Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(7), P. 789 - 789
Published: June 28, 2024
Bone
defects
caused
by
trauma,
tumor
resection,
and
infections
are
significant
clinical
challenges.
Excessive
reactive
oxygen
species
(ROS)
usually
accumulate
in
the
defect
area,
which
may
impair
function
of
cells
involved
bone
formation,
posing
a
serious
challenge
for
repair.
Due
to
potent
ROS
scavenging
ability,
as
well
potential
anti-inflammatory
immunomodulatory
activities,
antioxidants
play
an
indispensable
role
maintenance
protection
health
have
gained
increasing
attention
recent
years.
This
narrative
review
aims
give
overview
main
research
directions
on
application
antioxidant
compounds
repair
over
past
decade.
In
addition,
positive
effects
various
their
biomaterial
delivery
systems
summarized
provide
new
insights
exploring
antioxidant-based
strategies
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(9), P. 8263 - 8263
Published: May 5, 2023
Hormones
are
indispensable
for
bone
development,
growth,
and
maintenance.
While
many
of
the
genes
associated
with
osteogenesis
well
established,
it
is
recent
findings
in
endocrinology
that
advancing
fields
biology
toxicology.
Endocrine-disrupting
chemicals
(EDCs)
defined
as
interfere
function
endocrine
system.
Here,
we
report
discoveries
describing
key
hormone
pathways
involved
EDCs
alter
these
pathways.
can
lead
to
morphological
changes
via
altering
receptors,
signaling
pathways,
gene
expression.
The
objective
this
review
highlight
harmful
effects
environmental
toxicants
on
formation
impacted.
Understanding
mechanisms
how
contributes
providing
a
comprehensive
toxicological
profile
chemical.
Experimental Cell Research,
Journal Year:
2023,
Volume and Issue:
430(1), P. 113717 - 113717
Published: July 8, 2023
Oxidative
stress
is
one
of
the
most
important
factors
in
changing
bone
homeostasis.
Redox
homeostasis
plays
a
key
role
osteogenic
differentiation
mesenchymal
stem
cells
(BMSCs)
and
angiogenesis
ability
human
umbilical
vein
endothelial
(HUVECs)
for
regeneration.
Currently,
this
study
assessed
effects
punicalagin
(PUN)
on
BMSCs
HUVECs.
Cell
viability
was
determined
by
CCK-8
assay.
A
flow
cytometry
analysis
adopted
to
detect
macrophage
polarization.
The
production
reactive
oxygen
(ROS),
glutathione
(GSH),
malonaldehyde
(MDA)
superoxide
dismutase
(SOD)
activities
were
evaluated
using
commercially-available
kits.
Osteogenic
capacity
ALP
activity,
staining
ARS
staining.
expression
osteogenic-related
proteins
(OCN,
Runx-2,
OPN)
Nrf/HO-1
levles
Western
blotting.
Osteogenic-related
genes
(Osterix,
COL-1,
BMP-4,
ALP)
RT-PCR.
Migration
invasion
HUVECs
wound
healing
assay
Transwell
Angiogenic
detected
tube
formation
angiogenic-related
(VEGF,
vWF,
CD31)
Results
showed
that
PUN
alleviated
oxidative
TNF-α,
enhanced
Moreover,
regulate
immune
microenvironment
promoting
polarization
M2
macrophages
reduce
related
products
activating
Nrf2/HO-1
pathway.
Altogether,
these
results
suggested
can
promote
BMSCs,
HUVECs,
alleviate
via
pathway,
offering
as
novel
antioxidant
agent
treating
loss
diseases.
Endocrine Connections,
Journal Year:
2023,
Volume and Issue:
12(11)
Published: Sept. 18, 2023
Osteoporosis
(OP)
is
a
systemic
bone
disease
in
which
density
and
quality
decrease
fragility
increases
due
to
variety
of
causes,
making
it
prone
fractures.
The
development
OP
closely
related
oxidative
stress.
Uric
acid
(UA)
the
end
product
purine
metabolism
human
body.
Extracellular
UA
has
antioxidant
property
thought
have
protective
effect
on
metabolism.
However,
process
degradation
can
lead
intracellular
stress,
together
with
UA-induced
inflammatory
factors,
leads
increased
destruction.
In
addition,
inhibit
vitamin
D
production,
resulting
secondary
hyperparathyroidism
further
exacerbating
UA-associated
loss.
This
review
summarizes
relationship
between
serum
uric
levels
mineral
density,
turnover
markers
so
on,
hope
providing
new
insights
into
pathogenesis
treatment
OP.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Oct. 23, 2023
Osteoporosis
is
a
common
metabolic
disease
in
middle-aged
and
elderly
people.
It
characterized
by
reduction
bone
mass,
compromised
microstructure,
heightened
fragility,
an
increased
susceptibility
to
fractures.
The
dynamic
imbalance
between
osteoblast
osteoclast
populations
decisive
factor
the
occurrence
of
osteoporosis.
With
increase
population
society,
incidence
osteoporosis,
disability,
mortality
have
gradually
increased.
Polyphenols
are
fascinating
class
compounds
that
found
both
food
medicine
exhibit
variety
biological
activities
with
significant
health
benefits.
As
component
food,
polyphenols
not
only
provide
color,
flavor,
aroma
but
also
act
as
potent
antioxidants,
protecting
our
cells
from
oxidative
stress
reducing
risk
chronic
disease.
Moreover,
these
natural
anti-inflammatory
properties,
which
aid
immune
response
regulation
potentially
alleviate
symptoms
diverse
ailments.
gut
microbiota
can
degrade
into
more
absorbable
metabolites,
thereby
increasing
their
bioavailability.
shape
its
abundance.
Therefore,
studying
synergistic
effect
may
help
treatment
prevention
By
delving
how
enhance
bioavailability
abundance,
this
review
offers
valuable
information
references
for
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(7), P. 789 - 789
Published: June 28, 2024
Bone
defects
caused
by
trauma,
tumor
resection,
and
infections
are
significant
clinical
challenges.
Excessive
reactive
oxygen
species
(ROS)
usually
accumulate
in
the
defect
area,
which
may
impair
function
of
cells
involved
bone
formation,
posing
a
serious
challenge
for
repair.
Due
to
potent
ROS
scavenging
ability,
as
well
potential
anti-inflammatory
immunomodulatory
activities,
antioxidants
play
an
indispensable
role
maintenance
protection
health
have
gained
increasing
attention
recent
years.
This
narrative
review
aims
give
overview
main
research
directions
on
application
antioxidant
compounds
repair
over
past
decade.
In
addition,
positive
effects
various
their
biomaterial
delivery
systems
summarized
provide
new
insights
exploring
antioxidant-based
strategies
