Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 347 - 347

Published: Jan. 21, 2025

Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations

Language: Английский

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The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 16, 2024

Importance Research is beginning to elucidate the sophisticated mechanisms underlying microbiota-gut-brain-immune interface, moving from primarily animal models human studies. Findings support dynamic relationships between gut microbiota as an ecosystem (microbiome) within (host) and its intersection with host immune nervous systems. Adding this effects on epigenetic regulation of gene expression further complicates strengthens response. At heart inflammation, which manifests in a variety pathologies including neurodegenerative diseases such Alzheimer’s disease, Parkinson’s Multiple Sclerosis (MS). Observations Generally, research date limited has focused bacteria, likely due simplicity cost-effectiveness 16s rRNA sequencing, despite lower resolution inability determine functional ability/alterations. However, omits all other fungi, viruses, phages, are emerging key members microbiome. Much been done pre-clinical and/or small studies more developed parts world. The observed promising but cannot be considered reliable or generalizable at time. Specifically, causal determined currently. More followed by then little MS. data for MS encouraging this. Conclusions relevance While still nascent, interface may missing link, hampered our progress understanding, let alone preventing, managing, putting into remission diseases. Relationships must first established humans, have shown poorly translate complex physiology environments, especially when investigating microbiome where often overly simplistic. Only can robust conducted humans using mechanistic model

Language: Английский

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Mechanistic insights into connexin-mediated neuroglia crosstalk in neurodegenerative diseases

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 11, 2025

Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s (PD), Multiple Sclerosis (MS), and Huntington’s (HD), although distinct in their clinical manifestations, share a common hallmark: disrupted neuroinflammatory environment orchestrated by dysregulation of neuroglial intercellular communication. Neuroglial crosstalk is physiologically ensured extracellular mediators the activity connexins (Cxs), forming proteins gap junctions (Gjs) hemichannels (HCs), which maintain intracellular homeostasis. However, accumulating evidence suggests that Cxs can also act pathological pore conditions, thereby contributing to neurodegenerative phenomena synaptic dysfunction, oxidative stress, ultimately cell death. This review explores mechanistic insights Cxs-mediated communication progression diseases discusses therapeutic potential targeting restore cellular

Language: Английский

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The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12555 - 12555

Published: Aug. 8, 2023

This review explores the emerging role of hydrogen sulfide (H

Language: Английский

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Epidrugs in the Therapy of Central Nervous System Disorders: A Way to Drive on?

Cells, Journal Year: 2023, Volume and Issue: 12(11), P. 1464 - 1464

Published: May 24, 2023

The polygenic nature of neurological and psychiatric syndromes the significant impact environmental factors on underlying developmental, homeostatic, neuroplastic mechanisms suggest that an efficient therapy for these disorders should be a complex one. Pharmacological interventions with drugs selectively influencing epigenetic landscape (epidrugs) allow one to hit multiple targets, therefore, assumably addressing wide spectrum genetic central nervous system (CNS) disorders. aim this review is understand what fundamental pathological would optimal target epidrugs in treatment or complications. To date, use histone deacetylases DNA methyltransferase inhibitors (HDACis DNMTis) clinic focused neoplasms (mainly glial origin) based cytostatic cytotoxic actions compounds. Preclinical data show besides activity, deacetylases, methyltransferases, bromodomains, ten-eleven translocation (TET) proteins expression neuroimmune inflammation mediators (cytokines pro-apoptotic factors), neurotrophins (brain-derived neurotropic factor (BDNF) nerve growth (NGF)), ion channels, ionotropic receptors, as well pathoproteins (β-amyloid, tau protein, α-synuclein). Based profile activities, may favorable neurodegenerative diseases. For neurodevelopmental disorders, drug addiction, anxiety depression, schizophrenia, epilepsy, contemporary still require further development concerning tuning pharmacological effects, reduction toxicity, protocols. A promising strategy clarify potential targets therapeutic means cure profiling mechanisms, which have evolved upon physiological lifestyle factors, such diet physical exercise, are effective management diseases dementia.

