Immune aging and infectious diseases DOI Creative Commons
Ruochan Chen,

Zou Ju,

Jun Chen Chen

et al.

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract The rise in global life expectancy has led to an increase the older population, presenting significant challenges managing infectious diseases. Aging affects innate and adaptive immune systems, resulting chronic low-grade inflammation (inflammaging) function decline (immunosenescence). These changes would impair defense mechanisms, susceptibility infections reduce vaccine efficacy adults. Cellular senescence exacerbates these issues by releasing pro-inflammatory factors, further perpetuating inflammation. Moreover, comorbidities, such as cardiovascular disease diabetes, which are common adults, amplify dysfunction, while immunosuppressive medications complicate responses infections. This review explores molecular cellular mechanisms driving inflammaging immunosenescence, focusing on genomic instability, telomere attrition, mitochondrial dysfunction. Additionally, we discussed how aging-associated alterations influence bacterial, viral, parasitic evaluated emerging antiaging strategies, aimed at mitigating effects improve health outcomes aging population.

Language: Английский

Innovative Plant Exosome Delivery System for Enhancing Antiaging Potency on Skin DOI
Wei Wei, Xiaobing Ren, Yi Fan

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Plant exosomes, small vesicles released by plant cells that contain various bioactive molecules, have garnered great attention for their potential applications in medicine, yet delivery skincare remain underexploited. Resveratrol (RES), renowned its remarkable antiaging properties, faces challenges transdermal absorption due to the stratum corneum barrier, hindering efficacy. To address this, we developed a system incorporating RES-loaded (Leontopodium alpinum) exosome (LEOEXO@RES). Evaluation through both vitro and vivo experiments demonstrated LEOEXO@RES's enhanced of compounds multifaceted impact. Specifically, this approach not only promoted environmentally responsible waste reuse but also achieved harmonious synergy between LEOEXO carriers RES, enhancing overall The LEOEXO@RES effectively ameliorated inflammation levels inhibited cellular senescence, highlighting promising applications.

Language: Английский

Citations

0
Inflammatory, mitochondrial, and senescence-related markers: Underlying biological pathways of muscle aging and new therapeutic targets DOI Creative Commons
Anna Picca, Biliana Lozanoska‐Ochser, Riccardo Calvani

et al.

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 178, P. 112204 - 112204

Published: May 18, 2023

The maintenance of functional health is pivotal for achieving independent life in older age. aged muscle characterized by ultrastructural changes, including loss type I and II myofibers a greater proportion cytochrome c oxidase deficient succinate dehydrogenase positive fibers. Both intrinsic (e.g., altered proteostasis, DNA damage, mitochondrial dysfunction) extrinsic factors denervation, metabolic regulation, declines satellite cells, inflammation) contribute to aging. Being hub several cellular activities, mitochondria are key myocyte viability dysfunction has been implicated age-associated physical decline. organelles via quality control (MQC) processes is, therefore, crucial skeletal myofiber organismal health. autophagy-lysosome pathway emerged as critical step MQC disposing proteins their tagging autophagosome incorporation delivery the lysosome clearance. This was found be physically inactive adults. A relationship between this tissue composition lower extremities well performance also identified. Therefore, integrating structure measures evaluation may promising strategy devising interventions fostering

Language: Английский

Citations

10
Pro‐Inflammatory Proteins Associated with Frailty and Its Progression—A Longitudinal Study in Community‐Dwelling Women DOI Creative Commons
Adam Mitchell, Linnea Malmgren, Patrik Bartosch

et al.

