Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 18, 2024
Abstract
Given
the
huge
impact
of
COVID-19
pandemic,
it
appears
paramount
importance
to
assess
cognitive
effects
on
population
returning
work
after
resolution.
Serum
levels
neurofilament
light
chain
(sNfL)
and
glial
fibrillary
acidic
protein
(sGFAP)
represent
promising
biomarkers
neuro-axonal
damage
astrocytic
activation.
In
this
cohort
study,
we
explored
association
between
sNfL
sGFAP
concentrations
performance
in
a
group
147
adult
workers
with
previous
asymptomatic
SARS-CoV-2
infection
or
mild
COVID-19,
one
week
and,
49
them,
ten
months
SARS-Cov2
negativization
compared
them
82
age
BMI-matched
healthy
controls
(HCs).
were
assessed
using
SimoaTM
assay
Neurology
2-Plex
B
Kit.
patients
interviewed
one-on-one
by
trained
physicians
had
complete
list
questionnaires,
including
Cognitive
Failure
Questionnaire
(CFQ).
At
first
assessment
(T0),
significantly
higher
than
HCs
(p
<
0.001
for
both).
The
eleven
impairment
others
=
0.005
subsequent
follow-up
(T1),
showed
significant
decrease
(median
18.3
pg/mL;
median
77.2
pg/mL),
although
they
still
7.2
pg/mL,
63.5
pg/mL).
Our
results
suggest
an
ongoing
involving
neurons
astrocytes
negativization,
which
reduce
even
if
evident
HCs.
Myalgic
Encephalomyelitis,
also
known
as
Chronic
Fatigue
Syndrome
(ME/CFS)
and
Long
COVID
are
characterized
by
debilitating
post-exertional
malaise
other
core
symptoms
related
to
immune
dysregulation
resultant
from
post-viral
infection,
including
mitochondrial
dysfunction,
chronic
neuroinflammation
gut
dysbiosis.
The
reported
associations
between
altered
microbiota
composition
cardinal
of
ME/CFS
COVID,
suggesting
that
use
microbial
preparations,
such
probiotics,
restoring
the
homeostasis
brain-immune-gut
axis
may
help
in
management
both
conditions.
Therefore,
this
review
aims
investigate
implications
alerted
microbiome
assess
evidence
supporting
microbial-based
synbiotics,
postbiotics
alone
and/or
combination
with
nutraceuticals
fatigue,
inflammation,
well
neuropsychiatric
gastrointestinal
among
patients
COVID.
Reviews in Medical Virology,
Journal Year:
2024,
Volume and Issue:
34(4)
Published: June 27, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
was
reported
in
December
2019
and
rapidly
became
a
pandemic
as
disease
(COVID-19).
Apart
from
other
organs,
presence
of
specific
receptor
angiotensin-converting
enzyme
(ACE2)
corresponding
proteases
such
transmembrane
serine
protease
2,
basigin
cysteine
cathepsin
L
make
follicular
somatic
cells
well
oocyte
potential
targets
for
SARS-CoV-2
infection.
The
causes
inflammation
hypoxia
that
generate
reactive
oxygen
species
(ROS)
critically
ill
patients.
In
addition,
large
number
casualties
insecurity
life
due
to
repeated
waves
infection
psychological
stress
cortisol
resulting
the
further
generation
ROS.
excess
levels
ROS
under
physiological
range
cause
meiotic
instability,
while
high
result
oxidative
trigger
various
death
pathways
affect
quality
oocytes.
Although,
emerging
evidence
suggests
utilises
cellular
machinery
ovarian
cells,
generates
impairs
oocytes,
underlying
mechanism
viral
entry
into
host
cell
its
negative
impact
on
remains
poorly
understood.
Therefore,
this
review
summarises
follicles
oocytes
functions
stressed
women.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 12, 2024
Omicron
variant
impacts
populations
with
its
rapid
contagiousness,
and
part
of
patients
suffered
from
persistent
symptoms
termed
as
long
COVID.
The
molecular
immune
mechanisms
this
currently
dominant
global
leading
to
COVID
remain
unclear,
due
heterogeneity
across
populations.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8045 - 8045
Published: July 24, 2024
Oxidative
stress
is
a
major
source
of
ROS-mediated
damage
to
macromolecules,
tissues,
and
the
whole
body.
It
an
important
marker
in
severe
picture
pathological
conditions.
The
discovery
free
radicals
biological
systems
gives
"start"
studying
various
processes
related
development
progression
many
diseases.
From
this
moment
on,
enrichment
knowledge
about
participation
free-radical
pathogenesis
cardiovascular,
neurodegenerative,
endocrine
diseases,
inflammatory
conditions,
infections,
including
COVID-19,
increasing
exponentially.
Excessive
responses
abnormal
reactive
oxygen
species
(ROS)
levels
may
disrupt
mitochondrial
dynamics,
risk
cell
damage.
In
addition,
low
serum
albumin
changes
normal
physiological
balance
between
reduced
oxidized
can
be
serious
prerequisite
for
impaired
antioxidant
capacity
body,
worsening
condition
patients.
This
review
presents
interrelationship
oxidative
stress,
inflammation,
levels,
which
are
hallmarks
COVID-19.
