Nanoparticles as a novel key driver for the isolation and detection of circulating tumour cells DOI Creative Commons
Shahab Bashir,

Muhammad Amn Zia,

Madiha Shoukat

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 29, 2024

Circulating tumour cells (CTCs), derived from primary tumours, play a pivotal role in cancer metastasis by migrating into the peripheral bloodstream. These are paramount clinical research, serving as early diagnostic markers for metastatic cancer. Analysing CTC counts and their biomarker characteristics can provide invaluable insights identification, profiling, capabilities. However, rarity diverse nature of CTCs bloodstream present significant challenges to isolation detection, especially initial stages metastasis. Recent advancements nanotechnology have led development innovative separation detection methods. This review focuses on applying nanoparticles, nanomaterials, microfluidic platforms simplify CTCs. The infusion this field marks crucial turning point, enabling necessary progress advance research.

Language: Английский

Liquid biopsy in cancer current: status, challenges and future prospects DOI Creative Commons
Liwei Ma, Huiling Guo, Yunxiang Zhao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Dec. 1, 2024

Cancer has a high mortality rate across the globe, and tissue biopsy remains gold standard for tumor diagnosis due to its level of laboratory standardization, good consistency results, relatively stable samples, accuracy results. However, there are still many limitations drawbacks in application tumor. The emergence liquid provides new ideas early prognosis Compared with biopsy, advantages treatment various types cancer, including non-invasive, quickly so on. Currently, detection received widely attention. It is now undergoing rapid progress, it holds significant potential future applications. Around now, biopsies encompass several components such as circulating cells, DNA, exosomes, microRNA, RNA, platelets, endothelial cells. In addition, advances identification indicators have significantly enhanced possibility utilizing clinical settings. this review, we will discuss application, challenges some common tumors from perspective diverse systems tumors, look forward development prospects field cancer treatment.

Language: Английский

Citations

47
Designing Multivalent Aptamers: Recent Advancements in Diagnostic and Therapeutic Approaches for Cancer Treatment DOI
Zahra Moradi, Khalil Abnous, Seyed Mohammad Taghdisi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106614 - 106614

Published: Jan. 1, 2025

Language: Английский

Citations

2
Circulating Tumor Cells as Predictive and Prognostic Biomarkers in Solid Tumors DOI Creative Commons
Maurizio Capuozzo, Francesco Ferrara,

Mariachiara Santorsola

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(22), P. 2590 - 2590

Published: Nov. 8, 2023

Circulating tumor cells (CTCs) have emerged as pivotal biomarkers with significant predictive and prognostic implications in solid tumors. Their presence peripheral blood offers a non-invasive window into the dynamic landscape of cancer progression treatment response. This narrative literature review synthesizes current state knowledge surrounding multifaceted role CTCs predicting clinical outcomes informing prognosis across spectrum malignancies. delves evolving CTC-based research, emphasizing their potential early indicators disease recurrence, metastatic potential, therapeutic resistance. Moreover, we underscored nature for personalized medicine. A descriptive critical analysis CTC detection methodologies, relevance, associated challenges is also presented, focus on recent advancements emerging technologies. Furthermore, examine integration liquid biopsies practice, highlighting guiding decisions, monitoring efficacy, facilitating precision oncology. highlights transformative impact management tumors by promoting deeper understanding relevance advancing field

Language: Английский

Citations

29
Detection and Molecular Characterization of Circulating Tumour Cells: Challenges for the Clinical Setting DOI Open Access
Αreti Strati, Athina Markou,

Evgenia Kyriakopoulou

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(7), P. 2185 - 2185

Published: April 6, 2023

Over the last decade, liquid biopsy has gained much attention as a powerful tool in personalized medicine since it enables monitoring cancer evolution and follow-up of patients real time. Through minimally invasive procedures, provides important information through analysis circulating tumour cells (CTCs) tumour-derived material, such DNA (ctDNA), miRNAs (cfmiRNAs) extracellular vehicles (EVs). CTC already had an impact on prognosis, detection minimal residual disease (MRD), treatment selection patients. Numerous clinical trials nowadays include arm. is now exponentially expanding field almost all types solid cancers. Functional studies, mainly based CTC-derived cell-lines explants (CDx), provide insights into metastatic process. The purpose this review to summarize latest findings significance CTCs for management patients, covering four years. This focuses providing comprehensive overview breast, prostate non-small-cell lung cancer. unique potential single-cell understanding metastasis biology, importance quality control standardization methodologies used field, also discussed.

Language: Английский

Citations

26
Preparation and characterization of anticorrosive and antibacterial coatable nanocomposite based on zinc phosphate modified by Hydroxy Apatite/alginate: Investigation of electrochemical impedance spectroscopy (EIS) DOI Creative Commons

Arezoo Mohammadkhani,

Faezeh Mohammadkhani,

Mirabdullah Seyed Sadjadi

et al.

