Measurement of Cerebral Blood Flow by ASL MRI in Rat Models of Psychopathology and Psychopharmacological Interventions DOI
Eva Dražanová, Jana Kučerová

Published: Nov. 19, 2024

Language: Английский

Vaporized Δ9-THC in utero results in reduced birthweight, increased locomotion, and altered wake-cycle activity dependent on dose, sex, and diet in the offspring DOI

Nicole Roeder,

Samantha L. Penman, Brittany Richardson

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 340, P. 122447 - 122447

Published: Jan. 21, 2024

Language: Английский

Citations

5

The marijuana-schizophrenia multifaceted nexus: Connections and conundrums towards neurophysiology DOI
Pukar Khanal, Vishal S. Patil, B. M. Patil

et al.

Computational Biology and Chemistry, Journal Year: 2023, Volume and Issue: 107, P. 107957 - 107957

Published: Sept. 13, 2023

Language: Английский

Citations

12

A HIDDEN MARK OF A TROUBLED PAST: NEUROIMAGING AND TRANSCRIPTOMIC ANALYSES REVEAL INTERACTIVE EFFECTS OF MATERNAL IMMUNE ACTIVATION AND ADOLESCENT THC EXPOSURE SUGGESTIVE OF INCREASED NEUROPSYCHIATRIC RISK DOI Creative Commons
Mario G. Moreno, Víctor Luján, Shishir Baliyan

et al.

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: 5(3), P. 100452 - 100452

Published: Jan. 23, 2025

Maternal exposure to infections during gestation has been shown predispose individuals neuropsychiatric disorders. Additionally, clinical data suggest that cannabis use may trigger the onset of schizophrenia in vulnerable individuals. However, direction causality remains unclear. To elucidate this issue, we utilized a rat model maternal immune activation combined with increasing doses Δ9-tetrahydrocannabinol adolescence both male and female rats. We investigated several behaviors adulthood relevant for disorders, including impairments working memory, deficits sensorimotor gating, alterations social behavior, anhedonia, potential changes implicit learning (conditioned taste aversion). Furthermore, conducted longitudinal positron emission tomography study target affected brain regions and, subsequently, collected samples one such region (the orbitofrontal cortex) RNA sequencing analyses, which were also performed on peripheral blood mononuclear cells identify biomarkers. While adolescent did not unmask latent behavioral disruptions, scans revealed dependent combination hits. transcriptomic studies demonstrated dopaminergic, glutamatergic, serotoninergic genes, exposures most cases shifting expression from downregulation upregulation. In cells, interactive effects observed inflammatory pathways, some genes proposed as These results these 2 vulnerability factors leaves lasting mark body, potentially predisposing disorders even before manifest.

Language: Английский

Citations

0

Consumption of the prebiotic-rich chicory taproot contrasts the cognitive and motivational consequences of chronic corticosterone exposure and modulates gut microbiota composition in mice DOI Creative Commons
Francesca Zoratto, Edoardo Pisa,

Claudia Soldati

et al.

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100520 - 100520

Published: April 1, 2025

Language: Английский

Citations

0

Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model DOI Creative Commons
Kateřina Horská, Silje Skrede, Jan Kučera

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(2)

Published: Feb. 1, 2024

Abstract Aim Widely used second‐generation antipsychotics are associated with adverse metabolic effects, contributing to increased cardiovascular mortality. To develop strategies prevent or treat preclinical models have a clear role in uncovering underlying molecular mechanisms. However, few exceptions, studies been performed healthy animals, neglecting the contribution of dysmetabolic features inherent psychotic disorders. Methods In this study, methylazoxymethanol acetate (MAM) was prenatally administered pregnant Sprague–Dawley rats at gestational day 17 induce well‐validated neurodevelopmental model schizophrenia mimicking its assumed pathogenesis persistent phenotype. Against background, effects acute treatment olanzapine and haloperidol were examined female rats. Results Prenatally MAM‐exposed animals exhibited several features, including lipid disturbances. Half MAM exposed had pronounced serum profile alteration compared non‐MAM controls, interpreted as reflection delicate MAM‐induced balance disrupted by olanzapine. accordance drugs' clinical profiles, olanzapine‐associated more than haloperidol‐associated MAM. Conclusion Our results demonstrate vulnerability rats, indicating that findings from likely provide an underestimated impression dysfunction antipsychotics. context disturbances, possess relevant search for adequate animal should receive attention within field experimental psychopharmacology.

Language: Английский

Citations

3

Cannabinoids and monoaminergic system: implications for learning and memory DOI Creative Commons
Sha Zhao,

Zhaoliang Gu,

Ya-Nan Yue

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 14, 2024

Cannabinoids and the endocannabinoid system (ECS) have been intensively studied for their neuroregulatory roles in central nervous (CNS), especially regulating learning memory. However, many experimental clinical studies obtained conflicting results indicating a complex network of interaction underlying regulation memory by different cannabinoids ECS. The ECS influences neuronal synaptic communications, therefore may exert via impact on other neurotransmitters. monoaminergic includes variety neurotransmitters, such as dopamine, norepinephrine, serotonin, which play important mood, cognition, reward. among cannabinoids, has drawn particular attention, contributions to In this review, we summarized current understanding how contribute process memory, discussed neurotransmission during process.

