Renoprotective effect of liraglutide on diabetic nephropathy by modulation of Krüppel-like transcription factor 5 expression in rats DOI
Anfal F. Bin Dayel, Nouf M. Al‐Rasheed, Asma S. Alonazi

et al.

Journal of Pharmacy and Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Objectives Diabetic nephropathy (DN) is a serious consequence of diabetes that can develop through the lysophosphatidic acid axis. The purpose this study was to determine whether antidiabetic drug liraglutide slow development diabetic kidney damage by altering axis via KLF5. Methods Wistar albino rats were divided into nondiabetic and (resulting from an intraperitoneal streptozotocin dose 30 mg/kg high-fat diet). These further four groups: control, liraglutide-treated nondiabetic, diabetic. control groups received normal saline for 42 days, while 21 followed subcutaneous (200 μg/kg/day) days. Subsequently, serum levels DN biomarkers evaluated, tissues histologically examined. protein expression PCNA, autotaxin, KLF5 detected. Key findings Liraglutide treatment in decreased biomarkers, histological abnormalities tissues, Conclusion progression modulating KLF5-related Thus, may be effective preventing or mitigating diabetes-related damage.

Language: Английский

Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-α, NF-κB, and Bax DOI Creative Commons
Ahmed M. Abd-Eldayem,

Sohayla Mahmoud Makram,

Basim Anwar Shehata Messiha

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 28, 2024

Abstract Cyclosporine A (CsA) is employed for organ transplantation and autoimmune disorders. Nephrotoxicity a serious side effect that hampers the therapeutic use of CsA. Hesperidin sitagliptin were investigated their antioxidant, anti-inflammatory, tissue-protective properties. We aimed to investigate compare possible nephroprotective effects hesperidin sitagliptin. Male Wistar rats utilized induction CsA nephrotoxicity (20 mg/kg/day, intraperitoneally 7 days). Animals treated with (10 orally 14 days) or (200 Blood urea, serum creatinine, albumin, cystatin-C (CYS-C), myeloperoxidase (MPO), glucose measured. The renal malondialdehyde (MDA), glutathione (GSH), catalase, SOD estimated. Renal TNF-α protein expression was evaluated. Histopathological examination immunostaining study Bax, Nrf-2, NF-κB performed. Sitagliptin attenuated CsA-mediated elevations blood CYS-C, glucose, MDA, MPO, preserved SOD, GSH. They reduced expressions TNF-α, NF-κB, pathological kidney damage. Nrf2 in raised. could protect against through mitigation oxidative stress, apoptosis, inflammation. proved be more beneficial than hesperidin.

Language: Английский

Citations

15
Emerging role of antidiabetic drugs in cardiorenal protection DOI Creative Commons

Wen-Jia Fu,

Jin-Ling Huo,

Zi‐Hui Mao

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 6, 2024

The global prevalence of diabetes mellitus (DM) has led to widespread multi-system damage, especially in cardiovascular and renal functions, heightening morbidity mortality. Emerging antidiabetic drugs sodium-glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1RAs), dipeptidyl peptidase-4 (DPP-4i) have demonstrated efficacy preserving cardiac function, both type diabetic non-diabetic individuals. To understand the exact impact these on cardiorenal protection underlying mechanisms, we conducted a comprehensive review recent large-scale clinical trials basic research focusing SGLT2i, GLP-1RAs, DPP-4i. Accumulating evidence highlights diverse mechanisms including glucose-dependent independent pathways, revealing their potential disease. This provides critical insights into protective effects DPP-4i underscores importance medications mitigating progression complications, broader implications beyond glycemic management.

Language: Английский

Citations

7
Antiobesity and antidiabetes effects of Cyperus rotundus rhizomes presenting protein tyrosine phosphatase, dipeptidyl peptidase 4, metabolic enzymes, stress oxidant and inflammation inhibitory potential DOI Creative Commons

