Antioxidant and anti-inflammatory effects of selenomethionine promote osteogenesis via Wnt/β-Catenin pathway DOI Creative Commons
Guodong Zhao,

Yiting Zhang,

Yinping Tian

et al.

Biochemistry and Biophysics Reports, Journal Year: 2023, Volume and Issue: 36, P. 101559 - 101559

Published: Oct. 19, 2023

Recently, the antioxidant properties of natural compound, selenomethionine (Se-Met), have been recognized. However, its effect on osteogenic mineralization Wnt/β-Catenin pathway under conditions oxidative stress and inflammation remain unclear.This study utilized tert-butyl hydroperoxide (TBHP) to simulate inflammation. Se-Met was then subsequently used inhibit these effects in vitro.TBHP induces inflammatory responses by increasing expression reactive oxygen species NLRP3, whereas decreasing GPX4, thereby inhibiting viability MC3T3-E1 cells. TBHP further promotes lipid peroxidation damages ultrastructure mitochondria. Furthermore, inhibits levels β-Catenin, reducing activity Wnt pathway, which turn suppresses differentiation capacity. Importantly, significantly alters aforementioned enhance pathway-related proteins improving capacity cells.Se-Met enhances anti-inflammatory cells via signaling promote osteogenesis. Thus, plays a crucial role field bone homeostasis, presents an opportunity for future development novel drugs treating osteoporosis maintaining stability. detailed preclinical animal studies are required generate solid reliable data aid this development.

Language: Английский

Role of NLRP3 Inflammasome in Post-Spinal-Cord-Injury Anxiety and Depression: Molecular Mechanisms and Therapeutic Implications DOI
Tahmineh Mokhtari, Kadir Uludağ

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 15(1), P. 56 - 70

Published: Dec. 18, 2023

The majority of research on the long-term effects spinal cord injury (SCI) has primarily focused neuropathic pain (NP), psychological issues, and sensorimotor impairments. Among SCI patients, mood disorders, such as anxiety depression, have been extensively studied. It found that chronic stress NP negative consequences reduce quality life for individuals living with SCI. Our review examined both human experimental evidence to explore connection between changes following inflammatory pathways, a specific focus NLRP3 inflammasome signaling. We observed increased proinflammatory factors in blood, well brain tissues models. plays crucial role various diseases by controlling release molecules like interleukin 1β (IL-1β) IL-18. Dysregulation key regions associated processing, prefrontal cortex hippocampus, contributes development disorders In this review, we summarized recent expression regulation components related signaling Finally, discussed potential therapeutic approaches target regulate cytokines way treat

Language: Английский

Citations

24
Antidepressant effects of Parishin C in chronic social defeat stress-induced depressive mice DOI
Ning Jiang,

Caihong Yao,

Yiwen Zhang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 325, P. 117891 - 117891

Published: Feb. 7, 2024

Language: Английский

Citations

9
Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats DOI Creative Commons

Zhicheng Gao,

Kangxin Luo,

Yulin Hu

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 27, 2024

Abstract Melatonin improves chronic stress-induced hippocampal damage and depression-like behaviors, but the mechanism needs further study. This study was to explore of melatonin inhibiting microglia pyroptosis. In virtro experiments, improved corticosterone-induced ultrastructure microstructure HAPI cells by pyroptosis, thereby increasing cell survival rate. Protein-protein interaction network molecular autodocking predicted that Cathespin B might be target inhibition NLRP3-mediated inhibited expression. Both Cathepsin inhibitor CA-074Me NLRP3 knockout Similarly, agonist Pazopanib-induced activation B/NLRP3 signaling pathway vivo studies, restraint stress (CRS)-induced alleviated pyroptosis in rats. Inhibition CRS-induced behaviors addition, These results demonstrated could alleviate pathway, improving reveals prevention treatment stress-related encephalopathy.

Language: Английский

Citations

9
Trends in research on novel antidepressant treatments DOI Creative Commons
Agnieszka Zelek-Molik, Ewa Litwa

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Mood disorders, such as major depressive disorder and bipolar disorder, are among the most common mental illnesses a leading cause of disability worldwide. Key symptoms these conditions include depressed mood or anhedonia, sleep psychomotor disturbances, changes in appetite weight, fatigue loss energy. Prolonged cognitive disturbances further impair ability to think concentrate often accompanied by persistent feelings worthlessness excessive guilt. Collectively, underscore depression serious, long-term global health issue. In addition, clinical studies indicate growing number patients experiencing difficulties responding treatment, even long term. This phenomenon poses significant challenges for healthcare professionals, families, alike. As result, there is an urgent need therapies that both rapid-acting safe. review aims summarize prevailing trends research on novel antidepressants, emphasizing their diversity multi-directional mechanisms action. The development drugs increasingly focused achieving high efficacy, particularly treatment-resistant depression. Such advances offer potential rapid therapeutic effects without prolonged tedious administration older generation antidepressants. Findings from using animal models continue play crucial role predicting designing new strategies. These remain indispensable understanding physiological newly developed compounds, thereby guiding creation innovative treatments.

Language: Английский

Citations

1
A brain-targeted and ROS-responsive natural polysaccharide nanogel for enhancing antidepressant therapy DOI
Dong Xu,

Tao Qiao,

Yan-Ming Zhou

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160719 - 160719

Published: Feb. 1, 2025

Language: Английский

Citations

1
Medicinal chemistry strategies targeting NLRP3 inflammasome pathway: A recent update from 2019 to mid-2023 DOI

Meibo Duan,

Lei Sun, Xinzi He

et al.

