Drug repurposing for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: April 18, 2024

Abstract Cancer, a complex and multifactorial disease, presents significant challenge to global health. Despite advances in surgical, radiotherapeutic immunological approaches, which have improved cancer treatment outcomes, drug therapy continues serve as key therapeutic strategy. However, the clinical efficacy of is often constrained by resistance severe toxic side effects, thus there remains critical need develop novel therapeutics. One promising strategy that has received widespread attention recent years repurposing: identification new applications for existing, clinically approved drugs. Drug repurposing possesses several inherent advantages context since repurposed drugs are typically cost-effective, proven be safe, can significantly expedite development process due their already established safety profiles. In light this, present review offers comprehensive overview various methods employed repurposing, specifically focusing on treat cancer. We describe antitumor properties candidate drugs, discuss detail how they target both hallmarks tumor cells surrounding microenvironment. addition, we examine innovative integrating with nanotechnology enhance topical delivery. also emphasize role play when used part combination regimen. To conclude, outline challenges associated consider future prospects these transitioning into application.

Language: Английский

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Role of natural products in tumor therapy from basic research and clinical perspectives

Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(2)

Published: Jan. 1, 2024

Cancer is the leading cause of morbidity and mortality worldwide an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally increasing numbers natural approved for clinical studies involving cancer recent years. To gain more insight into that have undergone trials treatment, a comprehensive search was conducted. The https://clinicaltrials.gov website searched relevant product information up December 2022. terms included different types cancers, such as colorectal, lung, breast, gynecologic, kidney, bladder, melanoma, pancreatic, hepatocellular, gastric haematologic. Then, PubMed Web Science were articles February 2024. Hence, we listed existing about used treatment cancers discussed preclinical some promising their targets, indications, underlying mechanisms action. Our intent provide basic readers who interested or majoring obtain deeper understanding progress actions

Language: Английский

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Procyanidin B2: A promising multi-functional food-derived pigment for human diseases

Food Chemistry, Journal Year: 2023, Volume and Issue: 420, P. 136101 - 136101

Published: April 7, 2023

Language: Английский

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Revolutionizing Mushroom processing: Innovative techniques and technologies

Food Chemistry X, Journal Year: 2024, Volume and Issue: 23, P. 101774 - 101774

Published: Aug. 25, 2024

In recent years, the global mushroom industry has seen remarkable growth due to its nutritional benefits, increasing market value, and rising consumer demand. Mushrooms are valued for their unique flavor, low sugar salt, rich Vitamin D content. India as well across globe, cultivation is becoming increasingly popular among new entrepreneurs, leveraging diverse agro-climatic conditions substantial agricultural waste. Various government policies also fostering research development in this sector. To extend shelf life preserve quality, various preservation techniques employed, including drying, freezing, canning, high-pressure processing modified atmosphere packaging. Furthermore, cutting-edge technologies such nuclear magnetic resonance spectroscopy improving post-harvest processing, helping maintain sensory properties Automation transforming by enhancing efficiency scalability. This review examines innovative methods driving advancements production quality worldwide.

Language: Английский

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Optimizing CRISPR/Cas9 precision: Mitigating off-target effects for safe integration with photodynamic and stem cell therapies in cancer treatment

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117516 - 117516

Published: Sept. 26, 2024

Language: Английский

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Overcoming challenges in cancer treatment: Nano‐enabled photodynamic therapy as a viable solution

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 1, 2024

Abstract Cancer presents a formidable challenge, necessitating innovative therapies that maximize effectiveness while minimizing harm to healthy tissues. Nanotechnology has emerged as transformative force in cancer treatment, particularly through nano‐enabled photodynamic therapy (NE‐PDT), which leverages precise and targeted interventions. NE‐PDT capitalizes on photosensitizers activated by light generate reactive oxygen species (ROS) initiate apoptotic pathways cells. Nanoparticle enhancements optimize this process, improving drug delivery, selectivity, ROS production within tumors. This review dissects NE‐PDT's mechanistic framework, showcasing its potential harness apoptosis potent tool therapy. Furthermore, the explores synergy between complementary treatments like chemotherapy, immunotherapy, therapies, highlighting amplify responses, enhance immune recognition of cells, inhibit resistance mechanisms. Preclinical clinical advancements demonstrate efficacy across various types. Challenges translating into practice are also addressed, emphasizing need for optimizing nanoparticle design, refining dosimetry, ensuring long‐term safety. Ultimately, represents promising approach therapy, utilizing intricate mechanisms address therapeutic hurdles. The underscores importance understanding interplay nanoparticles, generation, pathways, contributing deeper comprehension biology novel strategies. As interdisciplinary collaborations continue thrive, offers hope effective interventions, where manipulation becomes central conquering cancer. article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease

