Biology Direct, Journal Year: 2025, Volume and Issue: 20(1)
Published: April 2, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 14360 - 14360
Published: Nov. 18, 2022
Clear cell renal carcinoma (ccRCC) is the most frequent histological kidney cancer subtype. Over last decade, significant progress has been made in identifying genetic and metabolic alterations driving ccRCC development. In particular, an integrated approach using transcriptomics, metabolomics, lipidomics led to a better understanding of as disease. The profiling this could help define predict its behavior terms aggressiveness, prognosis, therapeutic responsiveness, would be innovative strategy for choosing optimal therapy specific patient. This review article describes current state-of-the-art research on pathways potential applications. addition, clinical implication pharmacometabolomic intervention analyzed, which represents new field novel stage-related patient-tailored strategies according susceptibility classes drugs.
Language: Английский
Citations
119
Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1071 - 1071
Published: April 2, 2023
Renal cell carcinoma (RCC) is the seventh most common cancer in men and ninth women worldwide. There plenty of evidence about role immune system surveillance against tumors. Thanks to a better understanding immunosurveillance mechanisms, immunotherapy has been introduced as promising treatment recent years. long thought chemoresistant but highly immunogenic. Considering that up 30% patients present metastatic disease at diagnosis, around 20–30% undergoing surgery will suffer recurrence, we need identify novel therapeutic targets. The introduction checkpoint inhibitors (ICIs) clinical management RCC revolutionized approach this tumor. Several trials have shown therapy with ICIs combination or tyrosine kinase inhibitor very good response rate. In review article summarize mechanisms immunity modulation checkpoints discuss potential strategies renal treatment.
Language: Английский
Citations
75
Expert Review of Molecular Diagnostics, Journal Year: 2023, Volume and Issue: 23(4), P. 297 - 313
Published: March 24, 2023
Lipidomics focuses on the in-depth analysis of lipids, which are crucial macromolecules involved in a wide range metabolic pathways. The increased intracellular accumulation different classes lipids renal cell carcinoma (RCC) and prostate cancer (PCa) cells may be caused by elevated absorption or de novo lipogenesis as consequence lipid metabolism reprogramming. involvement cholesterol cancer's aberrant pathways has also been demonstrated.This review provides an update most important lipidomics studies applications RCC PCa, with particular focus how knowledge used to identify biomarkers novel therapeutic targets. In addition, application this methodologies have led subtypes identification patient's risk stratification. Tracking tumor progression using specific biofluid metabolite profiles offers huge translational opportunity for urological malignancies.Lipidomics is promising branch 'omics' approach should include next decade new standardized methods randomized clinical trials order reach aim use high-throughput technique patient-tailored therapy perspective.
Language: Английский
Citations
70
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4814 - 4814
Published: March 2, 2023
Mucin1 (MUC1), a glycoprotein associated with an aggressive cancer phenotype and chemoresistance, is aberrantly overexpressed in subset of clear cell renal carcinoma (ccRCC). Recent studies suggest that MUC1 plays role modulating metabolism, but its regulating immunoflogosis the tumor microenvironment remains poorly understood. In previous study, we showed pentraxin-3 (PTX3) can affect ccRCC by activating classical pathway complement system (C1q) releasing proangiogenic factors (C3a, C5a). this scenario, evaluated PTX3 expression analyzed potential activation on site immune modulation, stratifying samples tumors high (MUC1H) versus low (MUC1L). We found tissue was significantly higher MUC1H ccRCC. addition, C1q deposition expressions CD59, C3aR, C5aR were extensively present colocalized PTX3. Finally, increased number infiltrating mast cells, M2-macrophage, IDO1+ reduced CD8+ T cells. Taken together, our results modulate infiltrate, promoting immune-silent microenvironment.
Language: Английский
Citations
62
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4615 - 4615
Published: Feb. 27, 2023
Renal cancer management is challenging from diagnosis to treatment and follow-up. In cases of small renal masses cystic lesions the differential benign or malignant tissues has potential pitfalls when imaging even biopsy applied. The recent artificial intelligence, techniques, genomics advancements have ability help clinicians set stratification risk, selection, follow-up strategy, prognosis disease. combination radiomics features data achieved good results but currently limited by retrospective design number patients included in clinical trials. road ahead for radiogenomics open new, well-designed prospective studies, with large cohorts required validate previously obtained enter practice.
