Published: Nov. 19, 2024
Language: Английский
Life Sciences, Journal Year: 2024, Volume and Issue: 340, P. 122447 - 122447
Published: Jan. 21, 2024
Language: Английский
Citations
5
Computational Biology and Chemistry, Journal Year: 2023, Volume and Issue: 107, P. 107957 - 107957
Published: Sept. 13, 2023
Language: Английский
Citations
12
Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: 5(3), P. 100452 - 100452
Published: Jan. 23, 2025
Maternal exposure to infections during gestation has been shown predispose individuals neuropsychiatric disorders. Additionally, clinical data suggest that cannabis use may trigger the onset of schizophrenia in vulnerable individuals. However, direction causality remains unclear. To elucidate this issue, we utilized a rat model maternal immune activation combined with increasing doses Δ9-tetrahydrocannabinol adolescence both male and female rats. We investigated several behaviors adulthood relevant for disorders, including impairments working memory, deficits sensorimotor gating, alterations social behavior, anhedonia, potential changes implicit learning (conditioned taste aversion). Furthermore, conducted longitudinal positron emission tomography study target affected brain regions and, subsequently, collected samples one such region (the orbitofrontal cortex) RNA sequencing analyses, which were also performed on peripheral blood mononuclear cells identify biomarkers. While adolescent did not unmask latent behavioral disruptions, scans revealed dependent combination hits. transcriptomic studies demonstrated dopaminergic, glutamatergic, serotoninergic genes, exposures most cases shifting expression from downregulation upregulation. In cells, interactive effects observed inflammatory pathways, some genes proposed as These results these 2 vulnerability factors leaves lasting mark body, potentially predisposing disorders even before manifest.
Language: Английский
Citations
0
Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100520 - 100520
Published: April 1, 2025
Language: Английский
Citations
0
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(2)
Published: Feb. 1, 2024
Abstract Aim Widely used second‐generation antipsychotics are associated with adverse metabolic effects, contributing to increased cardiovascular mortality. To develop strategies prevent or treat preclinical models have a clear role in uncovering underlying molecular mechanisms. However, few exceptions, studies been performed healthy animals, neglecting the contribution of dysmetabolic features inherent psychotic disorders. Methods In this study, methylazoxymethanol acetate (MAM) was prenatally administered pregnant Sprague–Dawley rats at gestational day 17 induce well‐validated neurodevelopmental model schizophrenia mimicking its assumed pathogenesis persistent phenotype. Against background, effects acute treatment olanzapine and haloperidol were examined female rats. Results Prenatally MAM‐exposed animals exhibited several features, including lipid disturbances. Half MAM exposed had pronounced serum profile alteration compared non‐MAM controls, interpreted as reflection delicate MAM‐induced balance disrupted by olanzapine. accordance drugs' clinical profiles, olanzapine‐associated more than haloperidol‐associated MAM. Conclusion Our results demonstrate vulnerability rats, indicating that findings from likely provide an underestimated impression dysfunction antipsychotics. context disturbances, possess relevant search for adequate animal should receive attention within field experimental psychopharmacology.
Language: Английский
Citations
3
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: Aug. 14, 2024
Cannabinoids and the endocannabinoid system (ECS) have been intensively studied for their neuroregulatory roles in central nervous (CNS), especially regulating learning memory. However, many experimental clinical studies obtained conflicting results indicating a complex network of interaction underlying regulation memory by different cannabinoids ECS. The ECS influences neuronal synaptic communications, therefore may exert via impact on other neurotransmitters. monoaminergic includes variety neurotransmitters, such as dopamine, norepinephrine, serotonin, which play important mood, cognition, reward. among cannabinoids, has drawn particular attention, contributions to In this review, we summarized current understanding how contribute process memory, discussed neurotransmission during process.
