MNAM enhances Blautia abundance and modulates Th17/Treg balance to alleviate diabetes in T2DM mice DOI
Jingfan Zhang, Yu Chen, Li Ling

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116593 - 116593

Published: Oct. 1, 2024

Language: Английский

Intestine-Settled Electrospun Short-Fibers Modulate Epithelial Transport Proteins to Reduce Purine and Glucose Uptake DOI
Yunkai Tang, Juan Wang,

Zhengwei Cai

et al.

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 15, 2024

Language: Английский

Citations

3
T-Cell Receptor Sequences Identify Combined Coxsackievirus–Streptococci Infections as Triggers for Autoimmune Myocarditis and Coxsackievirus–Clostridia Infections for Type 1 Diabetes DOI Open Access
Robert Root‐Bernstein

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1797 - 1797

Published: Feb. 1, 2024

Recent research suggests that T-cell receptor (TCR) sequences expanded during human immunodeficiency virus and SARS-CoV-2 infections unexpectedly mimic these viruses. The hypothesis tested here is TCR in patients with type 1 diabetes mellitus (T1DM) autoimmune myocarditis (AM) the infectious triggers of diseases. Indeed, mimicking coxsackieviruses, which are implicated as both diseases, statistically significantly increased T1DM AM patients. However, TCRs Clostridia antigens T1DM, whereas Streptococcal AM. Notably, autoantigens, such insulin glutamic acid decarboxylase, cardiac myosin laminins. Thus, may be triggered by combined coxsackieviruses bacteria, while Streptococci. These results consistent epidemiological clinical data recent experimental studies cross-reactivities coxsackievirus, Clostridial, antibodies antigens. provide basis for developing novel animal models a generalizable method revealing etiologies other Theories to explain explored.

Language: Английский

Citations

2
Potential contribution of gut microbiota in the development of autoantibodies in T1D children carrying HLA-DRB1/DQB1 risk alleles: an experimental and in silico analysis DOI
Ata Shirizadeh, Zahra Razavi, Vahid Saeedi

et al.

Immunogenetics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Language: Английский

Citations

1
MNAM enhances Blautia abundance and modulates Th17/Treg balance to alleviate diabetes in T2DM mice DOI
Jingfan Zhang, Yu Chen, Li Ling

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116593 - 116593

Published: Oct. 1, 2024

Language: Английский

Citations

0