Language: Английский
Citations
58
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16515 - 16515
Published: Nov. 20, 2023
The crosstalk among the complement system, immune cells, and mediators of inflammation provides an efficient mechanism to protect organism against infections support repair damaged tissues. Alterations in this complex machinery play a role pathogenesis different diseases. Core proteins C3 C5, their activation fragments, receptors, regulators have been shown be active intracellularly as complosome. kidney is particularly vulnerable complement-induced damage, emerging findings revealed system dysregulation wide range disorders, including glomerulopathies ischemia-reperfusion injury during transplantation. Different studies that important component tumorigenesis its elements proved present TME various human malignancies. renal cell carcinoma (RCC) has recently explored. Clear papillary RCC upregulate most genes relative normal tissue. aim narrative review provide novel insights into disorders.
Language: Английский
Citations
52
Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 315 - 315
Published: March 7, 2024
Mucins are a family of high-molecular-weight glycoproteins. MUC1 is widely studied for its role in distinct types cancers. In many human epithelial malignancies, frequently overexpressed, and intracellular activities crucial cell biology. overexpression can enhance cancer proliferation by modulating metabolism. When cells lose their tight connections, due to the loss polarity, mucins become dispersed on both sides membrane, leading an abnormal mucin interactome with membrane. Tumor-related exhibits certain features, such as apical localization aberrant glycosylation that might cause formation tumor-related antigen epitopes. Renal carcinoma (RCC) accounts approximately 3% adult malignancies it most common kidney cancer. The exact this tumor unknown. Evidence suggests may play several oncogenic pathways, including proliferation, metabolic reprogramming, chemoresistance, angiogenesis. purpose review explore meaning tumors particular RCC.
Language: Английский
Citations
36
Urologic Oncology Seminars and Original Investigations, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
2
Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 19, 2025
Abstract Renal cell carcinoma (RCC), a therapeutically recalcitrant genitourinary malignancy, exemplifies the profound interplay between oncogenic signaling and metabolic adaptation. Emerging evidence positions reprogramming as central axis of RCC pathogenesis, characterized by dynamic shifts in nutrient utilization that transcend canonical Warburg physiology to encompass lipid anabolism, glutamine auxotrophy, microenvironment-driven plasticity. This orchestrated rewiring cellular energetics sustains tumor proliferation under hypoxia while fostering immunosuppression through metabolite-mediated T exhaustion myeloid-derived suppressor activation. Crucially, exhibits heterogeneity across histological subtypes intratumoral regions—a feature increasingly recognized determinant therapeutic resistance. Our review systematically deciphers molecular architecture metabolism, elucidating how VHL/HIF mutations, mTOR pathway dysregulation, epigenetic modifiers converge reshape glucose flux, droplet biogenesis, amino acid catabolism. We present novel insights into spatial zonation within tumors, where pseudohypoxic niches engage lactate shuttling cholesterol efflux adjacent vasculature, creating pro-angiogenic immunosuppressive microdomains. Therapeutically, we evaluate first-in-class inhibitors targeting rate-limiting enzymes de novo lipogenesis proposing biomarker-driven strategies overcome compensatory highlight synergy glutaminase PD-1 blockade reinvigorating CD8 + function, role lipid-loaded cancer-associated fibroblasts shielding tumors from ferroptosis. Finally, outline translational roadmap integrating multi-omics profiling, functional metabolomics, biology match vulnerabilities with precision therapies.
Language: Английский
Citations
2
BMC Urology, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 9, 2025
Clear cell renal carcinoma (ccRCC) is fundamentally a metabolic disease. To investigate the underlying metabolite changes in occurrence of ccRCC, we analyzed untargeted metabolomics 15 ccRCC samples and paired adjacent non-malignant tissues by UHPLC-MS/MS analyses. In this study, 511 differential metabolites were screened, which top ten up-regulated histamine, 1-methylnicotinamide, L-kynurenine, cortisol, tetrahydrocorticosterone, calcitriol, D-erythrose 4-phosphate, citric acid, sedoheptulose 1,7-bisphosphate, UDP-alpha-D-galactose, down-regulated D-cysteine, acetylcholine, pantothenic cytosine, UMP, biocytin, dUMP, 5-phosphoribosyl 1-pyrophosphate, cytidine-5'-monophosphate, 16α-hydroxyestrone. KEGG pathways enrichment analysis further demonstrated several highlighted pathways: steroid hormone biosynthesis, pyrimidine metabolism, vitamin digestion absorption. Our study reveals patterns provides insight into potential biomarker panel to diagnose ccRCC.
Language: Английский
Citations
1