MSC)
differentiation
secretome,
well
decrease
LPS-induced
inflammation
macrophages
by
blocking
mitogen-activated
protein
kinase
(MAPK)
pathway.
In
vivo
studies
confirmed
an
acceleration
healing
splinted
mouse
model.
This
study
suggests
that
play
crucial
role
known
modulating
inflammatory
phase
cellular
response
healing.
Transfer
into
clinics
impeded
high
complexity
raw
material.
Isolating
EVs
decreases
while
allowing
standardization
quality
control,
bringing
natural
nano-therapy
one
step
closer
clinics.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1582 - 1582
Published: Aug. 8, 2023
Dermatitis
is
an
inflammatory
condition
of
the
outer
layer
skin
that
causes
itching,
blisters,
redness,
swelling,
and
often
exudation,
scabs,
peeling.
Among
them,
purulent
inflammation
a
symptom
occurs
on
appears
in
form
boils
acne.
Various
studies
are
being
conducted
to
treat
these
diseases.
Accordingly,
Lonicera
japonica
Citri
Reticulatae
Pericarpium
Polyphenolic
Extract
(LCPE),
which
uses
herbal
preparations
such
as
japonica,
Pericarpium,
Glycyrrhiza
uralensis,
has
been
used
suppress
since
ancient
times,
its
anti-inflammatory
effect
can
be
observed
keratinocytes
after
inducing
inflammation.
In
this
study,
major
polyphenolic
compounds
LCPE
were
quantitatively
determined
by
analyzing
data
through
peak
values
using
high-performance
chromatography
(HPLC-MS/MS)
coupled
with
mass
spectrometry.
Additionally,
bioactive
targeting
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
analyzed
ultrafiltration
integrated
LC.
Several
most
significant
effects
selected
(chlorogenic
acid,
narirutin,
isorhamnetin).
Skin
induced
lipopolysaccharide
(LPS)
treated
show
effects.
After
treatment,
inflammation-mediating
cytokines
cyclooxygenase-2
(COX-2)
inducible
nitric
oxide
synthase
(iNOS)
decreased.
addition,
nuclear
factor
kappa
(NF-кB)
mitogen-activated
protein
kinase
(MAPK)
inhibited
important
pathways
related
Lastly,
molecular
modeling
was
performed
determine
binding
scores
inflammation-related
proteins
docking
for
compounds.
According
results,
effective
treating
LPS
reducing
potential
antioxidant
effects,
polyphenol
components
have
identified.
Saudi Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
31(4), P. 103963 - 103963
Published: Feb. 23, 2024
In
terms
of
the
economics
and
public
health,
chronic
wounds
exert
a
significant
detrimental
impact
on
health
care
system.
Bacterial
infections,
which
cause
formation
highly
resistant
biofilms
that
elude
standard
antibiotics,
are
main
chronic,
non-healing
wounds.
Numerous
studies
have
shown
phytochemicals
effective
in
treating
variety
diseases,
traditional
medicinal
plants
often
include
important
chemical
groups
such
alkaloids,
phenolics,
tannins,
terpenes,
steroids,
flavonoids,
glycosides,
fatty
acids.
These
substances
essential
for
scavenging
free
radicals
helps
reducing
inflammation,
fending
off
hastening
healing
species
can
survive
wound
conditions
because
employ
quorum
sensing
as
communication
technique
regulates
expression
virulence
components.
Fortunately,
several
anti-QS
characteristics
efficiently
block
QS
pathways,
prevent
drug-resistant
strains,
reduce
biofilm
development
This
review
emphasizes
potential
phytocompounds
crucial
agents
alleviating
bacterial
infections
promoting
by
inflammation
wounds,
exhibiting
avenues
future
therapeutic
approaches
to
mitigate
healthcare
burden
provided
these
challenging
conditions.
Wound Repair and Regeneration,
Journal Year:
2024,
Volume and Issue:
33(1)
Published: Nov. 28, 2024
Diabetes
mellitus
remains
a
global
challenge
to
public
health
as
it
results
in
non-healing
chronic
ulcers
of
the
lower
limb.
These
wounds
are
challenging
heal,
and
despite
different
treatments
available
improve
healing,
there
is
still
high
rate
failure
relapse,
often
necessitating
amputation.
Chronic
diabetic
do
not
follow
an
orderly
progression
through
wound
healing
process
associated
with
persistent
inflammatory
state
characterised
by
accumulation
pro-inflammatory
macrophages,
cytokines
proteases.
Photobiomodulation
has
been
successfully
utilised
involves
illuminating
at
specific
wavelengths
using
predominantly
light-emitting
diodes
or
lasers.
induces
diminishing
inflammation
oxidative
stress,
among
others.
Research
into
application
photobiomodulation
for
current
ongoing
drawn
attention
many
researchers
healthcare
sector.
This
review
focuses
on
pathway
influence
this
wavelengths.
