Effectiveness of Fecal Microbiota Transplantation in Nociplastic Pain Management: A Systematic Review DOI Creative Commons
Sebastián Eustaquio Martín Pérez,

Hakim Al Lal Abdel Lah,

Nelda Garcia

et al.

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 5 - 5

Published: Jan. 8, 2025

Nociplastic pain, commonly observed in conditions such as Fibromyalgia, chronic fatigue syndrome, and irritable bowel arises from altered central pain processing involves complex mechanisms, including interactions between the gut–brain axis immune dysregulation. Conventional therapies often fail to address this type of effectively, leading interest alternative approaches fecal microbiota transplantation. This technique has been proposed restore gut microbial balance modulate systemic inflammation, neuroinflammation, neurotransmitter signaling. systematic review, conducted according Preferred Reporting Items for Systematic Reviews Meta-analyses guidelines registered International Prospective Register (CRD42024611939), evaluated 13 studies with n = 409 participants, clinical trials, case reports, retrospective analyses. A quality assessment was performed using appraisal tools Cochrane RoB 2, ROBINS-I, NOS, CARE. The results suggest that transplantation may reduce intensity improve life, particularly patients Fibromyalgia syndrome. However, outcomes Chronic Fatigue Syndrome psoriatic arthritis were inconsistent limited by methodological flaws, small sample sizes, variability protocols donor selection. Although adverse events minimal, current evidence is insufficient support widespread use. High-quality, standardized are needed confirm efficacy Until then, its application should remain experimental interpreted caution.

Language: Английский

MicroRNAs and MAPKs: Evidence of These Molecular Interactions in Alzheimer’s Disease DOI Open Access
Ivana Raffaele, Serena Silvestro, Emanuela Mazzon

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4736 - 4736

Published: March 1, 2023

Alzheimer's disease (AD) is a neurodegenerative disorder known to be the leading cause of dementia worldwide. Many microRNAs (miRNAs) were found deregulated in brain or blood AD patients, suggesting possible key role different stages neurodegeneration. In particular, mitogen-activated protein kinases (MAPK) signaling can impaired by miRNA dysregulation during AD. Indeed, aberrant MAPK pathway may facilitate development amyloid-beta (Aβ) and Tau pathology, oxidative stress, neuroinflammation, cell death. The aim this review was describe molecular interactions between miRNAs MAPKs pathogenesis selecting evidence from experimental models. Publications ranging 2010 2023 considered, based on PubMed Web Science databases. According obtained data, several deregulations regulate conversely. Moreover, overexpressing silencing involved regulation seen improve cognitive deficits animal miR-132 particular interest due its neuroprotective functions inhibiting Aβ depositions, as well through ERK/MAPK1 modulation. However, further investigations are required confirm implement these promising results.

Language: Английский

Citations

21
Pathogenesis and therapy of radiation enteritis with gut microbiota DOI Creative Commons
Qilin Yang,

Bingzhi Qin,

Weiliang Hou

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 31, 2023

Radiotherapy is widely used in clinic due to its good effect for cancer treatment. But radiotherapy of malignant tumors the abdomen and pelvis easy cause radiation enteritis complications. Gastrointestinal tract contains numerous microbes, most which are mutualistic relationship with host. Abdominal results gut microbiota dysbiosis. Microbial therapy can directly target reverse dysbiosis, hence relieving intestinal inflammation. In this review, we mainly summarized pathogenesis novel radiation-induced injury dysbiosis envision opportunities challenges therapy.

Language: Английский

Citations

19
Deciphering the intricate linkage between the gut microbiota and Alzheimer's disease: Elucidating mechanistic pathways promising therapeutic strategies DOI Creative Commons
Junyi Liang,

Yueyang Wang,

Bin Liu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(4)

Published: April 1, 2024

Abstract Background The gut microbiome is composed of various microorganisms such as bacteria, fungi, and protozoa, constitutes an important part the human gut. Its composition closely related to health disease. Alzheimer's disease (AD) a neurodegenerative whose underlying mechanism has not been fully elucidated. Recent research shown that there are significant differences in microbiota between AD patients healthy individuals. Changes may lead development harmful factors associated with AD. In addition, play role progression through gut–brain axis. However, exact nature this relationship understood. Aims This review will elucidate types functions their explore depth potential mechanisms occurrence prospects for treatment strategies. Methods Reviewed literature from PubMed Web Science using key terminologies microbiome. Results Research indicates can directly or indirectly influence metabolites, endotoxins, vagus nerve. Discussion discusses future challenges directions regarding Conclusion While many unresolved issues remain AD, feasibility immense treating by modulating evident.

Language: Английский

Citations

8
Probiotics and the microbiota-gut-brain axis in neurodegeneration: Beneficial effects and mechanistic insights DOI
Fatemeh Taghizadeh Ghassab,

Fatemeh Shamlou Mahmoudi,

Reyhaneh Taheri Tinjani

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 350, P. 122748 - 122748

Published: June 5, 2024

Language: Английский

Citations

7
The gastrointestinal tract and Parkinson’s disease DOI Creative Commons

Alissa S. Higinbotham,

Camilla Kilbane

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 15, 2024

Parkinson's disease (PD) is the second most common (De Lau and Breteler, 2006) rapidly rising neurodegenerative in world (GBD 2016 collaborators, 2018); population of patients living with PD expected to double over next twenty years (Dorsey et al., 2018). The incidence prevalence not fully understood, but factors such as prolonged survival, reduced rates smoking, exposures environmental pollutants toxins likely contribute (Bloem 2021).The pathological hallmark idiopathic Lewy body, a neuronal inclusion largely composed aggregated alpha synuclein substantia nigra pars compacta dopaminergic neurons other brain regions (Koga 2021). Clinically, characterized by bradykinesia plus resting tremor, rigidity, and/or postural instability according United Kingdom Disease Society Brain Bank criteria (Gibb Lees, 1988). preceded prodromal period that often associated development "non-motor symptoms" (Table 1). Non-motor symptoms include hyposmia, sleep disorders, rapid eye movement (REM) behavior disorder, mood changes, autonomic nervous system involvement, pain syndromes, cognitive changes (Kalia Lang, 2015). While both motor non-motor disability, negative impact on perceived quality life was found be larger for (Santos-Garcia de la Fuente-Fernandez, 2013).