Language: Английский

Citations

3

Cannabis and sport: A World Anti‐Doping perspective DOI Creative Commons
Thomas J. Hudzik, Marilyn A. Huestis, Sabina Strano Rossi

et al.

Addiction, Journal Year: 2023, Volume and Issue: 118(11), P. 2040 - 2042

Published: Aug. 13, 2023

It is the opinion of World Anti-Doping Agency (WADA) that cannabis should remain a banned substance in sport. The purpose this editorial to briefly summarize elements discussion leading continued ban Cannabis availability and its subsequent use, misuse incidence use disorder are increasing globally [1], even as potency plant, gauged by delta-9-tetrahydrocannabinol (∆9-THC content), continues increase [2]. not known what proportion top-level athletes regularly consume cannabis. However, recent review self-reports included more than 46000 suggests using no different from age-matched general population [3]. competition all sports when 2004 List Prohibited Substances Methods was first released under Code [4]. has since revisited updated cannabinoid category include synthetic cannabinoids, reporting thresholds specifically exempt cannabidiol. In response stakeholder requests, WADA Executive Committee asked for status Ad hoc committees conducted scientific, ethical medical effects cannabis, focusing upon primary psychoactive ingredient, ∆9-THC, among 100 distinct cannabinoids within plant. For any or method be considered inclusion per Code, two following three equally-important criteria must met: (1) it enhances potential enhance sport performance, (2) represents an actual risk health athlete (3) violates spirit defined Code. 2022, reviewed 2700 articles present exercise. Inclusion scientific study further discussed aided adherence principles, where appropriate. This application rigorous methods, such randomization subjects treatment groups, placebo controls blinding both subject experimenter. Publication peer-reviewed journal required, greater emphasis placed studies had results which were independently replicated. enabled Expert List, Athletic, Ethical Health, Medical Research most current science issue independent opinions on subject. Finally, part process, world experts addiction behavior consulted validate conclusions committees. Perspectives mixed criterion. There rigorously indicated direct ergogenic effect Nonetheless, number reports suggested other benefits may conferred drug, reduction pain anxiety [5, 6] associated with athletic competition. Some report benefit facilitating recovery reducing pain. Hence, while there perceived some athletes, data support performance enhancement. far agreement second criterion—actual athlete. comprehensive historical literature well rapidly growing body contemporary supporting assertion can negatively impact health, safety wellbeing Acute intoxication result deficits reaction time, temporal estimation dexterity [7-11] psychiatric symptoms [12]. Not detected similar changes; will vary dose, route, subjects' experience test methods employed. Chronic, frequent increased disorder, recently Robinson colleagues [13], potentially long-term changes [14, 15], including precipitation severe mental illness [16]. evidence affect brain development anatomy adolescents young adults [17-19], although consequences these yet firmly established. compromise qualifies emphasizes prohibition in-competition only, after 23:59 hours day prior decision limit 180 ng/ml ∆9-THC-COOH urine cut-off 150 ng/ml, plus uncertainty measurement 30 takes into account. Because high thresholds, primarily chronic, users consuming doses detected. Therefore, generally freedom who wishes legally outside Athletes have need medicinal request therapeutic exemption (TUE). Marilyn Huestis: Conceptualization (equal); writing—review editing (equal). Sabina Strano-Rossi: curation Yorck-Olaf Schumacher: validation; Peter Harcourt: (supporting). Richard Budgett: Mark Stuart: Justice Tettey: Irene Mazzoni: project administration resources Olivier Rabin: supervision Anne Danion: (supporting); Michael Culler: David Handelsman: Mario Thevis: Audrey Kinahan: None. No competing interests declared author. Data derived public domain resources.

Language: Английский

Citations

7

Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats DOI

Francesca Frescura,

Tibor Štark,

Edoardo Tiziani

et al.

Pharmacological Reports, Journal Year: 2024, Volume and Issue: 76(4), P. 887 - 894

Published: May 24, 2024

Language: Английский

Citations

2

DNA methylation at cannabinoid type 1 and dopamine D2 receptor genes in saliva samples of psychotic subjects: Is there an effect of Cannabis use? DOI Creative Commons
Martina Di Bartolomeo,

Andrea Čerňanová,

Veronika Petrušová

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107343 - 107343

Published: Aug. 8, 2024

Psychosis is a characterizing feature of many mental disorders that dramatically affects human thoughts and perceptions, influencing the ability to distinguish between what real not. Both genetic environmental factors, such as stressful events or drug use, play pivotal role in development symptomatology therefore changes epigenome may be relevance modeling psychotic phenotype. According well-documented dysregulation endocannabinoid dopaminergic system genes schizophrenia, we investigated DNA methylation cannabinoid type 1 receptor (CNR1) dopamine D2 (DRD2) saliva samples from subjects using pyrosequencing. The epigenetic mark was significantly higher directly correlated for both compared healthy controls. We also showed these levels were lower reporting current delta-9-tetrahydrocannabinol (THC) consumption, well-known risk factor developing psychosis throughout lifespan, resembling those controls at least DRD2 gene. Overall, our data confirm key CNR1 gene regulation suggest specific CpG sites potential biomarkers, but just not consuming THC.

Language: Английский

Citations

2

Maternal Immune Activation and Endocannabinoid System: Focus on Two-Hit Models of Schizophrenia DOI Creative Commons
Michele Santoni, Marco Pistis

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

1