Language: Английский

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Anticancer perspectives of genistein: a comprehensive review

International Journal of Food Properties, Journal Year: 2023, Volume and Issue: 26(2), P. 3305 - 3341

Published: Nov. 27, 2023

There is a significant load of degenerative and chronic illnesses, especially cancer, which one the main reasons for morbidity death globally. Polyphenolic phytochemicals found in many plant diets have been shown epidemiologic preclinical studies to chemopreventive activities against numerous cancer types. As result, there growing interest possible medicines derived from natural compounds, such as polyphenols, may provide novel, cost-effective way reduce global burden. Various researchers link between soy-rich diet tumor avoidance, has linked existence genistein, phenolic component soy-based diets. Genistein controlled strong anti-inflammatory actions through blocking different signaling pathways (PGs) Prostaglandins, pro-inflammatory (ROS) reactive oxygen species cytokines, (iNOS) inducible nitric oxide synthase (NF-κB) nuclear factor kappa-B. Furthermore, therapeutic effects genistein conveyed various pathological situations modifying intracellular paths Akt, mTOR, PI3K, PPARγ, NF-κB, Nrf2 AMPK. works chemotherapeutic drug several cancers, primarily cell cycle, apoptosis, angiogenesis, well limiting metastasis. also exhibits synergistic attitude with renowned anticancer including adriamycin, tamoxifen docetaxel indicating role grouping treatment. The study presents recent data available on genistein's beneficial forms cancers.

Language: Английский

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Nano‐phototherapy: Favorable prospects for cancer treatment

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2023, Volume and Issue: 16(1)

Published: Sept. 26, 2023

Abstract Nanotechnology‐based phototherapies have drawn interest in the fight against cancer because of its noninvasiveness, high flexibility, and precision terms targeting drug delivery based on surface properties size. Phototherapy has made remarkable development recent decades. Approaches to phototherapy, which utilize nanomaterials or nanotechnology emerged contribute advances around nanotechnologies medicine, particularly for cancers. A brief overviews photodynamic therapy as well mechanism treatment is provided. We emphasize design novel nanoparticles utilized while summarizing representative progress during years. Finally, forecast important future research this area, we examine viability promise systems clinical anticancer applications briefly make mention elimination all reactive metabolites pertaining nano formulations inside living organisms providing insight into mechanistic processes. Future developments therapeutic prospects treatments are anticipated. Our viewpoints might encourage scientists create more potent phototherapy‐based modalities. This article categorized under: Therapeutic Drug Discovery > Nanomedicine Oncologic Disease

Language: Английский

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Effects of in vitro fecal fermentation on the metabolism and antioxidant properties of cyanidin-3-O-glucoside

Food Chemistry, Journal Year: 2023, Volume and Issue: 431, P. 137132 - 137132

Published: Aug. 18, 2023

Language: Английский

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Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10796 - 10796

Published: Oct. 8, 2024

Cancer treatment continues to be a substantial problem due tumor complexities and persistence, demanding novel therapeutic techniques. This review investigates the synergistic potential of combining photodynamic therapy (PDT) tailored medication delivery technologies increase mitochondrial toxicity improve cancer outcomes. PDT induces selective cellular damage death by activating photosensitizers (PS) with certain wavelengths light. However, PDT's efficacy can hampered issues such as poor light penetration lack selectivity. To overcome these challenges, targeted drug systems have emerged promising technique for precisely delivering medicines cells while avoiding off-target effects. We investigate how targeting damage, which is critical causing cell death. The combination method seeks capitalize on advantages both modalities: activation specific delivery. current preclinical clinical evidence supporting this therapy, focusing case studies experimental models. also addresses safety, distribution efficiency, resistance mechanisms, costs. prospects further research include advances in agents technology, focus personalized treatment. In conclusion, provides frontier ability limits open way more effective, treatments.

Language: Английский

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