Understanding vaginal biofilms: The first step in harnessing antimicrobial nanomedicine DOI Creative Commons
Sybil Obuobi, Nataša Škalko‐Basnet

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 1190 - 1208

Published: Nov. 12, 2024

In spite of multipurpose technologies offering broad-spectrum prevention for sexually transmitted infections (STIs) and contraception, the STIs incidences rise worldwide. The situation is even more alarming considering continuous in antimicrobial resistance (AMR) that limits therapy options. this review we address specific challenges efficiently treating vaginal locally, at infection site, by understanding underlying barriers to efficient treatment such as biofilms. Knowledge on biofilms remains, up now, rather scarce requires attention. We therefore propose a 'back basics' insight seeks probe complexity role microbiota, its relationship with implications future therapeutic modalities utilizing advanced nano delivery systems. Our key objective highlight interplay between biofilm, (nano)formulation outcome than provide an overview all nanoformulations were challenged against focused anatomy female reproductive organ physiological changes from birth, unique microenvironment premenopausal postmenopausal women, biofilm current nanomedicine-based approaches treat site. Finally, offer our perspectives associated considerations can aid design development safer potent products persisting infections.

Language: Английский

Nanotherapeutics in pulmonary infections DOI
Sanchit Arora,

Archna Panghal,

Jayant Kumar

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 81 - 114

Published: Jan. 1, 2025

Language: Английский

Citations

0
Preparation and Evaluation of Meclinertant-loaded PLGA/Chitosan Nanoparticles as a Potential Treatment for Non-Small Cell Lung Cancer Using A549 Cells. DOI Creative Commons
Parth Patel,

Nicole Oyinade Shoyele,

Sunday Shoyele

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106831 - 106831

Published: March 1, 2025

Language: Английский

Citations

0
Nanotechnology in Diabetes Management: Advancements in PLGA-Based Drug Delivery DOI

Saranya Balasubramaniyam,

Thirumalaikumaran Rathinam,

M. Srinivasan

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Language: Английский

Citations

0
Microneedle Delivery of Heterologous Microparticulate COVID-19 Vaccine Induces Cross Strain Specific Antibody Levels in Mice DOI Creative Commons

Tanisha Arte,

Smital Patil,

Emmanuel Adediran

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 380 - 380

Published: April 1, 2025

Background: In recent years, the COVID-19 pandemic has significantly impacted global health, largely driven by emergence of various genetic mutations within SARS-CoV-2 virus. Although phase passed, full extent virus’s evolutionary trajectory remains uncertain, highlighting need for continued research in vaccine development to establish a cross-reactive approach that can effectively address different variants. This proof-of-concept study aimed assess effectiveness microparticulate delivery through minimally invasive microneedle route administration, using heterologous prime–booster strategy against Method: uses whole inactivated virus Delta variant prime dose and Omicron booster dose, with alum as an adjuvant. The formulation microparticles involves encapsulating antigens poly lactic-co-glycolic acid (PLGA) polymer, which provides sustained release enhances immunogenicity while protecting antigen. Microparticles were tested vitro assays, characterization included particle size, zeta potential, encapsulation efficacy. Furthermore, serum was collected post-administration mice antibody levels. Result: assays confirmed non-cytotoxicity ability activate immune response particles. Administering this via microneedles proven effective delivering vaccines skin. We also observed higher antigen-specific levels cross-reactivity strains. Conclusions: Our adjuvanted microparticulate-based showed among strains successfully delivered microneedles.

Language: Английский

Citations

0
The role of polymer type and surfactant composition on the toxicological profile of nanoparticles: an in vitro comparative study DOI

Daniela Mathes,

Letícia Bueno Macedo,

Taís Baldissera Pieta

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: April 7, 2025

Nanotechnology is expanding rapidly, leading to the continual development of new applications. Therefore, it crucial understand effects nanoparticles (NPs) and their components develop more efficient formulations with greater potential Here, we evaluated influence polymer surfactant composition on NP toxicity. Our results revealed significant variations in toxicity based composition. The type used prepare NPs affects properties, especially terms cell tolerance. Notably, viability ranged from 6% 100% depending NPs' In general, Eudragit® RL 100 exhibited cytotoxicity hemolysis rates than those PCL, PLGA, chitosan. This highlights critical role selection determining Additionally, including Span 80® matrix amplified its toxic effects, which emphasizes importance choice design. Both nanospheres nanocapsules same displayed comparable toxicological profiles. Although smaller higher toxicity, a direct correlation between size could not be established, since increased was primarily attributed presence Finally, all formulations, except 100, maintained colloidal stability protein-rich environment, indicating that no secondary structures were formed. our data suggest constituents can critically contribute highlighting safety studies better nanoformulations.

Language: Английский

Citations

0
Poly(lactic-co-glycolic) Acid (PLGA) Nanoparticles and Transdermal Drug Delivery: An Overview DOI
Lalit Kumar, Gauree Kukreti,

Ritesh Rana

et al.

Current Pharmaceutical Design, Journal Year: 2023, Volume and Issue: 29(37), P. 2940 - 2953

Published: Oct. 1, 2023

Biodegradable polymeric nanoparticles have garnered pharmaceutical industry attention throughout the past decade. PLGA [Poly(lactic-co-glycolic acid)] is an excellent biodegradable polymer explored for preparation of that are administered through various routes like intravenous and transdermal. PLGA's versatility makes it a good choice nanoparticles.