Background:
Nutritional
status
and
oxidative
stress
have
been
implicated
in
the
pathogenesis
persistence
of
long
COVID,
but
data
patients
undergoing
hemodialysis
(HD)
are
limited.
The
present
study
aimed
to
investigate
association
between
pre-infection
nutritional
status,
stress,
one-year
COVID
HD
patients.
Methods:
This
prospective
observational
cohort
enrolled
115
with
confirmed
COVID-19.
was
assessed
using
Controlling
Status
(CONUT)
score
twice:
before
infection
three
months
post-infection.
Oxidative
markers
included
malondialdehyde
(MDAs),
ceruloplasmin,
transferrin,
sulfhydryl
groups.
endpoint
persistence.
Results:
Moderate
CONUT
scores
were
associated
heightened
severe
undernutrition
risk
(p
&lt;
0.0001),
elevated
MDAs
reduced
ceruloplasmin
levels
=
0.0009)
at
post-COVID-19
compared
light
scores.
Pre-infection
independently
predicted
post-COVID
damage
[OR
2.3
(95%CI
1.2;
4.6),
p
0.0001]
[HR
4.6
1.4;
9.9),
0.0001],
even
after
adjusting
for
potential
confounders.
Conclusion:
increased
intensity
PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(8), P. e0309348 - e0309348
Published: Aug. 28, 2024
The
complex
effects
of
Long-COVID,
a
syndrome
marked
by
enduring
symptoms
after
COVID-19
infection,
with
an
emphasis
on
patients'
differing
degrees
fibro
fatigue
(FF).
Electrolyte
disturbances
may
affect
the
severity
FF
and
be
used
as
predictive
tool
for
severe
in
Long-COVID
patients.
Pathophysiology,
Journal Year:
2024,
Volume and Issue:
31(3), P. 436 - 457
Published: Aug. 28, 2024
The
assessment
of
endothelial
dysfunction
and
free
radical
homeostasis
parameters
were
performed
in
92
women,
aged
45
to
69
years,
divided
into
the
following
groups:
women
without
COVID-19
(unvaccinated,
no
antibodies,
control);
with
acute
phase
infection
(main
group,
COVID-19+);
12
months
post
COVID-19+;
anti-SARS-CoV-2
IgG
symptoms
last
(asymptomatic
COVID-19).
Compared
control,
patients
main
group
had
lower
glutathione
peroxidase
(GPx)
superoxide
dismutase
(SOD)
activities,
decreased
advanced
glycation
end
products
(AGEs)
level,
higher
reductase
(GR)
activity,
S
transferases
pi
(GSTpi),
thiobarbituric
acid
reactants
(TBARs),
endothelin
(END)-1,
END-2
concentrations
(all
Likarska sprava,
Journal Year:
2024,
Volume and Issue:
1, P. 15 - 23
Published: March 29, 2024
Стаття
присвячена
дослідженню
психоневрологічних
розладів
та
біохімічних
показників,
таких
як
середні
молекули,
окисна
модифікація
білків
перекисне
окислення
ліпідів,
що
виникають
у
пацієнтів
після
перенесеної
коронавірусної
хвороби
(COVID-19).
Автори
аналізують
результати
досліджень,
спрямованих
на
визначення
впливу
COVID-19
центральну
нервову
систему,
зокрема
нейрони
астроцити.
Дослідження
зосереджено
вивченні
зв'язку
між
нейрозапаленням
психічними
розладами,
можливостях
протизапального
лікування
в
контексті
постковідного
синдрому.
Окремий
акцент
робиться
визначенні
оптимальних
методів
діагностики
моніторингу
рівнів
середніх
молекул,
а
також
розгляді
важливості
окисної
модифікації
патогенезі
Ця
стаття
спрямована
фахівців
галузі
неврології,
психіатрії
імунології,
всіх,
хто
зацікавлений
аспектів
післяковідного
синдрому
можливих
стратегій
цих
порушень.
GeroScience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 29, 2024
Post-COVID
syndrome
manifests
with
numerous
neurological
and
cognitive
symptoms,
the
precise
origins
of
which
are
still
not
fully
understood.
As
females
older
adults
more
susceptible
to
developing
this
condition,
our
study
aimed
investigate
how
post-COVID
alters
intrinsic
brain
dynamics
in
whether
biological
sex
training
might
modulate
these
effects,
a
specific
focus
on
females.
The
participants,
aged
between
60
75
years,
were
divided
into
three
experimental
groups:
healthy
old
female,
female
male.
They
underwent
an
adaptive
task-switching
protocol.
We
analysed
multiscale
entropy
spectral
power
density
resting-state
EEG
data
collected
before
after
assess
neural
signal
complexity
oscillatory
power,
respectively.
found
no
difference
males
training,
indicating
that
similarly
affected
both
sexes.
However,
was
effective
only
males,
by
modulating
local
processing
capacity.
This
improvement
further
evidenced
comparing
females,
wherein
latter
group
showed
increased
finer
timescale
(1-30
ms)
higher
frequency
band
(11-40
Hz)
but
differences
disappeared
following
training.
Our
results
suggest
syndrome,
there
is
pronounced
shift
from
global
processing,
potentially
contributing
accelerated
aging
condition.
seems
offer
promising
intervention
method
for
changes
dynamics,
especially
among
