Introduction to special issue on ‘physiological and evolutionary mechanisms of aging’ DOI Creative Commons
Gustavo Barja, Reinald Pamplona

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 184, P. 112324 - 112324

Published: Nov. 22, 2023

What are the structural components and physiological mechanisms determining aging process? Can different described in biology converge into a core of coordinated effectors? Why some human beings, for instance, can reach 115-122 years age while rats live at best maximum 4 years? rate be modified? How much lifespan extended? Is programmed or non-programmed This special issue includes invited articles to explore aging, both classical updated hypotheses on evolutionary meaning aging. Breakthroughs aging-related research currently unveiling longevity factors highly conserved during evolution animal species discovering details how why molecular cellular processes decline physiologically normal Investigations model organisms humans uncovering potential approaches extend not only mean individual survival but also (from here on) longevity. Experimental Gerontology presents this Special Issue (SI) highlighting recent advances mechanistic understanding longevity, interventions that lifespan. SI address most reasonably well known tries evaluate available evidence supporting opposed biological exists all?. The is composed ten peer reviewed reviews primary articles, covering basic concepts with specific focus mitochondrial function, mitROS production (mitROSp), mitDNA damage caloric restriction; autophagy; role dietary antioxidants; drug has consistently demonstrated (ITP/NIA/NIH program performed three independent laboratories) increases mammals over controls: rapamycin; heterochronic parabiosis; secondary inflammaging; epigenetics control nuclear program, hypothetical existence peripheral central clocks.

Language: Английский

Association between systemic immune-inflammation index and low muscle mass in US adults: a cross-sectional study DOI Creative Commons
Lin Shi, Liang Zhang, Dan Zhang

et al.

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: July 24, 2023

Chronic inflammatory responses have been reported to be associated with low muscle mass and systemic immune-inflammation index(SII) is a novel indicator of inflammation. The purpose our study was clarify the relationship between SII mass.This cross-sectional based on National Health Nutrition Examination Survey (2011-2018). calculated as platelet count × neutrophil count/lymphocyte count. Appendicular skeletal index used define mass. individuals were divided into four groups by quartile (Q1-Q4). Multivariate weighted logistic regression analysis, smooth curve fitting subgroup analysis investigate sarcopenia. Subgroup demographic clinical variables.There 10,367 enrolled in final analysis. overall mean age 39.39 years 49.17% males. prevalence population 8.77%. indicated near-linear In multivariate odds ratio (OR) Q4 1.28 (95% CI, 1.16-1.40) for when compared lowest SII. still increased risk independently.The levels an large population. Our understanding inflammation Anti-inflammation therapy may important

Language: Английский

Citations

30
Association between oxidative balance score and sarcopenia in US adults: NHANES 2011–2018 DOI Creative Commons

Weihang Xu,

Dongmei Mu,

Yuehui Wang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 24, 2024

Sarcopenia, a condition characterized by diminished skeletal muscle mass, strength, and function, accompanied inflammation oxidative stress, remains an area of limited exploration concerning its correlation with the Oxidative Balance Score (OBS).

Language: Английский

Citations

14
Systemic immune-inflammation index and all-cause and cause-specific mortality in sarcopenia: a study from National Health and Nutrition Examination Survey 1999-2018 DOI Creative Commons

Qing-Yue Zeng,

Qin Yu, Yi Shi

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 4, 2024

Background Sarcopenia, common in the elderly, often linked to chronic diseases, correlates with inflammation.The association between SII and mortality sarcopenia patients is underexplored, this study investigates relationship a U.S. adult cohort. Methods We analyzed 1999–2018 NHANES data, focusing on 2,974 adults sarcopenia. Mortality outcomes were determined by linking National Death Index (NDI) records up December 31, 2019. Using weighted sampling design, participants grouped into three groups Systemic Immune-Inflammation (SII). used Cox regression models, adjusting for demographic clinical variables, explore SII’s all-cause cause-specific sarcopenia, performing sensitivity analyses robustness. Results Over median follow-up of 9.2 years, 829 deaths occurred. Kaplan-Meier analysis showed significant survival differences across groups. The highest group higher hazard ratios (HRs) both crude adjusted models. had HR all-cause(1.57, 1.25–1.98), cardiovascular(1.61, 1.00–2.58), cancer(2.13, 1.32–3.44), respiratory disease mortality(3.21, 1.66–6.19) fully Subgroup revealed various demographics, including age, gender, presence diabetes or cardiovascular disease. Sensitivity analyses, excluding those who died within two years follow-up, under 45 largely reflected these results, consistently demonstrating HRs all types unadjusted Conclusion Our first demonstrate increased risks population.

