Journal of Dental Sciences,
Journal Year:
2024,
Volume and Issue:
19(3), P. 1320 - 1327
Published: May 18, 2024
Oral
Lichen
Planus
(OLP)
presents
a
significant
challenge
in
diagnosis
due
to
its
varied
clinical
manifestations
and
the
absence
of
specific
biomarkers.
Timely
accurate
is
crucial,
particularly
given
association
with
oral
squamous
cell
carcinoma
(OSCC).
This
review
aims
explore
potential
role
exosomes,
small
extracellular
vesicles,
pathogenesis
OLP
their
utility
as
diagnostic
Exosomes
facilitate
exchange
information
between
cells
modulate
immune
responses
by
carrying
various
bioactive
molecules
such
proteins,
lipids,
nucleic
acids.
In
context
OLP,
exosomes
derived
from
affected
tissues
or
are
thought
contribute
disease
progression
mediating
transfer
pro-inflammatory
molecules,
including
cytokines
like
interleukin-6
tumour
necrosis
factor-alpha
chemokines
CCL2,
CCL5
microRNAs
miR-155,
miR-146a,
miR-21,
miR-34a,
etc.
Additionally,
distinct
molecular
contents
lesions
may
accurately
represent
pathological
changes
occurring
these
tissues.
suggests
be
used
non-invasive
biomarkers
for
diagnosing
tracking
disease.
Understanding
microenvironment
within
this
critical
advancing
our
knowledge
identifying
new
therapeutic
strategies.
However,
challenges
remain
characterising
translation.
Further
research
warranted
address
fully
exploit
exosomes'
other
inflammatory
diseases.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(32), P. 22193 - 22207
Published: July 4, 2024
Glycans
cover
the
cell
surface
to
form
glycocalyx,
which
governs
a
myriad
of
biological
phenomena.
However,
understanding
and
regulating
glycan
functions
is
extremely
challenging
due
large
number
heterogeneous
glycans
that
engage
in
intricate
interaction
networks
with
diverse
biomolecules.
Glycocalyx-editing
techniques
offer
potent
tools
probe
their
functions.
In
this
study,
we
devised
HaloTag-based
technique
for
manipulation,
enables
introduction
chemically
synthesized
onto
specific
protein
(protein
interest,
POI)
concurrently
incorporates
fluorescent
units
attach
homogeneous,
well-defined
fluorescence-labeled
POIs.
Leveraging
glycan-display
system,
investigated
influence
interactions
between
Gal-3
various
Journal of Biological Chemistry,
Journal Year:
2024,
Volume and Issue:
300(4), P. 107170 - 107170
Published: March 15, 2024
Intercellular
miRNA
exchange
acts
as
a
key
mechanism
to
control
gene
expression
post-transcriptionally
in
mammalian
cells.
Regulated
export
of
repressive
miRNAs
allows
the
inflammatory
cytokines
activated
macrophages.
Intracellular
trafficking
from
endoplasmic
reticulum
endosomes
is
rate
determining
step
process
and
plays
an
important
role
controlling
cellular
levels
processes
We
have
identified
SNARE
protein
Syntaxin5
(STX5)
show
synchronized
pattern
with
activity
loss
macrophage
STX5
both
necessary
sufficient
for
activation
clearance
intracellular
pathogen
Leishmania
donovani
infected
Exploring
how
immunostimulant,
we
de
novo
RNA
binding
property
this
that
binds
specific
facilitates
their
accumulation
cooperative
manner
human
ELAVL1
HuR
(Human
antigen
R).
This
ensures
miRNA-repressed
cytokines.
Conversely,
its
dual
export,
prevents
lysosomal
targeting
by
enhancing
fusion
miRNA-loaded
plasma
membrane
ensure
accelerated
release
extracellular
vesicles
associated
miRNAs.
Journal of Dental Sciences,
Journal Year:
2024,
Volume and Issue:
19(3), P. 1320 - 1327
Published: May 18, 2024
Oral
Lichen
Planus
(OLP)
presents
a
significant
challenge
in
diagnosis
due
to
its
varied
clinical
manifestations
and
the
absence
of
specific
biomarkers.
Timely
accurate
is
crucial,
particularly
given
association
with
oral
squamous
cell
carcinoma
(OSCC).
This
review
aims
explore
potential
role
exosomes,
small
extracellular
vesicles,
pathogenesis
OLP
their
utility
as
diagnostic
Exosomes
facilitate
exchange
information
between
cells
modulate
immune
responses
by
carrying
various
bioactive
molecules
such
proteins,
lipids,
nucleic
acids.
In
context
OLP,
exosomes
derived
from
affected
tissues
or
are
thought
contribute
disease
progression
mediating
transfer
pro-inflammatory
molecules,
including
cytokines
like
interleukin-6
tumour
necrosis
factor-alpha
chemokines
CCL2,
CCL5
microRNAs
miR-155,
miR-146a,
miR-21,
miR-34a,
etc.
Additionally,
distinct
molecular
contents
lesions
may
accurately
represent
pathological
changes
occurring
these
tissues.
suggests
be
used
non-invasive
biomarkers
for
diagnosing
tracking
disease.
Understanding
microenvironment
within
this
critical
advancing
our
knowledge
identifying
new
therapeutic
strategies.
However,
challenges
remain
characterising
translation.
Further
research
warranted
address
fully
exploit
exosomes'
other
inflammatory
diseases.
