Postgraduate Medical Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 16, 2024
Abstract
Chronic
constipation
is
a
prevalent
clinical
condition.
Its
etiology
and
pathogenesis
have
not
yet
been
fully
understood.
In
recent
years,
mounting
evidence
suggests
close
association
between
chronic
intestinal
dysbiosis,
including
alterations
in
the
colony
structure
metabolites,
as
well
modulation
of
bowel
movements
via
brain–gut–microbiota
axis.
With
deepening
related
research,
probiotic-related
therapies
are
expected
to
become
potential
first-line
treatment
for
future.
this
review,
we
summarize
current
research
insights
into
intricate
relationships
gut
microbiota
briefly
discuss
several
different
approaches
treating
constipation.
The
findings
from
review
may
advance
our
understanding
pathological
mechanisms
underlying
and,
ultimately,
translate
them
improvements
patient
care.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3573 - 3573
Published: July 11, 2023
Evidence
suggests
the
involvement
of
microbiota,
including
oral,
intra-tumoral
and
gut,
in
pancreatic
cancer
progression
response
to
therapy.
The
gut
microbiota
modulates
bile
acid
pool
is
associated
with
maintaining
host
physiology.
Studies
have
shown
that
acid/gut
axis
dysregulated
cancer.
Bile
receptor
expression
levels
are
as
well.
also
acids
can
cause
cell
injury
facilitate
proliferation.
its
metabolites,
acids,
altered
other
conditions
considered
risk
factors
for
development
alter
responses
chemotherapeutic
treatments,
thus
affecting
patient
outcomes.
Altogether,
these
findings
suggest
microbial
and/or
profiles
could
serve
biomarkers
detection.
This
review
will
discuss
current
knowledge
on
interaction
between
metabolism
Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(6)
Published: May 30, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
prevalent
reproductive,
endocrine,
and
metabolic
disease
that
affects
5–18%
of
women
worldwide,
with
rising
incidence.
Hyperandrogenemia
insulin
resistance
are
two
key
pathophysiological
factors
contribute
to
PCOS,
both
which
variety
health
issues
such
as
menstrual
irregularities,
obesity,
dysfunctional
glucose
lipid
homeostasis,
infertility,
mental
disorders,
cardiovascular
cerebrovascular
diseases.
Despite
ongoing
studies,
the
origin
pathogenesis
PCOS
remain
elusive;
there
also
clinical
need
for
simpler,
more
effective,
longer
lasting,
comprehensive
treatments
PCOS.
The
gut–fat
axis,
critical
regulatory
route
metabolism,
endocrine
function,
immune
response,
has
received
considerable
interest
in
recent
years
research
etiology
treatment
illnesses
type
2
diabetes
mellitus
non-alcoholic
fatty
liver
disease.
latest
revealed
significant
alterations
homogeneity
phylogenetic
diversity
gut
microbiota.
Animal
using
fecal
microbiota
transplantation
confirmed
importance
regulating
sensitivity
sex
hormone
balance
Furthermore,
studies
have
shown
decrease
volume
and/or
activity
brown
adipose
tissue
(BAT)
patients,
change
alters
adipokine
release,
leading
hyperandrogenemia,
aggravating
progression.
Given
function
BAT
increasing
energy
expenditure
alleviating
parameters,
efforts
activate
or
induce
browning
white
emerged
possible
Recent
suggested
can
influence
creation
via
metabolites
short-chain
acids
bile
acids,
well
gut–brain
axis.
Cold
exposure,
healthy
dieting,
metformin,
bariatric
surgery,
glucagon-like
peptide
1
receptor
agonists
melatonin
all
been
basic
modulate
by
influencing
microbiota,
demonstrating
potential.
However,
into
regulation
mechanisms
gut–BAT
axis
required
produce
comfortable,
safe
tailored
therapeutics
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(7), P. 348 - 348
Published: June 21, 2024
Pancreatic
cancer
(PC)
is
a
dangerous
digestive
tract
tumor
that
becoming
increasingly
common
and
fatal.
The
most
form
of
PC
pancreatic
ductal
adenocarcinoma
(PDAC).
Bile
acids
(BAs)
are
closely
linked
to
the
growth
progression
PC.
They
can
change
intestinal
flora,
increasing
permeability
allowing
gut
microbes
enter
bloodstream,
leading
chronic
inflammation.
High
dietary
lipids
increase
BA
secretion
into
duodenum
fecal
levels.
BAs
cause
genetic
mutations,
mitochondrial
dysfunction,
abnormal
activation
intracellular
trypsin,
cytoskeletal
damage,
NF-κB,
acute
pancreatitis,
cell
injury,
necrosis.
act
on
different
types
cells
receptors,
altering
Ca
Critical Reviews in Oncology/Hematology,
Journal Year:
2024,
Volume and Issue:
203, P. 104480 - 104480
Published: Aug. 22, 2024
Gastrointestinal
(GI)
cancer
continues
to
pose
a
significant
global
health
challenge.
Recent
advances
in
our
understanding
of
the
complex
relationship
between
host
and
gut
microbiota
have
shed
light
on
critical
role
metabolic
interactions
pathogenesis
progression
GI
cancer.
In
this
study,
we
examined
how
interact
with
influence
signalling
pathways
that
impact
formation
tumours.
Additionally,
investigated
potential
therapeutic
approach
manipulating
for
use
clinical
settings.
Revealing
molecular
exchanges
facilitates
deeper
underlying
mechanisms
drive
development.
Metabolic
hold
promise
identification
microbial
signatures
or
associated
specific
stages
Hence,
study
provides
strategies
diagnosis,
treatment
management
cancers
improve
patient
outcomes.
Postgraduate Medical Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 16, 2024
Abstract
Chronic
constipation
is
a
prevalent
clinical
condition.
Its
etiology
and
pathogenesis
have
not
yet
been
fully
understood.
In
recent
years,
mounting
evidence
suggests
close
association
between
chronic
intestinal
dysbiosis,
including
alterations
in
the
colony
structure
metabolites,
as
well
modulation
of
bowel
movements
via
brain–gut–microbiota
axis.
With
deepening
related
research,
probiotic-related
therapies
are
expected
to
become
potential
first-line
treatment
for
future.
this
review,
we
summarize
current
research
insights
into
intricate
relationships
gut
microbiota
briefly
discuss
several
different
approaches
treating
constipation.
The
findings
from
review
may
advance
our
understanding
pathological
mechanisms
underlying
and,
ultimately,
translate
them
improvements
patient
care.