Faiza I. A. Abdella,

Amani Toumi,

Sarra Boudriga

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27598 - e27598

Published: March 1, 2024

Diabetes is a significant global health concern that increases the vulnerability to various chronic illnesses. In view of this issue, current research aimed examine effects administering an extract derived from tubers Cyperus rotundus L (CrE) on obesity, type 1 diabetes, and liver-kidney toxicity. Through utilization HPLC-DAD analysis, it was discovered contained several components, including quercetin (47.8%), luteolin glucoside (17%), (7.56%), apigenin-7-glucoside (6.29%), naringinin (4.52%), seven others. vitro experiments they have demonstrated CrE effectively inhibited key digestive enzymes associated with obesity 2 such as DPP-4, PTP1B, lipase, α-amylase, evidenced by their respective IC50 values are about 23, 51,83, 67 μg/ml respectively. Furthermore, when diabetic rats were administered CrE, activity pancreatic linked inflammation, namely 5-lipoxygenase (5-LO), hyaluronidase (HAase), myeloperoxidase (MPO), significantly suppressed 48, 41, 75, 47%, Moreover, exhibited protective β-cells inhibiting formation thiobarbituric acid reactive substances (TBARS) 65% induction superoxide Dismutase (SOD), catalase (CAT) glutathione peroxidase (GPX) activities 62, 108, 112% respectively compared untreated rat. Additionally, intestinal, pancreatic, serum lipase α-amylase activities. rats, administration glycogen phosphorylase (GP) stimulated synthase (GS) 45 30%; increased liver content 45%. modulated hepatic involved in carbohydrate metabolism, hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), glucose-6-phosphatase (G6P), fructose-1,6-bisphosphatase (FBP). Notably, average food water intake (AFI AWI) treated reduced 15 16% those without any treatment. Therefore, study effectiveness preventing treating diabetes.

Language: Английский

Citations

7
Therapeutic potential of stromal vascular fraction in early diabetic nephrotoxicity: a histomorphometric and immunohistochemical analysis in type 2 diabetes rat model DOI Open Access
Amany Hamoud, Hanaa Wanas, Ahmed Bayoumi

et al.

Folia Morphologica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Diabetic nephropathy (DN), a common complication of type 2 diabetes (T2D), significantly contributes to end-stage kidney disease (ESKD). Despite conventional treatments aimed at slowing progression, there is pressing need for novel therapies. This study evaluates the potential therapeutic impact adipose tissue derived stromal vascular fraction (SVF) on early diabetic nephrotoxicity in rat model. Thirty-one male albino rats were divided into control and groups, with latter further split untreated (T2Da) SVF-treated (T2Db) subgroups. Biochemical, histological, immunohistochemical, morphometric analyses conducted. We demonstrated that SVF treatment reduced oxidative stress, lowered serum creatinine, improved renal architecture by mitigating fibrosis cellular infiltration, suggesting enhanced regeneration inflammation. also facilitated repair, indicated increased endothelial cell proliferation glomerular damage. underscores SVF's as promising regenerative approach managing early-stage DN, warranting research elucidate its mechanisms.

Language: Английский

Citations

0
Glp-1 Mimetic of Sitagliptin Improved Oxidative Stress and Liver Function Tests via Suppressing NOX-4 Enzyme in Hepatic Tissues of Diabetic Rats DOI
Mohammad Amin Hemmati,

Behina Foroozanmehr,

Ali Fardin

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151455 - 151455

Published: Feb. 1, 2025

Language: Английский

Citations

0
Current Advances in Protein Phosphatases in Kidney Disease DOI Creative Commons

Marina Rousseau,

Pedro Geraldes

Current Opinion in Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 100828 - 100828

Published: April 1, 2025

Language: Английский

Citations

0
Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs DOI
Yanjun Wu, Jiayuan Mo, Jing Liang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155499 - 155499

Published: March 3, 2024

Language: Английский

Citations

3
Deciphering the role of MicroRNAs in diabetic nephropathy: Regulatory mechanisms and molecular insights DOI
Nourhan M. Abdelmaksoud, Tohada M. AL‐Noshokaty, Rehab Abdelhamid

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155237 - 155237

Published: March 4, 2024

Language: Английский

Citations

2
Molecular mechanisms of diabetic nephropathy: A narrative review DOI
Tian Sun,

Yina Guo,

Yanting Su

et al.

Cell Biology International, Journal Year: 2024, Volume and Issue: 48(9), P. 1240 - 1253

Published: June 30, 2024

Abstract Diabetic nephropathy (DN) is the predominant secondary resulting in global end‐stage renal disease. It attracting significant attention both domestic and international research due to its widespread occurrence, fast advancement, limited choices for prevention treatment. The pathophysiology of this condition intricate involves multiple molecular cellular pathways at various levels. This article provides a concise overview processes involved development DN. discusses factors, such as signaling pathways, cytokines, inflammatory responses, oxidative stress, damage, autophagy, epigenetics. aim offer clinicians valuable reference DN's diagnosis, treatment, intervention.

Language: Английский

Citations

2
Special Issue IJMS—Molecular Mechanisms of Diabetic Kidney Disease DOI Open Access
Ligia Petrică

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 790 - 790

Published: Jan. 8, 2024

Diabetic kidney disease (DKD), as a major microvascular complication of both type 1 and 2 diabetes mellitus (DM), accounts for over 40% patients that reach end-stage renal are referred to replacement therapies [...]

Language: Английский

Citations

1