Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 28, 2024

The influence of gut microbiota on physiological processes is rapidly gaining attention globally. Despite being under-studied, there are available data demonstrating a microbiota-gonadal cross-talk, and the importance this axis in reproduction. This study reviews impacts In addition, possible mechanisms by which modulates male female reproduction presented. Databases, including Embase, Google scholar, Pubmed/Medline, Scopus, Web Science, were explored using relevant key words. Findings showed that promotes gonadal functions modulating circulating levels steroid sex hormones, insulin sensitivity, immune system, microbiota. Gut also alters ROS generation activation cytokine accumulation. conclusion, demonstrate existence axis, role functions. However, majority compelling evidences from animal studies with great dearth human data. Therefore, validating reports experimental models important.

Language: Английский

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Polysaccharide-Based Edible Gels as Functional Ingredients: Characterization, Applicability, and Human Health Benefits

Gels, Journal Year: 2022, Volume and Issue: 8(8), P. 524 - 524

Published: Aug. 21, 2022

Nowadays, edible materials such as polysaccharides have gained attention due to their valuable attributes, especially gelling property. Polysaccharide-based gels (PEGs) can be classified (i) hydrogels, (ii) oleogels and bigels, (iii) aerogels, cryogels xerogels, respectively. PEGs different characteristics benefits depending on the functional groups of polysaccharide chains (e.g., carboxylic, sulphonic, amino, methoxyl) preparation method. However, are found in incipient phase research most studies related preparation, characterization, sustainable raw materials, applicability. Furthermore, all these aspects treated separately for each class PEG, without offering an overview those already obtained PEGs. The novelty this manuscript is offer classification, definition, formulation, characterization applicability food sector packaging, improving profile agent, delivery systems) medical/pharmaceutical also critically discussed. Ultimately, correlation between PEG consumption properties human health intestinal microecology, "

Language: Английский

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Gut microbiota dependant trimethylamine N-oxide and hypertension

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: April 6, 2023

The human gut microbiota environment is constantly changing and some specific changes influence the host’s metabolic, immune, neuroendocrine functions. Emerging evidence of microbiota’s role in development cardiovascular disease (CVD) including hypertension remarkable. There showing that alterations especially gut-dependant metabolite trimethylamine N-oxide associated with hypertension. However, there a scarcity literature addressing pathogenesis. In this review, we discuss impact dependant pathogenesis We present from both animal studies further new insights relating to potential therapies for managing by altering microbiota.

Language: Английский

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Prebiotics, probiotics, synbiotics and postbiotics to adolescents in metabolic syndrome

Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(6), P. 1433 - 1446

Published: April 22, 2024

The prevalence of childhood and adolescent obesity has globally reached alarming dimensions many adolescents affected by already present one or more obesity-related comorbidities. In recent years, emerging evidence supporting the role gut microbiota in pathophysiology metabolic diseases been reported use prebiotics, probiotics, synbiotics postbiotics as a strategy to manipulate become popular. aim this review is explore relationship between syndrome discuss potential for prevention treatment clinical picture adolescence. According most literature, probiotics have no clear effect on MetS, but possible modulation anthropometric parameters observed after synbiotic supplementation. Only study examined alleviating complications children with not adolescents. More extensive research needed support conclusions drawn so far develop effective microbiome-based interventions that may help improving quality life exposed increasing MetS.

Language: Английский

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Sex differences in the oral microbiome, host traits, and their causal relationships

iScience, Journal Year: 2022, Volume and Issue: 26(1), P. 105839 - 105839

Published: Dec. 22, 2022

The oral microbiome has been implicated in a growing number of diseases; however, determinants the and their roles remain elusive. Here, we investigated (saliva tongue dorsum) metagenome, whole genome, other omics data total 4,478 individuals demonstrated that composition its major contributing host factors significantly differed between sexes. We thus conducted sex-stratified metagenome-genome-wide-association study (M-GWAS) identified 11 differential genetic associations with (psex-difference < 5 × 10-8). Furthermore, performed Mendelian randomization (MR) analyses abundant causalities serum metabolites. Notably, sex-specific microbes-hormonal interactions explained mostly observed sex hormones differences such as significant enrichments for aldosterone females androstenedione males. These findings illustrate necessity stratification deepen our understanding interplay

Language: Английский

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Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: Oct. 4, 2022

