The RAAS system SNPs polymorphism is associated with essential hypertension risk in rural areas in northern China DOI Creative Commons
Cheng Jin, Jing Cui, Yuanyuan Li

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(14), P. 2694 - 2704

Published: Jan. 1, 2024

Epidemiological evidence has shown that genetics and environment are associated with the risk of hypertension. However, specific SNP effects a cluster crucial genes in RAAS system on hypertension unclear.

Language: Английский

The diverse landscape of RNA modifications in cancer development and progression DOI
Hyung Seok Kim, Jung Woo Eun, Seonghoe Jang

et al.

Genes & Genomics, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 6, 2024

Language: Английский

Citations

1
Comprehensive multi-omics analysis identifies NUSAP1 as a potential prognostic and immunotherapeutic marker for lung adenocarcinoma DOI Creative Commons
Jun Ma, Wenjing Zhu, Ran Zhou

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 22(2), P. 328 - 340

Published: Dec. 31, 2024

While NUSAP1's association with various tumors is established, its predictive value for prognosis and immunotherapy in lung adenocarcinoma (LUAD) remains unconfirmed. We analyzed Nucleolar Spindle-Associated Protein 1 (NUSAP1) gene expression TCGA GTEx datasets validated it clinicopathological tissues using qRT-PCR immunohistochemistry. Additionally, we investigated relationship patient across five GEO cohorts. The IMvigor210 cohort was utilized to explore efficacy. Furthermore, single-cell RNA-sequencing data used examine the correlation between NUSAP1 immune cell infiltration. Finally, m6A methylation. significantly elevated tumor tissues, correlating poorer LUAD patients. It exhibited a significant infiltration microenvironment, predominantly expressed Tprolif cells. patients heightened may derive greater benefit from anti-PD-L1 treatment. tightly linked Enrichment analysis revealed key biological functions, including lipid metabolism cycle regulation. Our comprehensive underscores potential as prognostic immunotherapeutic biomarker LUAD, warranting further investigation.

Language: Английский

Citations

1
Exploring the importance of m5c in the diagnosis and subtype classification of COPD using the GEO database DOI
Jianjun Wu, Xiaoning Li, Deyu Kong

et al.

Gene, Journal Year: 2023, Volume and Issue: 895, P. 147987 - 147987

Published: Nov. 14, 2023

Language: Английский

Citations

1
The RAAS system SNPs polymorphism is associated with essential hypertension risk in rural areas in northern China DOI Creative Commons
Cheng Jin, Jing Cui, Yuanyuan Li

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(14), P. 2694 - 2704

Published: Jan. 1, 2024

Epidemiological evidence has shown that genetics and environment are associated with the risk of hypertension. However, specific SNP effects a cluster crucial genes in RAAS system on hypertension unclear.

Language: Английский

Citations

0