International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3858 - 3858
Published: April 18, 2025
Diagnosing
traumatic
brain
injury
(TBI)
remains
challenging
due
to
an
incomplete
understanding
of
its
neuropathological
mechanisms.
TBI
is
recognised
as
a
complex
condition
involving
both
primary
and
secondary
injuries.
Although
oxidative
stress
non-specific
molecular
phenomenon
observed
in
various
conditions,
it
plays
crucial
role
response
recovery.
Due
these
aspects,
we
aimed
evaluate
the
interaction
between
some
known
biomarkers
providing
evidence
for
possible
relevance
clinical
diagnosis
outcome
prediction.
We
found
that
while
many
currently
validated
interact
with
pathways,
their
patterns
variation
could
assist
diagnosis,
prognosis,
outcomes
prediction
cases.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(11), P. 9605 - 9605
Published: May 31, 2023
S100B
is
a
calcium-binding
protein
mainly
concentrated
in
astrocytes
the
nervous
system.
Its
levels
biological
fluids
are
recognized
as
reliable
biomarker
of
active
neural
distress,
and
more
recently,
mounting
evidence
points
to
Damage-Associated
Molecular
Pattern
molecule,
which,
at
high
concentration,
triggers
tissue
reactions
damage.
and/or
distribution
patients
experimental
models
different
disorders,
for
which
used
biomarker,
directly
related
progress
disease.
In
addition,
diseases
such
Alzheimer’s
Parkinson’s
diseases,
amyotrophic
lateral
sclerosis,
multiple
traumatic
vascular
acute
injury,
epilepsy,
inflammatory
bowel
disease,
alteration
correlates
with
occurrence
clinical
toxic
parameters.
general,
overexpression/administration
worsens
presentation,
whereas
deletion/inactivation
contributes
amelioration
symptoms.
Thus,
may
be
proposed
common
pathogenic
factor
sharing
symptoms
etiologies
but
appearing
share
some
processes
reasonably
attributable
neuroinflammation.
EBioMedicine,
Journal Year:
2024,
Volume and Issue:
100, P. 104955 - 104955
Published: Jan. 3, 2024
Cancer
treatment
with
immune
checkpoint
inhibition
(ICI)
can
cause
immune-related
adverse
events
in
the
central
nervous
system
(CNS
irAE).
There
are
no
blood
biomarkers
to
detect
CNS
irAE.
We
investigated
if
concentrations
of
S100-calcium-binding
protein
B
(S100B)
and
neurofilament
light
chain
(NfL)
be
used
as
for
irAE
assessed
incidence
a
cohort
ICI-treated
patients.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 10335 - 10335
Published: June 19, 2023
Advances
in
spine
surgery
enable
technically
safe
interventions
older
patients
with
disabling
disease,
yet
postoperative
delirium
(POD)
poses
a
serious
risk
for
recovery.
This
study
investigates
biomarkers
of
pro-neuroinflammatory
states
that
may
help
objectively
define
the
pre-operative
POD.
enrolled
aged
≥60
scheduled
elective
under
general
anesthesia.
Biomarkers
state
included
S100
calcium-binding
protein
β
(S100β),
brain-derived
neurotrophic
factor
(BDNF),
Gasdermin
D,
and
soluble
ectodomain
triggering
receptor
expressed
on
myeloid
cells
2
(sTREM2).
Postoperative
changes
Interleukin-6
(IL-6),
Interleukin-1β
(IL-1β),
C-reactive
(CRP)
were
assessed
as
markers
systemic
inflammation
preoperatively,
intraoperatively,
early
postoperatively
(up
to
48
h).
Patients
POD
(n
=
19,
75.7
±
5.8
years)
had
higher
levels
sTREM2
(128.2
69.4
pg/mL
vs.
97.2
52.0
pg/mL,
p
0.049)
D
(2.9
1.6
2.1
1.4
0.29)
than
those
without
25,
75.6
5.1
years).
STREM2
was
additionally
predictor
(OR
1.01/(pg/mL)
[1.00-1.03],
0.05),
moderated
by
IL-6
(Wald-χ2
4.06,
0.04).
showed
significant
increase
IL-6,
IL-1β,
S100β
first
day.
identified
potential
predisposes
development
Future
studies
should
confirm
these
results
larger
cohort
determine
their
an
objective
biomarker
inform
prevention
strategies.