Journal of Bone and Mineral Research, Journal Year: 2023, Volume and Issue: 38(8), P. 1076 - 1091

Published: May 31, 2023

The complex pathophysiology underlying biological aging creates challenges for identifying biomarkers associated with frailty. This longitudinal, nontargeted proteomics study aimed to identify proteins frailty, particularly the change from nonfrail frail. population-based Osteoporosis Prospective Risk Assessment cohort includes women all of whom are 75 years old at inclusion (n = 1044) and reassessed 80 715) 85 382). A deficits in health frailty index (FI) 92 plasma (Olink CVD-II panel) were available ages. identical age facilitated differentiating chronological aging. Bidirectional analyses, performed cross-sectionally longitudinally, used regression models controlled false discovery rate (FDR), across 5- 10-year time windows longitudinal mixed models. Frailty outcomes index, status (frail defined as FI ≥ 0.25), status, together protein expression or expression. Elevated levels 32 positively FI, ages (range: β-coefficients 0.22-2.06; FDR 0.021-0.024), which 18 also odds ratios 1.40-5.77; 0.022-0.016). Based on accrued data, eight core (CD4, FGF23, Gal-9, PAR-1, REN, TNFRSF10A TNFRSF11A, TNFRSF10B) proposed. one-unit was additively increased over 5 10 0.52-1.59; p < 0.001). Increments baseline consistently a (5 years, β-range 0.05-1.35; 0.51-1.48; increase an probability being frail (FI 0.25) (β-range: 0.14-0.61). Mirroring multisystem deterioration that typifies their pathways reflect pathologies, including renal system, skeletal homeostasis, TRAIL-activated apoptotic signaling. compelling candidates understanding development progression advancing age, intrinsic musculoskeletal component. © 2023 Authors. Journal Bone Mineral Research published by Wiley Periodicals LLC behalf American Society (ASBMR).

Language: Английский

Citations

10
Identifying genetic determinants of sarcopenia-related traits: a Mendelian randomization study of druggable genes DOI

Jihao Wu,

Xiong Chen, Ruijun Li

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 160, P. 155994 - 155994

Published: Aug. 6, 2024

Language: Английский

Citations

3
Cellular senescence and frailty: a comprehensive insight into the causal links DOI
Serena Marcozzi, Giorgia Bigossi, Maria Giuliani

et al.

GeroScience, Journal Year: 2023, Volume and Issue: 45(6), P. 3267 - 3305

Published: Oct. 4, 2023

Language: Английский

Citations

7
Bibliometric and scientometric analysis on biomarkers and molecular mechanisms for physical frailty and sarcopenia DOI Creative Commons
Valentina Ginevičienė, Erinija Pranckevičienė, Justina Kilaitė

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 5, 2024

Introduction The influence of physical frailty and sarcopenia (PFS) on the well-being older people continuous pressure healthcare systems has prompted a research pathophysiology molecular mechanisms these conditions. Nonetheless some biomarkers have been suggested as potential markers for PFS none them shown to highlight complex nature PFS, which reveals that there is need an understanding possible biomarker candidates. aim this study was identify current hotspots, status, trends in field PFS. Methods bibliometric scientometric analyses were performed using VOSviewer (version 1.6.18) open source software platform Cytoscape v.3.9 (for visualizing constructing network keywords). Data publications (from 1997 2023) related obtained (in May from database Science Citation Index Expanded Web Science, Scopus, PubMed. keywords Scopus used perform meaningful keyword analysis. A relationships build Cytoscape. Results In study, we present relation other potentially designating processes reveal identities contexts are discussed. Conclusions Over recent years, scientific interest increased focused inflammatory process probably will be concentrated myokines (such cytokines small proteins) synthetized released by skeletal muscles response activity. Moreover, proteomic genetic deeply involved

Language: Английский

Citations

2
Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment DOI Creative Commons
Yiming Pan, Lina Ma

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In older adults, physical frailty and cognitive impairment contribute to adverse outcomes. However, the research on mechanisms underlying is limited. Low-grade chronic inflammation a characteristic of aging. Particularly, an imbalance in pro- anti-inflammatory may be involved neurodegenerative disorders. Therefore, exploring inflammatory markers crucial fully understanding these establishing substantial link between two Notably, few studies have focused both impairment, posing major challenge elucidating them. efforts are required for better prevention impairment. this review, we explored role as potential

