Formulation and development of a body gel scrub using Areca catechu L. seed extract and microbeads DOI Creative Commons
Jiraporn Chingunpitak, Attawadee Sae Yoon,

Katanyoo Pannoi

et al.

Pharmacia, Journal Year: 2023, Volume and Issue: 70(4), P. 1373 - 1383

Published: Nov. 21, 2023

The purpose of this study was to develop and evaluate an antioxidant body gel scrub formulation including Areca seed extract beads. ethanol had IC50 183.30 µg/ml, a radical scavenging activity 49.196%, total phenolic content 21.21 ± 2.32 µg/ml. With pH 6.98 at 25 °C viscosity 5,590.457 cP, the optimized contained 1% w/w extract, 5% polyvinyl alcohol, 0.5% Carbomer Ultrez 21, microbeads. efficiency 68.66%. Stability tests were carried out under accelerated heating cooling conditions 40 2 °C, 75 % RH for 48 hours, followed by 4 hours each cycle 24 days (6 cycles) 30 75% RH, no significant changes in physical or chemical properties observed. This shows potential use skincare applications due its stability.

Language: Английский

Biological Effects and Biomedical Applications of Areca Nut and Its Extract DOI Creative Commons
Ting Tong,

Aiqing Xu,

Shuhua Tan

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(2), P. 228 - 228

Published: Feb. 8, 2024

The dried, mature fruit of the palm tree species

Language: Английский

Citations

7
Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control DOI Creative Commons

Yuanyuan Sun,

Jian Feng,

Wencheng Hou

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Areca nut (AN), the fruit or seed of catechu Linn, has many uses, including chewing and medicinal purposes. It sparked worries about health due to presence alkaloids. Chewing AN may have a variety negative consequences; however, use no notable adverse effects. To completely understand effectively AN, researchers investigated its chemical makeup biological activity, analyzed variations between different species periods, improved extraction processing procedures. Today, an increasing number are exploring underlying reasons for variations, as well molecular mechanisms biosynthesis components, comprehend change at genetic level. This review presents overview clinical study, pharmacology, detection main bioactive components in factors influencing their content, delving into omics applications research. On basis discussions summaries, this identifies current research gaps proposes future directions investigation.

Language: Английский

Citations

4
Areca catechu L. Extract Inhibits Colorectal Cancer Tumor Growth by Modulating Cell Apoptosis and Autophagy DOI Creative Commons
Meng-Hsiu Tsai, Chang‐Han Chen, Chien-Lin Chen

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 128 - 128

Published: Feb. 17, 2025

Colorectal cancer (CRC) is a common globally, and chemotherapy often causes severe complications, necessitating effective drugs with minimal side effects. As Areca catechu L. extract (ACE) Traditional Chinese Medicine that contains numerous active compounds anticancer effects, in this study, the Cell Counting Kit-8 (CCK-8) assay was used to determine ACE's effect on CRC cell lines, revealing it significantly inhibits CoLo320DM HCT116 cells. In vivo experiments NU-Foxn1nu mice indicated ACE tumor growth, while flow cytometry revealed higher concentrations increased apoptosis ROS levels. Next-generation sequencing (NGS) showed increases fold changes apoptosis, DNA damage, autophagy-related genes inhibiting proliferation Wnt signaling pathway genes. We conducted Western blotting confirm these findings. Overall, demonstrates potential as drug candidate by promoting autophagy, reducing viability thus offering new approach for colorectal treatment

Language: Английский

Citations

0
Assessing the carcinogenic potential and molecular mechanisms of arecoline in human lungs: from in silico methods to in vitro validation DOI Creative Commons
Wenwen Wang

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118108 - 118108

Published: March 28, 2025

Language: Английский

Citations

0
Analysis of areca alkaloids and their conversions using CE-C4D and identification by CE-MS DOI

Jinying Huang,

Juntao Ran,

Jingtong Xia

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144228 - 144228

Published: April 1, 2025

Language: Английский

Citations

0
Arecoline regulates glycolipid and endoplasmic reticulum metabolisms in adult grass carp (Ctenopharyngodon idella) DOI Creative Commons

Liangqin Wu,

Na Yao,

Wei‐Dan Jiang

et al.

Animal nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Effect of areca nut extracts on growth performance, slaughtering performance, and meat quality of broiler chickens DOI Creative Commons

Juan Xu,

Mengyao Li, Rong Li

et al.

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Introduction Since the comprehensive ban on addition of antibiotics to livestock and poultry feeds in China, search for safe natural antibiotic substitutes has become a hot spot animal breeding industry. Areca catechu L (AN), known as leader among four southern medicinal herbs, possesses functions such insecticidal, antibacterial, antiinflammatory, promoting gastrointestinal motility preventing Alzheimer's disease. Nevertheless, ANE is rarely used feed additive AA broilers, its specific role remains unclear. This study was conducted investigate effects different levels areca nut extracts (ANE) growth performance, slaughter performance meat quality broiler chickens. Methods 128 one-day-old Arbor Acres broilers were randomly divided into eight groups 16 birds each, housed three cages with 5-6 per cage, or without supplementation (0, 100, 150, 200, 250, 300, 350, 400 mg/kg, respectively). Results The entire experiment duration 49 days. Adding 100 200 mg/kg diet could significantly increase body weight at 21 days age ( P ≤ 0.001), reduce feed-to-weight ratio from 1 0.001). supplemented average = Compared control group, dosages improve pH 45min , yellowness, shear force 0.043) pectoral leg muscles broilers. Additionally, contents crude fat protein, which are nutritional components ANE-supplemented groups, an extent higher than those group 0.036). raised expression muscle development-related genes, including Myf5, Myf6, MyoD1, IGF-1 IGF-2 0.032). Discussion In conclusion, An appropriate amount been demonstrated boost facilitate development, no remarkable influence performance. ideal dosage 100–200 ANE. findings this offer valuable insights potential benefits production, provide basis further research development new additive.