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 260, P. 115750 - 115750

Published: Aug. 23, 2023

Language: Английский

Citations

17
Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases DOI Creative Commons
Wen-xi Sun, Ancha Baranova, Dongming Liu

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 27, 2024

The high comorbidity of major depressive disorder (MDD) with other diseases has been well-documented. However, the pairwise causal connections for MDD comorbid networks are poorly characterized. We performed Phenome-wide Mendelian randomization (MR) analyses to explore bidirectional associations between (N = 807,553) and 877 common from FinnGen datasets 377,277). inverse variance weighting method was primary technique, methods (weighted median MR-Egger) were used sensitivity analyses. Our MR showed that genetic liability is causally associated risks 324 disease phenotypes (average b: 0.339), including 46 psychiatric behavioral disorders 0.618), 18 neurological 0.348), 44 respiratory 0.345), 40 digestive 0.281), circulatory 0.237), 37 genitourinary 0.271), 66 musculoskeletal connective 0.326), 22 endocrine 0.302), others. In a reverse analysis, total 51 components predisposing various risk 0.086), 5 infectious 0.056), 11 0.106), 14 oncological 0.108), 0.114). Bidirectional identified 15 diseases. For most analyses, little evidence heterogeneity pleiotropy detected. findings confirmed extensive significant role predisposition in contributing human phenotypes, which more pronounced than those seen analysis influences on MDD.

Language: Английский

Citations

7
Exo-miR-144-3p as a promising diagnostic biomarker for depressive symptoms in heart failure DOI Creative Commons

Ruting Wang,

Kai Huang, Yuehua Feng

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106415 - 106415

Published: Jan. 1, 2024

The prevalence of depression is higher in heart failure (HF) patients. Early screening depressive symptoms HF patients and timely intervention can help improve patients' quality life prognosis. This study aims to explore biomarkers for disease diagnosis by examining the expression profile serum exosomal miRNAs with symptoms. Serum RNA was isolated extracted from 6 (HF-DS) without (HF-NDS). High-throughput sequencing performed obtain miRNA profiles target genes were predicted screened differentially expressed miRNAs. Biological functions analyzed through Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG). Subsequently, we collected RNAs HF-DS (n = 20) HF-NDS 20). selected results validated using reverse transcription quantitative polymerase chain reaction (RT-qPCR). Finally, diagnostic efficacy predicting evaluated receiver operating characteristic (ROC) curves. A total 19 significantly high-throughput sequencing, consisting 12 up-regulated 7 down-regulated RT-qPCR validation demonstrated that level exo-miR-144-3p group, levels exo-miR-625-3p exo-miR-7856-5p up-regulated. negatively correlated severity patients, area under curve (AUC) diagnosing 0.763. In this study, examined found lower associated more severe Exo-miR-144-3p a potential biomarker

Language: Английский

Citations

5
Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography DOI Creative Commons
Eric Mayor

Frontiers in Aging, Journal Year: 2023, Volume and Issue: 4

Published: June 1, 2023

In the last decades, important progress has been achieved in understanding of neurotrophic effects intermittent fasting (IF), calorie restriction (CR) and exercise. Improved neuroprotection, synaptic plasticity adult neurogenesis (NSPAN) are essential examples these effects. The importance this respect metabolic switch from glucose to ketone bodies as cellular fuel highlighted. More recently, mimetics (CRMs; resveratrol other polyphenols particular) have investigated thoroughly relation NSPAN. narrative review sections manuscript, recent findings on functions synthesized most molecules involved presented. researched signaling pathways (PI3K, Akt, mTOR, AMPK, GSK3β, ULK, MAPK, PGC-1α, NF-κB, sirtuins, Notch, Sonic hedgehog Wnt) processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart then briefly This provides an accessible entry point literature. annotated bibliography section contribution, brief summaries provided about 30 literature reviews relating interest IF, CR, CRMs Most selected address perspective healthier aging (sometimes discussing epigenetic factors) reduction risk for neurodegenerative diseases (Alzheimer’s disease, Huntington’s Parkinson’s disease) depression improvement cognitive function.

Language: Английский

Citations

13
Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression DOI Creative Commons
Qiu-Qin Han, Wenhui Li, Peiqing Chen

et al.

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(9), P. 1890 - 1898

Published: Dec. 14, 2023

Previous studies have demonstrated a bidirectional relationship between inflammation and depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat, NLR family pyrin domain-containing 3 (NLRP3) inflammasomes is closely related to pathogenesis various neurological diseases. In patients with major depressive disorder, NLRP3 inflammasome levels are significantly elevated. Understanding role that inflammasome-mediated neuroinflammation plays in depression may be beneficial for future therapeutic strategies. this review, we aimed elucidate mechanisms lead activation as well provide insight into strategies target inflammasome. Moreover, outlined inflammasome, including inflammatory pathway inhibitors, natural compounds, other compounds been shown effective treating Additionally, summarized application inhibitors clinical trials Currently, there scarcity dedicated investigating applications treatment. The modulation microglia holds promise management Further investigations necessary ascertain efficacy safety these approaches potential novel antidepressant treatments.

Language: Английский

Citations

13