The Associations of Cardiometabolic and Dietary Variables with Clinical Periodontitis in Adults with and without Type 2 Diabetes: A Cross-Sectional Study DOI Open Access
Arpita Basu, Leigh Ann Richardson,

Alicia Carlos

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 81 - 81

Published: Dec. 26, 2023

Periodontitis is a commonly occurring inflammatory oral disease affecting large proportion of global and US adults characterized by the destruction tooth-supporting apparatus. Its etiology multifactorial, type 2 diabetes diet play critical roles in its remission progression. However, few studies have addressed nutritional serum vitamin D status with periodontitis presence diabetes. A cross-sectional study (n = 78), sub-set age- BMI-matched case–control 50), were conducted to examine differences dietary cardiometabolic variables, or without Participants provided fasting blood samples 24-h recalls on at least two different days. Data health history, body weight, height, habits, clinical features also collected. The Mann–Whitney U Test (with exact p-value estimation Monte Carlo simulation) was used continuous ordinal variables. Results revealed significantly lower D, intake fruits, vegetables, dairy, vitamins C vs. sub-study (all p < 0.05). In overall sample, presented higher caries risk measures numbers teeth than those diabetes; plaque bleeding scores did not differ status. Finally, significant associations food habits observed, especially consuming protein-rich foods twice day score, daily consumption fried fast fewer number present findings show inadequacies among periodontitis, further aggravates observed malnourishment health.

Language: Английский

A review of deep learning in dentistry DOI Creative Commons
Chenxi Huang, Jiaji Wang, Shuihua Wang‎

et al.

Neurocomputing, Journal Year: 2023, Volume and Issue: 554, P. 126629 - 126629

Published: July 27, 2023

Oral diseases have a significant impact on human health, often going unnoticed in their early stages. Deep learning, promising field artificial intelligence, has shown remarkable success various domains, especially dentistry. This paper aims to provide an overview of recent research deep learning applications dentistry, with focus dental imaging. algorithms perform well difficult tasks such as image segmentation and recognition, enabling accurate identification oral conditions abnormalities. Integration other health data offers holistic understanding the relationship between systemic health. However, there are still many challenges that need be addressed.

Language: Английский

Citations

47
Vitamin intake and periodontal disease: a meta-analysis of observational studies DOI Creative Commons

Nannan Mi,

Miaomiao Zhang, Ying Zheng

et al.

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 20, 2024

Language: Английский

Citations

8
Nutritional Deficiencies and Associated Oral Health in Adolescents: A Comprehensive Scoping Review DOI Creative Commons
Man Hung,

Amy Blazejewski,

Samantha Lee

et al.

Children, Journal Year: 2024, Volume and Issue: 11(7), P. 869 - 869

Published: July 18, 2024

Introduction: The shift to processed foods in American diets has increased vitamin and mineral deficiencies among adolescents, impacting growth health, often manifesting as oral lesions. This review study aimed explore the link between nutritional adolescent health improve guidance prevent long-term issues. Methods: A systematic of literature from 2013 2023 was conducted on adolescents aged 10–19 years, using PRISMA guidelines. Searches PubMed, Web Science, Dentistry & Oral Sciences Source—Ebscohost, Scopus included peer-reviewed articles, excluding reviews non-empirical studies. Data were screened extracted with independent for accuracy. Results: Malnutrition strongly correlates poor health. Undernourished children have a 60% increase dental caries, exacerbated by high sugar intake. Early malnutrition delays eruption, temporarily protecting against while stunting infections cause enamel defects. Chronic conditions like cerebral palsy celiac disease worsen risks persisting into adulthood. Conclusions: Nutritional are interconnected, requiring integrated healthcare. interventions holistic strategies can outcomes reduce burdens. Comprehensive education routine evaluations essential prevention treatment, enhancing across all demographics.

