Associations between per-and polyfluoroalkyl substances (PFAS) and county-level cancer incidence between 2016 and 2021 and incident cancer burden attributable to PFAS in drinking water in the United States

Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Background Exposure to per- and polyfluoroalkyl substances (PFAS) has been linked with various cancers. Assessment of PFAS in drinking water cancers can help inform biomonitoring prevention efforts. Objective To screen for incident cancer (2016–2021) assess associations contamination the US. Methods We obtained county-level age-adjusted incidence from Surveillance, Epidemiology, End Results (SEER) Program. Data on levels public systems were Third (UCMR3; 2013–2015) Fifth (UCMR5; 2023–2024) Unregulated Contaminant Monitoring Rule. UCMR3 measured PFOS, PFOA, PFNA, PFHxS, PFHpA, PFBS. UCMR5 expanded measurements include PFBA, PFHxA, PFPeA, PFPeS. created indicators detection and, UCMR5, concentrations above Maximum Levels (MCLs). MCLs PFOA PFOS are 4 ng/L, PFNA PFHxS 10 ng/L. used Poisson regression models between or MCL violation incidence, adjusting potential confounders. estimated number attributable cases. was associated increased digestive, endocrine, oral cavity/pharynx, respiratory systems. Incidence rate ratios (IRRs) ranged 1.02 1.33. The strongest association observed PFBS cavity/pharynx (IRR: 1.33 [1.04, 1.71]). Among males, urinary, brain, leukemia, soft tissues. females, thyroid, tissue. is contribute 4626 [95% CI: 1,377, 8046] cases per year based data 6864 991, 12,804] UCMR5. Impact statement ecological study examined two waves (2013–2015 2016 2021. found that organ system including lung, digestive system, urinary tissue, thyroid. Some have not widely studied their PFAS. also sex differences risks. This first exposure

Language: Английский

---

Association between exposure to per- and polyfluoroalkyl substances (PFAS) and chronic cough in American adults: Results from NHANES 2003–2012

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117901 - 117901

Published: Feb. 1, 2025

Chronic cough, which affects approximately 10 % of the global population, is recognized as a significant health issue, especially among females. Recent research suggests that chronic cough may be an independent disease rather than merely symptom other conditions. This study focuses on potential role exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) in development noting PFAS has been linked various adverse outcomes. We aimed explore association between risk U.S. analyzing data from National Health Nutrition Examination Survey (NHANES) 2003 2012 examining sex-based differences. Our findings reveal several factors independently associated with increased incidence including elevated levels serum perfluorobutane sulfonic acid (PFBS) perfluoroheptanoic (PFHP). The multi-pollutant models consistently demonstrated positive correlation higher adult males, PFBS PFHP primary contributors. However, due cross-sectional design NHANES study, further necessary elucidate precise mechanisms by contribute cough.

Language: Английский

---

Association between per- and polyfluoroalkyl substances exposure and prevalence of chronic obstructive pulmonary disease: The mediating role of serum albumin

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171742 - 171742

Published: March 15, 2024

No study has examined the association between per- and polyfluoroalkyl substances (PFAS) exposure chronic obstructive pulmonary disease (COPD) risk. This aims to explore this relationship. enrolled 4541 individuals who had unavailable data on PFAS, COPD, covariates from NHANES 2007–2018. Serum PFAS including perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS) were analyzed, because of high detective rates. Considering skew distribution levels, natural logarithm-transformed (Ln-PFAS) was used. Logistic regression analysis, restricted cubic spline (RCS), weighted quantile sum (WQS) performed single, nonlinear, mixed effects. A mediating analysis used evaluate mediated effects albumin. Individuals with COPD higher levels PFHxS, PFNA, PFOA, PFOS compared those without COPD. Ln-PFNA (OR males: 1.92, 95 % CI:1.31 2.80, P: <0.001; OR females: 1.07, CI: 0.81 1.40, 0.636) ln-PFOA 2.17, CI:1.38 3.41, 1.49, 1.08 2.05, 0.016) associated risk especially in males. The interaction PFNA sex significant (P interaction: <0.001). RCS curve demonstrated nonlinear relationship nonlinear:0.001), ln-PFNA nonlinear:0.045), WQS showed correlated males (OR: 1.44, CI:1.18 1.75, Albumin PFOA (mediated proportion: −17.94 %). concludes are linked a males, serum albumin plays role Thess findings beneficial for prevention Further studies required potential mechanisms.