Abstract Background and purpose Stroke is associated with high disability mortality rates increases the incidence of organ-related complications. Research has revealed that outcomes prognosis stroke are regulated by state intestinal microbiota. However, possibility manipulation microbiota can alter sex-related remain unknown. Methods To verify different effects from sexes on outcomes, we performed mouse fecal transplantation (FMT) established a model ischemic stroke. Male female mice received either male or through FMT. Ischemic was triggered MCAO (middle cerebral artery occlusion), sham surgery served as control. Over next few weeks, underwent neurological evaluation metabolite inflammatory level detection, collected samples for 16S ribosomal RNA analysis. Results We found when were not treated FMT, (especially Firmicutes-to-Bacteroidetes ratio) levels three main metabolites tended to resemble those after experimental stroke, indicating induce an ecological imbalance in biological community. Through intragastric administration, gut altered other sex. In general, MCAO, survival rate increased, infarct area reduced, behavioral test performance improved, release beneficial promoted inflammation mitigated. contrast, much more hampered terms protection against brain damage recovery function. Conclusion A female-like community reduces systemic proinflammatory cytokines Poor be positively modulated following supplementation

Language: Английский

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Sex Hormones–Gut Microbiome Axis: An Update of What Is Known So Far

Current Opinion in Endocrine and Metabolic Research, Journal Year: 2025, Volume and Issue: unknown, P. 100571 - 100571

Published: Jan. 1, 2025

Language: Английский

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Potential relationship of the gut microbiome with testosterone level in men: a systematic review

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19289 - e19289

Published: April 15, 2025

The gut microbiome influences the metabolism and health of several organs beyond has recently gained considerable attention. plays a central role in food digestion, absorption, nutrition, general health. Hence, become research subject for almost all conditions. Imbalance or dysbiosis can cause different issues men, including reproductive sexual associated with testosterone levels. Several studies have investigated relationship between In this systematic review, we aimed to examine levels men. Literature searches were conducted by scanning PubMed, ProQuest, EBSCO, Taylor & Francis Online, Wiley Springer Link, Web Science, Google Scholar, Science Direct databases relevant keywords following preferred reporting items review guidelines. This included cross-sectional, case-control, retrospective, prospective cohort studies. Quality assessment was using Newcastle-Ottawa Scale. We found significant positive correlation microbes play substantial roles production. Mechanisms been proposed as factors that contribute levels, namely hypothalamus-pituitary-gonad axis modulation, androgen metabolism, intestinal homeostasis, balancing bone morphogenic protein (BMP) Wnt diverse microbiome. Ruminococcus showed stronger than other microorganisms. complex correlations metabolism. However, most influence on cannot be easily identified requires further research.

Language: Английский

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Probiotics in Women and Pediatrics Health; A Narrative Review

Al- Anbar Medical Journal, Journal Year: 2023, Volume and Issue: 0(0), P. 0 - 0

Published: June 15, 2023

Probiotic use to improve health is not new; but recently, it has attracted much attention concerning human and diseases. The gut a delicate ecosystem where bacteria host cells interact with each other. This an important part of homeostasis development. Disruption this sensitive may have detrimental repercussions linked impaired microbiota (GM). GM were extensively examined as underlying mechanism for disease development progression. Additionally, was used tailored method preventing treating disease. Because the strong association between GM, health, disease, there been interest in employing probiotics or living microorganisms, regulate prevent cure specific Herein, probiotics' role enhancing women's pediatric well-being addressed marker therapeutic avenues; we discussed indications, efficacy, safety profiles, future prospects clinical practice.

Language: Английский

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Dietary Patterns, Gut Microbiota Remodeling, and Cardiometabolic Disease

Metabolites, Journal Year: 2023, Volume and Issue: 13(6), P. 760 - 760

Published: June 17, 2023

The cardiovascular and metabolic disorders, collectively known as cardiometabolic disease (CMD), are high morbidity mortality pathologies associated with lower quality of life increasing health-care costs. influence the gut microbiota (GM) in dictating interpersonal variability CMD susceptibility, progression treatment response is beginning to be deciphered, mutualistic relation established between GM diet. In particular, dietary factors emerge pivotal determinants shaping architecture function resident microorganisms human gut. turn, intestinal microbes absorption, metabolism, storage ingested nutrients, potentially profound effects on host physiology. Herein, we present an updated overview major components GM, highlighting beneficial detrimental consequences diet–microbiota crosstalk setting CMD. We also discuss promises challenges integrating microbiome data planning aimed at restraining onset a more personalized nutritional approach.

Language: Английский

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