Language: Английский

Citations

6
The potential of the gut microbiome for identifying Alzheimer’s disease diagnostic biomarkers and future therapies DOI Creative Commons
Yu Zhan, Murad Al‐Nusaif, Cong Ding

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: April 27, 2023

Being isolated from the peripheral system by blood–brain barrier, brain has long been considered a completely impervious tissue. However, recent findings show that gut microbiome (GM) influences gastrointestinal and disorders such as Alzheimer’s disease (AD). Despite several hypotheses, neuroinflammation, tau hyperphosphorylation, amyloid plaques, neurofibrillary tangles, oxidative stress, being proposed to explain origin progression of AD, pathogenesis remains incompletely understood. Epigenetic, molecular, pathological studies suggest GM AD development have endeavored find predictive, sensitive, non-invasive, accurate biomarkers for early diagnosis monitoring progression. Given growing interest in involvement current research endeavors identify prospective both preclinical clinical diagnoses, well targeted therapy techniques. Here, we discuss most on changes microbiome-based biomarkers, diagnostic uses, approaches. Furthermore, addressed herbal components, which could provide new venue research.

Language: Английский

Citations

15
Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues DOI Creative Commons
Junyi Liang,

Bin Liu,

Xiaohong Dong

et al.

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Sept. 18, 2023

Alzheimer’s disease (AD) emerges as a perturbing neurodegenerative malady, with profound comprehension of its underlying pathogenic mechanisms continuing to evade our intellectual grasp. Within the intricate tapestry human health and affliction, enteric microbial consortium, ensconced within milieu gastrointestinal tract, assumes role cardinal significance. Recent epochs have borne witness investigations that posit marked divergences in composition gut microbiota between individuals grappling AD those favored by robust health. The composite vicissitudes configuration assembly are posited choreograph participatory inception progression AD, facilitated conduit acknowledged gut-brain axis. Notwithstanding, precise nature this interlaced relationship remains enshrouded recesses obscurity, poised for an exhaustive revelation. This review embarks upon endeavor focalize meticulously mechanistic sway exerted plunging profoundly into execution interventions govern microorganisms. In doing so, it bestows relevance therapeutic stratagems form bedrock AD’s management, all whilst casting prospective gaze horizon medical advancements.

Language: Английский

Citations

14
Gut Microbial Metabolome and Dysbiosis in Neurodegenerative Diseases: Psychobiotics and Fecal Microbiota Transplantation as a Therapeutic Approach—A Comprehensive Narrative Review DOI Open Access
Sara Uceda, Víctor Echeverry‐Alzate, Manuel Reiriz

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13294 - 13294

Published: Aug. 27, 2023

The comprehensive narrative review conducted in this study delves into the mechanisms of communication and action at molecular level human organism. addresses complex mechanism involved microbiota-gut-brain axis as well implications alterations microbial composition patients with neurodegenerative diseases. pathophysiology diseases neuronal loss or death is analyzed, main metabolites bidirectional through axis. In addition, interventions targeting gut microbiota restructuring fecal transplantation use psychobiotics-pre- pro-biotics-are evaluated an opportunity to reduce symptomatology associated neurodegeneration these pathologies. This provides valuable information facilitates a better understanding neurobiological be addressed treatment

Language: Английский

Citations

13
The molecular interplay between human and bacterial amyloids: Implications in neurodegenerative diseases DOI
Neha Jain

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Journal Year: 2024, Volume and Issue: 1872(4), P. 141018 - 141018

Published: April 17, 2024

Language: Английский

Citations

5
Blood-derived factors to brain communication in brain diseases DOI Creative Commons

Jiachen He,

Yanming Zhang, Yansu Guo

et al.

Science Bulletin, Journal Year: 2024, Volume and Issue: 69(22), P. 3618 - 3632

Published: Sept. 20, 2024

Brain diseases, mainly including acute brain injuries, neurodegenerative and mental disorders, have posed a significant threat to human health worldwide. Due the limited regenerative capability existence of blood-brain barrier, was previously thought be separated from rest body. Currently, various cross-talks between central nervous system peripheral organs been widely described, brain-gut axis, brain-liver brain-skeletal muscle brain-bone axis. Moreover, several lines evidence indicate that leveraging systemic biology intervention approaches, but not lifestyle interventions, exercise, diet, blood administration, immune responses, demonstrated influence on progress prognosis diseases. The advancement innovative proteomic transcriptomic technologies has enriched our understanding nuanced interplay An array novel or underappreciated blood-derived factors identified play pivotal roles in mediating these communications. In this review, we provide comprehensive summary blood-to-brain communication following Special attention is given instrumental role signals, positing them as contributors complex process insights presented here aim bridge current knowledge gaps inspire therapeutic strategies for

Language: Английский

Citations

5