Language: Английский

Citations

13
Restoring Mitochondrial Function and Muscle Satellite Cell Signaling: Remedies against Age-Related Sarcopenia DOI Creative Commons
Emanuele Marzetti, Biliana Lozanoska‐Ochser, Riccardo Calvani

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 415 - 415

Published: March 28, 2024

Sarcopenia has a complex pathophysiology that encompasses metabolic dysregulation and muscle ultrastructural changes. Among the drivers of intracellular changes fibers in sarcopenia, mitochondria their quality control pathways play relevant roles. Mononucleated stem cells/satellite cells (MSCs) have been attributed critical role repair after an injury. The involvement supporting MSC-directed is unclear. There evidence reduction mitochondrial biogenesis blunts repair, thus indicating delivery functional to injured muscles can be harnessed limit fibrosis enhance restoration function. Injection autologous respiration-competent from uninjured sites damaged tissue shown reduce infarct size cell survival preclinical models ischemia-reperfusion. Furthermore, incorporation donor into MSCs enhances lung cardiac repair. This strategy also tested for regeneration purposes traumatic injuries. Indeed, systemic promotes restores mass function while reducing during recovery In this review, we discuss contribution altered MSC sarcopenia illustrate prospect harnessing as therapeutic against age-related sarcopenia.

Language: Английский

Citations

9
Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study DOI Creative Commons
Esra Çataltepe, Eda Çeker, Ayse Fadiloglu

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 13, 2025

Chronic inflammation is increasingly recognized as a crucial contributor to sarcopenia pathogenesis, but accurate diagnosis remains challenge. Our study aims investigate the relationship between and Systemic Immune-Inflammation Index (SII), comprehensive indicator of inflammation. This cross-sectional enrolled 632 patients. All participants underwent geriatric assessment. Sarcopenia was assessed through evaluation handgrip strength calf circumference. To determine SII, we used formula: Platelet count (109/mm3)×Neutrophil (109/mm3) / Lymphocyte (109/mm3). The average age 74.8 ± 6.4, 62.3% (n = 394) were female. Patients grouped non-sarcopenic sarcopenic. group had 536 patients (84.8%), while sarcopenic comprised 96 (15.2%). Sarcopenic showed higher median SII score than (p < 0.001). Multivariate logistic regression analysis revealed that significantly independently associated with even after adjusting for potential confounding factors (β 1.002, 95% CI 1.001–1.003, p ROC identified optimal cut-off in predicting > 765. At this threshold, negative predictive values determined be 88.1%, specificity 88%. outpatient population, population-specific may serve novel, simple, practical biomarker diagnosing sarcopenia.

Language: Английский

Citations

1
Mitochondrial mechanisms in the pathogenesis of chronic inflammatory musculoskeletal disorders DOI Creative Commons
Kailun Wu,

Ju-sheng Shieh,

Ling Qin

et al.

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 8, 2024

Abstract Chronic inflammatory musculoskeletal disorders characterized by prolonged muscle inflammation, resulting in enduring pain and diminished functionality, pose significant challenges for the patients. Emerging scientific evidence points to mitochondrial malfunction as a pivotal factor contributing these ailments. Mitochondria play critical role powering skeletal activity, but context of persistent disruptions their quantity, configuration, performance have been well-documented. Various disturbances, encompassing alterations dynamics (such fission fusion), calcium regulation, oxidative stress, biogenesis, process mitophagy, are believed central progression disorders. Additionally, unfolded protein responses accumulation fatty acids within cells may adversely affect internal milieu, impairing equilibrium functioning. The structural discrepancies between different subsets namely, intramyofibrillar subsarcolemmal mitochondria likely impact metabolic capabilities susceptibility influences. release signals from damaged is known incite responses. Intriguingly, migrasomes extracellular vesicles serve vehicles intercellular transfer mitochondria, aiding removal impaired regulation inflammation. Viral infections implicated inducing stress on mitochondria. Prolonged dysfunction vital organelles sustains harm, irregularities, heightened cytokine release, impeding body’s ability repair tissues. This review provides comprehensive analysis advancements understanding changes intracellular environment, architecture distribution, dynamics, autophagy, cytokines associated with vesicular structures, membranes chronic Strategies targeting key elements regulating quality exhibit promise restoration function, alleviation enhancement overall outcomes. Graphical

Language: Английский

Citations

7
Association of composite dietary antioxidant index and muscle mass in individuals with metabolic associated fatty liver disease DOI
Jing Guo, Lin Shi, Yan Sun

et al.

