Association between composite dietary antioxidant index and hyperlipidemia in adults based on the NHANES

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 18, 2025

Hyperlipidemia, a major risk factor for cardiovascular diseases, can potentially be alleviated by dietary antioxidants. This study explored the relationship between hyperlipidemia and Composite Dietary Antioxidant Index (CDAI), which measures antioxidant intake from carotenoids, selenium, zinc, vitamins A, C, E. Analyzing data 27,493 participants aged 20 older National Health Nutrition Examination Survey (NHANES) conducted 2001 2018, we used weighted regression models to assess this association while adjusting multiple covariates. Restricted cubic splines were also applied check any non-linear relationships. Findings revealed that higher CDAI scores significantly correlated with lower prevalence. Specifically, each unit increase in log-transformed was linked 14% decrease (OR = 0.86, 95% CI: 0.77-0.95). Participants top quartile had 15% prevalence compared those bottom 0.85, No significant observed (p 0.822). In conclusion, increased intake, as measured CDAI, is associated reduced hyperlipidemia, underscoring role of antioxidants its management.

Language: Английский

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Insulin–Heart Axis: Bridging Physiology to Insulin Resistance

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8369 - 8369

Published: July 31, 2024

Insulin signaling is vital for regulating cellular metabolism, growth, and survival pathways, particularly in tissues such as adipose, skeletal muscle, liver, brain. Its role the heart, however, less well-explored. The requiring significant ATP to fuel its contractile machinery, relies on insulin manage myocardial substrate supply directly affect cardiac muscle metabolism. This review investigates insulin–heart axis, focusing insulin’s multifaceted influence function, from metabolic regulation development of physiological hypertrophy. A central theme this pathophysiology resistance profound implications health. We discuss intricate molecular mechanisms by which modulates glucose fatty acid metabolism cardiomyocytes, emphasizing pivotal maintaining energy homeostasis. disrupts these processes, leading disturbances, autonomic dysfunction, subcellular abnormalities, activation renin–angiotensin–aldosterone system. These factors collectively contribute progression diabetic cardiomyopathy other cardiovascular diseases. linked hypertrophy, fibrosis, diastolic systolic heart failure, exacerbating risk coronary artery disease failure. Understanding axis crucial developing therapeutic strategies mitigate complications associated with diabetes.

Language: Английский

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Machine learning algorithms for predictive modeling of dyslipidemia-associated cardiovascular disease risk in pregnancy: a comparison of boosting, random forest, and decision tree regression

Bulletin of the National Research Centre/Bulletin of the National Research Center, Journal Year: 2025, Volume and Issue: 49(1)

Published: Jan. 9, 2025

Abstract Background Cardiovascular diseases (CVD) are major contributors to maternal mortality and morbidity during pregnancy increased atherogenic index of plasma levels is associated with a higher risk CVD obesity. Methods In this study, we utilized three different machine learning algorithms (boosting, random forest, decision tree regression) predict dyslipidemia-associated cardiovascular disease using lipid profile parameters based on cross-sectional study datasets 112 pregnant women aged between 15 49 conducted at Aminu Kano Teaching Hospital. Results The results showed that forest regression outperformed both boosting regression, recording the lowest error criteria (MSE = 0.071 RMSE 0.266) for evaluating model. These findings indicated all have potential effectively model data from indices but were found outperform models respective R 2 values 0.95 0.92. Conclusions Overall, highlights accuracy (random boosting, trees) in predicting could contribute development effective strategies prevention treatment diseases.

Language: Английский

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Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 776 - 776

Published: Feb. 23, 2025

Dyslipidemia, characterized by abnormal blood lipid levels, is a major public health concern due to its association with atherosclerotic cardiovascular disease (ASCVD) and other cardiometabolic disorders. In this context, appropriate nutrition patterns are pivotal as they represent the basic approach for providing wide range of substantial advantages. The best evidence dyslipidemia management offered Mediterranean Diet, Plant-Based High-Fiber Diet Anti-inflammatory while DASH Ketogenic have also been shown target additional pathological features like hypertension comorbidities. bioactive compounds that enriched in these able manage include monounsaturated fatty acids such ω-3, polyphenols oleuropein, resveratrol, flavonoids, catechins, carotenoids, phytosterols soluble unsoluble fibers. Diets rich can improve profile mitigating oxidative stress, reducing low-grade chronic inflammation, modulating macronutrient absorption mechanisms, thereby supporting health. Additionally, lifestyle interventions regular physical activity, weight loss, reduced alcohol consumption smoking cessation further ameliorate metabolism circulated profile. Furthermore, emerging insights from nutrigenomics underscore potential proper diet address genetic factors optimize treatment outcomes. role context implications discussed review, emphasizing evidence-based personalized approaches.