Language: Английский

---

Emerging perfluoroalkyl substances retard skeletal growth by accelerating osteoblasts senescence via ferroptosis

Environmental Research, Journal Year: 2024, Volume and Issue: 258, P. 119483 - 119483

Published: June 22, 2024

Language: Английский

---

Associations of PFAS and pesticides with lung function changes from adolescence to young adulthood in the ESPINA study

International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 265, P. 114526 - 114526

Published: Feb. 3, 2025

Language: Английский

---

Exposure-effect of PFOS and PFOA on lung function: An integrated approach with epidemiological, cellular, and animal studies

Environmental Research, Journal Year: 2025, Volume and Issue: 272, P. 121175 - 121175

Published: Feb. 19, 2025

Language: Английский

---

Associations between co-exposure to per- and polyfluoroalkyl substances and metabolic diseases: The mediating roles of inflammation and oxidative stress

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 953, P. 176187 - 176187

Published: Sept. 10, 2024

Language: Английский

---

Occurrence of a “forever chemical” in the atmosphere above pristine Amazon Forest

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 944, P. 173918 - 173918

Published: June 12, 2024

Per- and polyfluoroalkyl substances (PFAS), often referred to as "forever chemicals", are a class of man-made, extremely stable chemicals, which widely used in industrial commercial applications. Exposure some PFAS is now known be detrimental human health. By virtue long residence times, they detected the environment, including remote locations such Arctics, where origin poorly understood. It has been suggested that may transported through contaminated waters, leading accumulation coastal areas, can aerosolised via sea spray, thereby extending their geographical distribution far beyond original source regions. The aim this work investigate, for first time, whether chemicals" could areas considered pristine, from sites. This study was performed at Amazonian Tall Tower Observatory (ATTO), unique site situated middle Amazon rainforest, restricted PFAS, perfluorooctanoic acid (PFOA), observed with concentrations reaching up 2 pg/m3. A clear trend increasing concentration sampling height air masses south over Manaus had highest concentrations. Atmospheric lifetime estimations, removal mechanisms supported by measurements two heights (320 42 m above rainforest), spikes indicated long-range transport PFOA pristine rainforest. Potential sources, activities urban were explored, historical fire management practices considered. research presents atmosphere Remarkably, even natural appreciable levels detected. provides valuable insights into anthropogenic chemical" ecosystem should raise awareness potential environmental implications.

Language: Английский

---

Per- and poly-fluoroalkyl substances (PFAS) effects on lung health: a perspective on the current literature and future recommendations

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: July 18, 2024

Per- and poly-fluoroalkyl substances (PFAS) are a broad class of synthetic compounds widely used in commercial applications. The persistent nature PFAS the environment has earned them epithet “forever chemicals.” Concerns arise from widespread exposure to occupational, household, environmental sources. This use is particularly concerning, as emerging epidemiological evidence highlights their adverse effects on lung health. Such impacts include impaired fetal development, reduced immune function children, potential links cancer. Both vivo vitro studies illuminate mechanisms underlying such health outcomes subsequent inhalation exposure, which may immunomodulation, oxidative stress, disruptions epithelial barriers. However, evidence-based information focusing PFAS-mediated injury lacking. Additionally, discrepancies between data collected animal highlight need for improved approaches better understand toxicity results exposure. To address these gaps, we recommend leveraging route-to-route extrapolation risk assessment, prioritizing research understudied PFAS, adopting physiologically relevant, high-throughput approaches. These strategies aimed at enhancing our understanding effects, aiding more informed management decisions. In this review, summarize current literature emphasizing its health, through inhalation. We then discuss knowledge tissue- cellular-level caused by PFAS.

Language: Английский

---

Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 98(1), P. 207 - 221

Published: Nov. 13, 2023

Abstract Perfluorooctane sulfonate (PFOS) is widely used in industry and consumer products. Previous studies have showed that PFOS gestational exposure associated with offspring lung damage rat. However, the underlying mechanisms remain poorly understood. In this study, we investigated role of gasdermin E (GSDME) injury its using vivo vitro approaches. Pregnant SD rats were exposed to (1 mg/kg BW/d) between day 12–18, tissue was evaluated on postnatal 7. treated animals exhibited alveolar septal thickening inflammation-related damages, an increased expression GSDME type II epithelial cells (AECII). Furthermore, experiments demonstrated (with 225 μM up) upregulated caspase-3/GSDME signaling pathway AECII. Also, ultrastructure analysis revealed significant changes endoplasmic reticulum (ER) structure PFOS-induced pyroptotic cells, which consistent ER stress detected these cells. Additionally, led stress-related proteins, including p-PERK, p-eIF2α, ATF4, CHOP. Subsequently, specific inhibitors, found PERK/ATF4 acted as upstream signal regulating GSDME-dependent pyroptosis. Overall, our findings show pyroptosis plays a crucial induced by exposure, may function possible mediator process.

Language: Английский

---