Treatment algorithm for chronic vertebrogenic back pain: the role of chondroprotectors DOI Creative Commons
О С Левин, Е Е Васенина,

Alexander Nebozhin

et al.

The Clinician, Journal Year: 2023, Volume and Issue: 17(2), P. 55 - 66

Published: Oct. 22, 2023

Back pain constitutes one of the major medico-social problems healthcare. The development a unified approach to diagnosis and treatment back is hindered since it difficult assess various approaches its treatment, especially chronic forms. Yet recent data witnessing important role neuroinflammatory process in pathogenesis degenerative forms discopathy suggest that traditional approach, which includes physical therapy exercises non-steroidal anti-inflammatory drugs myorelaxants, could be enhanced by using characterized slow structure-modifying action on structure cartilaginous tissue intervertebral discs joints. Given intelligent use manual therapy, needle reflex kinesiotherapy, as well modification psychosocial factors pre-determine yellow flag phenomenon, application sustained-release symptomatic increases efficacy prevents subsequent episodes. As today, placebo-controlled study has proven Alflutop, can administered both intramuscularly paravertebrally. This not only improves patients’ condition but also reduces burden associated with for society.

Language: Английский

High-Tech Methods of Cytokine Imbalance Correction in Intervertebral Disc Degeneration DOI Open Access
N. А. Shnayder,

Azamat V. Ashhotov,

Vera V. Trefilova

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13333 - 13333

Published: Aug. 28, 2023

An important mechanism for the development of intervertebral disc degeneration (IDD) is an imbalance between anti-inflammatory and pro-inflammatory cytokines. Therapeutic non-therapeutic approaches cytokine correction in IDD either do not give expected result, or a short period time. This explains relevance high-tech medical care, which part specialized care includes use new resource-intensive methods treatment with proven effectiveness. The aim review to update knowledge about based on IDD. It demonstrates promise management patients resistant previously used therapies, including: cell therapy (stem implantation, implantation autologous cultured cells, tissue engineering); genetic technologies (gene modifications, microRNA, molecular inducers IDD); influencing inflammatory cascade discs mediated by abnormal activation inflammasomes; senolytics; exosomal therapy; other factors (hypoxia-induced factors; lysyl oxidase; corticostatin; etc.).

Language: Английский

Citations

7
Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration DOI Creative Commons
Nan Wang,

Weihao Rong,

Yimin Xie

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 188, P. 112380 - 112380

Published: Feb. 22, 2024

Intervertebral disc degeneration (IVDD) constitutes a crucial pathological foundation for spinal degenerative diseases (SDD) and stands as primary contributor to both low back pain (LBP) disability. The progression of IVDD is linked structural functional alterations in tissues, where an imbalance the inflammatory microenvironment can induce extracellular matrix (ECM) degradation, senescence, apoptosis. This key pathomechanism disease's development, gaining considerable attention recent years. study aims conduct bibliometric analysis publications pertaining mechanisms quantitatively assess current research hotspots directions.

Language: Английский

Citations

2
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy DOI Creative Commons
Tao Xu,

Hongqi Zhao,

Jian Li

et al.

JOR Spine, Journal Year: 2024, Volume and Issue: 7(2)

Published: April 17, 2024

Intervertebral disk degeneration (IVDD) is a common spine disease, and inflammation considered to be one of its main pathogenesis. Apigetrin (API) natural bioactive flavonoid isolated from various herbal medicines shows attractive anti-inflammatory antioxidative properties; whereas, there no exploration the therapeutic potential API on IVDD. Here, we aim explore role IVDD in vivo vitro.

Language: Английский

Citations

2
Sinomenine Ameliorates IL-1β-Induced Intervertebral Disc Degeneration in Rats Through Suppressing Inflammation and Oxidative Stress via Keap1/Nrf2/NF-κB Signaling Pathways DOI Creative Commons

Gongbiao Lu,

Cunxin Zhang, Kang Li

et al.

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 4777 - 4791

Published: Oct. 1, 2023

Purpose: To investigate the molecular mechanism underlying inhibitory effect of sinomenine (SN) on interleukin-1β (IL-1β)-induced apoptosis in nucleus pulposus cells (NPCs), and to evaluate potential role SN preventing intervertebral disk degeneration (IDD). Methods: The Rat NPCs were cultured vitro identified using Hematoxylin-Eosin (HE) staining, toluidine blue immunofluorescence analysis. pretreated with or without SN, then induced IL-1β assess cell viability, ROS levels, apoptotic rates, wound healing ability. Relevant protein expression was detected Elisa, qPCR Western Blot techniques. either alone combination Nrf2-IN-1 SC, before being undergo by IL-1β. Apoptosis Hoechst while techniques assessed expression. caudal discs IDD, injection, co-injected levels IDD evaluated HE staining modified saffron-O-fix green cartilage staining. qPCR, Results: significantly reduced NPC activity, accumulation apoptosis, decreased rate, promoted secretion inflammatory factors, inhibited extracellular matrix synthesis. However, pretreatment effectively reversed these effects. Inhibition Keap1/Nrf2 signaling pathway activation NF-κB attenuated cytoprotective effects increased apoptosis. Acupuncture combined injection markedly disc rat spine, upregulated factors secretion, downregulated intervention notably enhanced antioxidant enzyme outcomes. Conclusion: can prevent IL-1β-induced ameliorate activating inhibiting pathway. Keywords: sinomenine, degeneration, cells, Nrf2,

Language: Английский

Citations

4
Treatment algorithm for chronic vertebrogenic back pain: the role of chondroprotectors DOI Creative Commons
О С Левин, Е Е Васенина,

Alexander Nebozhin

et al.

The Clinician, Journal Year: 2023, Volume and Issue: 17(2), P. 55 - 66

Published: Oct. 22, 2023

Back pain constitutes one of the major medico-social problems healthcare. The development a unified approach to diagnosis and treatment back is hindered since it difficult assess various approaches its treatment, especially chronic forms. Yet recent data witnessing important role neuroinflammatory process in pathogenesis degenerative forms discopathy suggest that traditional approach, which includes physical therapy exercises non-steroidal anti-inflammatory drugs myorelaxants, could be enhanced by using characterized slow structure-modifying action on structure cartilaginous tissue intervertebral discs joints. Given intelligent use manual therapy, needle reflex kinesiotherapy, as well modification psychosocial factors pre-determine yellow flag phenomenon, application sustained-release symptomatic increases efficacy prevents subsequent episodes. As today, placebo-controlled study has proven Alflutop, can administered both intramuscularly paravertebrally. This not only improves patients’ condition but also reduces burden associated with for society.

Language: Английский

Citations

0