Investigational New Drugs, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 26, 2024
Language: Английский
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: Nov. 27, 2023
Abstract Immunotherapies have revolutionized the treatment paradigms of various types cancers. However, most these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune checkpoint blockade, or enhancing immunostimulatory bispecific T cell engager and chimeric antigen receptor (CAR)-T cell. Although agents already achieved great success, only a tiny percentage patients could benefit from immunotherapies. Actually, immunotherapy efficacy is determined multiple components in tumor microenvironment beyond immunity. Cells innate arm system, such as macrophages, dendritic cells, myeloid-derived suppressor neutrophils, natural killer unconventional also participate cancer evasion surveillance. Considering that cornerstone antitumor response, utilizing immunity provides potential therapeutic options for control. Up to now, exploiting agonists stimulator interferon genes, CAR-macrophage -natural therapies, metabolic regulators, novel exhibited potent activities preclinical clinical studies. Here, we summarize latest insights into roles cells discuss advances arm-targeted strategies.
Language: Английский
Citations
85
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14815 - 14815
Published: Oct. 1, 2023
The epithelial–mesenchymal transition (EMT) is a cellular reprogramming process that occurs during embryonic development and adult tissue homeostasis. This involves epithelial cells acquiring mesenchymal phenotype. Through EMT, cancer acquire properties associated with more aggressive EMT its opposite, mesenchymal–epithelial (MET), have been described in tumors over the past ten years, including colorectal (CRC). When activated, expression of marker E-cadherin decreased vimentin raised. As result, temporarily take on phenotype, becoming motile promoting spread tumor cells. Epithelial–mesenchymal plasticity (EMP) has become hot issue CRC because strong inducers (such as transforming growth factor β, TGF-β) can initiate regulate metastasis, microenvironment, immune system resistance CRC. In this review, we into account significance EMT-MET impact cells’ prognosis analysis connection between stem (CCSCs) will help to further clarify current meager understandings EMT. Recent advances affecting important transcription factors CCSCs are highlighted. We come conclusion regulatory network for complicated, great deal crosstalk alternate paths. More thorough research required effectively connect clinical management biomarkers targeted treatments
Language: Английский
Citations
60
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 16, 2024
Abstract Metastasis is the leading cause of high mortality in colorectal cancer (CRC), which not only driven by changes occurring within tumor cells, but also influenced dynamic interaction between cells and components microenvironment (TME). Currently, exploration TME remodeling its impact on CRC metastasis has attracted increasing attention owing to potential uncover novel therapeutic avenues. Noteworthy, emerging studies suggested that tumor-associated macrophages (TAMs) played important roles secreting a variety cytokines, chemokines, growth factors proteases. Moreover, TAMs are often associated with poor prognosis drug resistance, making them promising targets for therapy. Given prognostic clinical value TAMs, this review provides an updated overview origin, polarization function discusses mechanisms promote metastatic cascade CRC. Potential TAM-targeting techniques personalized theranostics emphasized. Finally, future perspectives challenges translational applications development proposed help develop TAM-based strategies precision medicine holistic healthcare.
Language: Английский
Citations
22
Life, Journal Year: 2023, Volume and Issue: 13(2), P. 333 - 333
Published: Jan. 26, 2023
Prostate cancer is the most prevalent type of in senior American men. Currently, five-year survival rate after initial diagnosis prostate close to 100%. However, it also second leading cause death men due dissemination cells outside causing growth other organs, known as metastatic cancer. The tumor microenvironment (TME) plays a critical role development, progression and metastasis One major components TME contains various types immune cells, often recruited by formation areas. interactions among infiltrating affect outcome Here, we summarize mechanisms use regulate possibly lead development treatment strategies. Furthermore, information here may give rise preventative strategies that focus on targeting patients.