Language: Английский

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The epigenetic modification of DNA methylation in neurological diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 23, 2024

Methylation, a key epigenetic modification, is essential for regulating gene expression and protein function without altering the DNA sequence, contributing to various biological processes, including transcription, embryonic development, cellular functions. Methylation encompasses methylation, RNA methylation histone modification. Recent research indicates that vital establishing maintaining normal brain functions by modulating high-order structure of DNA. Alterations in patterns can exert significant impacts on both function, playing role development numerous diseases, such as neurological disorders, cardiovascular diseases well cancer. Our current understanding etiology emphasizes multifaceted process includes neurodegenerative, neuroinflammatory, neurovascular events. Epigenetic modifications, especially are fundamental control critical onset progression disorders. Furthermore, we comprehensively overview mechanism processes regulation diseases. Understanding mechanisms dynamics neural provide valuable insights into human biology potentially lead novel therapies

Language: Английский

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Mechanism of KAT2A regulation of H3K36ac in manganese-induced oxidative damage to mitochondria in the nervous system and intervention by curcumin

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 273, P. 116155 - 116155

Published: Feb. 27, 2024

Excessive exposure to manganese in the environment or workplace is strongly linked neurodegeneration and cognitive impairment, but precise pathogenic mechanism preventive measures are still not fully understood. The study aimed investigate -induced oxidative damage nervous system from an epigenetic perspective, focusing on H3K36ac-dependent antioxidant pathway. Additionally, it sought examine potential of curcumin preventing manganese-induced damage. Histopathology transmission electron microscopy revealed that apoptosis necrosis neurons mitochondrial ultrastructure were observed striatum manganese-exposed rats. suppressed expression genes, leading rats' SH-SY5Y cells. With higher doses manganese, levels histone acetyltransferase lysine 2 A (KAT2A) H3K36ac level decreased. ChIP-qPCR confirmed enrichment promoter regions genes SOD2, PRDX3, TXN2 was reduced cells after exposure, decreased these genes. Overexpression KAT2A confirms attenuates by regulating levels, which turn controls cell model. Furthermore, might control influencing expression, boosting reducing In conclusion, regulation stress acetylation may be important neurotoxicity. This could achieved near region mitochondrial-associated via KAT2A. Curcumin mitigates mitochondria plays a crucial protective role injury system.

Language: Английский

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The Major Hypotheses of Alzheimer’s Disease: Related Nanotechnology-Based Approaches for Its Diagnosis and Treatment

Cells, Journal Year: 2023, Volume and Issue: 12(23), P. 2669 - 2669

Published: Nov. 21, 2023

Alzheimer’s disease (AD) is a well-known chronic neurodegenerative disorder that leads to the progressive death of brain cells, resulting in memory loss and other critical body functions. In March 2019, one major pharmaceutical companies its partners announced currently, there no drug cure AD, all clinical trials new ones have been cancelled, leaving many people without hope. However, despite clear message startling reality, research continued. Finally, last two years, Food Drug Administration (FDA) approved first-ever medications treat Alzheimer’s, aducanumab lecanemab. Despite researchers’ support this decision, are serious concerns about their effectiveness safety. The validation by Centers for Medicare Medicaid Services still pending, lecanemab was authorized considering data from phase III trials. Furthermore, numerous reports suggest patients died when undergoing extended treatment. While evidence may provide some relief those suffering impact remains topic ongoing debate within medical community. fact even though considerable efforts regarding pharmacological treatment, definitive AD has found yet. Nevertheless, it strongly believed modern nanotechnology holds promising solutions effective strategies development diagnostic tools treatments AD. This review summarizes hallmarks etiological mechanisms, challenges. It explores existing therapeutic methods potential nanotechnology-based approaches recognizing monitoring at risk irreversible neuronal degeneration. Overall, provides broad overview interested evolving areas neuroscience, related nanotechnology. With further development, offer hope millions affected devastating disease.

Language: Английский

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Unraveling the Epigenetic Landscape: Insights into Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(6), P. 553 - 553

Published: May 29, 2024

Parkinson’s disease (PD), multiple sclerosis (MS), and amyotrophic lateral (ALS) are examples of neurodegenerative movement disorders (NMDs), which defined by a gradual loss motor function that is frequently accompanied cognitive decline. Although genetic abnormalities have long been acknowledged as significant factors, new research indicates epigenetic alterations crucial for the initiation development disease. This review delves into complex interactions exist between pathophysiology NMDs mechanisms such DNA methylation, histone modifications, non-coding RNAs. Here, we examine how these changes could affect protein aggregation, neuroinflammation, gene expression patterns, thereby influencing viability functionality neurons. Through clarification terrain underpinning disorders, this seeks to enhance comprehension underlying illness augment creation innovative therapeutic strategies.

Language: Английский

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Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study

Epigenetics & Chromatin, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 30, 2025

Language: Английский

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