Current, emerging, and potential therapies for non-alcoholic steatohepatitis DOI Creative Commons
Zhen Yang, Lin Wang

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 30, 2023

Non-alcoholic fatty liver disease (NAFLD) has been identified as the most common chronic worldwide, with a growing incidence. NAFLD is considered hepatic manifestation of metabolic syndrome that emerges from multiple factors (e.g., oxidative stress, disorders, endoplasmic reticulum cell death, and inflammation). steatohepatitis (NASH), an advanced form NAFLD, reported to be leading cause cirrhosis carcinoma, it progressing rapidly. Since there no approved pharmacotherapy for NASH, considerable number therapeutic targets have emerged deepening research on NASH pathogenesis. In this study, potential properties regulating metabolism, gut microbiome, antioxidant, microRNA, inhibiting apoptosis, targeting ferroptosis, stem cell-based therapy in are reviewed evaluated. single-drug treatment affected by individual heterogeneous responses side effects, imperative precisely carry out targeted low toxicity. Lastly, agent delivery based exosomes proposed such drugs different mechanisms can incorporated generate high-efficiency low-toxicity individualized medicine.

Language: Английский

Lactobacillus acidophilus suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma through producing valeric acid DOI Creative Commons
Harry Cheuk-Hay Lau, Xiang Zhang, Fenfen Ji

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 100, P. 104952 - 104952

Published: Jan. 4, 2024

Gut probiotic depletion is associated with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC). Here, we investigated the prophylactic potential of Lactobacillus acidophilus against NAFLD-HCC.

Language: Английский

Citations

43
NAFLD/MASLD and the Gut–Liver Axis: From Pathogenesis to Treatment Options DOI Creative Commons
Natalia G. Vallianou, Dimitris Kounatidis,

Sotiria Psallida

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(7), P. 366 - 366

Published: June 28, 2024

Nonalcoholic fatty liver disease (NAFLD) poses an emerging threat topublic health. steatohepatitis (NASH) is reported to be the most rapidly rising cause of hepatocellular carcinoma in western world. Recently, a new term has been proposed: metabolic dysfunction-associated steatotic (MASLD). The introduction this terminology sparked debate about interchangeability these terms. pathogenesis NAFLD/MASLD thought multifactorial, involving both genetic and environmental factors. Among factors, alterations gut microbiota dysbiosis have recently garnered significant attention. In context, review will further discuss gut-liver axis, which refers bidirectional interaction between human liver. Additionally, therapeutic potential probiotics, particularly next-generation probiotics genetically engineered bacteria, explored. Moreover, role prebiotics, synbiotics, postbiotics, phages as well fecal transplantation analyzed. Particularly for lean patients with NAFLD/MASLD, who limited treatment options, approaches that modify diversity composition may hold promise. However, due ongoing safety concerns modulate microbiota, large-scale studies are necessary better assess their efficacy treating NAFLD/MASLD.

Language: Английский

Citations

22
Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways DOI Creative Commons

Enzo Pereira de Lima,

Renato Cesar Moretti,

Karina Torres Pomini

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 519 - 519

Published: July 12, 2024

Glycolipid metabolic disorders (GLMDs) are various resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake a lack physical activity may contribute oxidative stress (OxS) systemic inflammation. This study aimed review the connection between GLMD, OxS, metainflammation, onset CRVD. GLMD is due causing dysfunction synthesis, breakdown, absorption glucose lipids body, excessive ectopic accumulation these molecules. mainly neuroendocrine dysregulation, insulin resistance, metainflammation. many inflammatory markers defense cells play vital role related tissues organs, such as blood vessels, pancreatic islets, liver, muscle, kidneys, adipocytes, promoting lesions that affect interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, sphingosine-1-phosphate (S1P) crucial since they glucolipid metabolism. The consequences this system organ damage morbidity mortality.

Language: Английский

Citations

21
Phocaeicola vulgatus alleviates diet-induced metabolic dysfunction-associated steatotic liver disease progression by downregulating histone acetylation level via 3-HPAA DOI Creative Commons
Shengxi Jin, Peng Chen, Jing Yang

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 5, 2024

Diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent disorder with limited effective interventions available. A novel approach to address this issue through gut microbiota-based therapy. In our study, we utilized multi-omics analysis identify Phocaeicola vulgatus (P. vulgatus) as potential probiotic for the treatment of MASLD. Our findings from murine models clearly illustrate that supplementation P. mitigates development This beneficial effect partly attributed metabolite 3-Hydroxyphenylacetic acid (3-HPAA) produced by vulgatus, which reduces acetylation levels H3K27 and downregulates transcription Squalene Epoxidase (SQLE), rate-limiting enzyme in steroid biosynthesis promotes lipid accumulation cells. study underscores significant role MASLD critical importance its 3-HPAA regulating homeostasis. These offer promising avenue early intervention therapy context

Language: Английский

Citations

19
From probiotics to postbiotics: Concepts and applications DOI Creative Commons
Hongmei Chen, Ning Ma,

Yue Feng

et al.