Language: Английский

Citations

2
Waist-to-calf circumstance ratio and cognitive function among Chinese older adults: Mediating roles of physical performance and social activity DOI Creative Commons
Xia Cao,

Binfang Yang,

Jiansong Zhou

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: April 17, 2023

Background In light of the potentially detrimental effects central fat and decreased muscle mass on cognitive function, it would be beneficial to learn more about mediating mechanisms underpinning association between two. The purpose this study is determine waist-to-calf circumstance ratio (WCR) as well investigate whether physical performance social activity mediate relationship WCR function among older Chinese adults. Methods An analysis 9,652 adults was conducted during 2018 wave Longitudinal Health Longevity Survey (CLHLS). Mini-Mental State Examination (MMSE) a self-reported scale were used measure performance, activity, respectively. Multiple linear regression mediation analyses conducted. Results findings suggest that high had significant negative with ( B = −0.535, 95% CI: −0.754, −0.317). Mediation revealed influenced old adults' in three ways: first, through partial effect −0.270; −0.340, −0.203); second, −0.035; −0.055, −0.017); third, serial −0.021, −0.029, −0.015). Conclusion results adverse impact possible by which takes place. Multidimensional health interventions aimed at improving physical, social, functioning sarcopenic obesity are recommended.

Language: Английский

Citations

6
A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022 DOI Creative Commons
Yujie Zhang,

Ye Zhao,

Jiaqi Rong

et al.

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 183, P. 112316 - 112316

Published: Oct. 19, 2023

In recent years, the impact of inflammation regulation on progression sarcopenia has garnered significant attention in research. However, there been a lack bibliometric analysis literature pertaining to sarcopenia. This study was designed for purpose exploring current research trends this field as well general situations and hot spots through analysis. Searches were performed Web Science Core Collection articles related from 2007 2022, selected compliance with PRISMA guidelines. A variety data analyzed visualized using VOSviewer CiteSpace, including countries, institutions, authors, keywords, journals, publications. 1833 obtained last 16 years all. The number publications citations increased notable rise occurring after 2016. Based results, United States, University Melbourne, Nutrients, Marzetti Emanuele most productive respectively. primary keywords oxidative stress insulin resistance, burst detection found that is possibility future will focus "Inflammatory Bowel Disease". first interaction between stress, resistance regarded priorities. As becomes more prevalent, be placed determining molecular mechanisms therapeutic targets regulating intervene

Language: Английский

Citations

5
Identification and immune landscape of sarcopenia-related molecular clusters in inflammatory bowel disease by machine learning and integrated bioinformatics DOI Creative Commons

Chongkang Yue,

Huiping Xue

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 30, 2024

Sarcopenia, a prevalent comorbidity of inflammatory bowel disease (IBD), is characterized by diminished skeletal muscle mass and strength. Nevertheless, the underlying interconnected mechanisms remain elusive. This study identified distinct expression patterns sarcopenia-associated genes (SRGs) across individuals with IBD in samples normal tissue. By analyzing SRG profiles, we effectively segregated 541 into three clusters, each marked its unique immune landscape. To unravel transcriptional disruptions these Weighted Gene Co-expression Network Analysis (WGCNA) algorithm was employed to spotlight key linked cluster. A diagnostic model based on four (TIMP1, PLAU, PHLDA1, TGFBI) established using Random Forest LASSO (least absolute shrinkage selection operator) algorithms, validated GSE179285 dataset. Moreover, GSE112366 dataset facilitated exploration gene dynamics within ileum mucosa UC patients pre- post-Ustekinumab treatment. Additionally, insights intricate relationship between cells pivotal were gleaned from single-cell RNA GSE162335. In conclusion, our findings collectively underscored role sarcopenia-related pathogenesis IBD. Their potential as robust biomarkers for future therapeutic strategies particularly promising, opening avenues deeper understanding improved management conditions.

Language: Английский

Citations

1