Language: Английский

Citations

9
Investigating the Effect of Surface Hydrophilicity on the Destiny of PLGA-Poloxamer Nanoparticles in an In Vivo Animal Model DOI Open Access
Teresa Silvestri, Lucia Grumetto, Ilaria Neri

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14523 - 14523

Published: Sept. 25, 2023

This study aimed to examine the impact of different surface properties poly(lactic-co-glycolic) acid (PLGA) nanoparticles (P NPs) and PLGA-Poloxamer (PP on their in vivo biodistribution. For this purpose, NPs were formulated via nanoprecipitation loaded with diphenylhexatriene (DPH), a fluorescent dye. The obtained underwent comprehensive characterization, encompassing morphology, technological attributes, DPH release rate, thermodynamic properties. produced then administered wild-type mice intraperitoneal injection, and, at scheduled time intervals, animals euthanized. Blood samples, as well liver, lungs, kidneys, extracted for histological examination biodistribution analysis. findings investigation revealed that presence poloxamers led smaller NP sizes induced partial crystallinity NPs. results from experiments evidenced both, P PP NPs, exhibited comparable concentrations bloodstream, while could not be detected other organs examined. Conversely, primarily sequestered by lungs lesser extent, kidneys. Future research endeavors will focus investigating behavior drug-loaded pathological animal models.

Language: Английский

Citations

7
Protective efficacy of Eimeria maxima EmLPL and EmTregIM-1 against homologous challenge in chickens DOI Creative Commons

Quanjia Xiang,

Yun Wan,

Xianglin Pu

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(7), P. 103865 - 103865

Published: May 16, 2024

Chicken coccidiosis has inflicted significant economic losses upon the poultry industry. The primary strategies for preventing and controlling chicken include anticoccidial drugs vaccination. However, these approaches face limitations, such as drug residues resistance associated with drugs, safety concerns related to live vaccines. Consequently, urgent development of innovative vaccines, subunit is imperative. In previous study, we screened 2 candidate antigens: Eimeria maxima lysophospholipase (EmLPL) E. regulatory T cell inducing molecule 1 (EmTregIM-1). To investigate immune protective effect antigens against (E. maxima) infection, constructed recombinant plasmids, namely pET-28a-EmLPL pET-28a-EmTregIM-1, proceeded induce expression proteins EmLPL (rEmLPL) EmTregIM-1 (rEmTregIM-1). immunogenic properties were confirmed through western blot analysis. Targeting EmTregIM-1, developed vaccines encapsulated them in PLGA nanoparticles, resulting nano-vaccines: PLGA-rEmLPL PLGA-rEmTregIM-1. efficacy was assessed animal protection experiments. results demonstrated that rEmLPL rEmTregIM-1 successfully recognized by anti-E. sera His-conjugated mouse monoclonal antibodies. Immunization both nano-vaccines containing markedly mitigated weight loss reduced oocyst shedding chickens infected maxima. Furthermore, indexes (ACI) exceeded 160, whereas those PLGA-rEmTregIM-1 above 120 but did not reach indicating superior formulations. By contrast, afforded comparatively lower. Thus, identified a promising antigen vaccine infection.

Language: Английский

Citations

2
“Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems” DOI
Sudharshan Reddy Dachani, Ankur Vashi, Anand B. Mundada

et al.

Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 16, 2024

Polymers have become a versatile tool in pharmaceutical chemistry through techniques and new formulation. This review presents an overview of the general topic drug delivery polymers, places particular focus on their specific contributions, discusses significant issues like biocompatibility, controlled release targeted delivery. Unlike previous reviews, it captures recent development biodegradable, smart stimuli-responsive abilities to improve therapy outcomes patient adherence treatments. Furthermore, this work also has enhanced understanding advanced polymer-based systems such as polymeric nanoparticles, bioconjugation strategies natural with examples various therapeutic areas. The stands for itself by expanding discussion regulatory clinical realism difficulties well safety, efficacy, acceptance considerations. In addition, emphasizes role interdisciplinary intersectoral cooperation cross-country collaborations developing polymers-based applications precision medicine. way, provides fresh view both present advancements future possibilities technologies dedicated achievements globally inspire researchers practitioners.

Language: Английский

Citations

2
Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization DOI Creative Commons
Iriczalli Cruz‐Maya,

Carmine Schiavone,

Rosalia Ferraro

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 193 - 193

Published: Jan. 29, 2024

Innovations in drug delivery systems are crucial for enhancing therapeutic efficiency. Our research presents a novel approach based on using electro-fluid dynamic atomization (EFDA) to fabricate core-shell monophasic particles (CSMp) from sodium alginate blends of varying molecular weights. This study explores the morphological characteristics these relation material properties and process conditions, highlighting their potential applications. A key aspect our work is development mathematical model that simulates release kinetics small molecules, specifically diclofenac. By assessing diffusion different molecules gel formulations through transport rheological models, we have created predictive tool evaluating efficiency delivery. findings underscore two critical, independent parameters optimizing release: external shell thickness diffusivity ratios within dual layers. allows precise control over timing intensity profile. advances understanding EFDA fabrication CSMp offers promising avenues by tailoring profiles particle characteristic manipulation.

Language: Английский

Citations

1