Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 19, 2024
Abstract
Background
Despite
the
presence
of
evidence
indicating
a
correlation
between
Acute
Pancreatitis
(AP)
and
Major
Depressive
Disorder
(MDD),
precise
mechanisms
underlying
co-occurrence
these
two
conditions
remain
unclear.
The
aim
this
study
was
to
investigate
potential
crosstalk
genes,
pathways
immune
cell
AP
MDD.
Methods
We
downloaded
MDD
data
from
Gene
Expression
Omnibus
(GEO)
database.
Shared
genes
were
identified
using
differential
expression
analysis
weighted
gene
co-expression
network
(WGCNA).
Subsequently,
differentially
expressed
(DEGs)
analyzed
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
enrichment
analyses.
Core
screened
by
cross
overlap
WGCNA
DEGs.
sensitivity
specificity
candidate
evaluated
least
absolute
shrinkage
selection
operator
(LASSO)
regression,
receiver
operating
characteristic
(ROC)
curve
plotted.
Finally,
CIBERSORT
used
analyze
infiltration,
Spearman
cells
computed
psych
package.
Results
By
intersecting
DEGs,
TBC1D2,
SFXN,
F12
as
key
cross-talk
results
LASSO
demonstrated
that
three
core
have
significant
diagnostic
value
for
infiltration
indicated
Macrophages
M2,
M0,
memory
resting
CD4
T
cells,
B
are
crucially
involved
in
pathogenesis
Conclusion
This
represents
first
attempt
genetic
relationship
bioinformatics
tools.
TBC1D2、SFXN
most
important
Macrophages,
cells-driven
responses
may
play
an
role
association
Cells,
Journal Year:
2024,
Volume and Issue:
13(5), P. 423 - 423
Published: Feb. 28, 2024
The
involvement
of
central
and
peripheral
inflammation
in
the
pathogenesis
prognosis
major
depressive
disorder
(MDD)
has
been
demonstrated.
increase
pro-inflammatory
cytokines
(interleukin
(IL)-1β,
IL-6,
IL-18,
TNF-α)
individuals
with
depression
may
elicit
neuroinflammatory
processes
inflammation,
mechanisms
that,
turn,
can
contribute
to
gut
microbiota
dysbiosis.
Together,
neuroinflammation
dysbiosis
induce
alterations
tryptophan
metabolism,
culminating
decreased
serotonin
synthesis,
impairments
neuroplasticity-related
mechanisms,
glutamate-mediated
excitotoxicity.
This
review
aims
highlight
inflammatory
(neuroinflammation,
dysbiosis)
involved
pathophysiology
MDD
explore
novel
anti-inflammatory
therapeutic
approaches
for
this
psychiatric
disturbance.
Several
lines
evidence
have
indicated
that
addition
antidepressants,
physical
exercise,
probiotics,
nutraceuticals
(agmatine,
ascorbic
acid,
vitamin
D)
possess
effects
their
antidepressant
properties.
Further
studies
are
necessary
benefits
these
alternative
therapies
MDD.
Human & Experimental Toxicology,
Journal Year:
2023,
Volume and Issue:
42
Published: March 1, 2023
Recent
extensive
evidence
suggests
that
ambient
fine
particulate
matter
(PM2.5,
with
an
aerodynamic
diameter
≤2.5
μm)
may
be
neurotoxic
to
the
brain
and
cause
central
nervous
system
damage,
contributing
neurodevelopmental
disorders,
such
as
autism
spectrum
neurodegenerative
diseases,
Alzheimer's
disease
Parkinson's
disease,
mental
schizophrenia,
depression,
bipolar
disorder.
PM2.5
can
enter
via
various
pathways,
including
blood-brain
barrier,
olfactory
system,
gut-brain
axis,
leading
adverse
effects
on
CNS.
Studies
in
humans
animals
have
revealed
PM2.5-mediated
mechanisms,
neuroinflammation,
oxidative
stress,
systemic
inflammation,
gut
flora
dysbiosis,
play
a
crucial
role
CNS
damage.