Language: Английский

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The role of hydrogen in the prevention and treatment of coronary atherosclerotic heart disease

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 972, P. 176586 - 176586

Published: April 12, 2024

Language: Английский

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The Role of Triglyceride/HDL Ratio, Triglyceride–Glucose Index, and Pan-Immune-Inflammation Value in the Differential Diagnosis of Acute Coronary Syndrome and Predicting Mortality

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4832 - 4832

Published: Aug. 16, 2024

Objectives: We aimed to evaluate the predictive importance of various clinical and laboratory parameters in differential diagnosis Acute Coronary Syndrome (ACS). Understanding these predictors is critical for improving diagnostic accuracy, guiding therapeutic decisions, ultimately enhancing patient outcomes. Methods: The study included a total 427 patients diagnosed with ACS, comprising 142 unstable angina, non-ST elevation myocardial infarction (NSTEMI), 143 ST (STEMI). data were collected from medical records treated at tertiary care hospital between January 2020 December 2024. In addition other biochemical parameters, triglyceride/HDL ratio (THR), triglyceride–glucose index (TGI), Pan-Immune-Inflammation Value (PIV) calculated compared. Results: THR, TGI, PIV, mortality rate statistically higher STEMI group (p = 0.034, p 0.031, 0.022, 0.045, respectively). risk factors found be significantly associated multiple logistic regression analysis age, cholesterol, triglycerides, diabetes mellitus, smoking, cTnI, LVEF, PIV. High THR increases (AUC 0.67, 95% CI: 0.62–0.72, 0.020). ACS 0.70, 0.65–0.75, 0.004). THRs above 3.5 are risk. Sensitivity 75% specificity 60%. TGI 0.73, 0.68–0.78, 0.007). TGIs 8.5 78% 63%. PIVs increase 0.75, 0.70–0.80, 0.009). 370 80% 65%. combination cTnI has highest capability over individual mortality. Conclusions: that PIV increase, low presence smoking have values ACS. Unlike studies literature, this first which evaluated together prediction.

Language: Английский

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Moxonidine Increases Uptake of Oxidised Low-Density Lipoprotein in Cultured Vascular Smooth Muscle Cells and Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3857 - 3857

Published: Feb. 14, 2023

This study aimed to investigate the effect of sympatholytic drug moxonidine on atherosclerosis. The effects oxidised low-density lipoprotein (LDL) uptake, inflammatory gene expression and cellular migration were investigated in vitro cultured vascular smooth muscle cells (VSMCs). atherosclerosis was measured by examining aortic arch Sudan IV staining quantifying intima-to-media ratio left common carotid artery apolipoprotein E-deficient (ApoE−/−) mice infused with angiotensin II. levels circulating lipid hydroperoxides mouse plasma ferrous oxidation-xylenol orange assay. Moxonidine administration increased LDL uptake VSMCs via activation α2 adrenoceptors. receptors efflux transporter ABCG1. inhibited mRNA genes VSMC migration. ApoE−/− (18 mg/kg/day) decreased formation artery, associated hydroperoxide levels. In conclusion, mice, which accompanied an increase VSMCs, migration, ABCG1 plasma.

Language: Английский

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The association of exposure to polychlorinated biphenyls with lipid profile and liver enzymes in umbilical cord blood samples

Chemosphere, Journal Year: 2024, Volume and Issue: 350, P. 141096 - 141096

Published: Jan. 2, 2024

Language: Английский

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Triglyceride-glucose index, symptomatic intracranial artery stenosis and recurrence risk in minor stroke patients with hypertension

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: April 19, 2023

The triglyceride-glucose (TyG) index, a simple measure of insulin resistance, is associated with intracranial atherosclerosis (ICAS) and stroke. In hypertensive populations, this association may be pronounced. aim was to investigate the relationship between TyG symptomatic (sICAS) recurrence risk in ischemic stroke patients hypertension.This prospective, multicenter cohort study included acute minor preadmission diagnosis hypertension from September 2019 November 2021 3-month follow-up. presence sICAS determined by combination clinical manifestations, location infarction, corresponding artery moderate-to-severe stenosis. ICAS burden degree number occurrences. Fasting blood glucose (FBG) triglyceride (TG) were measured calculate TyG. main outcome during 90-day Multivariate regression models used explore TyG, sICAS, recurrence.There 1281 mean age 61.6 ± 11.6 years; 70.1% male, 26.4% diagnosed sICAS. There 117 who experienced Patients categorized according quartiles After adjusting for confounders, greater (OR 1.59, 95% CI 1.04-2.43, p = 0.033) significantly higher (HR 2.02, 1.07-3.84, 0.025) fourth quartile than first quartile. restricted cubic spline (RCS) plot revealed linear threshold value 8.4. then dichotomized into low high groups threshold. combined had 2.54, 1.39-4.65) without An interaction effect on found (p 0.043).TyG significant factor patients, there synergistic recurrence.The registered 16 August at https://www.chictr.org.cn/showprojen.aspx?proj=41160 (No. ChiCTR1900025214).

Language: Английский

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Ezetimibe Loaded Nanostructured Lipid Carriers Tablets: Response Surface Methodology, In-vitro Characterization, and Pharmacokinetics Study in Rats

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 9, 2025

Language: Английский

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