Case Studies in Chemical and Environmental Engineering, Journal Year: 2024, Volume and Issue: 9, P. 100694 - 100694

Published: March 18, 2024

In This study, three new surface-modified antibacterial and anticorrosive nanocomposites (zinc Phosphate- Polyvinyl Pyrrolidone, Zinc Pyrrolidone/Hydroxy Apatite Apatite/Alginate) were synthesized in low-temperature by facile efficient method. We crosslink Alg with Zn2+ Ca2+ to make it insoluble enhancing of their physical biological properties Apatite/Alginate). Nanocrystals characterized (XRD), (FT-IR), (EDX), (SEM) (TEM). the TEM image showed that core shell nanocrystal had good dispersion a particle size 8–36, 12–38 10–45 nm, respectively. Antibacterial rate Apatite/Alginate NPs reached near 100%. To analyze EIS results obtained from equivalent circuits, parameters such as Rct, CPEdl, Rf, n, CPEf, Rt extracted. Nyquist diagrams demonstrated sample better protection than Pyrrolidone sample, at all immersion time. The phase angle (-θ 11°/96 h) was greater value compared Alginate 10°/96 4.2°/96 h), indicating transition capacitive inductive behavior longer times.

Language: Английский

Citations

14
Updates on liquid biopsies in neuroblastoma for treatment response, relapse and recurrence assessment DOI Creative Commons
Leila Jahangiri

Cancer Genetics, Journal Year: 2024, Volume and Issue: 288-289, P. 32 - 39

Published: Sept. 3, 2024

Neuroblastoma is a paediatric malignancy of the sympathoadrenal or Schwann cells derived from neural crest. Risk stratification in neuroblastoma informed by MYCN amplification, age, stage, ploidy, and segmental chromosomal alterations. High-risk cases bear dismal overall survival. A panel pathology imaging modalities are utilised for diagnosis, while treatment strategies depend on risk group. Despite this, relapse can occur 50% high-risk patients remission post-treatment. Liquid biopsies typically comprise sampling peripheral blood attractive since they less invasive than surgical tumour tissue biopsies. retrieve circulating DNA RNA released tumours addition to cells. These biological materials be analyse genetic Monitoring tumour-derived molecular information assist diagnostics, targeted therapy selection, reflecting minimal residual disease, relapse, recurrence. This study aims review latest research liquid disease assessing efficacy, recurrence neuroblastoma. deeper understanding application could inform future prospective clinical trials, time, facilitate their routine implementation practice.

Language: Английский

Citations

13
Liquid Biopsy in the Clinical Management of Cancers DOI Open Access

Ho-Yin Ho,

Kei-See Chung,

Chau-Ming Kan

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8594 - 8594

Published: Aug. 6, 2024

Liquid biopsy, a noninvasive diagnosis that examines circulating tumor components in body fluids, is increasingly used cancer management. An overview of relevant literature emphasizes the current state liquid biopsy applications care. Biomarkers particularly DNA (ctDNA), RNAs (ctRNA), cells (CTCs), extracellular vesicles (EVs), and other components, offer promising opportunities for early diagnosis, treatment selection, monitoring, disease assessment. The implementation precision medicine has shown significant potential various types, including lung cancer, colorectal breast prostate cancer. Advances genomic molecular technologies such as next-generation sequencing (NGS) digital polymerase chain reaction (dPCR) have expanded utility enabling detection somatic variants actionable alterations tumors. also demonstrated predicting responses, monitoring minimal residual (MRD), assessing heterogeneity. Nevertheless, standardizing techniques, interpreting results, integrating them into clinical routine remain challenges. Despite these challenges, implications management, offering dynamic approach to understanding biology guiding personalized strategies.

Language: Английский

Citations

12
Advancements in Circulating Tumor Cell Research: Bridging Biology and Clinical Applications DOI Open Access
P Salu, Katie M. Reindl

Cancers, Journal Year: 2024, Volume and Issue: 16(6), P. 1213 - 1213

Published: March 20, 2024

Circulating tumor cells (CTCs) are released from the primary and metastatic intravasate into blood or lymphatic vessels, where they transported to distant sites act as seeds that initiate cancer metastases development of further lesions. Recent advances in CTC research have shown their relevance prognostic markers for early disease detection, predictive biomarkers relapse, response medical intervention therapy. The rapidly evolving landscape biology has opened new avenues understanding progression, metastasis, treatment response. Additionally, translating these findings clinical applications holds promise improving diagnostics, prognosis, personalized therapeutic strategies. This review discusses significance CTCs associated challenges. We explore recent developments detection characterization implications practice.

Language: Английский

Citations

10
Emerging biomarkers and molecular targets for precision medicine in cervical cancer DOI

Pankaj Garg,

Madhu Krishna,

Ayalur Raghu Subbalakshmi

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(3), P. 189106 - 189106

Published: May 1, 2024

Language: Английский

Citations

9
Label-Free and Rapid Microfluidic Design Rules for Circulating Tumor Cell Enrichment and Isolation: A Review and Simulation Analysis DOI Creative Commons
Muhammad Asraf Mansor, Chun Yang,

Kar Lok Chong

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 6306 - 6322

Published: Feb. 11, 2025

Enriching and isolating circulating tumor cells (CTCs) have attracted significant interest due to their important role in early cancer diagnosis prognosis, allowing for minimally invasive approaches providing vital information about metastasis at the cellular level. This review comprehensively summarizes recent developments microfluidic devices CTC enrichment isolation. The advantages limitations of several are discussed, design specifications highlighted. We also developed a set methodologies rules label-free microfluidics such as spiral, deterministic lateral displacement (DLD) dielectrophoresis (DEP) allow researchers develop systematically effectively, promoting rapid research on design, fabrication, experimentation.

Language: Английский

Citations

1