Role of the microbiota-gut-brain axis in postacute COVID syndrome

AJP Gastrointestinal and Liver Physiology, Journal Year: 2023, Volume and Issue: 324(4), P. G322 - G328

Published: March 7, 2023

The COVID-19 pandemic has resulted in the infection of hundreds millions individuals over past 3 years, coupled with deaths. Along these more acute impacts infection, a large subset patients developed symptoms that collectively comprise "postacute sequelae COVID-19" (PASC, also known as long COVID), which can persist for months and maybe even years. In this review, we outline current knowledge on role impaired microbiota-gut-brain (MGB) axis signaling development PASC potential mechanisms involved, may lead to better understanding disease progression treatment options future.

Language: Английский

---

Central diabetes insipidus: a late sequela of BNT162b2 SARS-CoV-2 mRNA vaccine?

BMC Endocrine Disorders, Journal Year: 2023, Volume and Issue: 23(1)

Published: Feb. 22, 2023

Abstract Background The development of an effective vaccine is a powerful tool to contain the global spread coronavirus disease 2019 (COVID-19). Still, it raises potential safety concerns about subsequent enhancement associated immunopathology. Increasing evidence shows that endocrine system, including hypophysis, may be involved in COVID-19. Moreover, occasional but increasing reports disorders involving thyroid have been reported after severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine. Among them, few cases encompass pituitary. Here we report rare case central diabetes insipidus following SARS-CoV-2 vaccination. Case presentation We 59-year-old female patient with 25-year history Crohn's long-term remission, who presented sudden onset polyuria eight weeks administration mRNA Laboratory evaluation was consistent isolated insipidus. Magnetic resonance imaging displayed involvement infundibulum and posterior hypophysis. Eighteen months vaccination, she still under desmopressin treatment had stable pituitary stalk thickening on magnetic imaging. Although disease-associated hypophysitis has reported, scarce. In absence other recognizable causes hypophysitis, believe hypophysis our triggered by Conclusions potentially Further studies are needed understand better mechanisms underlying autoimmune endocrinopathies context COVID-19 infection

Language: Английский

---

Conceptual foundations of acetylcarnitine supplementation in neuropsychiatric long COVID syndrome: a narrative review

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 274(8), P. 1829 - 1845

Published: Jan. 3, 2024

Abstract Post-acute sequelae of COVID-19 can present as multi-organ pathology, with neuropsychiatric symptoms being the most common symptom complex, characterizing long COVID a syndrome significant disease burden for affected individuals. Several typical COVID, such fatigue, depressive and cognitive impairment, are also key features other psychiatric disorders myalgic encephalomyelitis/chronic fatigue (ME/CFS) major disorder (MDD). However, clinically successful treatment strategies still lacking often inspired by options diseases similar clinical presentations, ME/CFS. Acetylcarnitine, shortest metabolite class fatty acid metabolites called acylcarnitines one abundant blood in humans be used dietary/nutritional supplement proven efficacy MDD, ME/CFS disorders. Basic research recent decades has established general, acetylcarnitine particular, important regulators indicators mitochondrial function physiological processes neuroinflammation energy production pathways. In this review, we will compare basis fatigue-associated diseases. We review molecular mechanisms associated altered metabolism potential to interfere these therapeutic agent. Finally, current evidence propose future investigate option COVID.

Language: Английский

---

The Dual Pandemics of COVID-19 and Obesity: Bidirectional Impact

Diabetes Therapy, Journal Year: 2022, Volume and Issue: 13(10), P. 1723 - 1736

Published: Aug. 27, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has been shown to disrupt many organ systems in human body. Though several medical disorders have affected by this infection, a few illnesses addition may also play role determining outcome of COVID-19. Obesity is one such disease which not only occurrence but can result worse clinical infection. This manuscript summarizes most recent evidence supporting bidirectional impact and obesity. It highlights how presence obesity be detrimental given patient because mechanical limitations lung compliance activation thrombo-inflammatory pathways. sociodemographic changes brought about pandemic turn facilitated already increasing prevalence importance recognizing these pathways further help policy that facilitate appropriate measures prevent worsening two pandemics.

Language: Английский

---

Post-pandemic insights on COVID-19 and premature ovarian insufficiency

Open Life Sciences, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

The COVID-19 pandemic has raised concerns regarding its potential impact on premature ovarian insufficiency (POI). This overview examines the possible interactions between and POI, while also suggesting preventive measures. viral infection's inflammatory response immune dysregulation may adversely affect tissues, leading to inflammation damage. Additionally, alterations in vascular function could impair blood flow hormonal imbalances disrupt normal function. Long-term health effects, such as "long COVID," exacerbate these issues through chronic dysfunction. Public measures, vaccination home isolation, indirectly protect by reducing systemic inflammation. Vaccines mitigate severity of COVID-19's function, isolation reduce stress However, further research is needed validate mechanisms.