Clinics and Research in Hepatology and Gastroenterology, Journal Year: 2024, Volume and Issue: 48(2), P. 102284 - 102284

Published: Jan. 15, 2024

Language: Английский

Citations

4
Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians DOI Creative Commons
Ceereena Ubaida‐Mohien, Ruin Moaddel, Sally Spendiff

et al.

Aging Cell, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Physical function declines with aging, yet there is considerable heterogeneity, some individuals declining very slowly while others experience accelerated functional decline. To gain insight into mechanisms promoting high physical we performed proteomics, targeted metabolomics, and kynurenine-focused metabolomic analyses on serum specimens from three groups of octogenarians: High-functioning master athletes (HF, n = 16), healthy normal-functioning non-athletes (NF, 12), lower functioning (LF, 11). Higher performance status was associated evidence consistent with: Lower levels circulating proinflammatory markers, as well unperturbed tryptophan metabolism, the normal kynurenic pathway; higher lysophosphatidylcholines that have been previously better mitochondrial oxidative capacity; activity integrated stress response; SASP protein members; proteins reflect neurodegeneration/denervation. Extending observations previous studies focused biomarkers aging predict poor function, our findings show many same exhibit attenuated changes in those who maintain a function. Because cross-sectional nature this study, results should be interpreted caution, bidirectional causality, where behavior both cause outcome differences biomarker changes, remains possible interpretation.

Language: Английский

Citations

0
Genetics of Female Pelvic Organ Prolapse: Up to Date DOI Creative Commons
Yuting Li, Zihan Li, Yinuo Li

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1097 - 1097

Published: Sept. 1, 2024

Pelvic organ prolapse (POP) is a benign disease characterized by the descent of pelvic organs due to weakened floor muscles and fascial tissues. Primarily affecting elderly women, POP can lead various urinary gastrointestinal tract symptoms, significantly impacting their quality life. The pathogenesis predominantly involves nerve–muscle damage disorders in extracellular matrix metabolism within floor. Recent studies have indicated that genetic factors may play crucial role this condition. Focusing on linkage analyses, single-nucleotide polymorphisms, genome-wide association studies, whole exome sequencing review consolidates current research predisposition POP. Advances epigenetics are also summarized highlighted, aiming provide theoretical recommendations for risk assessments, diagnoses, personalized treatment patients with

Language: Английский

Citations

3
Introduction to special issue on ‘physiological and evolutionary mechanisms of aging’ DOI Creative Commons
Gustavo Barja, Reinald Pamplona

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 184, P. 112324 - 112324

Published: Nov. 22, 2023

What are the structural components and physiological mechanisms determining aging process? Can different described in biology converge into a core of coordinated effectors? Why some human beings, for instance, can reach 115-122 years age while rats live at best maximum 4 years? rate be modified? How much lifespan extended? Is programmed or non-programmed This special issue includes invited articles to explore aging, both classical updated hypotheses on evolutionary meaning aging. Breakthroughs aging-related research currently unveiling longevity factors highly conserved during evolution animal species discovering details how why molecular cellular processes decline physiologically normal Investigations model organisms humans uncovering potential approaches extend not only mean individual survival but also (from here on) longevity. Experimental Gerontology presents this Special Issue (SI) highlighting recent advances mechanistic understanding longevity, interventions that lifespan. SI address most reasonably well known tries evaluate available evidence supporting opposed biological exists all?. The is composed ten peer reviewed reviews primary articles, covering basic concepts with specific focus mitochondrial function, mitROS production (mitROSp), mitDNA damage caloric restriction; autophagy; role dietary antioxidants; drug has consistently demonstrated (ITP/NIA/NIH program performed three independent laboratories) increases mammals over controls: rapamycin; heterochronic parabiosis; secondary inflammaging; epigenetics control nuclear program, hypothetical existence peripheral central clocks.

Language: Английский

Citations

2