Tumor Cell Communications as Promising Supramolecular Targets for Cancer Chemotherapy: A Possible Strategy DOI Open Access
И. В. Алексеенко, Lyudmila Zhukova, L. G. Kondratyeva

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10454 - 10454

Published: Sept. 27, 2024

Fifty-two years have passed since President Nixon launched the “War on Cancer”. Despite unparalleled efforts and funds allocated worldwide, outlined goals were not achieved because cancer treatment approaches such as chemotherapy, radiation therapy, hormonal targeted therapies fully met expectations. Based recent literature, a new direction in therapy can be proposed which targets connections between cells their microenvironment by chemical means. Cancer–stromal synapses immunological immune provide an attractive target for this approach. Such form ligand–receptor clusters interface of interacting cells. They share common property involving intercellular spatially proximate cooperatively acting proteins. Synapses space focused signaling molecules exchange. Thus, disassembly cancer–stromal may potentially cause collapse various tumors. Additionally, clustered arrangement synapse components offers opportunities to enhance safety precision using crosslinking agents inactivate even reduced concentrations. Furthermore, attaching cleavable cell-permeable toxic agent(s) crosslinker further anti-cancer effect therapeutics. The highlighted approach promises universal, relatively simple cost-efficient. We also hope that, unlike chemotherapeutic drugs that interact with single target, supramolecular large include many different emergence resistance characteristic chemo- immunotherapy is extremely unlikely.

Language: Английский

The Therapeutic Mechanisms of Mesenchymal Stem Cells in MS—A Review Focusing on Neuroprotective Properties DOI Open Access
Sonia Gavasso, Torbjørn Kråkenes,

Håkon Olsen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1365 - 1365

Published: Jan. 23, 2024

In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress compartmentalized inflammation within central nervous system (CNS) and promote remyelination regeneration. Mesenchymal stem cells (MSCs) represent promising therapeutic option, as they have been shown migrate site of CNS injury exert neuroprotective properties, including immunomodulation, neurotrophic factor secretion, endogenous neural cell stimulation. This review summarizes current understanding underlying mechanisms discusses translation MSC transplantation their derivatives from pre-clinical demyelinating models clinical trials MS patients.

Language: Английский

Citations

11
Transfer and fates of damaged mitochondria: role in health and disease DOI Open Access
Hanbing Li,

Weiyun Sun,

Wenwen Gong

et al.

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Intercellular communication is pivotal in mediating the transfer of mitochondria from donor to recipient cells. This process orchestrates various biological functions, including tissue repair, cell proliferation, differentiation and cancer invasion. Typically, dysfunctional depolarized are eliminated through intracellular or extracellular pathways. Nevertheless, increasing evidence suggests that intercellular damaged associated with pathogenesis diverse diseases. review investigates prevalent triggers mitochondrial damage underlying mechanisms transfer, elucidates role directional both physiological pathological contexts. Additionally, we propose potential previously unknown explore their prospective roles disease prevention therapy.

Language: Английский

Citations

7
Exosome Mediated Cell-Cell Crosstalk in Tissue Injury and Repair DOI
Anita Yadav,

Aparajita Nandy,

Anu Sharma

et al.

Results and problems in cell differentiation, Journal Year: 2024, Volume and Issue: unknown, P. 249 - 297

Published: Jan. 1, 2024

Language: Английский

Citations

6
Extracellular vesicles DOI Creative Commons
Juan Wang, Maureen M. Barr, Ann M. Wehman

et al.

Genetics, Journal Year: 2024, Volume and Issue: 227(4)

Published: June 17, 2024

Abstract Extracellular vesicles (EVs) encompass a diverse array of membrane-bound organelles released outside cells in response to developmental and physiological cell needs. EVs play important roles remodeling the shape content differentiating can rescue damaged from toxic or dysfunctional content. send signals transfer metabolites between tissues organisms regulate development, respond stress tissue damage, alter mating behaviors. While many EV functions have been uncovered by characterizing ex vivo isolated body fluids cultured cells, research using nematode Caenorhabditis elegans has provided insights into functions, biogenesis, uptake pathways. The C. field also developed methods analyze endogenous within organismal context development adult physiology free-living, behaving animals. In this review, we summarize major themes that emerged for their relevance human health disease. We highlight diversity biogenesis mechanisms, locations, worm discuss open questions unexplored topics tenable elegans, given model is ideal light electron microscopy, genetic screens, genome engineering, high-throughput omics.

Language: Английский

Citations

5
Predicting intercellular communication based on metabolite-related ligand-receptor interactions with MRCLinkdb DOI Creative Commons
Yuncong Zhang, Yang Yu, Liping Ren

et al.