Language: Английский

Citations

6
Periodontal Disease and Other Adverse Health Outcomes Share Risk Factors, including Dietary Factors and Vitamin D Status DOI Open Access
William B. Grant, Barbara M. van Amerongen, Barbara J. Boucher

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2787 - 2787

Published: June 17, 2023

For nearly a century, researchers have associated periodontal disease (PD) with risks of other adverse health outcomes such as cardiovascular disease, diabetes mellitus, and respiratory diseases, well pregnancy outcomes. Those findings led to the hypothesis that PD causes those either by increasing systemic inflammation or action periodontopathic bacteria. However, experiments largely failed support hypothesis. Instead, association is casual, not causal, due shared underlying modifiable risk factors, including smoking, diet, obesity, low levels physical activity, vitamin D status. Diabetes mellitus also considered factor for PD, whereas red processed meat are most important dietary factors diabetes. Because generally develops before outcomes, diagnosis can alert patients they could reduce lifestyle changes. In addition, type 2 often be reversed rapidly adopting an anti-inflammatory, nonhyperinsulinemic diet emphasizes healthful, whole plant-based foods. This review describes evidence proinflammatory prohyperinsulinemia diets status We make recommendations regarding patterns, food groups, serum 25-hydroxyvitamin concentrations. Oral professionals should routinely inform their severe many making appropriate

Language: Английский

Citations

14
Bone Formation and Maintenance in Oral Surgery: The Decisive Role of the Immune System—A Narrative Review of Mechanisms and Solutions DOI Creative Commons

Élisa Choukroun,

Maximilien Parnot,

Jérôme Surmenian

et al.

Bioengineering, Journal Year: 2024, Volume and Issue: 11(2), P. 191 - 191

Published: Feb. 16, 2024

Based on the evidence of a significant communication and connection pathway between bone immune systems, new science has emerged: osteoimmunology. Indeed, system considerable impact health diseases, as well formation during grafts its stability over time. Chronic inflammation induces excessive production oxidants. An imbalance levels oxidants antioxidants is called oxidative stress. This physio-pathological state causes both molecular cellular damage, which leads to DNA alterations, genetic mutations cell apoptosis, thus, impaired immunity followed by delayed or compromised wound healing. Oxidative stress experienced body affect regeneration maintenance around teeth dental implants. As remodeling are interconnected, loss consequence dysregulation. Therefore, oral tissue deficiencies such periodontitis peri-implantitis should be regarded diseases. Bone management strategies include biological surgical solutions. These protocols tend improve through antioxidant enhance prevent loss. narrative review aims highlight relationship inflammation, oxidation, in cavity. It intends help clinicians detect high-risk situations surgery propose clinical solutions that will patients’ responses treatment outcomes.

Language: Английский

Citations

5
METTL3 promotes the osteogenic differentiation of human periodontal ligament cells by increasing YAP activity via IGF2BP1 and YTHDF1‐mediated m6A modification DOI
Xuefei Sun,

Xiujiao Meng,

Y. Piao

et al.

Journal of Periodontal Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Abstract Aims N6‐Methyladenosine (m 6 A) has been confirmed to play a dynamic role in osteoporosis and bone metabolism. However, whether m A is involved the osteogenic differentiation of human periodontal ligament cells (hPDLCs) remains unclear. The present study aimed verify methyltransferase‐like 3 (METTL3)‐mediated modification hPDLCs. Methods METTL3, Runx2, Osx, YAP mRNA expression was determined by qPCR. RUNX2, OSX, YTHDF1, YAP, IGF2BP1, eIF3a protein measured Western blotting immunofluorescence assays. levels were evaluated methylated RNA immunoprecipitation (MeRIP) dot blot analyses. MeRIP‐seq RNA‐seq used screen potential candidate genes. Nucleic acid interactions detected immunoprecipitation. Alizarin red staining evaluate Gene transcription promoter activities assessed luciferase reporter assays ( n ≥ 3). Results METTL3 modifications increased synchronously with hPDLCs p = .0016). gene identified RNA‐seq, its simultaneously increased. IGF2BP1‐mediated stability .0037), which turn promoted .0147). Furthermore, translation efficiency recruiting YTHDF1 initiation complex .0154), thereby promoting .0012). Conclusion Our revealed that METTL3‐initiated methylation promotes increasing increase translation. findings reveal mechanism METTL3‐mediated during hPDLC osteogenesis, providing therapeutic target for periodontitis alveolar defects.

Language: Английский

Citations

5
Increased of IL-18 levels are associated with periodontitis: a systematic review and meta-analysis DOI Creative Commons
Mario Alberto Alarcón‐Sánchez, Norma Samanta Romero-Castro, Julieta Saraí Becerra‐Ruiz

et al.

BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 23, 2024

The presence of a polymicrobial dysbiotic film in direct and constant contact with periodontal tissues initiates the host immune response. Interleukin 18 (IL-18) triggers up-regulates production other proinflammatory cytokines (TNF-α, IL-1β, IL-6), creating vicious cycle that expands inflammatory destructive process tissue. A systematic review meta-analysis was carried out main propose to investigate IL-18 expression different biological samples from subjects chronic periodontitis. protocol followed PRISMA guidelines registered Open Science Framework (OSF): https://doi.org/10.17605/OSF.IO/BS9GM . digital search conducted databases PubMed, ScienceDirect, Google Scholar, Web Dentistry & Oral Sciences Source were consulted March 15th, 2005 February 10th, 2023. Study quality assessed using JBI tool for cross-sectional studies clinical trials. performed random/fixed effects model evaluate concentration serum, plasma, saliva, gingival tissue GCF exposure group compared control group. strategy provided total 3,156 articles, which investigations met inclusion criteria 15 articles quantitatively analyzed. number patients studied 1,275 (682 cases 593 controls). revealed significantly elevated levels saliva periodontitis healthy (Serum: SMD = 62.73, 95%CI: 25.43-100.03, Z 3.29, p 0.001*; Saliva: 243.63, 8.68-478.59, 2.03, 0.042*; GCF: 150.26, 56.86-243.66, 3.15, 0.02*). could have potential be used as complementary diagnostic tools radiographic parameters

Language: Английский

Citations

4
Oral Health Status and Factors Associated with Oral Health in Patients with Alzheimer’s Disease: A Matched Case-Control Observational Study DOI Open Access
Reza Aghasizadeh Sherbaf,

George Michael Kaposvári,

Katalin Nagy

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1412 - 1412

Published: Feb. 20, 2025

Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disease, ranking as the seventh leading cause of death in both sexes. There increasing awareness role periodontal and severe tooth loss modifiable risk factor for developing AD. The aim present observational study was to assess AD patients with non-affected healthy controls context their dental health outcomes; additionally, potential impact anamnestic factors lifestyle habits on oral outcomes also studied. Methods: A total n = 41 receiving treatment at Department Psychiatry, University Szeged, were compared age- gender-matched from individuals seeking retirement homes (mean age 83.32 ± 7.82 years). Dental status indices assessed according World Health Organization (WHO) criteria. Results: Overall, 51.2%, 68.3%, 87.8% received mood stabilizers, drugs non-cognitive symptoms cognitive symptoms, respectively. Severe observed 43.9% 56.1% controls, no significant differences among regarding studied (p > 0.05 all indicators). had significantly higher plaque (%) (59.06 15.45 vs. 41.35 7.97; p < 0.001), bleeding probing (BOP%) (62.65 12.00 40.12 10.86; pocket depth [PD] (2.63 0.56 2.29 0.13; 0.002) attachment [AL] (2.85 0.79 2.39 0.41; 0.026) values, controls. Smoking (vs. non-smokers; 56.28 12.36 51.40 13.23, 0.038) consumption alcohol non-drinkers; 58.68 9.86 54.78 14.86, 0.040) associated [%], while similar effects shown parameters 0.05). In contrast, coffee intake vitamin supplement use effect or cases). Conclusions: results our underscore substantial needs patients, calling heightened healthcare professionals.

Language: Английский

Citations

0
Unraveling the Molecular Mechanisms of Vitamin Deficiency in Alzheimer's Disease Pathophysiology DOI Creative Commons

Vipul Sharma,

Khadga Raj Aran

Aging and Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 100226 - 100226

Published: March 1, 2025

Language: Английский

Citations

0
Chemometric Tools Associated with Quality Parameters for Evaluation of Mauritia flexuosa L.f. Oil in the State of Pará (Brazil) DOI Creative Commons
Braian Saimon Frota da Silva, Nelson Rosa Ferreira, Fábio dos Santos Gil

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1585 - 1585

Published: April 30, 2025

Mauritia flexuosa L.f. oil has high added value due to its antioxidant activity. This study evaluated the quality of 50 samples from eight regions Pará, using analytical and chemometric methods. Total carotenoids, polyphenols, flavonoids, vitamin C, acidity, peroxide, saponification, fatty acid indices were analyzed. Samples with higher residual load identified by Mahalanobis distance. Principal component analysis (PCA) highlighted total carotenoids as most relevant parameter, identifying three groups different levels biological activity (low, medium, high) significant cumulative variance. ANOVA did not indicate differences between regarding acids, but oleic was predominant in five regions. Nine are suitable for food sector, while others can be directed applications. The maximum concentrations C 1899 μg/g, 161.69 GAE/100 g, 125.02 mg EC/100 24.17 mg/100 respectively. demonstrated usefulness tools control this bioinput, facing local bioeconomy.

Language: Английский

Citations

0