Language: Английский
Citations
3
Addiction, Journal Year: 2023, Volume and Issue: 118(11), P. 2040 - 2042
Published: Aug. 13, 2023
It is the opinion of World Anti-Doping Agency (WADA) that cannabis should remain a banned substance in sport. The purpose this editorial to briefly summarize elements discussion leading continued ban Cannabis availability and its subsequent use, misuse incidence use disorder are increasing globally [1], even as potency plant, gauged by delta-9-tetrahydrocannabinol (∆9-THC content), continues increase [2]. not known what proportion top-level athletes regularly consume cannabis. However, recent review self-reports included more than 46000 suggests using no different from age-matched general population [3]. competition all sports when 2004 List Prohibited Substances Methods was first released under Code [4]. has since revisited updated cannabinoid category include synthetic cannabinoids, reporting thresholds specifically exempt cannabidiol. In response stakeholder requests, WADA Executive Committee asked for status Ad hoc committees conducted scientific, ethical medical effects cannabis, focusing upon primary psychoactive ingredient, ∆9-THC, among 100 distinct cannabinoids within plant. For any or method be considered inclusion per Code, two following three equally-important criteria must met: (1) it enhances potential enhance sport performance, (2) represents an actual risk health athlete (3) violates spirit defined Code. 2022, reviewed 2700 articles present exercise. Inclusion scientific study further discussed aided adherence principles, where appropriate. This application rigorous methods, such randomization subjects treatment groups, placebo controls blinding both subject experimenter. Publication peer-reviewed journal required, greater emphasis placed studies had results which were independently replicated. enabled Expert List, Athletic, Ethical Health, Medical Research most current science issue independent opinions on subject. Finally, part process, world experts addiction behavior consulted validate conclusions committees. Perspectives mixed criterion. There rigorously indicated direct ergogenic effect Nonetheless, number reports suggested other benefits may conferred drug, reduction pain anxiety [5, 6] associated with athletic competition. Some report benefit facilitating recovery reducing pain. Hence, while there perceived some athletes, data support performance enhancement. far agreement second criterion—actual athlete. comprehensive historical literature well rapidly growing body contemporary supporting assertion can negatively impact health, safety wellbeing Acute intoxication result deficits reaction time, temporal estimation dexterity [7-11] psychiatric symptoms [12]. Not detected similar changes; will vary dose, route, subjects' experience test methods employed. Chronic, frequent increased disorder, recently Robinson colleagues [13], potentially long-term changes [14, 15], including precipitation severe mental illness [16]. evidence affect brain development anatomy adolescents young adults [17-19], although consequences these yet firmly established. compromise qualifies emphasizes prohibition in-competition only, after 23:59 hours day prior decision limit 180 ng/ml ∆9-THC-COOH urine cut-off 150 ng/ml, plus uncertainty measurement 30 takes into account. Because high thresholds, primarily chronic, users consuming doses detected. Therefore, generally freedom who wishes legally outside Athletes have need medicinal request therapeutic exemption (TUE). Marilyn Huestis: Conceptualization (equal); writing—review editing (equal). Sabina Strano-Rossi: curation Yorck-Olaf Schumacher: validation; Peter Harcourt: (supporting). Richard Budgett: Mark Stuart: Justice Tettey: Irene Mazzoni: project administration resources Olivier Rabin: supervision Anne Danion: (supporting); Michael Culler: David Handelsman: Mario Thevis: Audrey Kinahan: None. No competing interests declared author. Data derived public domain resources.
Language: Английский
Citations
7
Pharmacological Reports, Journal Year: 2024, Volume and Issue: 76(4), P. 887 - 894
Published: May 24, 2024
Language: Английский
Citations
2
Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107343 - 107343
Published: Aug. 8, 2024
Psychosis is a characterizing feature of many mental disorders that dramatically affects human thoughts and perceptions, influencing the ability to distinguish between what real not. Both genetic environmental factors, such as stressful events or drug use, play pivotal role in development symptomatology therefore changes epigenome may be relevance modeling psychotic phenotype. According well-documented dysregulation endocannabinoid dopaminergic system genes schizophrenia, we investigated DNA methylation cannabinoid type 1 receptor (CNR1) dopamine D2 (DRD2) saliva samples from subjects using pyrosequencing. The epigenetic mark was significantly higher directly correlated for both compared healthy controls. We also showed these levels were lower reporting current delta-9-tetrahydrocannabinol (THC) consumption, well-known risk factor developing psychosis throughout lifespan, resembling those controls at least DRD2 gene. Overall, our data confirm key CNR1 gene regulation suggest specific CpG sites potential biomarkers, but just not consuming THC.
Language: Английский
Citations
2
Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
1