Animal Research and One Health, Journal Year: 2023, Volume and Issue: 1(1), P. 92 - 114

Published: July 3, 2023

Abstract In recent years, the important role of gut microbiota in promoting animal health and regulating immune function livestock poultry has been widely reported. The issue problems causes significant economic losses each year. Probiotics postbiotics have developed as additives due to their beneficial effects balancing host microbiota, enhancing intestinal epithelial barrier, immunity, whole‐body metabolism. are composed complex ingredients, with different components compositions having effects, requiring classification for discussing mechanisms action. considerable prospects preventing various diseases industry feed medical applications. This review highlights application value probiotics potential probiotic products, emphasizing concept, mechanism action, application, improve productivity poultry.

Language: Английский

Citations

40
Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies DOI
Muthukumaran Jayachandran, Shen Qu

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 24(6), P. 1189 - 1204

Published: Oct. 16, 2023

Language: Английский

Citations

29
Gut Microbiota and Bacterial Translocation in the Pathogenesis of Liver Fibrosis DOI Open Access
Roman Maslennikov, Elena Poluektova, O. Yu. Zolnikova

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16502 - 16502

Published: Nov. 19, 2023

Cirrhosis is the end result of liver fibrosis in chronic diseases. Studying mechanisms its development and developing measures to slow down regress it based on this knowledge seem be important tasks for medicine. Currently, disorders gut–liver axis have great importance pathogenesis cirrhosis. However, gut dysbiosis, which manifests as increased proportions microbiota Bacilli Proteobacteria that are capable bacterial translocation a decreased proportion Clostridia strengthen intestinal barrier, occurs even at pre-cirrhotic stage disease. This leads translocation, process by those microbes enter blood portal vein then tissue, where they activate Kupffer cells through Toll-like receptor 4. In response, produce profibrogenic cytokines, hepatic stellate cells, stimulating their transformation into myofibroblasts collagen other elements extracellular matrix. Blocking with antibiotics, probiotics, synbiotics, methods could progression fibrosis. was shown number animal models but requires further verification long-term randomized controlled trials humans.

Language: Английский

Citations

26
Prevention of Metabolic Syndrome by Phytochemicals and Vitamin D DOI Open Access
Kazuki Santa,

Yoshio Kumazawa,

Isao Nagaoka

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2627 - 2627

Published: Jan. 30, 2023

In recent years, attention has focused on the roles of phytochemicals in fruits and vegetables maintaining improving intestinal environment preventing metabolic syndrome. A high-fat high-sugar diet, lack exercise, excess energy accumulation body can cause syndrome induce obesity, diabetes, disorders circulatory system liver. Therefore, prevention is important. The current review shows that simultaneous intake contained citruses grapes together with vitamin D improves state gut microbiota immunity, related diseases. Phytochemicals include polyphenols such as hesperidin, rutin, naringin; those quercetin, procyanidin, oleanolic acid. these D, along prebiotics probiotics, nurture good microbiota. general, Firmicutes are obese-prone Bacteroidetes lean-prone microbiota; regulatory T cells, which suppress inflammatory responses upregulate immunity. Maintaining suppresses TNF-α, an cytokine also considered to be a pathogenic contributor adipokine, prevents chronic inflammation, thereby helping prevent enhances adiponectin, protector adipokine For reduction various disease risks, will important for human health future.

Language: Английский

Citations

23
Probiotic Supplementation, Hepatic Fibrosis, and the Microbiota Profile in Patients with Nonalcoholic Steatohepatitis: A Randomized Controlled Trial DOI Creative Commons

Giselle S. Escouto,

Gabriela Z. Port,

Cristiane Valle Tovo

et al.

Journal of Nutrition, Journal Year: 2023, Volume and Issue: 153(7), P. 1984 - 1993

Published: May 22, 2023

Language: Английский

Citations

23
New Insights into the Pathogenesis of Metabolic-Associated Fatty Liver Disease (MAFLD): Gut–Liver–Heart Crosstalk DOI Open Access
Keungmo Yang, Myeong Jun Song

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 3970 - 3970

Published: Sept. 14, 2023

Metabolism-associated fatty liver disease (MAFLD) is a multifaceted that involves complex interactions between various organs, including the gut and heart. It defined by hepatic lipid accumulation related to metabolic dysfunction, obesity, diabetes. Understanding intricate interplay of gut–liver–heart crosstalk crucial for unraveling complexities MAFLD developing effective treatment prevention strategies. The gut–liver participates in regulation inflammatory processes through host–microbiome interactions. Gut microbiota have been associated with development progression MAFLD, its dysbiosis contributes insulin resistance, inflammation, oxidative stress. Metabolites derived from enter systemic circulation influence both heart, resulting axis playing an important role MAFLD. Furthermore, growing evidence suggests endothelial inflammation may contribute increased risk cardiovascular (CVD). Additionally, dysregulation metabolism also lead cardiac dysfunction heart failure. Overall, molecular pathways CVD patients This review emphasizes current understanding as foundation optimizing patient outcomes

Language: Английский

Citations

22