BMC Biology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 8, 2024

Abstract Background Metabolite-associated cell communications play critical roles in maintaining human biological function. However, most existing tools and resources focus only on ligand-receptor interaction pairs where both partners are proteinaceous, neglecting other non-protein molecules. To address this gap, we introduce the MRCLinkdb database algorithm, which aggregates organizes data related to L-R interactions cell-cell communication, providing a valuable resource for predicting intercellular communication based metabolite-related interactions. Results Here, manually curated metabolite-ligand-receptor (ML-R) from literature known databases, ultimately collecting over 790 670 mouse ML-R Additionally, compiled information 1900 enzymes 260 transporter entries associated with these metabolites. We developed Metabolite-Receptor Cell Link Database (MRCLinkdb) store data. Meanwhile, platform also offers extensive presenting interactions, including fundamental metabolite overall expression landscape of metabolite-associated gene sets (such as receptor, enzymes, proteins) single-cell transcriptomics sequencing (covering 35 26 tissues, 52 44 types) bulk RNA-seq/microarray (encompassing 62 39 tissues). Furthermore, introduces web server dedicated analysis is freely available at https://www.cellknowledge.com.cn/mrclinkdb/ . Conclusions In addition supplementing may provide new perspectives decoding advancing prediction

Language: Английский

Citations

5
Reliable Hallmarks and Biomarkers of Senescent Lymphocytes DOI Open Access

Yuliya S. Martyshkina,

Valeriy Tereshchenko, Daria A. Bogdanova

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15653 - 15653

Published: Oct. 27, 2023

The phenomenon of accumulation senescent adaptive immunity cells in the elderly is attracting attention due to increasing risk global epidemics and aging population. Elderly people are predisposed various infectious age-related diseases at higher vaccination failure. increases background inflammation, “Inflammaging”, causing lymphocyte exhaustion cardiovascular, neurodegenerative, autoimmune cancer diseases. Here, we present a comprehensive contemporary review mechanisms phenotype senescence immune system. Although modern research has not yet identified specific markers lymphocytes, several sets facilitate separation population based on normal memory exhausted for further genetic functional analysis. reasons predisposition CD8+ T-lymphocytes compared CD4+ also discussed. We point out approaches senescent-lymphocyte-targeting using small molecules (senolytics), antibodies immunization against cells. suppression most relevant area aimed developing anti-aging anti-cancer therapy prolonging lifespan

Language: Английский

Citations

12
Human stem cells with in vivo high plasticity generated by cell–cell communication DOI Creative Commons
Shao-wei Li, Xi Chen, Jingxue Xin

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(11)

Published: March 11, 2025

Stem cells possess inherent properties of self-renewal and differentiation, thus hold significant promise for regenerating damaged tissues or replacing lost cells. Unless their therapeutic effects are solely mediated by paracrine, transplanted stem need to be highly plastic adapt the host tissue environment differentiate into constituent tissue-specific repair. used in current cell-based therapies either have limited differentiation potential pluripotent but must strictly restricted avoid tumorigenicity risk vivo. Here, we describe derivation human adult high-plasticity cells, which call guide-integrated (giaSCs), from interaction blood-derived guide umbilical cord tissue–derived mesenchymal stromal (UC-MSCs). The a cell population derived peripheral blood adults. Unidirectional transfer through nanotube-like structures granular substances recipient UC-MSCs gave rise giaSCs. Topical application giaSCs full-layer excisional wounds wild-type mice led reconstitution skin tissue. Systemically administered migrated reside mouse small intestinal lipopolysaccharides then differentiated epithelial These transplantation experiments demonstrated that vivo high plasticity. Additional vitro data showed low immunogenicity nontumorigenic. indicate offer promising approach therapy.

Language: Английский

Citations

0
ИНФЛАМЕЙДЖИНГ: РОЛЬ СЕНЕСЦЕНТНЫХ КЛЕТОК В ПАТОГЕНЕЗЕ ОСТЕОАРТРИТА DOI
Vladimir N. Khabarov,

Е.С. Миронова

Успехи геронтологии, Journal Year: 2025, Volume and Issue: 37(6), P. 777 - 786

Published: Feb. 20, 2025

Language: Русский

Citations

0
Межклеточная коммуникация: как клетки создали нас, наши эмоции и сознание DOI
Alexander P. Khudiakov

Published: May 2, 2025

В данном исследовании предложена гипотеза о происхождении эмоций и сознания в результате межклеточной коммуникации процессе интеграции многоклеточных организмов. Многоклеточные организмы ограничены возможности непосредственно реагировать на стимулы из-за неоднородности реакций разных клеток. Клетки вынуждены координировать свои действия друг с другом, сообщая своих гомеостатических состояниях посредством химических электрических сигналов. Совокупность сигналов отдельных клеток формирует субъективную дифференцированную оценку состояния многоклеточного организма качестве первичных позволяет перейти от автоматических к активному оптимизационному поведению, основанному конкуренции мотивов. Таким образом, сознание — это функция живых существ (изначально - клеток), а свою форму оно обрело единый субъект.

Language: Русский

Citations

0
MTFR2‐Mediated Fission Drives Fatty Acid and Mitochondrial Co‐Transfer from Hepatic Stellate Cells to Tumor Cells Fueling Oncogenesis DOI Creative Commons
Zhang La, Baoyong Zhou, Jun Yang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract The tumor margin of hepatocellular carcinoma (HCC) is a critical zone where cancer cells invade the surrounding stroma, exhibiting unique and more invasive metabolic migratory features compared to center, driving expansion beyond primary lesion. Studies have shown that at this interface, HCC primarily rely on fatty acid oxidation meet their energy demands, although underlying mechanisms remain unclear. This study demonstrates activated hepatic stellate (HSCs) play pivotal role in sustaining needs cells. Specifically, it discovered mitochondrial fission regulator 2 (MTFR2) HSCs interacts with dynamin‐related protein 1 (DRP1, known machinery), preventing its lysosomal degradation, which turn promotes fission. MTFR2‐driven enhances transfer both acids mitochondria cells, supplying essential substrates reinforcing machinery for growth. findings suggest targeting may offer novel therapeutic avenue interfering crosstalk between stromal niche.

Language: Английский

Citations

0