Language: Английский

Citations

0
A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression DOI Creative Commons
Zhongjing Jiang,

Linhua Deng,

Gang Xiang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 430 - 430

Published: March 31, 2024

Iron overload-associated osteoporosis presents a significant challenge to bone health. This study examines the effects of arecoline (ACL), an alkaloid found in areca nut, on metabolism under iron overload conditions induced by ferric ammonium citrate (FAC) treatment. The results indicate that ACL mitigates FAC-induced inhibition osteogenesis zebrafish larvae, as demonstrated increased skeletal mineralization and upregulation osteogenic genes. attenuates FAC-mediated suppression osteoblast differentiation MC3T3-E1 cells. RNA sequencing analysis suggests protective are related regulation ferroptosis. We demonstrate inhibits ferroptosis, including oxidative stress, lipid peroxidation, mitochondrial damage, cell death FAC exposure. In this study, we have identified heme oxygenase-1 (HO-1) critical mediator inhibiting ferroptosis promoting osteogenesis, which was validated HO-1 knockdown knockout experiments. links activation context metabolism. These findings provide new insights into mechanisms underlying modulation ACL. Targeting HO-1/ferroptosis axis is promising therapeutic approach for treating overload-induced diseases.

Language: Английский

Citations

3
Anti-Neuroinflammatory Potential of Areca Nut Extract and Its Bioactive Compounds in Anthracene-Induced BV-2 Microglial Cell Activation DOI Open Access

Sakawrat Janpaijit,

Monruedee Sukprasansap, Tewin Tencomnao

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2882 - 2882

Published: Aug. 28, 2024

Particulate matter (PM2.5) containing polycyclic aromatic hydrocarbons (PAHs) is of considerable environmental importance worldwide due to its adverse effects on human health, which are associated with neurodegenerative diseases (NDDs). Areca catechu L. (AC) fruit known possess various pharmacological properties; however, the anti-neuroinflammatory roles AC suppression PAH-induced neuroinflammation still limited. Thus, we focused and related signaling cascades active compounds against anthracene-induced toxicity inflammation in mouse microglial BV-2 cells. Phytochemicals ethanolic extract (ACEE) were identified using LC-MS, molecular docking was conducted screen interaction between target proteins. Significant bioactive ACEE such as arecoline, (−)-epicatechin, syringic acid evinced through LC-MS spectrum. The study revealed that (−)-epicatechin showed highest binding affinities NF-κB. For cell-based approaches, anthracene induced intracellular ROS, mRNA levels TNF-α, IL-1β, IL-6, release TNF-α enhancing JNK, p38, NF-κB pathways. However, co-treatment cells or could reverse those changes. overall suggested ACEE-derived may be developed a potential agent by preventing inflammation-mediated NDDs.

Language: Английский

Citations

3
Exploring the Perceptions of Indian Mental Health Professionals Regarding Areca (Betel) Nut Products: A Cross-sectional Study DOI Creative Commons
Anusa Arunachalam Mohandoss, Shahul Ameen, Rooban Thavarajah

et al.

Indian Journal of Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Background: Areca nut (AN) and AN products (ANPs) are commonly used as psychoactive substances with marked dependence potential. Scant information exists on the Indian mental health professionals’ (MHPs) knowledge of AN-ANPs, attitude toward AN-ANP use/users, behavior regarding their clients’ use. To address this gap, a survey was undertaken to assess MHPs’ knowledge, attitudes, behavioral responses use addiction. Methods: We developed pretested, customized questionnaire conducted cross-sectional online among random sample MHPs. Results: The 209 respondents included 91 psychiatrists, 105 clinical psychologists, 13 other MHPs from diverse settings. Among them, 46.89% believed that does not fit definition abuse/addiction per Diagnostic Statistical Manual Mental Disorders, Fifth Edition or International Classification Diseases 10th Revision (ICD-10)/ICD-11. MHPs, 60.4%, 48.6%, 61.5% were unaware any cessation protocols. addictive potential tobacco rated severe by 68.1% psychiatrists 51.4% psychologists; 46.2% it moderate. without moderate 50.5% psychologists mild psychiatrists. Of sample, 67.46% discussed harmful effects AN-ANPs clients, while 74.6% said few none clients sought help for cessation. Conclusion: Major lacunae detected in understanding about management aspects, etc. An urgent need has been revealed sensitization programs development evidence-based

Language: Английский

Citations

1