Expert Review of Molecular Diagnostics,
Journal Year:
2024,
Volume and Issue:
24(1-2), P. 39 - 47
Published: Jan. 6, 2024
Diffuse
axonal
injury
(DAI),
with
high
mortality
and
morbidity
both
in
children
adults,
is
one
of
the
most
severe
pathological
consequences
traumatic
brain
injury.
Currently,
clinical
diagnosis,
disease
assessment,
disability
identification,
postmortem
diagnosis
DAI
mainly
limited
by
absent
specific
molecular
biomarkers.
Clinical Chemistry,
Journal Year:
2024,
Volume and Issue:
70(8), P. 1023 - 1036
Published: April 24, 2024
Despite
the
use
of
validated
guidelines
in
management
mild
traumatic
brain
injury
(mTBI),
processes
to
limit
unnecessary
scans
are
still
not
sufficient
and
need
be
improved.
The
blood
biomarkers
represents
a
relevant
adjunct
identify
patients
at
risk
for
intracranial
requiring
computed
tomography
(CT)
scan.
Clinical Chemistry and Laboratory Medicine (CCLM),
Journal Year:
2023,
Volume and Issue:
62(5), P. 891 - 899
Published: Nov. 30, 2023
To
compare
for
the
first
time
performance
of
"GFAP
and
UCH-L1"
vs.
S100B
in
a
cohort
patients
managed
mild
traumatic
brain
injury
(mTBI)
according
to
actualized
French
guidelines.
International Journal of Gynecology & Obstetrics,
Journal Year:
2024,
Volume and Issue:
166(3), P. 954 - 968
Published: April 1, 2024
Despite
their
general
good
health,
an
increasing
proportion
of
elderly
individuals
require
surgery
due
to
increase
in
average
lifespan.
However,
because
increased
vulnerability,
these
patients
need
be
handled
carefully
make
sure
that
does
not
cause
more
harm
than
good.
Age-related
postoperative
cognitive
disorders
(POCD)
and
delirium
(POD),
two
serious
consequences
are
marked
by
adverse
neuropsychologic
alterations
after
surgery,
particularly
dangerous
for
the
elderly.
In
context
gynecologic
procedures,
POCD
POD
examined
this
narrative
review.
The
main
question
is
how
limit
rates
older
women
undergoing
procedures
maximizing
risk-benefit
balance.
Three
crucial
endpoints
considered:
(1)
surgical
lower
POD,
(2)
anesthetic
techniques
lessen
occurrence
(3)
identification
at
high
risk
post-surgery
impairments.
Risks
associated
with
laparoscopic
include
Trendelenburg
posture
CO
NeuroImage Clinical,
Journal Year:
2024,
Volume and Issue:
43, P. 103647 - 103647
Published: Jan. 1, 2024
Mild
traumatic
brain
injury
(mTBI),
often
called
concussion,
is
a
prevalent
condition
that
can
have
significant
implications
for
people's
health,
functioning
and
well-being.
Current
clinical
practice
relies
on
self-reported
symptoms
to
guide
decision-making
regarding
return
sport,
employment,
education.
Unfortunately,
reliance
subjective
evaluations
may
fail
accurately
reflect
the
resolution
of
neuropathology,
exposing
individuals
with
mTBI
an
increased
risk
further
head
trauma.
No
objective
technique
currently
exists
assess
microstructural
alterations
tissue
which
characterise
mTBI.
MRI-based
T2
relaxation
quantitative
imaging
susceptible
detecting
fluid
properties
in
hypothesised
indicate
neuroinflammation.
This
study
aimed
investigate
potential
individual-level
relaxometry
evaluate
cellular
damage
from
20
male
participants
acute
sports-related
(within
14
days
post-injury)
44
healthy
controls
were
recruited
this
study.
Each
participant's
voxel-wise
map
was
analysed
against
control
averages
using
z-test
false
discovery
rate
correction.
Five
re-scanned
after
recovery
results
compared
their
maps
reduction
times
significantly
19/20
(95
%)
controls,
regions
including
hippocampus,
frontal
cortex,
parietal
insula,
cingulate
cortex
cerebellum.
Results
suggest
presence
cerebral
Longitudinal
indicated
all
five
participants,
indicating
possible
over
time.
research
highlights
MRI
as
non-invasive
method
assessing
subtle
pathology
Identifying
monitoring
changes
content
could
aid
predicting
developing
individualised
treatment
plans
Future
should
validate
measure
other
markers
inflammation
(e.g.
blood
biomarkers)
test
whether
T2-relaxometry
related
In
addition,
future
utilise
larger
groups
establish
normative
ranges
compute
robust
z-score
analyses.
