Ausdauer: Mikrozirkulation, aerober Energiestoffwechsel, Sarkopenie, Schmerzen DOI

Wolfgang Laube

Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 135 - 224

Published: Jan. 1, 2023

Therapeutic targeting of obesity-induced neuroinflammation and neurodegeneration DOI Creative Commons
Jialiu Zeng,

Lenny Yi Tong Cheong,

Chih Hung Lo

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

Obesity is a major modifiable risk factor leading to neuroinflammation and neurodegeneration. Excessive fat storage in obesity promotes the progressive infiltration of immune cells into adipose tissue, resulting release pro-inflammatory factors such as cytokines adipokines. These inflammatory mediators circulate through bloodstream, propagating inflammation both periphery central nervous system. Gut dysbiosis, which results leaky intestinal barrier, exacerbates plays significant role linking pathogenesis neurodegeneration gut-brain/gut-brain-liver axis. Inflammatory states within brain can lead insulin resistance, mitochondrial dysfunction, autolysosomal increased oxidative stress. disruptions impair normal neuronal function subsequently cognitive decline motor deficits, similar pathologies observed neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, Parkinson's disease. Understanding underlying disease mechanisms crucial for developing therapeutic strategies address defects these metabolic pathways. In this review, we summarize provide insights different strategies, methods alter gut lifestyle changes, dietary supplementation, well pharmacological agents derived from natural sources, that target obesity-induced

Language: Английский

Citations

3
Roles of SIRT3 in cardiovascular and neurodegenerative diseases DOI
Liang Chen, Anqi Zhao, Ying Li

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102654 - 102654

Published: Jan. 1, 2025

Language: Английский

Citations

2
Gastrodin alleviates mitochondrial dysfunction by regulating SIRT3-mediated TFAM acetylation in vascular dementia DOI
Yongxin Chen, Hong Yang,

Da-song Wang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155369 - 155369

Published: Jan. 21, 2024

Language: Английский

Citations

12
Oroxylin A suppress LL-37 generated rosacea-like skin inflammation through the modulation of SIRT3-SOD2-NF-κB signaling pathway DOI

Chunmei Feng,

Haiyan Zhang, Peiru Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 129, P. 111636 - 111636

Published: Feb. 15, 2024

Language: Английский

Citations

5
A new andrographolide derivative ADA targeting SIRT3-FOXO3a signaling mitigates cognitive impairment by activating mitophagy and inhibiting neuroinflammation in Apoe4 mice DOI

Yunfeng Zhou,

Qian Zhao, Yixuan Zhang

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 124, P. 155298 - 155298

Published: Dec. 17, 2023

Language: Английский

Citations

13
Lycium barbarum glycopeptide attenuates intracerebral hemorrhage-induced inflammation and oxidative stress via activation of the Sirt3 signaling pathway DOI
Changsheng Ma, Bo Han,

Shu-Chen Meng

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114518 - 114518

Published: March 30, 2025

Language: Английский

Citations

0
Luteolin attenuates trimethyltin chloride-induced hippocampal neurotoxicity through SIRT3/NRF2/HO-1 activation DOI

Ning Ding,

Pengyu Wang, Fang Yu

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110461 - 110461

Published: April 1, 2025

Language: Английский

Citations

0
Assessment of biomarkers in biological fluids and neuroimaging changes in patients with Alzheimer’s disease and glaucoma DOI
А Н Боголепова, E V Makhnovich, Е. А. Коваленко

et al.

Published: March 30, 2025

Language: Английский

Citations

0
Melatonin modulates the Notch1 signaling pathway and Sirt3 in the hippocampus of hypoxic-ischemic neonatal rats DOI Creative Commons
Atefeh Mohammadi, Walter Balduini, Silvia Carloni

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 23, 2024

The Notch1 signaling pathway plays a crucial role in the development of central nervous system, governing pivotal functional activities brain, such as neurogenesis. Sirt3 is instrumental managing mitochondrial homeostasis and essential to cell survival. Dysregulation these pathways implicated pathogenesis wide range diseases, including neurodegenerative disorders stroke. We have previously shown that melatonin significantly improved perinatal brain damage caused by hypoxia-ischemia (HI) through activation several protective mechanisms restoring mitochondria status increasing hippocampal proliferation. This study assessed whether affects after neonatal HI. Results show HI increased expression both neurons glial cells well key proteins NICD, HES1, c-Myc. Melatonin prevented induced HI, maintaining NICD HES1 control levels. In same neurons, also prevents depletion summary, this provides new insights into effects on vivo ischemia. suggest rapid modulation may support neuronal survival during

Language: Английский

Citations

3
A review on SIRT3 and its natural small molecule activators as a potential Preventive and therapeutic target DOI
Yuanyuan Liu, Haidong Wei, Jianhong Li

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 963, P. 176155 - 176155

Published: Oct. 31, 2023

Language: Английский

Citations

7