Additionally,
exposure
induce
epigenetic
alterations,
hypomethylation
of
DNA,
which
contribute
pathogenesis
some
Through
literature
analysis,
we
suggest
promising
therapeutic
targets
for
alleviating
PM2.5-induced
neurological
damage
include
inhibiting
microglia
overactivation,
regulating
microbiota
antibiotics,
targeting
signaling
PKA/CREB/BDNF
WNT/β-catenin.
several
studies
observed
association
between
changes
neuropsychiatric
disorders.
This
review
summarizes
discusses
possible
mechanisms
by
causes
neurotoxicity.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(23), P. 16870 - 16870
Published: Nov. 28, 2023
Major
depressive
disorder
(MDD)
has
a
high
prevalence
and
is
major
contributor
to
the
global
burden
of
disease.
This
psychiatric
results
from
complex
interaction
between
environmental
genetic
factors.
In
recent
years,
role
gut
microbiota
in
brain
health
received
particular
attention,
compelling
evidence
shown
that
patients
suffering
depression
have
dysbiosis.
Several
studies
reported
dysbiosis-induced
inflammation
may
cause
and/or
contribute
development
through
dysregulation
gut-brain
axis.
Indeed,
as
consequence
dysbiosis,
neuroinflammatory
alterations
caused
by
microglial
activation
together
with
impairments
neuroplasticity
symptoms.
The
modulation
been
recognized
potential
therapeutic
strategy
for
management
MMD.
this
regard,
physical
exercise
positively
change
composition
diversity,
can
underlie,
at
least
part,
its
antidepressant
effects.
Given
this,
present
review
will
explore
relationship
exercise,
depression,
an
emphasis
on
non-invasive
modulating
and,
regulating
axis
alleviating
MDD-related
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(9), P. 1890 - 1898
Published: Dec. 14, 2023
Previous
studies
have
demonstrated
a
bidirectional
relationship
between
inflammation
and
depression.
Activation
of
the
nucleotide-binding
oligomerization
domain,
leucine-rich
repeat,
NLR
family
pyrin
domain-containing
3
(NLRP3)
inflammasomes
is
closely
related
to
pathogenesis
various
neurological
diseases.
In
patients
with
major
depressive
disorder,
NLRP3
inflammasome
levels
are
significantly
elevated.
Understanding
role
that
inflammasome-mediated
neuroinflammation
plays
in
depression
may
be
beneficial
for
future
therapeutic
strategies.
this
review,
we
aimed
elucidate
mechanisms
lead
activation
as
well
provide
insight
into
strategies
target
inflammasome.
Moreover,
outlined
inflammasome,
including
inflammatory
pathway
inhibitors,
natural
compounds,
other
compounds
been
shown
effective
treating
Additionally,
summarized
application
inhibitors
clinical
trials
Currently,
there
scarcity
dedicated
investigating
applications
treatment.
The
modulation
microglia
holds
promise
management
Further
investigations
necessary
ascertain
efficacy
safety
these
approaches
potential
novel
antidepressant
treatments.
BMC Women s Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 15, 2025
The
etiology
of
depression
involves
many
biological
and
environmental
factors,
among
which
the
inflammatory
process
is
an
important
contributor.
However,
role
pro-inflammatory
cytokines
in
postmenopausal
unclear.
Therefore,
we
aimed
to
explore
association
between
serum
concentrations
four
(IL-1β,
IL-6,
IL-18,
TNF-α)
depressive
symptoms
women
who
had
been
receiving
menopause
hormone
therapy
(MHT)
for
at
least
6
months
not
received
MHT.
This
study
included
a
total
136
Chinese
aged
40
65
years
visited
gynecology
outpatient
department
June
2020
December
2022.
They
were
divided
into
POST
group
(n
=
94)
+
MHT
42)
group.
Demographic
information
was
collected,
Hamilton
Rating
Scale
Depression
(HAMD)
used
assess
depression.
circulating
levels
IL-1β,
TNF-α
determined
using
ELISA
kits.
According
HAMD
score,
39.36%
participants
14.29%
considered
have
significantly
lower
IL-18
than
Multiple
linear
regression
analysis
showed
that
(β
3.996,
95%
CI
0.508–7.484),
4.784,
0.939–8.629)
significant
predictors
HAMD-24
scores
In
addition,
age
found
be
positively
related
with
level
0.531,
0.063–0.999).
Postmenopausal
score
as
well
did
receive
Further,
associated