Language: Английский
Citations
25
Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111605 - 111605
Published: Jan. 20, 2025
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(8), P. 1122 - 1122
Published: Aug. 9, 2023
Diseases are evolving as living standards continue to improve. Cancer is the main cause of death and a major public health problem that seriously threatens human life. Colorectal cancer one top ten most common malignant tumors in China, ranking second after gastric among gastrointestinal tumors, its incidence rate increasing dramatically each year due changes dietary habits lifestyle world’s population. Although conventional therapies, such surgery, chemotherapy, radiotherapy, have profoundly impacted treatment colorectal (CRC), drug resistance toxicity remain substantial challenges. Natural products, therapeutic agents, considered safest alternative for treating CRC. In addition, there evidence natural products can induce apoptosis, inhibit cell cycle arrest, reduce invasion migration colon cells by targeting regulating expression function miRNAs. Here, we summarize recent research findings on miRNA-regulation-based antitumor mechanisms various active ingredients highlighting how target miRNA regulation prevention treatment. The application delivery systems predictive disease biomarkers also discussed. Such approaches will contribute discovery new regulatory associated with pathways provide theoretical basis developing novel drugs compounds identifying targets.
Language: Английский
Citations
14
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Sept. 11, 2024
Language: Английский
Citations
5
Cancer Immunology Immunotherapy, Journal Year: 2024, Volume and Issue: 73(4)
Published: March 2, 2024
Abstract Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment (TME). In colorectal liver metastasis (CLM), TAM morphology correlates with prognosis, smaller TAMs (S-TAMs) conferring a more favorable prognosis than larger (L-TAMs). However, metabolic profile in vivo human populations remains unknown. Multiparametric flow cytometry was used to freshly isolate S- and L-TAMs from surgically resected CLM patients ( n = 14S-, 14L-TAMs). Mass spectrometry-based metabolomics analyses were implemented for characterization populations. Gene expression analysis protein activity support biochemical effects enzyme–substrate link between riboflavin (lysine-specific demethylase 1A, LSD1) morphologies. characterized by positive correlation strong association Riboflavin both in-vitro M2 polarized modulates LSD1 activity. The inflammatory stimuli promoted TNFα induced increased transporter SLC52A3 macrophages. modulation riboflavin-LSD1 axis represents potential target reprogramming subtypes, paving way promising anti-tumor therapeutic strategies.
Language: Английский
Citations
4
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(2)
Published: March 1, 2024
The research of liver metastasis is a developing field. ability tumor cells to invade the depends on complicated interactions between metastatic and local subpopulations in (including Kupffer cells, hepatic stellate sinusoidal endothelial immune-related cells). These are mainly mediated by intercellular adhesion release cytokines. Cell populations microenvironment can play dual role progression through different mechanisms. At same time, we see participation parenchymal nonparenchymal process tumors. Therefore, purpose this article summarize relationship cellular components emphasize importance occurrence or potential regression metastasis.
Language: Английский
Citations
3
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(8)
Published: April 1, 2024
Abstract Liver metastasis (LM) is an important factor leading to colorectal cancer (CRC) mortality. However, the effect of T‐cell exhaustion on LM in CRC unclear. Single‐cell sequencing data derived from Gene Expression Omnibus database. Data were normalized using Seurat package and subsequently clustered annotated into different cell clusters. The differentiation trajectories epithelial cells T characterized based pseudo‐time analysis. Single‐sample gene set enrichment analysis (ssGSEA) was used calculate scores for clusters identify enriched biological pathways. Finally, communication performed. Nine subpopulations identified samples with LM. proportion increased can be subdivided NK/T cells, regulatory (Treg) exhausted (Tex). In LM, adhesion proliferation activity Tex promoted. Epithelial categorized six subpopulations. transformation primary involved two evolutionary branches cells. at beginning trajectory but end receptor ligands CEACAM5 ADGRE5‐CD55 played critical roles interactions between Treg cell‐epithelial cell, which may promote epithelial‐mesenchymal transition process CRC. are able CRC, turn promotes tumour development. This provides a new perspective treatment diagnosis
Language: Английский
Citations
2