Language: Английский

---

mTORC1 syndrome (TorS): unifying paradigm for PASC, ME/CFS and PAIS

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 9, 2025

Post-acute SarS-Cov2 (PASC), Myalgia encephalomyelitis/Chronic fatigue syndrome (ME/CFS) and infection (PAIS) consist of chronic post–acute infectious syndromes, sharing exhaustive fatigue, post exertional malaise, intermittent pain, postural tachycardia neuro-cognitive-psychiatric dysfunction. However, the concerned shared pathophysiology is still unresolved in terms upstream drivers transducers. Also, risk factors which may determine vulnerability/progression to phase remain be defined. In lack a cohesive pathophysiology, syndromes unmet therapeutic needs. 'mTORC1 Syndrome' (TorS) implies an disease entity driven by sustained hyper-activation mammalian target rapamycin C1 (mTORC1), resulting variety aspects Metabolic Syndrome (MetS), non-alcoholic fatty liver disease, obstructive pulmonary some cancers, neurodegeneration other [Bar-Tana Trends Endocrinol Metab 34:135–145, 2023]. TorS offer insight PASC, ME/CFS PAIS drivers, vulnerability treatment options.

Language: Английский

---

Neuropsychiatric Manifestations of Long COVID-19: A Narrative Review of Clinical Aspects and Therapeutic Approaches

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 439 - 439

Published: March 11, 2025

The COVID-19 (C-19) pandemic has highlighted the significance of understanding long-term effects this disease on quality life those infected. Long (L-C19) presents as persistent symptoms that continue beyond main illness period, usually lasting weeks to years. One lesser-known but significant aspects L-C19 is its impact neuropsychiatric manifestations, which can have a profound effect an individual’s life. Research shows creates issues such mental fog, emotional problems, and brain symptoms, along with sleep changes, extreme fatigue, severe head pain, tremors seizures, pain in nerves. People cognitive problems plus fatigue mood disorders experience great difficulty handling everyday activities, personal hygiene, social interactions. Neuropsychiatric make people withdraw from activity hurt relationships, thus causing feelings loneliness. unpredictable state generates heavy psychological pressure through suffering, including depression anxiety. changes impairment, swings it hard for work or study effectively, decreases their output at school lowers job contentment. purpose narrative review summarize clinical data present literature regarding manifestations L-C19, identify current methods diagnosis treatment lead correct management condition, highlight these patients’

Language: Английский

---

Determination of Cortisol Levels in a Small Volume of Saliva of COVID-19-Recovering Patients During Treatment with Psychotropic Drugs

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 697 - 697

Published: March 12, 2025

Background/Objectives: Cortisol levels are increased in stressful situations but can also result from a history of COVID-19 infection. Long-term exposure to high cortisol has destructive effect on the CNS (Central Nervous System) and lead depression, among other things. The most commonly used psychotropic drugs reduce concentrations. Methods: aim our study was develop an analytical method determine level hormone small volume saliva (200 µL) patients using CNS-active drugs. Solid-phase extraction isolate analyte, determination performed by liquid chromatography with diode array detector (LC DAD). Results: developed validated. Its linearity determined be range 4–500 ng/mL (R2 > 0.9986) intra- inter-day precision expressed as coefficient variation (CV%) did not exceed 12%. then applied post-COVID-19-recovered healthy volunteers. were 12.24 ± 7.33 recovered 4.11 1.46 subjects, respectively. A comparison results showed that volunteers significantly different statistically. Conclusions: allowed for saliva. Comparison concentration individuals recoveries indicates both groups differed statistically, patients. obtained indicate concentrations

Language: Английский

---

Review of the relationship between growth hormone and SARS-CoV-2 infection

Future Virology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: April 11, 2025

Language: Английский

---

The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post-COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(17), P. 5478 - 5478

Published: Aug. 23, 2023

Post-COVID-19 condition (commonly known as Long COVID) is a heterogeneous clinical in which Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and brain fog stand out among the different symptoms syndromes. Cerebral metabolic alterations neuroendocrine disorders seem to constitute an important part of pathophysiology (PCC). Given substantial lack specific drugs effective therapeutic strategies, hypothalamic phospholipid liposomes, have been on market for several years adjuvant therapy cerebral resulting from disorders, might represent potential option overall strategy that aims control PCC-associated Their pharmacological mechanisms effects strongly support their effectiveness PCC. Our initial experience seems corroborate this rationale. Further controlled research warranted order verify hypothesis.

Language: Английский

---