Polymers,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1509 - 1509
Published: March 17, 2023
The
tendency
of
population
aging
is
continuously
increasing,
which
directly
correlated
with
a
significative
number
associated
pathologies.
Several
metabolic
bone
diseases
such
as
osteoporosis
or
chronic
kidney
disease–mineral
and
disorders
involve
high
risk
fractures.
Due
to
the
specific
fragility,
bones
will
not
self-heal
supportive
treatments
are
necessary.
Implantable
substitutes,
component
tissue
engineering
(BTE)
strategy,
proved
be
an
efficient
solution
for
this
issue.
aim
study
was
develop
composites
beads
(CBs)
application
in
complex
field
BTE,
by
assembling
features
both
biomaterials’
classes:
biopolymers
(more
specific,
polysaccharides:
alginate
two
different
concentrations
guar
gum/carboxymethyl
gum)
ceramics
calcium
phosphates),
combination
described
first
time
literature.
CBs
prepared
double
crosslinking
(ionic
physically)
showed
adequate
physico-chemical
characteristics
capabilities
(morphology,
chemical
structure
composition,
mechanical
strength,
vitro
behaviour
four
acellular
simulated
body
fluids)
repair.
Moreover,
preliminary
studies
on
cell
cultures
highlighted
that
were
free
cytotoxicity
did
affect
morphology
density
cells.
results
indicated
based
higher
concentration
gum
have
superior
properties
than
those
carboxymetilated
guar,
especially
terms
fluids.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 31, 2024
Bone
defects
caused
by
tumors,
osteoarthritis,
and
osteoporosis
attract
great
attention.
Because
of
outstanding
biocompatibility,
osteogenesis
promotion,
less
secondary
infection
incidence
ratio,
stimuli-responsive
biomaterials
are
increasingly
used
to
manage
this
issue.
These
respond
certain
stimuli,
changing
their
mechanical
properties,
shape,
or
drug
release
rate
accordingly.
Thereafter,
the
activated
materials
exert
instructive
triggering
effects
on
cells
tissues,
match
properties
original
bone
establish
tight
connection
with
ambient
hard
tissue,
provide
suitable
strength.
In
review,
basic
definitions
different
categories
presented.
Moreover,
possible
mechanisms,
advanced
studies,
pros
cons
each
classification
discussed
analyzed.
This
review
aims
an
outlook
future
developments
in
biomaterials.
